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The 10 Most Recommended Pharma & Life Sciences Solution providers in 2019

This month, Insights Success has come up with a very contemporary topic and has dealt under the issue of “The 10 Most Recommended Pharma & Life Sciences Solution providers in 2019”. Here we have tried to focus on the different business portfolios with unique service solutions

This month, Insights Success has come up with a very contemporary topic and has dealt under the issue of “The 10 Most Recommended Pharma & Life Sciences Solution providers in 2019”. Here we have tried to focus on the different business portfolios with unique service solutions

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VOL 04<br />

April <strong>2019</strong><br />

ISSUE 01<br />

<strong>The</strong><br />

<strong>10</strong> <strong>Most</strong><br />

<strong>Recommended</strong><br />

<strong>Pharma</strong><br />

&<br />

<strong>Life</strong> <strong>Sciences</strong><br />

<strong>Solution</strong><br />

<strong>providers</strong> <strong>in</strong> <strong>2019</strong><br />

Sarjen<br />

Systems<br />

Promot<strong>in</strong>g Indian <strong>Pharma</strong><br />

Research on Global Scene<br />

Nikur Mody<br />

Founder


From <strong>The</strong><br />

Editor<br />

RAPIDLY<br />

EVOLVING<br />

INDUSTRY<br />

PHARMA<br />

&<br />

LIFE<br />

SCIENCE<br />

THE OUTLOOK


decade ago, the global <strong>in</strong>dustry of pharma and life<br />

Ascience, which was of 390 billion USD, has now crossed 1<br />

trillion USD and still it is march<strong>in</strong>g forward majestically.<br />

“One of the biggest challenges to medic<strong>in</strong>e is the <strong>in</strong>corporation of<br />

<strong>in</strong>formation technology <strong>in</strong> our practices” said Samuel Wilson.<br />

Today, to rema<strong>in</strong> competitive <strong>in</strong> this dynamic environment, the<br />

<strong>Pharma</strong> and <strong>Life</strong> <strong>Sciences</strong> organizations are quickly adapt<strong>in</strong>g<br />

and respond<strong>in</strong>g to the on-go<strong>in</strong>g changes <strong>in</strong> market conditions,<br />

customer requirements, and government and <strong>in</strong>dustry<br />

regulations. <strong>The</strong> giant companies are controll<strong>in</strong>g the one-third of<br />

the market and produc<strong>in</strong>g revenue around <strong>in</strong> billions of USD,<br />

while many large numbers of start-ups and SMBs are compet<strong>in</strong>g<br />

to get their share of pie, and benchmark their existence <strong>in</strong> this<br />

fiercely competitive doma<strong>in</strong>.<br />

Predict<strong>in</strong>g the future for better analysis of patient adherence and<br />

improv<strong>in</strong>g time to market rema<strong>in</strong>s the key element of success.<br />

Access<strong>in</strong>g, analys<strong>in</strong>g and manag<strong>in</strong>g the vast volumes of data<br />

have been a very critical task to pharma and life sciences<br />

companies, as they improve bus<strong>in</strong>ess efficiency and<br />

performance.<br />

And, this is where this ‘Next Generation’ architecture the Big Data<br />

and Analytics are help<strong>in</strong>g to improve the efficiency and the<br />

development processes.<br />

On the conclud<strong>in</strong>g note, today the world is leverag<strong>in</strong>g<br />

technology <strong>in</strong>telligently to ga<strong>in</strong> competitive advantage. <strong>The</strong><br />

profound market research is done <strong>in</strong> order to provide a plethora<br />

of solutions. With chang<strong>in</strong>g times, the <strong>in</strong>dustry is uncover<strong>in</strong>g<br />

<strong>in</strong>novations that are revolutioniz<strong>in</strong>g the current product l<strong>in</strong>es and<br />

unfold<strong>in</strong>g <strong>in</strong>f<strong>in</strong>ite opportunities for betterment of the mank<strong>in</strong>g.<br />

Shruti P. Jambhale<br />

Shruti P. Jambhale


C o n<br />

Cover Story <strong>10</strong><br />

Sarjen Systems<br />

Promot<strong>in</strong>g Indian <strong>Pharma</strong><br />

Research on Global Scene<br />

cxo<br />

24<br />

18<br />

Interview With Insights Success<br />

Accurex Biomedical<br />

Pioneer <strong>in</strong> Manufactur<strong>in</strong>g<br />

and Market<strong>in</strong>g of In-vitro<br />

Diagnostic Reagents<br />

32<br />

Digitaliz<strong>in</strong>g<br />

<strong>Pharma</strong><br />

5 ways <strong>in</strong> which Digitalization<br />

is Transform<strong>in</strong>g Healthcare<br />

and <strong>Pharma</strong> Industry<br />

Healthcare<br />

Predictions<br />

Future Predictions of<br />

Electronic Health Records,<br />

<strong>2019</strong> and Beyond


t e n s<br />

Ashish <strong>Life</strong> Science<br />

Deliver<strong>in</strong>g Highest Quality<br />

Veter<strong>in</strong>ary Medic<strong>in</strong>es<br />

at Economical Price<br />

22<br />

Fermenta Biotech Ltd<br />

Discover | Develop | Deliver<br />

30<br />

Nucleome Informatics<br />

Unravel<strong>in</strong>g the Genomes<br />

for a Better Future<br />

38<br />

Articles<br />

26<br />

34<br />

Medic<strong>in</strong>e<br />

World Insights<br />

<strong>10</strong> Medic<strong>in</strong>es that<br />

Changed the World<br />

<strong>Pharma</strong><br />

Trends<br />

Top <strong>Pharma</strong>ceutical Trends<br />

to Watch Out <strong>in</strong> <strong>2019</strong><br />

C o n t e n s


Editor-<strong>in</strong>-Chief Pooja M. Bansal<br />

Manag<strong>in</strong>g Editor Devasish Kanojiya<br />

Executive Editor<br />

Shruti P. Jambhale<br />

Art & Design Head Amol Kamble<br />

Associate Designer Poonam<br />

Art & Picture Editor Rahul Kavnekar<br />

Co-designer<br />

Mayur Koli<br />

Bus<strong>in</strong>ess Development Manager<br />

Akansha Garewal<br />

Sales Executives Rutuja, Kaustubh, Shraddha, Joan<br />

Technical Specialist<br />

Amar, Pratiksha<br />

Digital Market<strong>in</strong>g Manager Prashant Chevale<br />

SME-SMO Executives Swati, Manoj<br />

Circulation Manager<br />

Tanaji<br />

sales@<strong>in</strong>sightssuccess.com<br />

April, <strong>2019</strong><br />

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RNI NUMBER: MAHENG/2018/75953


1T<br />

HE<br />

MOST RECOMMENDED<br />

PHARMA &<br />

L FE SCIENCES<br />

SOLUTION PROVIDERS IN <strong>2019</strong>


harma and life sciences companies are tak<strong>in</strong>g important steps to<br />

Padvance their bus<strong>in</strong>ess processes and drive greater efficiencies.<br />

