Catalytic Reductive Coupling Reactions - Michigan State University
Catalytic Reductive Coupling Reactions - Michigan State University
Catalytic Reductive Coupling Reactions - Michigan State University
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Total Synthesis of Amphidinolide T1 and T4MeMeHO♦OMeOCH 2* *O*MeOO♦nickel-catalyzed alkyne-aldehydereductive coupling (intramolecular)nickel-catalyzed alkyne-epoxidereductive coupling (intermolecular)HO♦MeOCH 2MeOOMeamphidinolide T1Meamphidinolide T4OONMeOMeMeTBSOTMSMePhNi(COD) 2 (10 mol%)Bu 3 P (20 mol%)Et 3 B,MeOTBSOTMSMePh81% yield>99% drMePhOHMeMePhMeColby, E. O’Brien, K.; Jamison, T. J. Am. Chem. Soc. 2005, 127, 4297—4307.OH40-44% yield>95:5 dr