Post-transcriptional control of gene expression
Post-transcriptional control of gene expression
Post-transcriptional control of gene expression
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Examples <strong>of</strong> RNA editing in mammalsTissue Target RNA Change CommentsIntestine Apolipoprotein B mRNA C U Converts a glutamine codon to a stop codonMuscle α-galactosidase mRNA U A Converts a phenylalanine codon into a tyrosine codonTestis, tumors Wilms tumor-1 mRNA U C Converts a leucine codon into a proline codonTumors Neur<strong>of</strong>ibromatosis type-1 mRNA C U Converts an arginine codon into a stop codonB lymphocytes Immunoglobulin mRNA Various Contributes to the <strong>gene</strong>ration <strong>of</strong> antibody diversityHIV-infected cells HIV-1 transcript G A,C UInvolved in regulation <strong>of</strong> the HIV-1 infection cycleBrain Glutamate receptor mRNA A inosine Multiple positions leading to various codon changes
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