<strong>The</strong> <strong>in</strong>dustry will embrace transformation <strong>in</strong>itiatives at a faster<br />

pace <strong>in</strong> com<strong>in</strong>g years, across multiple functional areas, <strong>in</strong>clud<strong>in</strong>g<br />

commercial, cl<strong>in</strong>ical, regulatory, and quality.<br />

In product development, companies are focused on streaml<strong>in</strong><strong>in</strong>g<br />

end-to-end processes to speed time to market and ma<strong>in</strong>ta<strong>in</strong> compliance.<br />

For commercial teams, driv<strong>in</strong>g smarter engagement with customers<br />

rema<strong>in</strong>s a core focus as they launch more specialized products.<br />

This month, Insights Success has come up with a very contemporary topic<br />

and has dealt under the issue of “<strong>The</strong> <strong>10</strong> <strong>Most</strong> <strong>Recommended</strong> <strong>Pharma</strong><br />

& <strong>Life</strong> <strong>Sciences</strong> <strong>Solution</strong> <strong>providers</strong> <strong>in</strong> <strong>2019</strong>”. Here we have tried to<br />

focus on the different bus<strong>in</strong>ess portfolios with unique service solutions,<br />

and Sarjen Systems Pvt. Ltd. has grabbed our attention most to become<br />

the Cover story of this magaz<strong>in</strong>e. This brand is one of the best when<br />

comes to the <strong>Pharma</strong> and <strong>Life</strong> Science <strong>Solution</strong> Providers.<br />

A Look <strong>in</strong>to<br />

the <strong>Pharma</strong><br />

&<br />

<strong>Life</strong> Science<br />

Canvas<br />

We have also focused on different companies those have come up with<br />

unique solutions. Ashish <strong>Life</strong> Science Pvt Ltd offers a range of cutt<strong>in</strong>g<br />

–edge veter<strong>in</strong>ary products with the world-class manufactur<strong>in</strong>g<br />

<strong>in</strong>frastructure and relationship driven approach. Fermenta Biotech<br />

Limited is a multifaceted organization with a high degree of focus on<br />

research, development and product delivery <strong>in</strong> the field of biotechnology,<br />

pharmaceutical and environmental solutions. Nucleome Informatics<br />

Private Limited plays a major role by provid<strong>in</strong>g Genomics and<br />

Bio<strong>in</strong>formatics analysis support.<br />

Alongside, the companies like Avesthagen Limited, Global Calcium<br />

Private Limited, Infionic Inc., Kare4u Healthcare <strong>Solution</strong>s Pvt., Nec<strong>Life</strong>,<br />

Syngene have also been featured <strong>in</strong> the list<strong>in</strong>g of “<strong>The</strong> <strong>10</strong> <strong>Most</strong><br />

<strong>Recommended</strong> <strong>Pharma</strong> & <strong>Life</strong> <strong>Sciences</strong> <strong>Solution</strong> <strong>providers</strong> <strong>in</strong> <strong>2019</strong>”.<br />

<strong>The</strong> <strong>in</strong>terview with Insights Success, Abh<strong>in</strong>av Thakur gave us glimpses<br />

on his brand Accurex Biomedical Pvt. Ltd. It is one of the top 3<br />

manufacturers of quality Cl<strong>in</strong>ical Chemistry Reagents and Ur<strong>in</strong>analysis<br />

Test Strips with over 34 years of expertise <strong>in</strong> this area.<br />

This magaz<strong>in</strong>e also <strong>in</strong>cludes leaders’ thoughts as well. Sudip Chhatui,<br />

the VP- Bus<strong>in</strong>ess and Operations discuss on the “5 ways <strong>in</strong> which digital<br />

is transform<strong>in</strong>g healthcare and <strong>Pharma</strong> <strong>in</strong>dustry” and Kumar<br />

Subramaniam, the Founder & CEO of 75Health highlights on the<br />

“Future Predictions of Electronic Health Records, <strong>2019</strong> and Beyond”.<br />

<strong>The</strong> editor’s thoughts are also part of this magaz<strong>in</strong>e where they have<br />

researched on contemporary topics like Top <strong>Pharma</strong>ceutical Trends to<br />

Watch Out <strong>in</strong> <strong>2019</strong> and <strong>10</strong> Medic<strong>in</strong>es that Changed the World.<br />

So have a look at the magaz<strong>in</strong>e and get the Insights of the <strong>Pharma</strong> and<br />

<strong>Life</strong> Science <strong>Solution</strong>s!


1T<br />

HE<br />

MOST RECOMMENDED<br />

PHARMA &<br />

L FE SCIENCES<br />

SOLUTION PROVIDERS IN <strong>2019</strong><br />

Sarjen<br />

Systems<br />

Promot<strong>in</strong>g Indian <strong>Pharma</strong><br />

Research on Global Scene<br />

COVER STORY


Nikur Mody<br />

Founder


Today, everyone is well aware<br />

that <strong>Pharma</strong> Research is the<br />

sector where there are only a<br />

few predom<strong>in</strong>ant players. <strong>The</strong>re are<br />

many companies, which are embrac<strong>in</strong>g<br />

the changes and creat<strong>in</strong>g a niche <strong>in</strong> the<br />

pharma & life science sector. Sarjen<br />

Systems is one such company which is<br />

provid<strong>in</strong>g affordable solutions by<br />

support<strong>in</strong>g and promot<strong>in</strong>g pharma<br />

research – a small step to br<strong>in</strong>g Indian<br />

pharma and pharma research on the<br />

global scene.<br />

With the Vision of “Hav<strong>in</strong>g a<br />

world-class organization with<br />

operational excellence and global<br />

reach”, Sarjen Systems has always<br />

ma<strong>in</strong>ta<strong>in</strong>ed standards to excel with<br />

m<strong>in</strong>imum fuss follow<strong>in</strong>g on the<br />

Mission of “Spread<strong>in</strong>g the power of<br />

bus<strong>in</strong>ess technology solutions to<br />

customers across the globe; add<strong>in</strong>g<br />

value to their bus<strong>in</strong>esses. And,<br />

encourag<strong>in</strong>g support for our employees<br />

who <strong>in</strong> turn would provide exceptional<br />

service to the customers”.<br />

‘<br />

DEVELOPING<br />

SOLUTIONS<br />

USING CUTTING-EDGE<br />

TECHNOLOGY<br />

&<br />

STRETCHING<br />

THE LIMITS TO<br />

GET THE BEST<br />

<strong>The</strong> Outset of the Sarjen Systems<br />

Nikur Mody is the Founder of Sarjen<br />

Systems and ever s<strong>in</strong>ce, he has always<br />

been <strong>in</strong>terested to strike out, pursu<strong>in</strong>g<br />

that seed of an idea with a zealous<br />

rage. Com<strong>in</strong>g from an IT background,<br />

his <strong>in</strong>terests led him to th<strong>in</strong>k of<br />

<strong>in</strong>troduc<strong>in</strong>g simplified approach to<br />

software development.<br />

In 90s, a lot of bus<strong>in</strong>ess software were<br />

enter<strong>in</strong>g <strong>in</strong>to the market and ga<strong>in</strong><strong>in</strong>g<br />

