Selected Major Grants and AwardsThe Cell Signaling and Gene Regulation Program has a funding base of $40,975,090 in annual total costs (current as of July 2009).This sum includes $7,151,438 in NCI funding and $25,178,189 in other NIH funding. Due to space constraints, only new awardspresented since January 1, 2008 with funding of $100,000 or more in annual total costs are listed here.Investigator Title Start DateWhite, KevinZhao, YinmingWhite, KevinChicago Systems Biology Center forthe Study of Transcriptional NetworksSystematic Screening for New HistoneMarksCenter for Bioinformatics andComputational BiologyEndDateAnnualTotal CostClassFunding Agency9/1/2008 8/31/2013 $3,021,428 N/A National Institutes of Health9/30/2008 8/3/2011 $790,454 R01 National Institutes of Health7/1/2008 6/30/2011 $765,000 N/ARosner, Marsha Signaling Pathways in Neuronal Cells 1/10/2009 12/31/2012 $421,202 R01McNally, ElizabethRoizman, BernardRoizman, BernardMcNally, ElizabethSarcoglycan in Myopathy and MuscleMembrane StabilityThe Functions of the US3 ProteinKinase of Herpes Simplex VirusDissection of the Functions of HerpesSimplex Virus ICPONuclear Membrane ProteinInteraction in Heart and MuscleDiseaseThe Searle Funds at theChicago Community TrustNational Inst. ofNeurological Disorders andStroke12/1/2008 11/30/2013 $390,000 R01 National Institutes of Health9/10/2008 8/31/2012 $385,000 R01 National Cancer Institute5/1/2008 4/30/2013 $382,057 R37 National Cancer Institute9/1/2008 5/31/2012 $378,614 R01Lin, Anning Wiring the UV Signaling Circuitry 2/8/2008 1/31/2013 $345,375 R01Rinker-Schaeffer,CarrieProstate Cancer MetastaticColonization: Role of MKK4National Heart, Lung, andBlood InstituteNational Institute ofEnvironmental HealthScience12/1/2008 11/30/2013 $328,815 R01 National Cancer InstituteSalgia, Ravi Role of Paxillin in Lung Cancer 6/2/2008 4/30/2013 $326,831 R01 National Cancer InstituteMillen, KathleenLiao, ShutsungMrksich, MilanLang, DeborahMacleod, KayKoide, ShoheiWu, Chung-IChmura, StevenPeter, MarcusMrksich, MilanZhao, YinmingMouse Models of Human CerebellarMalformationsMolecular Mechanisms of GrowthControl in Prostate CancerUltrahigh Performance Nanoantennasfor Surface Enhanced RamanSpectroscopyPax3, Melanocyte Stem Cells andMelanomaFunctions of BNIP3 in MammaryTumorigenesisNovel Affinity Reagents for EpigeneticsMarkersMicroRNA Evolution and SpeciesDivergence in DrosophiliaA Phase 1/2, Multi-Center, Safetyand Efficacy Study EvaluatingIntravenously Administered I-TM601in Patients with Progressive and/orRecurrent Malignant GliomaNovel Fas/CD95 SignalingMechanismsPeptide Arrays for UnderstandingHistone BiochemistryGlobal Characterization of LysineAcetylation in Cancer by a ProteomicsApproach8/15/2008 7/31/2009 $324,496 R56National Inst. ofNeurological Disorders andStroke2/1/2009 1/31/2013 $315,168 R01 National Cancer Institute5/1/2008 4/30/2009 $313,001 08 Department of Defense2/1/2009 12/31/2013 $312,000 R01 National Cancer Institute2/1/2009 12/31/2013 $303,853 R01 National Institutes of Health9/20/2008 7/31/2010 $301,864 N/A7/1/2008 6/30/2011 $301,309 R01National Institute on DrugAbuseNational Institute of GeneralMedical Sciences8/25/2008 8/24/2009 $290,258 N/A Transmolecular, Inc.9/17/2008 7/31/2012 $275,709 R01 National Cancer Institute4/1/2008 2/29/2012 $270,736 R01National Institute of GeneralMedical Sciences6/1/2008 4/30/2013 $261,083 R01 National Cancer Institute26UCCRC SCIENTIFIC REPORT 2009
Investigator Title Start DateSalgia, RaviSolway, JulianZhao, YinmingGreene, GeoffreyFerguson, EdwinSalgia, RaviNash, PiersKron, StephenKoide, ShoheiSalgia, RaviSalgia, RaviLengyel, ErnstRinker-Schaeffer,CarrieBoone, DavidSolway, JulianHaydon, RexRole of c-Met in SCLC and Potentialfor Novel TherapyEvaluation of Lovastatin in SeverePersistent Asthma (ElisPA)A Novel Proteomics Technology forProtein FarnesylationStructure-Function Analysis of ERAlpha/Beta Bound to Bazedoxifene/CEMixturesCharacterization of the Interactionsbetween a Stem Cell and its Niche InDrosophillaPhase I Safety, Pharmacokinetic andPharmacodynamic Study of PF-04217903 in Patients with AdvancedCancerProtein-protein Interactions in SignalTransductionMALDI Imaging of Cancer SignalingSignaturesHigh-Performance Affinity Reagentsfor Peptide EpitopesNovel Targeted Therapy in PancreaticCancerA Phase I Followed by a Randomized,Phase II Study of Carboplatin andEtoposide With or Without ObatoclaxAdministered Every 3 Weeks toPatients with Extensive State SmallCell Lung CancerDevelopment of Novel Therapeuticand Diagnostic Strategies for OvarianCancerIdentification of Effectors of MKK4-Mediated Suppression oin OvarianCancer Metastatic ColonizationFunctional Consequences ofAutophagy Mutations in Crohn’sDiseaseThe Influence of Budesonide andFormoterol on Force Fluctuation-Induced Relengthening of ContractedAirway Smooth MuscleSynergistic Use of Oteogenic BMP’s ina New Zealand White Rabbit Model ofSpine FusionEndDateAnnualTotal CostClassFunding Agency9/19/2008 2/28/2013 $251,380 R01 National