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Evaluating the “Good Death” Concept from Iranian Bereaved Family

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H O W W E D O I T<br />

Recognizing Depression in Patients with<br />

Cancer<br />

Alicia Morgans, MD, and Lidia Schapira, MD<br />

Caring for <strong>the</strong> “whole person” across <strong>the</strong> continuum<br />

of disease remains a top priority for<br />

clinicians. Strides in basic and translational<br />

research have opened new <strong>the</strong>rapeutic pathways<br />

that provide better targeted and effective treatments<br />

with fewer side effects. New ancillary and<br />

supportive <strong>the</strong>rapies have transformed and improved<br />

<strong>the</strong> experiences of patients undergoing anticancer<br />

treatments. Also, with increasing acceptance<br />

of multidisciplinary teams, we have <strong>the</strong><br />

opportunity to make timely referrals to colleagues<br />

who provide supportive and palliative care and targeted<br />

interventions to treat pain and disabling<br />

symptoms. If our goal is to recognize <strong>the</strong> full impact<br />

of cancer on <strong>the</strong> lives of patients and <strong>the</strong>ir families,<br />

it is important to address <strong>the</strong> emotional and psychological<br />

toll of diagnosis and treatment. Recognizing<br />

depressive symptoms and clinical depression<br />

is an important step toward optimizing <strong>the</strong> quality<br />

of life for patients with cancer.<br />

Data summarized in an excellent review by<br />

Pirl published in 2004 show that up to one in five<br />

Americans will experience depressive symptoms<br />

over <strong>the</strong> course of <strong>the</strong>ir lifetime and that approximately<br />

10%–25% of cancer patients meet criteria<br />

for clinical depression. 1,2 As our ability to<br />

treat depression has improved over <strong>the</strong> years,<br />

thanks in great part to advances in pharmacology<br />

and behavioral <strong>the</strong>rapies, it is now critically important<br />

to recognize and treat this debilitating<br />

disease in individuals with cancer. 3 Evidence exists<br />

that untreated depression is associated with a<br />

worse overall survival for some cancer patients<br />

and, paradoxically, that up to half of patients<br />

with cancer and concurrent depression are undertreated<br />

or receive no treatment. 4–6 Medical<br />

Manuscript submitted August 2, 2010; accepted December<br />

20, 2010.<br />

Correspondence to: Alicia K. Morgans, MD, Massachusetts<br />

General Hospital, 55 Fruit Street, Boston, MA 02114;<br />

telephone: (617) 724-4000; fax: (617) 643-0798; e-mail:<br />

amorgans@partners.org<br />

J Support Oncol 2011;9:54–58 © 2011 Published by Elsevier Inc.<br />

doi:10.1016/j.suponc.2011.01.004<br />

oncologists receive little or no formal training in<br />

psycho-oncology yet are often faced with patients<br />

who exhibit changes in mood and become<br />

progressively disabled by psychiatric symptoms.<br />

Methodical assessment and frequent inquiry may<br />

identify patients with cancer and depression.<br />

Peeling Back <strong>the</strong> Onion: Sorting<br />

through Symptoms to Reach a<br />

Diagnosis<br />

A diagnosis of cancer often precipitates intense<br />

emotions such as fear, sadness, and sometimes<br />

anger. 2 Individuals who may never have<br />

given much thought to <strong>the</strong>ir own death are confronted<br />

with <strong>the</strong> very real possibility of a shortened<br />

life and future suffering. Roles and relationships<br />

shift, careers are interrupted, and daily<br />

routines may be sacrificed to make room for cancer<br />

treatment. Add to this <strong>the</strong> financial worries<br />

that often accompany a serious illness and it is<br />

not surprising that patients may require some<br />

level of professional guidance or intervention in<br />

order to cope with <strong>the</strong> crisis. As a quick rule of<br />

thumb, it takes about 3–4 weeks after diagnosis<br />

to adjust, and during that period it is quite normal<br />

for patients to experience intense feelings. 7<br />

Weissman and Worden, among <strong>the</strong> first psychiatrists<br />

to study distress in cancer patients, described<br />

an acute syndrome of distress over existential<br />

plight with <strong>the</strong> diagnosis and with a<br />

recurrence that lasts about 100 days. 8 Most individuals,<br />

given time and adequate support, will<br />

find <strong>the</strong> inner resources to cope with distressing<br />

symptoms and find a new normal. Not all do<br />

however, and it is important for oncologists to<br />

inquire at regular intervals about how <strong>the</strong> patient<br />

is feeling and coping with illness. A recent study<br />

by Lo et al 9 found that predictors of depressive<br />

symptoms in patients with solid tumors included<br />

younger age, antidepressant use at baseline, lower<br />

self-esteem and spiritual well-being, greater attachment<br />

anxiety, hopelessness, <strong>the</strong> physical<br />

burden of symptoms, and proximity to death.<br />

54 www.SupportiveOncology.net THE JOURNAL OF SUPPORTIVE ONCOLOGY

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