momentum to get recognized. By the<br />

time, Mody realized that there were<br />

ongo<strong>in</strong>g gaps between bus<strong>in</strong>ess<br />

expectations and technology<br />

enthusiasts who would understand<br />

those expectations very differently.<br />

And, amaz<strong>in</strong>gly, Sarjen Systems was a<br />

result of this ideology and was founded<br />

<strong>in</strong> the late 90s to offer technology<br />

solutions understand<strong>in</strong>g and serv<strong>in</strong>g<br />

precise bus<strong>in</strong>ess expectations.<br />

It became easier for Sarjen Systems, to<br />

meticulously study customer processes,<br />

variations <strong>in</strong> them from customer-tocustomer,<br />

and employ a dedicated team<br />

of bus<strong>in</strong>ess technology consultants. Its<br />

primary function is to fulfill customer<br />

expectations and deliver that last-mile<br />

customization to achieve significant<br />

improvement <strong>in</strong> work efficiency.<br />

Leader, Motivator, and a Mentor<br />

Nikur Mody is a visionary, at the<br />

nucleus of the team of brilliant experts,<br />

guid<strong>in</strong>g and provid<strong>in</strong>g directions to the<br />

organization through the emerg<strong>in</strong>g<br />

<strong>in</strong>dustry and technology changes and<br />

evolv<strong>in</strong>g methodologies. This has<br />

helped Sarjen Systems start the next<br />

“great big” walk, play<strong>in</strong>g a key role <strong>in</strong><br />

shap<strong>in</strong>g the corporate functions of<br />

bus<strong>in</strong>ess development as well as<br />

f<strong>in</strong>ance.<br />

Nikur has completed an MBA <strong>in</strong><br />

International Bus<strong>in</strong>ess and F<strong>in</strong>ance<br />

after f<strong>in</strong>ish<strong>in</strong>g his Bachelor’s <strong>in</strong><br />

Eng<strong>in</strong>eer<strong>in</strong>g with specialization <strong>in</strong><br />

Computer Technology. His <strong>in</strong>novative<br />

but practical approach has helped<br />

Sarjen Systems’ customers to realize<br />

value proposition through software<br />

solutions. Hav<strong>in</strong>g worked with all<br />

functional areas at grass root level, has<br />

helped <strong>in</strong> envision<strong>in</strong>g <strong>in</strong>novative<br />

projects with great detail. Prior to<br />

Sarjen Systems, he has worked with IT<br />

companies like L&T Information<br />

Technology and Mastek Ltd. <strong>in</strong>


strategic plann<strong>in</strong>g where he engaged<br />

his technology and eng<strong>in</strong>eer<strong>in</strong>g skills<br />

to solve significant corporate<br />

challenges.<br />

Notable Software <strong>Solution</strong>s<br />

S<strong>in</strong>ce its found<strong>in</strong>g, Sarjen Systems has<br />

stood out through its own unique<br />

bus<strong>in</strong>ess style. And, has been known to<br />

architect, design and develop<br />

proprietary technology stack with<br />

enormous careful thought and<br />

consideration.<br />

<strong>The</strong> product story <strong>in</strong>cludes three<br />

flagship products which are an<br />

evolution of solutions progress<strong>in</strong>g to<br />

address client demands. It starts with<br />

Sarjen Systems develop<strong>in</strong>g<br />

<strong>Pharma</strong>NET for supply cha<strong>in</strong> and sales<br />

‘n distribution, for sales force<br />

automation – FFReport<strong>in</strong>g, and then<br />

FForce – a Field Sales Excellence<br />

platform.<br />

Some other unique solutions are:<br />

KnowledgeNET - a global Drug dossier<br />

publish<strong>in</strong>g and lifecycle management;<br />

RIMS for regulatory <strong>in</strong>formation<br />

management.<br />

ProcessXE - an MES <strong>in</strong> the form of<br />

pharmaceutical manufactur<strong>in</strong>g<br />

automation with eBMR, Dispens<strong>in</strong>g<br />

and logbooks.<br />

QEdge - an automated enterprise-wide<br />

quality management (eQMS) for<br />

quality processes to ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g<br />

tra<strong>in</strong><strong>in</strong>g records and eLearn<strong>in</strong>g to<br />

document control and management for<br />

controlled processes and practices.<br />

PvEdge - Drug safety database for<br />

pharmacovigilance of drugs, vacc<strong>in</strong>es,<br />

devices, cl<strong>in</strong>ical trials, veter<strong>in</strong>ary<br />

vigilance – <strong>in</strong>corporated with signal<br />

detection and literature automation.<br />

BizNET - Paperless cl<strong>in</strong>ical trial<br />

management which can cover several<br />

different types of trial protocols, study<br />

types.<br />

Whereas consult<strong>in</strong>g on SAP<br />

deployment, Computer System<br />

Validations (CSV), Data analytics and<br />

AI & Mach<strong>in</strong>e Learn<strong>in</strong>g (ML),<br />

extend<strong>in</strong>g applications as Mobility<br />

solutions are Sarjen Systems’ forte.<br />

<strong>The</strong> Plus Po<strong>in</strong>ts<br />

Start<strong>in</strong>g with the sales and distribution<br />

solution, <strong>Pharma</strong>NET and then<br />

<strong>in</strong>tegrated it with ERP to give a robust<br />

boost to have some vital complexities<br />

outside of ERP, Sarjen Systems kept on<br />

add<strong>in</strong>g one solution after another <strong>in</strong> its<br />

‘<br />

SARJEN<br />

SYSTEMS<br />

HAS AN<br />

AMALGAMATION<br />

OF TECHNOLOGY<br />

AND INDUSTRY<br />

KNOWLEDGE<br />

CATERING<br />

SOLUTIONS WITH<br />

SIMPLICITY, EFFICIENCY<br />

&<br />

VISIBILITY TO<br />

AN ENTERPRISE


solution list. In this broad spectrum,<br />

mobility solutions on one end and on<br />

the other end, develop<strong>in</strong>g and<br />

implement<strong>in</strong>g solutions for digital<br />

transformation of cl<strong>in</strong>ical research<br />

organizations, drug safety database,<br />

enterprise-wide quality management<br />

and many more. At the core of Sarjen<br />

Systems’ solution implementation<br />

success, there is a flexible delivery<br />

approach where it efficiently merges its<br />

doma<strong>in</strong> expertise with the proprietary<br />

technology stack. All the products can<br />

be<br />

‘<br />

easily <strong>in</strong>tegrated with <strong>in</strong>dustry<br />

CONSTANT<br />

GREATER<br />

GOALS<br />

ARE THE WAY<br />

TO KEEP<br />

MOMENTUM<br />

GOING AND<br />

SUCCEED<br />

standard enterprise applications. Also,<br />

the project management and consult<strong>in</strong>g<br />

teams seamlessly execute <strong>in</strong>tegrat<strong>in</strong>g<br />

of projects ensur<strong>in</strong>g high throughput.<br />

<strong>The</strong> solution<strong>in</strong>g for pharma and life<br />

science doma<strong>in</strong>s was the precursor of<br />

implement<strong>in</strong>g processes and<br />

ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g high quality standards<br />

with cont<strong>in</strong>ued improvements. This<br />

would help <strong>in</strong> ensur<strong>in</strong>g that there were<br />

no defects or bugs <strong>in</strong> delivery,<br />

documentation and ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g<br />

all-around quality standards. Sarjen<br />

Systems provides solutions and<br />

services across several <strong>in</strong>dustry<br />

doma<strong>in</strong>s <strong>in</strong>clud<strong>in</strong>g <strong>Pharma</strong>ceutical,<br />

