Hyaluronic Acid

Rheological BehaviorThe 100 mol.% modified hexyloxy-HAform spatially larger macromolecularcoils then the 6.9 mol.% modifiedchains. It seems, that the latter arepresent in a more dense configuration,what is reflected in the lower viscosity.The presence of the hydrophobicmicrodomains on the polymer chain isindicated by the decrease of the slopeof the reduced viscosity dependencies,i.e. the decrease of the Huggin'sconstant.Reduced viscosity1.00.80.60.40.20.00.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5Conc. (mg/mL)Huggin's plots of the η sp/c = f(c) dependencies ofthe 100 mol.%-modified hexyloxy-HA (empty circle)and native HA (full circle) as measured by theUbbelohde capillary viscometer at 25°C.36