No. 1031 - Miljøstyrelsen

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66 EPA DCN 86980000048. 1997. Three-Month Repeated Dose Inhalation Toxicity Study with Hexamethyldisiloxane in Rats. Siloxane Research Program, Reston. EPA DCN 86980000049. 1997. An Inhalation Range-Finding Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Male Rats. Siloxane Research Program, Reston. EPA DCN 86980000061. 1997. An Inhalation Range-Finding Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Male Rats. Siloxane Research Program, Reston. EPA DCN 86980000072. 1997. Immunological Evaluation of D4 Using 28- Day Exposure in Male and Female Rats. Siloxane Research Program, Reston. EPA DCN 86980000153. 1998. An Inhalation Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Female Rats Using Multiple Exposure Regimems. Siloxane Research Program, Reston. EPA DCN 86980000163. 1998. Absorption of C14- Octamethylcyclotetrasiloxane Using the Flow-Through Diffusion Cell System for In-vitro Dermal Absorption in Human Skin. Siloxane Research Program, Reston. EPA DCN 86980000182. 1998. Three-Month Repeated Dose Whole Body Inhalation Toxicity Study with Hexamethyldisiloxane in Rats. Siloxane Research Program, Reston. EPA DCN 86980000184. 1998. An Oral Gavage Study to Compare the Absorption Potential of 14C-Octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats When Delivered in Various Carriers. Siloxane Research Program, Reston. EPA DCN 86990000015. 1998. Clinical Studies on the Immune Effects of Gastrointestinal Exposure to Octamethylcyclotetrasiloxane (D4). Siloxane Research Program, Reston. EPA DCN 86990000017. 1998. Evaluation of Octamethylcyclotetrasiloxane (D4) as an Inhibitor of Human Cytochrome P450 Enzymes. Siloxane Research Program, Reston. EPA DCN 86990000029. 1999. Effects of Repeated Whole Body Inhalation Exposure to Octamethylcyclotetrasiloxane (D4) Vapors on Hepatic Microsomal CYP2B1/2 Induction in Female Fischer 344 Rats: A Dose- Response Study. Siloxane Research Program, Reston. EPA DCN 86990000032. 1999. A Two-Generation Inhalation reproductive Toxicity and Developmental Neurotoxicity Study of Decamethylcyclopentasiloxane (D5) in Rats. Siloxane Research Program, Reston. EPA DCN 86990000058. 1999. An Inhalation Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Female Rats Using Multiple and Single-Day Exposure Regimens. Siloxane Research Program, Reston. EPA DCN 86990000059. 1999. Interim Risk Assessment of D4 Reproductive Effects. Siloxane Research Program, Reston.
EPA, August 2003. Siloxane D5 in Drycleaning Applications. Fact Sheet. EPA/744-F-03-004. European Commission, Joint Research Centre (2000): International Uniform Chemical Information Database. IUCLID CD-ROM, Existing Chemicals – Year 2000 edition. http://ecb.jrc.it/IUCLID-Data-Sheet/556672.pdf European Commission, Joint Research Centre (2000): International Uniform Chemical Information Database. IUCLID CD-ROM, Existing Chemicals – Year 2000 edition. http://ecb.jrc.it/IUCLID-Data-Sheet/107460.pdf Fendinger, N.J., R.G. Lehmann & Mihaich. E.M. 1997. Polydimethylsiloxane. In: Chandra, H.G (Ed.). The handbook of environmental chemistry. Vol 3. part: Organosilicon Materials. Springer-Verlag, Berlin. Hobson, J.F., Atkinson, R and Carter, W.P.L. 1997. Volatile methylsiloxanes. In: Chandra, H.G (Ed.). The handbook of environmental chemistry. Vol 3. part: Organosilicon Materials. Springer-Verlag, Berlin. Huppmann, R., Lohoff, H.W. & Schröder, H. Fr. 1996. Cyclic siloxanes in the biological wastewater treatment process - determination, quantification and possibilities of elimination. Fresenius’ J. Anal. Chem. 354: 66-71. IARC, 1999. Surgical implants and other foreign bodies. Internationl Agency for