Healthcare, <strong>Life</strong> sciences, FMCG, and<br />

few others; comply<strong>in</strong>g with global<br />

regulatory guidel<strong>in</strong>es.<br />

Sarjen Systems’ USP<br />

· Expertise <strong>in</strong> <strong>Pharma</strong> and <strong>Life</strong> science<br />

doma<strong>in</strong>s<br />

· Proprietary Technology Stack ·<br />

Global Exposure/Presence<br />

· Complete solution basket – from<br />

Drug Development to Sales<br />

· Expert on cGxP and Regulatory<br />

guidel<strong>in</strong>es<br />

· <strong>Solution</strong>s compliant with Part 11<br />

(Annex 11, EMA and 21 CFR Part<br />

11, US FDA) and global guidel<strong>in</strong>es<br />

· Multiple Licens<strong>in</strong>g models to suit<br />

enterprise needs<br />

Unlocked Milestones<br />

Gett<strong>in</strong>g ISO 9001:2008 certification<br />

was the natural progression and it gave<br />

way to very structured quality<br />

management <strong>in</strong>tegrated with Sarjen<br />

Systems’ SDLC. <strong>The</strong>n, upgrad<strong>in</strong>g to<br />

risk and opportunity based ISO<br />

9001:2015 standards to achieve and<br />

ma<strong>in</strong>ta<strong>in</strong> control, and cont<strong>in</strong>ual<br />

improvement for processes, products<br />

and services. Cont<strong>in</strong>u<strong>in</strong>g them forward<br />

ensures structure, process-driven<br />

approach for seamless quality. Also,<br />

implement<strong>in</strong>g compliant GxP<br />

computerized systems us<strong>in</strong>g GAMP5<br />

driven risk-based validation for part 11<br />

compliance.<br />

Dynamic project management with the<br />

right set of people to develop solutions<br />

us<strong>in</strong>g cutt<strong>in</strong>g-edge technology,<br />

stretch<strong>in</strong>g the limits to get the best,<br />

achiev<strong>in</strong>g timel<strong>in</strong>es <strong>in</strong> the budget,<br />

ris<strong>in</strong>g to the challenge of def<strong>in</strong><strong>in</strong>g<br />

milestones, planned commitments and<br />

deliverables, ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g quality,<br />

track<strong>in</strong>g progress and overall<br />

strategiz<strong>in</strong>g the various stages of<br />

software development is Sarjen<br />

Systems’ highlight<strong>in</strong>g forte.<br />

Rewards and Recognitions<br />

Sarjen Systems was recently shortlisted<br />

as “Best Software Company” @<br />

Vibrant Gujarat Technology Summit.<br />

Sarjen Systems is a Microsoft Gold<br />

partner. Also, NASSCOM and Gesia<br />

member. <strong>The</strong>ir core team members<br />

have been <strong>in</strong>vited to speak at numerous<br />

events on various topics. <strong>The</strong>y have<br />

recently hosted a NASSCOM event.<br />

A Piece of Advice<br />

“One must focus on deep doma<strong>in</strong><br />

expertise and user-centric design with<br />

persistence to adapt, adopt and<br />

<strong>in</strong>novate. Small and mean<strong>in</strong>gful<br />

improvements will lead to hugely<br />

differentiat<strong>in</strong>g product <strong>in</strong> the long<br />

run.” – states Nikur Mody.<br />

Explor<strong>in</strong>g Market Leadership<br />

Sarjen Systems’ ongo<strong>in</strong>g adaptation of<br />

AI, ML, Blockcha<strong>in</strong> and Deep<br />

Learn<strong>in</strong>g has brought impactful change<br />

across its solutions. <strong>The</strong>se<br />

technological advancements of now<br />

and tomorrow, would not only improve<br />

overall efficiency and <strong>in</strong>culcate good<br />

practices but also <strong>in</strong>directly contribute<br />

to better and greater patient safety.<br />

Sarjen Systems is all set to cont<strong>in</strong>ue its<br />

habit of <strong>in</strong>novations by embedd<strong>in</strong>g<br />

new technologies and achieve a higher<br />

position as a lead<strong>in</strong>g software solutions<br />

provider, globally.


KNOW US BETTER<br />

• Founded Year:<br />

1998<br />

• Headquarter <strong>in</strong>:<br />

Ahmedabad, India<br />

• Major Operation Centers:<br />

Support offices <strong>in</strong> Mumbai,<br />

India; London, UK and<br />

Durham, USA<br />

• Total Number of Clients<br />

Served & Countries<br />

Served:<br />

<strong>10</strong>0+ clients <strong>in</strong> 50+<br />

countries<br />

• Our Tagl<strong>in</strong>e: Pioneer<strong>in</strong>g<br />

digital transformation for<br />

Indian <strong>Pharma</strong> research<br />

• URL: www.sarjen.com<br />

‘<br />

WE ARE<br />

A WORK CULTURE<br />

CREATING<br />

IDEA FLOWS MIND VERY EASILY<br />

OUT OF<br />

WHERE


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Interview with Insights Success<br />

Accurex<br />

Biomedical<br />

In today’s fast paced world, disease is<br />

not taken care of until body shows<br />

symptoms. Can high quality healthcare<br />

be delivered if patient’s physician is<br />

hurried, cold or uncar<strong>in</strong>g? That’s why<br />

many of the companies are <strong>in</strong>novat<strong>in</strong>g new<br />

technologies, new processes for timely<br />

diagnosis and treatment of diseases.<br />

Pioneer <strong>in</strong> Manufactur<strong>in</strong>g and<br />

Market<strong>in</strong>g of In-vitro<br />

Diagnostic Reagents<br />

In an <strong>in</strong>terview with Insights Success, Abh<strong>in</strong>av Thakur,<br />

Manag<strong>in</strong>g Director at Accurex Biomedical Pvt. Ltd. has<br />

shared some <strong>in</strong>sightful views and highlighted the <strong>in</strong>fluences made<br />

by their company. <strong>The</strong> company is one of the top 3 manufacturers<br />

of quality Cl<strong>in</strong>ical Chemistry Reagents and Ur<strong>in</strong>analysis Test<br />

Strips with over 34 years of expertise <strong>in</strong> this area.<br />

INTERVIEW WITH INSIGHTS SUCCESS<br />

1. Share with us the motivat<strong>in</strong>g factors that led towards the <strong>in</strong>ception of company?<br />

I was study<strong>in</strong>g <strong>in</strong> the USA when unfortunately, my father passed away prematurely. I came back to<br />

India to run the company for my family.<br />

At that po<strong>in</strong>t of time motivation for me was survival of the family bus<strong>in</strong>ess.<br />

