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West Newsmagazine 7-11-18

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24 I MATURE FOCUS I<br />

July <strong>11</strong>, 20<strong>18</strong><br />

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lected by Johns Hopkins researchers shows<br />

that a higher proportion of male to female<br />

sex hormones may also be a culprit.<br />

Although the researchers said that their<br />

observational study could not prove cause<br />

and effect, they said it does suggest that<br />

having a more “male-like” hormone profile<br />

seems to increase the risk of heart disease<br />

and stroke in women after menopause,<br />

independent of other risk factors.<br />

For the new study, the researchers<br />

looked at data from more than 2,800 postmenopausal<br />

women with an average age of<br />

65, who had participated in the federally<br />

funded Multi-Ethnic Study of Atherosclerosis<br />

[MESA]. Researchers initially took<br />

blood samples and measured levels of testosterone<br />

and estradiol [the main type of<br />

estrogen], then followed the participants<br />

for 12 years.<br />

When testosterone and estradiol levels<br />

were compared with instances of heart and<br />

cardiovascular diseases, they found that<br />

higher testosterone was associated with<br />

increased risk while higher estradiol levels<br />

were linked with lower risk. For every<br />

standardized unit increase in the ratio of<br />

testosterone to estrogen, there was a 19<br />

percent increase in the women’s cardiovascular<br />

disease risk, a 45-percent increase in<br />

coronary heart disease risk and a 31 percent<br />

increase in heart failure risk.<br />

“A woman’s sex hormone levels and<br />

ratios of them isn’t something that physicians<br />

regularly check,” said Dr. Erin<br />

Michos, associate professor of medicine<br />

at the Johns Hopkins University School of<br />

Medicine. “Because an imbalance in the<br />

proportion of testosterone to estrogen may<br />

affect heart disease risk, physicians may<br />

want to think about adding hormone tests<br />

to the toolbox of screenable risk factors,<br />

like blood pressure or cholesterol, to identify<br />

women who may be at higher risk of<br />

heart or vascular disease … But this needs<br />

further study.”<br />

Asked why higher levels of male hormones<br />

may affect women’s risk, Michos<br />

The simple step of taking a daily probiotic<br />

may help protect a woman’s bones from<br />

osteoporosis.<br />

said there is ample evidence from past<br />

studies that testosterone can raise a woman’s<br />

blood pressure and contribute to insulin<br />

resistance, which are harmful effects,<br />

whereas estrogen relaxes blood vessels<br />

and lowers bad cholesterol levels, both of<br />

which are positives for the heart and vascular<br />

systems.<br />

Benefits beyond the gut<br />

Probiotics are a popular daily supplement<br />

for adults of all ages to help promote<br />

a healthy balance of bacteria in the intestinal<br />

tract. Recently, Swedish scientists<br />

demonstrated that probiotics also may be<br />

useful in protecting women’s bones against<br />

fractures.<br />

In an experiment conducted at Sahlgrenska<br />

University Hospital in Sweden, women<br />

who were an average of 76 years old either<br />

received a probiotic powder or a placebo<br />

every day for a year. The groups were<br />

chosen at random, and neither the researchers<br />

nor the women knew who received the<br />

active powder during the study.<br />

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