Patterns of abnormal LFTs and their differential diagnosis

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“Liver function tests” • AST and ALT • alkaline phosphatase • (GGT) • Bilirubin • albumin • total protein – ie mostly indicators of liver damage
Interpretation of LFTs • AST / ALT – hepatocellular enzymes • AST – mitochondrial • ALT – cytosolic • AST / ALT ratio – ALT > AST – hepatitis – AST > ALT – alcohol (or in cirrhosis)
Page 1 and 2: Patterns of abnormal LFTs and their
Page 3: Tests of liver function • Synthet
Page 7 and 8: Interpretation of LFTs • Albumin
Page 9 and 10: Investigation of abnormal LFTs •
Page 11 and 12: Investigation of abnormal LFTs •
Page 13 and 14: Liver disease severity: • Biochem
Page 15 and 16: Child-Pugh score for cirrhosis seve
Page 17 and 18: Caveats • Abnormal LFTs do not al
Page 19 and 20: Case 1 Liver biopsy Miss KM, 21yrs
Page 21 and 22: Case 2 Mr J D Age 49 EtOH++ Abn LFT
Page 23 and 24: Case 3 Mrs SB Age 63 Type II diabet
Page 25 and 26: Case 3 - Mrs SB • ALT 57, AST 84,
Page 27: Conclusions • Interpreting LFTs e

Patterns of abnormal LFTs and their differential diagnosis

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