Now the motivation for me is to grow the company so I can have an impact on the economic<br />

development of our country. I strongly believe that strong economic development is the antidote the<br />

poverty.<br />

2. Brief us about the goal, vision and mission of the company; it has set to mark its exceptionality <strong>in</strong><br />

future.<br />

We are <strong>in</strong> the medical diagnostics <strong>in</strong>dustry and impact the lives of humans. 70% of medical<br />

decisions are made based on medical diagnostic reports. Hence our mission is to help save lives by<br />

provid<strong>in</strong>g accurate and precise medical diagnostic solutions to pathology laboratories.<br />

Our vision is to be one of the Top medical diagnostic companies of India by 2025.<br />

3. Which is you flagship product? Tell us someth<strong>in</strong>g about that. It would be great if you provide us 2-3<br />

notable feedbacks from of renowned clients/bus<strong>in</strong>ess leaders regard<strong>in</strong>g your products/services.<br />

<strong>The</strong> most common test <strong>in</strong> any pathology lab is blood glucose. Diabetic patients are aware about their<br />

blood sugar levels and blood glucose is also checked at home by many diabetics.<br />

If there is an error I the blood glucose report the chances of the patient question<strong>in</strong>g the report are<br />

very high when compared to other tests.<br />

If the patient f<strong>in</strong>ds out the results provided by the lab are <strong>in</strong>accurate by test<strong>in</strong>g <strong>in</strong> another lab or at<br />

home, then the lab loses a customer and its reputation.<br />

Consequently, blood glucose is one of the test on which the reputation of a lab depends.<br />

18 | | APRIL <strong>2019</strong>


Abh<strong>in</strong>av Thakur<br />

MD<br />

APRIL <strong>2019</strong> |<br />

| 19


Accurex today is the largest supplier of blood glucose<br />

reagents <strong>in</strong> the country because of the quality of our<br />

reagents.<br />

This proves that our quality of reagents is the best <strong>in</strong> the<br />

country.<br />

4. Tell us about the services you provide through your<br />

venture (apart from your flag-ship one).<br />

We also provide medical diagnostic <strong>in</strong>struments.<br />

5. What is the uniqueness of your products and services as<br />

compare to your competitors? K<strong>in</strong>dly elaborate <strong>in</strong><br />

detail.<br />

Our company was established <strong>in</strong> 1984. S<strong>in</strong>ce we have<br />

been <strong>in</strong> the market for over 34 years we have build a<br />

strong brand <strong>in</strong> the market. If it was not for the quality<br />

of our products it would not have been possible for us<br />

to survive <strong>in</strong> the market for over 34 years.<br />

Hence quality of our reagents and result<strong>in</strong>g brand for<br />

the last 34 years is our competitive advantage.<br />

6. Brief us about the Founder/CEO of the company and<br />

the major contribution of him/her towards the<br />

development of the company.<br />

My father, Mr. Anil Thakur was the Founder &<br />

Ex-Manag<strong>in</strong>g Director of Accurex Biomedical Pvt.<br />

Ltd. He was an excellent visionary. Under his<br />

leadership, Accurex had launched various <strong>in</strong>novative<br />

products and marketed them with <strong>in</strong>novative strategies.<br />

He established Accurex as a Customer-Oriented<br />

organization, and launched the 24 x 7 module for all<br />

Accurex customers to log on their compla<strong>in</strong>ts/queries<br />

24 hours a day; 7 days a week - the first-of-its-k<strong>in</strong>d <strong>in</strong><br />

India.<br />

Mr. Thakur took Accurex to <strong>in</strong>ternational platforms<br />

through Medica, APCCB and various other<br />

International exhibitions and conferences. His<br />

contribution towards Accurex for the last 20 years was<br />

enormous. Unfortunately, Mr. Thakur passed away on<br />

25 January, 2004. However Accurex will cont<strong>in</strong>ue to be<br />

guided by his ideals and vision. In the near future,<br />

Accurex will achieve a leadership position <strong>in</strong> the<br />

Asia-Pacific region which was his dream.<br />

7. What are the positive developments go<strong>in</strong>g on <strong>in</strong> the<br />

<strong>Pharma</strong> & <strong>Life</strong> <strong>Sciences</strong> <strong>Solution</strong> provider company?<br />

Po<strong>in</strong>t-of-care test<strong>in</strong>g (POCT), or bedside test<strong>in</strong>g is<br />

def<strong>in</strong>ed as medical diagnostic test<strong>in</strong>g at or near the<br />

po<strong>in</strong>t of care—that is, at the time and place of patient<br />

care. This contrasts with the historical pattern <strong>in</strong> which<br />

test<strong>in</strong>g was wholly or mostly conf<strong>in</strong>ed to the medical<br />

laboratory, which entailed send<strong>in</strong>g off specimens away<br />

from the po<strong>in</strong>t of care and then wait<strong>in</strong>g hours or days to<br />

learn the results, dur<strong>in</strong>g which time care must cont<strong>in</strong>ue<br />

without the desired <strong>in</strong>formation.<br />

POC test<strong>in</strong>g is gett<strong>in</strong>g popular <strong>in</strong> the medical<br />

diagnostic <strong>in</strong>dustry.<br />

Through POC test<strong>in</strong>g the lab tests are available at the<br />

doctors and patients at home. This is convenient to the<br />

patient.<br />

8. Your advice to budd<strong>in</strong>g entrepreneurs?<br />

Four mantras:<br />

1. Good Governance: Never compromise on your<br />

ethics. Sooner or later you will have to pay the<br />

price. Reputation built over years can be<br />

destroyed <strong>in</strong> hours if you compromise on ethics.<br />

2. Empower your team. Don’<br />

t dictate your terms to<br />

the team but <strong>in</strong>volve your team <strong>in</strong> the decision<br />

mak<strong>in</strong>g process to get ownership.<br />

3. Build a competitive advantage <strong>in</strong> your bus<strong>in</strong>ess<br />

or you will become a commodity soon and loose<br />

your market share. You need to keep <strong>in</strong>novat<strong>in</strong>g<br />

to build your competitive advantage.<br />

4. Purpose: You need to build a strong purpose for<br />

your bus<strong>in</strong>ess. If you don’<br />

t have a strong<br />

purpose then you will give up <strong>in</strong> the difficult<br />

times. Money cannot be the only purpose<br />

because if money is the only purpose then it will<br />

be short lived and you may end up tak<strong>in</strong>g<br />

short cuts.<br />

9. What the company desperately wants to achieve <strong>in</strong> the<br />

next few years?<br />

In the next few years we want to build our foundation<br />

strong so we can raise funds and grow to achieve our<br />

mission and vision.<br />

20 | | APRIL <strong>2019</strong>


Ashish <strong>Life</strong> Science<br />

Deliver<strong>in</strong>g Highest Quality Veter<strong>in</strong>ary Medic<strong>in</strong>es at Economical Price<br />

