Robert S. Mittler - Department of Surgery - Emory University

Completed:
Project Number (Principal Investigator) Dates of Approved Project: 8/1/2000 – 7/31/02
R21 AI 48471-01 (Robert S. Mittler)
Source: DAIDS/NIAID
Title of Project: The Effect of Anti-4-1BB on SIV-Specific Cellular Immunity. The goal of this
proposal is to determine whether humanized rat anti-human 4-1BB mAbs enhance development
of cell-mediated immunity in Rhesus macaques vaccinated with a DNA + MVA vaccine against
SIV. It is also a study to determine if these antibodies can induce protective anti-viral CTL
immunity in SIV infected macaques.
Role: Principal Investigator
Project Number (Principal Investigator) Dates of Approved Project: 03/01/02 – 02/29/06
1 RO1 CA 85860-01A1 (Robert .S. Mittler)
Source: NIH/NCI
Title of Project: Functional Analysis of anti-4-1BB mediated tumor immunity. The goal of this
project is to determine how best to utilize CD137 mediated signaling to achieve maximal antitumor
efficacy and to elucidate the CD137 mediated molecular and biochemical signaling
events that drive CD8 + T cells to eradicate tumors that they otherwise fail to respond to.
Project Number (Principal Investigator) Dates of Approved Project: 04/01/01–03/31/06
1RO1 AI RR49155 (Mark Feinberg)
Source: NIH/NIAIDS
Title of Project:
Cellular Immune Responses and AIDS Pathogenesis. This study is designed to test the
hypothesis that SIV pathology develops in monkeys of Asian descent because of a strong
CD8+ T cell response to the infection whereas monkeys of African descent do not develop
pathology as a consequence of infection because of an absence of a discernable CD8+ T cell
response.
Role: Co-Investigator
Project Number (Principal Investigator) Dates of Approved Project: 09/30/98 – 02/28/07
PO1 AI 044644-06 (Christian P. Larsen)
Source: NIH/NIAID
Title of Project: Transplant Tolerance: Costimulation, Cytokines & Chimerism. The objective of
this study is to understand the causes that give rise to rejection of transplanted organs and to
block them.
Role: Co-Principal Investigator
Current:
Project Number:
1RO1 AI059290-01 (Robert S. Mittler) Dates of Approved Project: 5/01/05-
1/31/10
Source: NIH/NIAIDS
Title of Project: CD137 signals in DC during antigen priming induce tolerance.
This study explores the mechanisms through which CD137 signaling regulates antigen priming
of T cells by dendritic cells.
Project Number (Principal Investigator) Dates of Approved Project: 9/1/2000-8/31/08
2000N-00065 (Robert S. Mittler)
Source: Centers for Disease Control (CDC)
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