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Conclusions<br />
‣ 3DCoSeedsis TM are applicable <strong>for</strong> EV isolation, analytic and functional<br />
characterization<br />
‣ Using the 3D microwell array more <strong>EVs</strong>/cell can be isolated in a considerably more<br />
cost- and ef<strong>for</strong>ts- efficient manner than 2D culture<br />
‣ 3D environment is likely to trigger release of smaller <strong>EVs</strong> with increased amounts of<br />
certain miRNAs and decreased amounts of their target proteins<br />
‣ Functional impact of 3D environment on <strong>EVs</strong> differs between cell lines and should be<br />
individually analyzed<br />
47 · April 4, <strong>2019</strong>
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