Post-transcriptional control of gene expression
Post-transcriptional control of gene expression
Post-transcriptional control of gene expression
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SummarydsRNA is an important regulator <strong>of</strong> <strong>gene</strong> <strong>expression</strong> in many eukaryotes;it triggers different types <strong>of</strong> <strong>gene</strong> silencing that are collectively referred toas RNA silencing or RNA interferenceKey stepprocessing <strong>of</strong> dsRNA (microRNAs percursors)(variable lenght and origin)into short RNA duplexes (siRNAs or miRNAs )dsRNA guide RNA silencingby specific and distinct mechanismsRNA cleavageTranslational repression <strong>of</strong> complementary ssRNAs(mRNAs, or viral genomic/antigenomic RNAs)Guiding chromatin modificationmiRNAs could be as important as transcription factorsin regulating <strong>gene</strong> <strong>expression</strong> in higher eukaryotes
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