Hyaluronic Acid

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DSC Thermal AnalysisAn endothermic peak temperature Tmat (+) 0.96°C is characteristic for freewater while the appearance of thebroad exothermic peak temperatureTcc2 at (-) 3.96°C reflects thepresence of the water hexamericstructure. The glass transitiontemperature was shifted to (+)31.00°C and the cold-crystallizationtemperature to (-) 0.58°C.Heat Flow (W/g)-0.08-0.10-0.12-0.14-0.16-0.18ExoT CCT CCT mT g-0.20-20 -10 0 10 20 30 40Temperature (°C)DSC heating curve of the 100 mol.% modifiedhexyloxy-HA.40
DSC Thermal AnalysisThe main DSC characteristics, i.e. Tcc((-) 1.01°C), Tm ((-) 0.80°C and Tg((+)30.29°C) were shifted to lowertemperatures compared to hexyloxymodified HA. A new endothermic peaktemperature at (+) 5.57°C ischaracteristic for the transition fromthe liquid crystalline state to theisotropic liquid state (T*).The lowering of the Tcc and the Tmpeak temperatures in comparison tothe original rooster comb HA can bedue to the weaker binding of watermolecules in the modified polymer.This interaction results from theformation of somehow spatiallyoriented hydrophobic and hydrophilicmoieties in the polymer backbone,thus leading to their self-association.Heat Flow (W/g)-1.48-1.50-1.52-1.54ExoT mT CCT *Liquid Crystal Phase-1.56-20 -10 0 10 20 30 40Temperature (°C)DSC heating curve of the 6.97 mol.% modifiedpentadecyloxy-HA.T g41
Page 1 and 2: Hyaluronic Acid: Structure, Propert
Page 3: Types of network structuresDivided
Page 7 and 8: Mechanical properties of polymeric
Page 9 and 10: Gel systemsGel definition:In 19. ce
Page 11 and 12: Gel systemsGel definition:Newtonian
Page 13 and 14: Gelation of polymersIs influenced b
Page 15 and 16: Natural biomaterials application In
Page 17 and 18: Intelligent polymeric surfaces/inte
Page 19 and 20: Intelligent polymeric surfaces/inte
Page 21 and 22: Role of gel systems in initiation o
Page 23 and 24: Macromolecular characterPolyelectro
Page 25 and 26: Macromolecular characterConformatio
Page 27 and 28: Hydrodynamic behavior and interacti
Page 29 and 30: Chemical derivatization of HA - Hyl
Page 31 and 32: CHEMICAL MODIFICATION OFHYALURONIC
Page 33 and 34: Molecular StructureThe monomer unit
Page 35 and 36: Rheological BehaviorThe dynamic vis
Page 37 and 38: Size Exclusion ChromatographyTo con
Page 39: DSC Thermal AnalysisEndothermic fre
Page 43 and 44: HA Alkylation - ConclusionsBased on

Hyaluronic Acid

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