Carolina Footsteps July 2018 Web Final

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8 TECH GIRL GENE EDITING Have you ever thought about the possibility of a permanent cure for ALL inherited diseases in the next two decades? A leading British researcher Dr Edze Westra, at the University of Exeter believes this is a possibility thanks to new gene editing therapies. This gene editing therapy is known as CRISPR. CRISPR is an acronym that stands for clustered regularly interspaced short palindromic repeats. It is a type of immunity system set up in the genetic code of our cells. These genes are repeated in short sequences at specifi c intervals, and when it detects a foreign gene — like if a virus is attempting to insert its DNA into the DNA sequence — a spacer is created between these repeats to offer protection from that virus. What CRISPR-Cas basically does is target and cut out disruptive gene at the spacers using a specifi c enzyme. How does it work? CRISPR allows scientists to precisely cut out tiny sections of faulty genes and replace them with healthy DNA. With CRISPR gene editing is more precise, cheaper and quicker than ever before. CRISPR is made up of two distinct parts. The fi rst part is a strand of RNA – which matches up with a section of DNA inside the target cell. This serves as guide for the second part – called Cas9 – to the target region, where it makes a snip across the DNA. After the target region of the DNA has been snipped off, a number of possibilities are opened up: Scientists could cut out a particular gene, interrupt the function of a particular gene, make precise changes to the DNA sequence, or slip in an entirely new gene. CRISPR is an exceptionally accurate method of genetic modifi cation. Dr Westra quoted earlier CRISPR will also allow scientist to screen embryos and substitute genes that trigger illness before babies are born. Thereby doctors can use gene editing therapy to prevent these inherited conditions from being passed onto future generations. Role of CRISPR in Preventing Cancer Cancer is caused by defective genes, CRISPR can be used to recreate these in the lab, and this will afford scientist the opportunity to explore the underlying biology of the disease and comprehend its development. Genes in cancer cells can be tweaked to isolate those that are crucial for the cells’ survival, and then targeted with new treatments. Furthermore, scientists could use the system to understand the underlying factors responsible for cancer cells resistance to drugs, potentially opening up new treatment to stop this from happening. The therapy can also be used to inhibit cancerous growth by removing faulty genes. In fact, CRISPR can now be used to repair a mutation in a gene that causes disease. For instance, researchers had genetically engineered immune cells and enhanced their ability to kill cancer cells in mice. The immune cells were modifi ed to express a protein substance called chimeric antigen receptors (CARs) on their surfaces, and this enabled the cells to identify and repel cancer cells that expressed the corresponding antigen. This type of immunotherapy is referred to as CAR T-cell therapy, a method of adoptive cell transfer. Using this method, a patient’s T cells, a type of immune cell, can be collected from the blood, engineered genetically to make them more potent at repelling cancer cells, stretched in the lab, and fi nally returned to the patient. Gene editing therapy is beginning to move from the lab to the bedside. Researchers in China have started testing CRISPR-edited immune cells in patients who have lung cancer, where they snipped out a gene that produces a stop signal, called PD-1, for the immune system. Their aim is to test if the CRISPR edit will increase the cells’ cancerkilling abilities. A team of scientists in the United States are also doing something similar but for several different cancers. Although we may have to wait a bit for the results, you can be sure that CRISPR will become extremely important in the next few decades. The development of gene editing in the next few years could usher in a golden age of health with an end to the plague of cancer, diabetes and other inherited disease. Looking Ahead CRISPR is an exciting technological development that’s opening up new possibilities for researchers across the globe working in a number of different fi elds. However, most of these studies are still conducted in the lab, so it’s still very early days and ideas on how to use the technology to treat diseases are only just being adapted. True CRIS- PR is lauded for its accuracy; a major concern lies with what could result if it misses its target. DNA is complex, and several genes are intricately linked, therefore modifying one gene may produce the desired result, but could inadvertently disrupt the function of other molecules and genes. Some stretches of DNA may look very similar because they are written using an alphabet of just four chemical letters, and as such both might be targeted by CRISPR, which again may result in undesirable effects. Therefore, scientists need to meticulously scrutinize the impact of their edits in these new lab development stages to make sure they’re not inadvertently upsetting other gene function, which might not be apparent instantly. There is need for risk to be measured. CRISPR holds a lot of promise, and it could mark the start of a new wave of cancer treatment; however, a lot of work must be done, and hopefully, those lab trials will provide some answers. It’s still in the distant future, and would be an incredibly complex fi eld of study, but it’s not impossible. In addition