Hyaluronic Acid

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HA primary molecular structureHA is a linear, unbranched polymer. By chemical and enzymatic methods, Meyerand co-workers found HA to be composed of a repeating disaccharide thatconsists of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcA) linked bya β 1-4 glycosidic bond. The disaccharides are linked by β 1-3 bonds to form the HAchain.22
Macromolecular characterPolyelectrolyte propertiesHA in solution behaved hydrodynamically like a large solvated sphere containing athousand times more water than organic material.Upon complete ionization of the carboxylic groups within D-glucuronic acid, thecharges are about 1 nm from each other. These charges are influenced by the ionicstrength and pH of the environment and, in turn, influence the shape of the chains andtheir interactions with surrounding molecules.In 1957, Laurent compared static light scattering and viscosity results of sodiumhyaluronate in water and cetylpyridinium hyaluronate in methanol. He showed that theradius of gyration, which was 200 nm in the former solution and 120 nm in the latter,depends on the solvent, and he argued that the decrease of the radius of gyration incetylpyridinium hyaluronate was due to a collapse of the chain as the charges becomeneutralized.Cleland showed that HA chains contract with increasing ionic strength and decreasingpH, which indicates their polyelectrolyte behavior.23
Page 1 and 2: Hyaluronic Acid: Structure, Propert
Page 3: Types of network structuresDivided
Page 7 and 8: Mechanical properties of polymeric
Page 9 and 10: Gel systemsGel definition:In 19. ce
Page 11 and 12: Gel systemsGel definition:Newtonian
Page 13 and 14: Gelation of polymersIs influenced b
Page 15 and 16: Natural biomaterials application In
Page 17 and 18: Intelligent polymeric surfaces/inte
Page 19 and 20: Intelligent polymeric surfaces/inte
Page 21: Role of gel systems in initiation o
Page 25 and 26: Macromolecular characterConformatio
Page 27 and 28: Hydrodynamic behavior and interacti
Page 29 and 30: Chemical derivatization of HA - Hyl
Page 31 and 32: CHEMICAL MODIFICATION OFHYALURONIC
Page 33 and 34: Molecular StructureThe monomer unit
Page 35 and 36: Rheological BehaviorThe dynamic vis
Page 37 and 38: Size Exclusion ChromatographyTo con
Page 39 and 40: DSC Thermal AnalysisEndothermic fre
Page 41 and 42: DSC Thermal AnalysisThe main DSC ch
Page 43 and 44: HA Alkylation - ConclusionsBased on

Hyaluronic Acid

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