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The Program fosters collaborations between basic scientistsand clinical researchers to ultimately identify potentialtherapeutic targets and facilitate the testing of smallmolecule inhibitors of such targets.Cell Signaling &Gene RegulationOverview & GoalsThe Cell Signaling and Gene Regulation Programfocuses on determining the basic cell signalingand gene expression mechanisms that underliekey events in malignant transformation anddevelopment. The Program brings togethera diverse group of 43 basic and translationalinvestigators from 12 departments with a wealthof experience in chemistry, cell signaling,systems biology, developmental biology, and drugdiscovery. These investigators are dedicatedto discovering mechanisms of abnormal cellgrowth that could lead to innovative anti-cancertreatments.in cancerous versus normal cells, analysis oftranscription factor biology (including nuclearhormone receptors), and the structural biologyof key proteins involved in cancer etiology. TheProgram fosters collaborations between basicscientists and clinical researchers to ultimatelyidentify potential therapeutic targets and facilitatethe testing of small molecule inhibitors of suchtargets.The research aims of the Cell Signaling andGene Regulation Program are to (1) elucidatethe molecular mechanisms of tissue specific andcell type specific gene expression; (2) elucidatethe cellular mechanisms underlying cell growth/division and cell survival/death; (3) understandthe multi faceted mechanisms leading tocancer metastases; (4) use large scale, highthroughput and systems biology approaches,as well as genetic evolutionary approaches tounderstand cancer biology; and (5) discover noveldevelopmental pathways relevant to cancer cellsignaling. Particular strengths of the programinclude an emphasis on the detailed mechanisticanalysis of signal transduction and apoptoticpathways, understanding cell cycle regulationProgram Leaders:Marsha R. Rosner, PhDSuzanne D. Conzen, MDUCCRC SCIENTIFIC REPORT 20097