to fully understanding where and how the desired edits might correct inherited rogue genes, there are huge moral questions to address, especially about issues surrounding the editing of human embryos. These kinds of discussions, public debates, and expert recommendations are already ongoing. Will CRISPR ultimately follow through on its promise? The answer lied in the not too distant future, but it’s an exciting time for science. Have you ever wondered.... If that Ad you ran Worked? We have a system that can track customer response to your ads. Maybe the ad you ran just did not get attention. We also have a split testing system that can let you know which ads your customers respond to. Whether it is Radio, TV, printed ads texting, or internet advertising, we can track the response and send you a report. Advertising is like fishing. Did you catch anything? Maybe it’s time to change the bait. Ad Trac Want to know more? Call .... 252-312-2302 July 2018
INSPIRATION July 2018 5 pet-friendly preparations for your summer travels PET CARE 9 My Jesus By Ron Ben-Dov Copyright 2/15/18 I don’t walk on water And I didn’t feed fi ve thousand I didn’t beat the devil And I can’t grant salvation But I know the one He does, and did, and will My Jesus is the one Copyright all rights reserved 53rjbd@gmail.com (BPT) - On your most challenging days you can always count on your pet to greet you at the door when you come home or cuddle up in your lap in the evening. They are a vital part of your home life all year long, but when your life takes you away from home - as it often does during summer travel - are you thinking of them before you head out the door? With so much to pack and prepare for your trip, it’s easy to forget about those you’ll leave behind, like your pets. That’s why if you’re planning to leave for a day or longer, you should make sure to employ these fi ve tips to make sure your pet is happy and safe while you’re away. * Find a quality pet sitter. Dogs need to be walked and let out during the day, so when you’re gone, you’ll need a pet sitter to fill these duties. Finding a quality, reliable pet sitter can be the difference between a happy pet and damage to your home when you return. Try to trade sits with a fellow pet owner, and if that’s not possible, the National Association of Professional Pet Sitters is a nonprofi t organization with resources to help you fi nd the best pet sitter for you. * Be mindful of the temperature. Knowing the temperature patterns in your destination city plays a big role in how you pack, but have you looked at what the weather has in store for your home while you’re gone? Allowing your home to get overly hot while you’re away isn’t good for your pet. You can control the temperature in your home - even while you’re away - with the Coleman Echelon Hx Touch-screen Thermostat. This WiFi-enabled smart thermostat provides more than just comfort, it monitors the temperature in your home, allowing you to always be aware of your home’s temperature. And best of all, it’s completely controllable from your smartphone, so even if you forget to make adjustments before you go, resetting the temperature in your home is just a click away. live in as well. Give it to them before you go by making sure the litter box or the yard is clean and that you’ve picked up as much clutter as possible. Wash the blankets that adorn their favorite sleeping places and make sure the space is ready for their use. * A little TV time. If commotion is the name of the game in your home, a house that is suddenly too quiet could have a negative impact on your pet. To alleviate this concern, leave the television on in one of the rooms so your pet can enjoy a little noise in the background. Just make sure you choose a room that is different from where your pet often sleeps so they can comfortably avoid the sound if they want to. * Leave a little bit of yourself. Is it possible to be in two places at once? In some ways yes. Leaving items out that smell like you - laundry or blankets, for example - can be a wonderful source of comfort in instances when your pet is feeling stressed. Just remember that if your pet likes to chew, these items could be their fi rst target, so only leave things you’re comfortable losing. Having a pet doesn’t mean you need to put your summer plans on hold, it just adds another layer to your planning process. Apply the tips above, and you and your pet will be happy and comfortable until the trip is over and you’re reunited. The author was born in Telaviv, Israel - In 2008 a life changing event occurred and the fl ow of faith based poetry has run ever since. Author of the following books: Faith Based Poetry Inspiration by God, Perspiration by Ron Inspiration by God, More Perspiration by Ron Inspiration by God, Even More Perspiration by Ron Inspiration by God, Perspiration by Ron, Volume IV Inspiration by God, Perspiration by Ron, Volume V Inspiration by God, Perspiration by Ron, Volume VI Inspiration by God, Perspiration by Ron, Volume VII School of Life – Secular Poetry American Legion Post 126 – Photo collection of members and activities of Hertford’s Post 126 * A little cleaning goes a long way. Your pet really isn’t that different from you; they appreciate a nice clean area to This could be your Ad! Call us at (252) 377-5296 Advertising with Carolina Footsteps Magazine is Local, Targets an audience and is Frequent. We display your business to different demographics, in Print, Internet, and Social Media. All at a cost that is less than regular print ads. TIPS TO KEEP YOUR PET SAFE DURING THE SUMMER MONTHS
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