Cancer Institute9/5/2008 8/31/2009 $231,000 R34National Institute of Allergyand Infectious Diseases1/16/2009 3/31/2010 $230,949 R33 National Cancer Institute4/25/2008 4/24/2009 $230,545 N/A1/1/2008 12/31/2011 $230,250 SSWyeth-AyerstPharmaceuticalsThe Ellison MedicalFoundation7/9/2008 7/8/2010 $208,209 N/A Pfizer, Inc.9/1/2008 8/31/2009 $180,562 N/A National Science Foundation7/16/2008 6/30/2010 $172,687 R21 National Cancer Institute4/4/2008 3/31/2010 $168,065 R21 National Cancer Institute3/1/2009 2/28/2011 $156,000 R21 National Cancer Institute5/28/2008 5/27/2010 $152,694 N/AGemin X BiotechnologiesInc.7/1/2008 6/30/2013 $150,000 N/A Burroughs Wellcome Fund6/1/2008 5/31/2009 $145,433 N/A Pardee Foundation, Elsa U.12/1/2008 11/30/2009 $139,274 N/A4/28/2008 4/27/2010 $126,906 N/A Astrazeneca1/1/2009 12/31/2009 $124,496 N/AKron, Stephen Chicago Laminome Project 11/1/2008 10/31/2010 $120,000 N/AMrksich, MilanSalgia, RaviRosner, MarshaCollaborative Proposal: EMT/MISC:Behavior Based Molecular RoboticsExpression and Function of the RONReceptor Tyrosine KinaseRegulation of Breast Cancer StemCells by Raf Kinase Inhibitory ProteinBroad Foundation, The Eliand Edythe L.Musculoskeletal TransplantFoundationThe Searle Funds at theChicago Community Trust9/1/2008 8/31/2011 $105,000 N/A National Science Foundation5/22/2008 5/21/2009 $100,000 N/A Biogen Idec Inc.1/1/2009 12/31/2009 $100,000 N/A Geyer Foundation, CharlotteCell Signaling &Gene RegulationUCCRC SCIENTIFIC REPORT 200927
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# Yang C, Karczmar GS, Medved M, Ot
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Selected Major Grants and AwardsThe
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Program 5Advanced Imaging
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MembersInvestigator*Hiroyuki Abe MD
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in as many as 86% of the measuremen
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investigators and engineers from co
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have important clinical implication
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Theme: Image-Guided TherapyCharles
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irradiated to a variety of doses ne
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Selected Publications* : Intraprogr
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* Jansen SA, Fan X, Karczmar GS, Ab
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Program 6Cancer Risk and Prevention
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MembersInvestigator*Habibul Ahsan M
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to prostate cancer. The work has ma
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Dr. Ahsan’s team showed that sele
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Theme: Psychological and Bio-Behavi
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Daniel McGehee, PhDAssociate Profes
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Sarah Gehlert, PhDProfessor of the
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Selected New Funding•• Lisa San
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Selected Publications* : Intraprogr
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Gehlert, Sarah PhD* Gehlert S, Sohm
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Olopade, Olufunmilayo MBBS* Bradbur
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Clinical Trials ActivityDr. Alessan
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The clinical trials activity of the
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Shared ResourcesDr. Vytas Bindokas
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Biostatistics Core FacilityScientif
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collaborations. The Facility mainta
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The services provided include:•
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Other Resources and Centers
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Cancer Resource CenterThe UCCRC off
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CECOS has successfully developed an
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Committee on ImmunologyThe Committe
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The University of Chicago Medical C
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HighlightsThe Gwen and Jules Knapp
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Leukemia and Lymphoma Society Speci
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Institute for Genomics and Systems
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Systems Biology Approach for the St
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Immunology and Cancer ProgramMaria-
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Cancer Risk and Prevention ProgramA
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www.uccrc.uchicago.eduEditor: Hoyee