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Laboratory news & BioScience March 2017

New Zealand's leading scientific publication for more than 20 years. This bi-monthly magazine provides the latest up to date information on new products and services to a readership which is carefully targeted and updated on a regular basis.

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NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

ISSUE 117 | MARCH <strong>2017</strong><br />

Brain imaging and causal assessment of impairments<br />

reveals metamemory regions<br />

From page 1<br />

dence there is between thought and language.<br />

Previous studies had investigated the neuronal<br />

activity during metacognitive perception<br />

in macaque monkeys and rats.<br />

These works looked at brain activity during<br />

the self-monitoring of real-time decisions.<br />

Since metamemory requires the reconstruction<br />

of past experiences it can be considered<br />

a more self-reflective metacognitive<br />

process.<br />

So far metamnemonic processes have only<br />

been observed in macaque monkeys, apes<br />

and dolphins, as well as humans, highlighting<br />

comparative cognitive capabilities among<br />

these species.<br />

seen – that is, an old remote memory – the<br />

brain was activated in the dorsal prefrontal<br />

cortex, around the posterior supraprincipal<br />

dimple (aPSPD), particularly within area 9 (or<br />

area 9/46).<br />

However when wagering on a memory of<br />

the last picture seen – a recent memory – the<br />

anterior part of the supplementary eye field<br />

(SEFa) within area 6 activated instead.<br />

The contribution of the supplementary eye<br />

field to perceptual metacognition has been<br />

previously suggested.<br />

However as the researchers point out in<br />

their report, this is the first observation of<br />

metacognitive roles for area 9, especially at<br />

aPSPD.<br />

Brain areas<br />

Certain areas of the brain have been identified<br />

as responsible for mnemonic processes<br />

revealing a multi-tiered brain wide network for<br />

memory.<br />

While this is now understood in some detail,<br />

what regions of the brain may be responsible<br />

for metamemory was totally unknown.<br />

The researchers found that when the macaque<br />

monkeys were engaged in metacognitive<br />

judgement of memories of the first picture<br />

Experimental design and metamemory task. Whole-brain functional localization of metamemory networks for “remote” and<br />

“recent” events via functional magnetic resonance imaging (fMRI) and behavioral reversible inactivation with a GABA-A receptor<br />

agonist (muscimol) in macaque monkeys performing a metamemory task. Courtesy of Science<br />

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