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Robert S. Mittler - Department of Surgery - Emory University

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79. Zhang, B., Maris, C.H., Foell, J., Whitmire, J., Niu, L., Song, J., Kwon, B.S., Vella, A.T.,<br />

Ahmed, R., Jacob, J., and <strong>Mittler</strong>, R.S. 2007. CD137 T cell costimulation<br />

induced suppression or enhanced immune function during acute viral infection.<br />

J. Clin. Invest. 117:3029.<br />

80. Lee, S.J., Rossi, R.J., Lee, S.K., Cr<strong>of</strong>t, M., Kwon, B.S., <strong>Mittler</strong>, R.S., Vella, A.T. 2007.<br />

CD134 costimulation couples the CD137 pathway to induce production <strong>of</strong> supereffector<br />

CD8 T cells that become IL-7 dependent. J. Immunol. 179:2203.<br />

81. Moens, L., Jeurissen A., <strong>Mittler</strong> R.S., Wuyts G., Michiels G., Boon L., Ceuppens J.L.,<br />

Bossuyt X. 2007. Distinct approaches to investigate the importance <strong>of</strong> the murine 4-1BB<br />

4-1BBL interaction in the antibody response to Streptococcus pneumoniae. J Leukoc<br />

Biol. 82:638.<br />

82. Polte T, Jagemann A, Foell J, <strong>Mittler</strong> R.S., Hansen G. 2007. CD137 ligand prevents the<br />

development <strong>of</strong> T-helper type 2 cell-mediated allergic asthma by interferon-gamma-<br />

producing CD8(+) T cells. Clin Exp Allergy 37:1374.<br />

83. McNamara, J.O., Kolonias, D., Pastor, F., <strong>Mittler</strong>, R.S., Chen, L., Giangrande, P.H.,<br />

Sullenger, B., and Gilboa, E. 2008. Costimulation <strong>of</strong> CD8+ T cells and Inhibition <strong>of</strong><br />

tumor growth with multivalent 4-1BB binding aptamers. J. Clin. Invest. 118:376.<br />

84. <strong>Robert</strong>son, S.J., Messer, R.J., Carmody, A.B., <strong>Mittler</strong>, R.S., Burlak, C., and Hazenkrug,<br />

K.J. 2008. CD137-costimulation <strong>of</strong> CD8+ T cells confers resistance to suppression by<br />

virus-induced regulatory T cells. J. Immunol. 180:5267.<br />

85. Lee, S-W, Park, Y., So, T., Kwon, B.S., Cheroutre, H., <strong>Mittler</strong>, R.S., and Cr<strong>of</strong>t, M.<br />

2008. A novel regulatory role for 4-1BB and 4-1BBL in myelopoiesis and the<br />

development <strong>of</strong> dendritic cells. Nat. Immunol. 9:917<br />

86. Bandyopadhyay S, Long M, Qui HZ, Hagymasi AT, Slaiby AM, Mihalyo MA, Aguila HL,<br />

<strong>Mittler</strong> R.S., Vella AT, Adler AJ. 2008. Self-antigen prevents CD8 T cell effector<br />

differentiation by CD134 and CD137 dual costimulation. J. Immunol. 181:7728.<br />

87. Paiardini, M, Cervasi, B., Engram, J.C., Gordon, S.N., Klatt, N.R., Muthukumar, a., Else,<br />

J., <strong>Mittler</strong>, R.S., Staprans, S.I., Sodora, D.L., Silvestri, G. 2009. Bone marrow-based<br />

homeostatic proliferation <strong>of</strong> mature T-cells in non-human primates: implications for AIDS<br />

pathogenesis.Blood 113:612.<br />

88. Lee, S.J., Long, M., Adler, A.J., <strong>Mittler</strong>, R.S., Vella, A.T. 2009. The IKK-neutralizing<br />

compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent<br />

activation-induced cell death. J. Leuk. Biol. 85:175<br />

89. Sumi T, Ishida W, <strong>Mittler</strong> R.S., Yagita H, Taguchi O, Fukushima A. 2009. Regulatory T<br />

Cells Participate in 4-1BB-Mediated Suppression <strong>of</strong> Experimental Allergic Conjunctivitis.<br />

Int. Arch Allergy Immunol. 148:305.<br />

90. Kim YH, Choi BK, Oh HS, Kang WJ, <strong>Mittler</strong> RS, Kwon BS. 2009. Mechanisms involved<br />

in synergistic anticancer effects <strong>of</strong> anti-4-1BB and cyclophosphamide therapy. Mol.<br />

Cancer Ther. 8:469.<br />

91. Lee SW, Salek-Ardakani S, <strong>Mittler</strong> RS, Cr<strong>of</strong>t M. 2009. Hypercostimulation through<br />

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