Meet the Profound Founder<br />

Raujesh Agarrwal, the Founder of Ashish <strong>Life</strong> Science<br />

Pvt. Limited, has completed PG <strong>in</strong> Family Managed<br />

Bus<strong>in</strong>ess. He is responsible for deploy<strong>in</strong>g the company’s<br />

strategic vision and develop<strong>in</strong>g bus<strong>in</strong>ess alliances as well<br />

as build<strong>in</strong>g the management team. He has been actively<br />

<strong>in</strong>volved <strong>in</strong> sales & market<strong>in</strong>g of the company products<br />

all over the world. Over the period of time, he appo<strong>in</strong>ted<br />

distribution & market<strong>in</strong>g channel <strong>in</strong> over 60 countries.<br />

Idea beh<strong>in</strong>d ‘ALS’<br />

After travell<strong>in</strong>g to many countries, Raujesh realized the<br />

potential of Indian veter<strong>in</strong>ary medic<strong>in</strong>e. He recognized<br />

the huge bus<strong>in</strong>ess prospective for Animal health products<br />

<strong>in</strong> International markets. See<strong>in</strong>g the vision and growth of<br />

the <strong>in</strong>dustry he decided to start manufactur<strong>in</strong>g and<br />

export<strong>in</strong>g veter<strong>in</strong>ary products.<br />

Raujesh Agarrwal, Founder<br />

Ashish <strong>Life</strong> Science Pvt. Ltd. (ALS) is<br />

established s<strong>in</strong>ce 2002. S<strong>in</strong>ce <strong>in</strong>ception, it is<br />

tak<strong>in</strong>g efforts to deliver significant value to its<br />

customers by understand<strong>in</strong>g their needs and <strong>in</strong>novat<strong>in</strong>g<br />

to offer the right choice of products. Over the years, it<br />

has built up a reputation for reliability and trust between<br />

company and its customers.<br />

ALS’s entire team is consistently evolv<strong>in</strong>g to meet its<br />

customers’ needs across the Globe. It offers a range of<br />

cutt<strong>in</strong>g –edge veter<strong>in</strong>ary products with the world-class<br />

manufactur<strong>in</strong>g <strong>in</strong>frastructure and relationship driven<br />

approach.<br />

“We pride ourselves on personal service, good work<strong>in</strong>g<br />

relationships, and satisfy<strong>in</strong>g our customers wherever<br />

they may be.” says Raujesh Agarrwal, the Founder.<br />

“We believe animals have been cater<strong>in</strong>g to service of<br />

mank<strong>in</strong>d and it is our duty to reciprocate back.” –states<br />

Raujesh.<br />

World-Class Quality Products<br />

<strong>The</strong> company has therefore, developed a strong focus on<br />

‘Animal Healthcare’. <strong>The</strong> provided quality is beyond the<br />

horizon of any negotiation. <strong>The</strong>refore, world-class<br />

manufactur<strong>in</strong>g facility has been set up that could meet<br />

str<strong>in</strong>gent cGMP Guidel<strong>in</strong>es of any regulatory body<br />

<strong>in</strong>clud<strong>in</strong>g World Health Organization. <strong>The</strong> company<br />

strictly follows cGMP <strong>in</strong> all aspects of production and<br />

distribution activities. Also, the manufactur<strong>in</strong>g facility is<br />

approved by various health authorities for supply of<br />

veter<strong>in</strong>ary medic<strong>in</strong>es.<br />

Inclusive Services<br />

ALS exhibits high diligence at every level and function.<br />

22 | | APRIL <strong>2019</strong>


MOST RECOMMENDED<br />

PHARMA &<br />

L FE SCIENCES<br />

SOLUTION PROVIDERS IN <strong>2019</strong><br />

Adherence to quality, best-<strong>in</strong>-class manufactur<strong>in</strong>g<br />

practices, highest level of laboratory certification and<br />

high service standards have enabled it to build last<strong>in</strong>g<br />

relationship across the globe.<br />

“As India is strong on human pharmaceuticals;<br />

therefore, we saw an opportunity for pharmaceutical <strong>in</strong><br />

the Animal space and decided to totally focus on animal<br />

products.” states Raujesh.<br />

Ris<strong>in</strong>g above the Horizon<br />

Beh<strong>in</strong>d the meteoric rise of ALS, there is a team of<br />

committed <strong>in</strong>dividuals. <strong>The</strong> team of ALS comprises of<br />

dedicated professionals who believe <strong>in</strong> learn<strong>in</strong>g, empathy<br />

and <strong>in</strong>novation. <strong>The</strong> entire team is relentlessly and<br />

passionately work<strong>in</strong>g towards the advancement of<br />

animal care.<br />

ALS operates across the entire spectrum of therapeutic<br />

segments – Antiparasitics, Ecoparasiticides, NSAIDs,<br />

Antibiotics, Antifungal, Antiprotozoal, Tonics and<br />

Neutraceuticals to name a few. Besides, it also offer all<br />

dosage forms – bolus, tablets, powder, suspensions,<br />

solutions, oral paste, <strong>in</strong>jectable and spray & o<strong>in</strong>tments<br />

ensur<strong>in</strong>g that its clients also have an ease and<br />

effectiveness of adm<strong>in</strong>istrations.<br />

Notable Achievements<br />

Ashish <strong>Life</strong> Science has won the “SME Bus<strong>in</strong>ess<br />

Excellence Awards 2014”, presented by D&B, <strong>The</strong><br />

Times Group and Federal Bank. Also, it has been<br />

recognized as “India’s small Giants” by India SME <strong>in</strong><br />

2014. Furthermore, Raujesh was <strong>in</strong>terviewed by ET now<br />

after ALS was recognized as an emerg<strong>in</strong>g “<strong>Pharma</strong><br />

Company <strong>in</strong> micro segment”.<br />

Additionally, ALS has won the prestigious “Top <strong>10</strong>0<br />

SMEBOI Awards” (achievers of 2012), the “Top <strong>10</strong>0<br />

SMEBOI Awards” (Achievers of 2013) and the “ECGC-<br />

D&B- Indian Exporters Excellence Awards 2015 – Best<br />

manufactur<strong>in</strong>g Exporters” Award along with the Golden<br />

Maharashtra MSME’s “Manufactur<strong>in</strong>g Summit 2015<br />

Award”. And, it has been featured <strong>in</strong> the well-known<br />

“Dollar Bus<strong>in</strong>ess magaz<strong>in</strong>e” <strong>in</strong> 2016.<br />

