No. 1031 - Miljøstyrelsen

10
CAS no Synonym
Test Exposure
route
Species / model Conc. Exposure
period
Result/Effects NOAEL /
LOAEL
EPA DCN/Ref.
556-67-2 D4 kinetics, effect on inhalation, human 10 ppm one hour mean deposition was 12%
not relevant 86980000017
immunologi-cal
parameters, blood
chemistry and pulmonary
factors
mouthpiece
and nasal
exposure
peak plasma concentration was 78 ng/ml
rapid elimination from plasma after exposure termination (25
ng/ml; 6 hr and 4 ng/ml; 24 hr)
no effect on blood chemistry
no immunotoxic or proinflammatory/adjuvant effects
1997
556-67-2 D4 kinetics, 13C-D4 dermal human (3♀,3♂) 1.4 g (♂), 1 g (♀) 1, 2, 4, 6 and D4 levels significantly elevated above baseline in blood and not relevant 86010000007
24 hours plasma at 1, 2, 4 and 6 hrs and in exhaled air at all time points
female subjects had significantly higher blood and plasma
levels compared to male subjects
2000
556-67-2 D4 kinetics, pilot study oral gavage, rat (♀) pre-treatment: PB: pre-treatment: Phenobarbital but not 3-MC pre-treatment increases the not relevant 86980000037
to determine if inducing
agents alter
the metabolic profile
of a single dose 14C-
D4
i.p. and i.v.
80 mg/kg i.p.; 3-
MC: 30 mg/kg i.p.
14C-D4: 70 mg/kg
i.v. or oral gavage
once per day
for 4 consecutive
days;
single administra-tion
of
14C-D4 the
next day
amount and rate of urinary excretion
PB pre-treatment did not change urinary metabolic of D4
profíle
evidence that PB-inducible enzymes are involved in metabolism
of D4 in rats
1997
556-67-2 D4 non-regulated study: intravenously rat (♀,♂), Fisher not stated no data ring opening and demethylation occurs (oxidation and hy- no data 86980000032
identification of
344
drolysis)
86980000072
metabolites in urine
(14C-D4)
major metabolites constituting 75 - 85% of the total radioactivity
were dimethylsilanediol, methylsilanetriol
minor metabolites were tetramethyldisiloxane-1,3-diol
[Me(2)Si(OH)-O-Si(OH)Me(2)], hexamethyltrisiloxane-1,5-diol
[Me(2)Si(OH)-OSiMe(2)-OSi(OH)Me(2)], trimethyldisiloxane-1,3,3-triol
[MeSi(OH)(2)-O-Si(OH)Me(2)], dimethyldisiloxane-1,1,3,3-tetrol
[MeSi(OH)(2)-O-Si(OH)(2)Me], and dimethyldisiloxane-1,1,1,3,3-pentol
[Si(OH)(3)-O-Si(OH)(2)Me].
no parent D4 present in urine
1997