Robert S. Mittler - Department of Surgery - Emory University

55. Wu, Z-Q, Khan, A.Q., Shen, Y., Wolcott, K.M., Dawick, W., Watts, T.H., Mittler, R.S.,
and Snapper, C.M. (2003). 4-1BB differentially regulates murine in vivo protein-and
polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae. Infect. and
Immun. 71:196.
56. Foell, J., McCausland, M., Burch, J., Corrazzi, N., Yan, X-J, Suwyn, C., O’Neil, S.P.,
Hoffmann, M.K., and Mittler, R.S. (2003) CD137 mediated T cell costimulation
terminates existing autoimmune disease in SLE-prone NZB/W F1 mice. Ann of the NY
Acad. Sci. 987:230-5.
57. Foell, J.L., Strahoutin, S., O’Neill, S.P., McCausland, M.M., Suwyn, C., Chander, P.N.,
Bapat, A. S., Yan, X-J, Chiorrazzi, N., Hoffmann, M.K., and Mittler, R.S. (2003).
Engagement of CD137 costimulatory molecules corrects a critical immune dysfunction
in SLE-prone NZB x NZW F1 mice. J. Clin. Invest. 10:1505-18.
58. Myers L., Takahashi, C., Mittler, R.S., Rossi, R.J., and Vella, A.T. (2003). 4-1BB
costimulation and TLR specific adjuvants combine to optimize peripheral T cell survival,
but consequently impair recall responsiveness. Proc. Soc. Nat. Acad. Sci. (USA)
100(9):5348-53.
59. Wang, J., Guo, Z., Dong, Y., Kim, O., Hart, J., Adams, A.,. Larsen, C.P., Mittler, R.S.,
and Newell, K.A. (2003). The role of 4-1BB in allograft rejection mediated by CD8 + T
cells. Amer. J. Transpl. 3:543-51.
60. Mittler R.S., Foell J., McCausland M., Strahotin S., Niu L., Bapat A., Hewes L.B.
(2004). Anti-CD137 antibodies in the treatment of autoimmune disease and cancer.
Immunol. Res. 29:197-208.
61. Foell. J.L., Diez-Mendiondo. B.I., Diez, O.H., Holzer , U., Ruck, P., Bapat, A.S.,
Hoffmann, M.K., Mittler, R.S., and Dannecker , G.E. (2004) Engagement of the CD137
(4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in
collagen-induced arthritis and establishes lasting disease resistance. Immunology
113:89. (Mittler and Dannecker are co-senior authors).
62. Lee, S.J., Myers, L., Muralimohan, G., Dai, J., Qiao, Y., Li, Z., Mittler, R.S., and Vella,
A.T. (2004). 4-1BB and OX40 dual costimulation synergistically stimulate primary
specific CD8 T cells for robust effector functions. J. Immunol. 173:3002
63. Munks MW, Mourich DV, Mittler RS, Weinberg AD, Hill AB. (2004). 4-1BB and
OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus
boost vaccine. Immunology112:559-66.
64. Cho HR, Kwon B, Yagita H, La S, Lee EA, Kim JE, Akiba H, Kim J, Suh JH, Vinay DS,
Ju SA, Kim BS, Mittler RS, Okumura K, Kwon BS. (2004). Blockade of 4-1BB
(CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int. 17:351.
65. Mittler, R.S. (2004) Suppressing the self in rheumatoid arthritis. (2004). Nat. Med.
10:1047.
66. Cuadros, C., Dominguez, A.L., Lollini, P-L, Croft, M., Mittler, R.S., Borgstrom, P.
Lustgarten, J. (2005). Vaccination with dendritic cells pulsed with apoptotic tumors in
combination with anti-OX40 and anti-4-1BB monoclonal antibodies induce a T cell
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