1T<br />

HE<br />

We believe that our<br />

customer's customer<br />

is our customer<br />

and satisfaction<br />

of these customers<br />

is our responsibility<br />

as well, and,<br />

we believe <strong>in</strong><br />

deliver<strong>in</strong>g Value<br />

Founder’s Piece of Advice<br />

“Today, there is strong awareness by people about<br />

generics. People have started question<strong>in</strong>g the cost of the<br />

product. Thus, this is forc<strong>in</strong>g companies to reasonably<br />

price their products.” says Raujesh. Furthermore, he said<br />

“It’s all about Vision – Passion – Commitment”.<br />

Rock-solid Future<br />

<strong>The</strong> company is hav<strong>in</strong>g crystal-clear vision and thus,<br />

gear<strong>in</strong>g up to adopt the future trends. It has established<br />

its name <strong>in</strong> the <strong>in</strong>ternational market and will cont<strong>in</strong>ue to<br />

surpass the expectations of the customer and always<br />

improve and deliver highest quality at economical price<br />

on timely basis.<br />

| 23<br />

APRIL <strong>2019</strong> |


Digitaliz<strong>in</strong>g <strong>Pharma</strong><br />

Author<br />

ABOUT THE<br />

Sudip Chhatui –VP,<br />

Bus<strong>in</strong>ess and Operations at<br />

Curofy<br />

Sudip hails from Kolkata<br />

NSIT, Delhi Alumni. He was<br />

the first person <strong>in</strong> the<br />

Curofy Market<strong>in</strong>g team,<br />

who jo<strong>in</strong>ed before the<br />

launch of the Curofy app.<br />

Initially set up and led the<br />

growth team and is now<br />

lead<strong>in</strong>g the Bus<strong>in</strong>ess<br />

development team Curofy.<br />

He is a startup enthusiast.<br />

And, he is one who loves<br />

travel<strong>in</strong>g. Also, a Real<br />

Madrid fan.<br />

24 | | APRIL <strong>2019</strong>


5<br />

PHARMA<br />

echnology is chang<strong>in</strong>g every <strong>in</strong>dustry <strong>in</strong> significant<br />

Tways. No one can dispute technology’s ability to<br />

enable us all to live longer and healthier lives.<br />

From surgical robots to “smart hospitals,” the digital<br />

transformation is revolutioniz<strong>in</strong>g pharma and healthcare<br />

<strong>in</strong>dustry.<br />

While talk<strong>in</strong>g about digitalization, a po<strong>in</strong>t which needs to<br />

be clarified is that it isn’t just about automation of process<br />

or job or even new technology. It is much bigger and more<br />

fundamental than that. Digital transformation is about us<strong>in</strong>g<br />

digital technologies and data to fulfil the need of the<br />

consumer.<br />

Data visualization to <strong>in</strong>crease accessibility<br />

WAYS IN WHICH<br />

DIGITALIZATION<br />

IS TRANSFORMING<br />

HEALTHCARE AND<br />

INDUSTRY<br />

F<strong>in</strong>ancial transparency:<br />

Technology helps people <strong>in</strong> gett<strong>in</strong>g <strong>in</strong>formation about<br />

healthcare expenses. Till now, if the patient was gett<strong>in</strong>g<br />

treated, it was often unclear whether the procedures be<strong>in</strong>g<br />

done are actually necessary or not. But, now the patients<br />

and their family are well aware of the treatments. <strong>The</strong>re’s<br />

also a lack of consistency for health care treatments, the<br />

same services and procedures vary <strong>in</strong> cost from state to<br />

state, sometimes even from one hospital to the next. In<br />

many cases, patients don’t know how much a procedure<br />

costs until it’s done and they’ve received the bill.<br />

Healthcare cost sometimes leads to personal bankruptcy.<br />

Digital transformation is help<strong>in</strong>g the system to improve the<br />

overall patient experience.<br />

Data visualization isn’t just any art, it’s grounded <strong>in</strong> real<br />

results and <strong>in</strong>dustry f<strong>in</strong>d<strong>in</strong>gs. With the new technology, the<br />

way people access and process <strong>in</strong>formation are chang<strong>in</strong>g.<br />

For example, smart health monitors that can collect<br />

personalized, real-time data, encourag<strong>in</strong>g healthier<br />

lifestyles help <strong>in</strong> gather<strong>in</strong>g more lifestyle data, and medical<br />

records. Compar<strong>in</strong>g the responses of patients with<br />

similarities <strong>in</strong> DNA, medical histories and lifestyle can<br />

allow us to understand health risks and the impact of<br />

different treatments. This shar<strong>in</strong>g of data-based <strong>in</strong>telligence<br />

if done <strong>in</strong> a tangible and accessible way, not just helps the<br />

scientifically-m<strong>in</strong>ded people but also helps the border<br />

audience.<br />

Access to a wide range of medical products<br />

<strong>The</strong> medical product <strong>in</strong>formation is easily accessiable<br />

nowadays, it is no more limited to pathways of pharma<br />

companies and the secrecy no longer exists. Information<br />

about every medic<strong>in</strong>al product is available on the <strong>in</strong>ternet.<br />

Patients and consumers can easily f<strong>in</strong>d various ways to cure<br />

there condition through the <strong>in</strong>ternet. <strong>The</strong>y can even f<strong>in</strong>d the<br />

alternatives to drugs without spend<strong>in</strong>g a penny.<br />

Digitalization streaml<strong>in</strong>es the process for efficiency:<br />

Future-forward technologies like AI that can make some of<br />

the major complex k<strong>in</strong>d of decisions us<strong>in</strong>g <strong>in</strong>-depth data<br />

and analytical calculations are transform<strong>in</strong>g strategic<br />

processes as we know them.<br />

Increas<strong>in</strong>g channel of communication:<br />

Earlier if a patient had any healthcare concerns they used to<br />

rush to the hospital. However, with a grow<strong>in</strong>g digital<br />

presence, patients now explore the <strong>in</strong>ternet for hospital<br />

sites, e-mailers to connect to the doctor. Other than this,<br />

patients have onl<strong>in</strong>e access to medical records which they<br />

can share with their doctors.<br />

Digital transformation is an ongo<strong>in</strong>g journey that requires<br />

putt<strong>in</strong>g the consumer at the centre of your bus<strong>in</strong>ess. It has<br />

created a whole new realm of possibility for the consumer,<br />

specifically with the advent of smartphones and their<br />

applications (apps). Smartphone apps are now considered<br />

helpful <strong>in</strong> enhanc<strong>in</strong>g patient education, facilitat<strong>in</strong>g<br />

communication and patient engagement.<br />

APRIL <strong>2019</strong> |<br />

| 25


Medic<strong>in</strong>e World Insights<br />

Penicill<strong>in</strong><br />

01<br />

<strong>10</strong> Medic<strong>in</strong>es<br />

that Changed<br />

the World<br />

It was discovered <strong>in</strong> 1928 by Scottish scientist<br />

Alexander Flem<strong>in</strong>g. Antibiotic, People began us<strong>in</strong>g<br />

<strong>in</strong> 1942 to treat <strong>in</strong>fections and it is used to treat<br />

<strong>in</strong>fections caused by certa<strong>in</strong> susceptible bacteria.<br />