Research on Cancer (IARC) – Summaries & Evaluation. Vol: 74 INCI. 2000. Inventory of ingredients used in cosmetic products, published in Section I of the Annex to Commission Decision 96/335/EC. 1 st Update EU Inventory 09/06/2000. The International <strong>No</strong>menclature of Cosmetic Ingredients. http://europa.eu.int/comm/food/fs/sc/sccp/out123cm_en.pdf IRG. 1998. Silicone gel breast implants. The report of the independent review group. http://www.silicone-review.gov. Kala S.V., Lykissa, E.D., Neely M.W. & Lieberman M.W. 1998. Low Molecular Weight Silicones are Widely Distributed after a Single Subcutaneous Injection in Mice. Short Communication. American J of Pathology 152:645-649. http://womnhlth.home.mindspring.com/studies/american_j_of_pathology.h tm Kirk Othmer. 1997. Kirk Othmer Encyclopedia of Industrial Chemistry. 4th edition. Wiley Interscience. Krogh, H. 1999. Problematiske stoffer i byggevarer. SBI-Meddelelse 122. Statens Byggeforskningsinstitut, Hørsholm. Looney,R.J., Frampton, M.W., Byam, J., Kenaga,C., Speers, D.M., Cox, C., Mast, R.W., Klykken, P.C., Morrow, P.E., & Utell, M.J. 1998. Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects. Toxicological Sciences 44: 214- 220. Mathisen, A., D. 2003: Telephone communication with Anne Dorthe Mathisen, SPT, the 2. of September 2003. 67
Page 1 and 2:
Siloxanes - Consumption, Toxicity a
Page 3 and 4:
Table of Contents PREFACE 5 SUMMARY
Page 5:
Preface Siloxanes, the building blo
Page 8 and 9:
8 products, clothes, health-care pr
Page 10 and 11:
10 A possible estrogenic effect con
Page 13 and 14:
Sammenfatning og konklusioner Denne
Page 15 and 16: Udledninger til miljøet Den væsen
Page 17 and 18: Prisen på alternativerne varierer
Page 19 and 20: 1 Introduction 1.1 What are siloxan
Page 21 and 22: Cyclic siloxanes with other functio
Page 23 and 24: Curing of one-component RTV silicon
Page 25 and 26: Table 1.2 Consumption of silicones
Page 27 and 28: tion and export of siloxanes regist
Page 29 and 30: CAS No. Name Import average tonnes
Page 31 and 32: • Defoamers, flow control agents
Page 33 and 34: Besides their technical properties,
Page 35 and 36: paint, coatings and waxes in total
Page 37 and 38: Table 2.5 Siloxanes in imported, ex
Page 39 and 40: Fate of the siloxanes The siloxanes
Page 41 and 42: • Mouldmaking (reproduction of co
Page 43 and 44: The main source of releases of silo
Page 45 and 46: • Immunotoxicity studies. Human c
Page 47 and 48: LD 50 following dermal application
Page 49 and 50: cinogenic hazard associated with D5
Page 51 and 52: following repeated exposures, the l
Page 53 and 54: Table 4.1 PBT profiler results for
Page 55 and 56: 5 Alternatives The use of some type
Page 57 and 58: Name of alternative Neopentylglycol
Page 59 and 60: 5.1.7 Summary and general experienc
Page 61 and 62: Table 5.2 Identified alternatives t
Page 63 and 64: References Allan, R.B., Kochs, P. &
Page 65: EPA DCN 86970000024. 1996. Pharmaco
Page 69 and 70: 69 Annex 1 Siloxanes listed in the
Page 71 and 72: 71 INCI name CAS No EINECS/ ELINCS
Page 79 and 80: Declared name CAS No. ACRYLATES / D
Page 81 and 82: Annex 3 Siloxanes in the Danish Pro
Page 83 and 84: Tonnes siloxanes Import Production
Page 89 and 90: tonnes siloxanes Import Production
Page 91 and 92: Annex 5 Siloxanes in cleaning and m
Page 93 and 94: tonnes siloxanes Import Production
Page 95 and 96: Annex 7 Database screening for deca
Page 97 and 98: Inhalation No relevant data found O
Page 99 and 100: PhysProp 2003. PHYSPROP DEMO-databa
Page 101 and 102: 10 CAS no Synonym Test Exposure rou
Page 103 and 104: 103 CAS no Synonym Test Exposure ro
Page 111: 111 CAS no Synonym 556-67-2, 541-02
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