Patterns of abnormal LFTs and their differential diagnosis

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Pros / cons with C-P score: • Very simple • Easily calculated • Good predictor • Subjective measures • “Ceiling” effect ie bili >300, alb 19 scores same as bili 65, alb 26
Caveats • Abnormal LFTs do not always indicate liver disease • Normal range is set by mean ± 2SD • 8.9% of US population have elevated LFTs Am J Gastro 2006;101:76
Page 1 and 2: Patterns of abnormal LFTs and their
Page 3 and 4: Tests of liver function • Synthet
Page 5 and 6: Interpretation of LFTs • AST / AL
Page 7 and 8: Interpretation of LFTs • Albumin
Page 9 and 10: Investigation of abnormal LFTs •
Page 11 and 12: Investigation of abnormal LFTs •
Page 13 and 14: Liver disease severity: • Biochem
Page 15: Child-Pugh score for cirrhosis seve
Page 19 and 20: Case 1 Liver biopsy Miss KM, 21yrs
Page 21 and 22: Case 2 Mr J D Age 49 EtOH++ Abn LFT
Page 23 and 24: Case 3 Mrs SB Age 63 Type II diabet
Page 25 and 26: Case 3 - Mrs SB • ALT 57, AST 84,
Page 27: Conclusions • Interpreting LFTs e

Patterns of abnormal LFTs and their differential diagnosis

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