Hyaluronic Acid

Role of gel systems in initiation ofpathological processes of tissueVITREOUSBODYDegradation and depolymerization of the gel systemhyaluronate-collagen in the vitreous body matrix incresestotal number of molecules in the closed volume of theeye, what triggers increase of the intraocular pressureand hence leads to the consecutive vigorous destructionof tertiary and quaternary structures of hyaluronate –collagen complex matrix.Ref.: Lapčík L., Chabreček P., Staško A.: Biopolymers,31, (1991), 1429.Lapčík L., Schurz J.: Colloid Polym. Sci., 269, (1991),633.!Riboflavinesensitizeproduction 1 O 2Loss ofviscoelasticityDegradation by 3 O 1 2O 220