Ether/General<br />

Anesthesia<br />

03<br />

<strong>The</strong> use of anaesthesia can be traced back to<br />

ancient civilizations when opium and other natural<br />

substances were used for the purpose. <strong>The</strong> first<br />

public demonstration of the use of Ether as an<br />

anaesthetic was done <strong>in</strong> 1846 by William T.G.<br />

Morton. Diethyl Ether or Ether is an organic<br />

compound hold<strong>in</strong>g anaesthetic properties and<br />

was widely used dur<strong>in</strong>g surgeries until 2005.<br />

02<br />

Insul<strong>in</strong><br />

A natural prote<strong>in</strong>, it needs to be adm<strong>in</strong>istered as<br />

medic<strong>in</strong>e for diabetic patients. First used <strong>in</strong> 1922<br />

by Frederick Bant<strong>in</strong>g, Charles Best and James<br />

Collip. It is used to treat diabetes and<br />

complications aris<strong>in</strong>g due to it and used along<br />

with glucose to treat high blood potassium levels.<br />

Oral<br />

Contraceptives<br />

04<br />

Oral Contraceptive pills are a method of hormonal<br />

contraception for birth control taken by women. In<br />

1950 Margaret Sanger jotted down her research<br />

f<strong>in</strong>d<strong>in</strong>gs to develop a birth control pill and <strong>in</strong> 1960,<br />

the first pill was approved. Some pills conta<strong>in</strong> both<br />

estrogen and progest<strong>in</strong> while some conta<strong>in</strong> only<br />

progest<strong>in</strong>. <strong>The</strong>y prevent fertilization by <strong>in</strong>hibit<strong>in</strong>g<br />

ovulation and thicken<strong>in</strong>g cervical mucus and<br />

depend on the user's adherence to the dosage.<br />

05<br />

Aspir<strong>in</strong><br />

A non-steroidal anti-<strong>in</strong>flammatory drug,<br />

acetylsalicylic acid (ASA) was first created <strong>in</strong> 1853<br />

by French Chemist Charles Frédéric Gerhardt and<br />

rechristened as Aspir<strong>in</strong> by Bayer for commercial<br />

use. It is used to treat pa<strong>in</strong>, fever and<br />

<strong>in</strong>flammation <strong>in</strong> general and used specifically <strong>in</strong><br />

case of heart attacks, and certa<strong>in</strong> types of cancer.<br />

26 | | APRIL <strong>2019</strong>


Mechloretham<strong>in</strong>e<br />

06<br />

Also known as Chlormeth<strong>in</strong>e and HN2 is a<br />

cytotoxic chemotherapy agent derived from<br />

mustard gas. Once used <strong>in</strong> warfare, their medical<br />

utility was first established by a team led by<br />

Cornelius P. Rhoads. Its derivatives are used to<br />

treat cancer and lymphoid malignancies like<br />

Hodgk<strong>in</strong>'s disease, prostate cancer and<br />

leukaemia.<br />

07<br />

Morph<strong>in</strong>e<br />

Chlorpromaz<strong>in</strong>e<br />

08<br />

A pa<strong>in</strong> medication extracted from plants which<br />

belong to the opiate family. First isolated dur<strong>in</strong>g<br />

the years 1803-1805 by Friedrich Serturner and<br />

commercially available <strong>in</strong> 1827. It acts on the<br />

central nervous system (CNS) to suppress the<br />

feel<strong>in</strong>g of pa<strong>in</strong> and is used to treat chronic, acute,<br />

myocardial and labour pa<strong>in</strong> and can be<br />

adm<strong>in</strong>istered orally or <strong>in</strong>jected.<br />

It was discovered <strong>in</strong> 1950 by chemist Paul<br />

Charpentier and was later produced as the first<br />

antipsychotic medic<strong>in</strong>e. Commonly marketed<br />

under the name of Thoraz<strong>in</strong>e it is used to treat<br />

psychotic disorders like schizophrenia, Bipolar<br />

disorder among others.<br />

09<br />

Stat<strong>in</strong>s<br />

Antiretroviral<br />

<strong>10</strong><br />

Stat<strong>in</strong>s are a class of lipid-lower<strong>in</strong>g medic<strong>in</strong>es<br />

that effectively reduce LDL cholesterol.<br />

Commonly sold as atorvastat<strong>in</strong> under the trade<br />

name Lipitor among others, it was first isolated by<br />

biochemist Akira Endo and approved for medical<br />

use <strong>in</strong> 1996. It is used to prevent cardiovascular<br />

diseases and abnormal lipid levels.<br />

Multiple Antiretroviral Medic<strong>in</strong>es are used to<br />

manage HIV/AIDS dur<strong>in</strong>g the Antiretroviral<br />

<strong>The</strong>rapy. Taken <strong>in</strong> comb<strong>in</strong>ation, these drugs<br />

prevent the growth of the virus to slow down and<br />

control the disease. <strong>The</strong> therapy first started as a<br />

solution to the dreaded disease <strong>in</strong> 1996.<br />

Sneha S<strong>in</strong>ha<br />

Editor<br />

APRIL <strong>2019</strong> |<br />

| 27


Fermenta Biotech Ltd<br />

Discover | Develop | Deliver<br />

Himachal Pradesh and was followed by another <strong>in</strong> 2011 at<br />

Dahej, Gujarat. Both the units are certificated by global<br />

accreditations. Align<strong>in</strong>g with world-class standards, a<br />

state-of-art R&D center is located at Thane that adds glory<br />

to FBL.<br />

Today, it is the only manufacturer and supplier of Vitam<strong>in</strong><br />

D3 (Cholecalciferol) <strong>in</strong> South-East Asia and shares the<br />

stage with a few manufacturers at the global platform.<br />

Hav<strong>in</strong>g a dom<strong>in</strong>ant presence over fifty countries and 300<br />

global customers, FBL exploits its experience to create a<br />

worldwide distribution network for pharmaceuticals, dietary<br />

and nutritional supplements, food, feed veter<strong>in</strong>ary and<br />

rodenticides.<br />

Prashant Nagre, CEO<br />

Nutrition and Preventive Health has taken gigantic<br />

leaps over the last decade. Emphasiz<strong>in</strong>g on<br />

creat<strong>in</strong>g an environment-friendly, susta<strong>in</strong>able<br />

world, the global nutraceutical <strong>in</strong>dustry is set to be a<br />

$578.23 billion <strong>in</strong>dustry by 2025 as per a report by<br />

ASSOCHAM.<br />

Conceptualized <strong>in</strong> 1986, Fermenta Biotech Ltd (FBL) is<br />

one of the lead<strong>in</strong>g entities with<strong>in</strong> the Indian sub-cont<strong>in</strong>ent<br />

that caters to this niche segment. This excerpt illustrates the<br />

successful voyage of FBL over the years, along with<br />

showcas<strong>in</strong>g the unique products and services while giv<strong>in</strong>g a<br />

glimpse of an adroit leader - Prashant Nagre, the CEO.<br />

Inception Saga – Go<strong>in</strong>g Down the Memory Lane!<br />

FBL, <strong>in</strong>cepted under the auspices of Duphar-Interfran Ltd<br />

(now known as DIL Ltd.), is the bra<strong>in</strong>child of late Mr.<br />

Vasant Kumar Datla. Start<strong>in</strong>g the journey from 1986, FBL<br />

has stamped its presence across the globe and created<br />

countless milestones and cont<strong>in</strong>ues to march forward. In<br />

1987, FBL’s first manufactur<strong>in</strong>g unit came up <strong>in</strong> Kullu,<br />

Marquee Products & Services<br />

Vitam<strong>in</strong> D3 is the flagship product of FBL and is also its<br />

largest portfolio <strong>in</strong> terms of bus<strong>in</strong>ess. Additionally, it has<br />

amassed expertise <strong>in</strong> <strong>in</strong>tegrated biotechnology solutions viz.<br />

enzymes as well as an Environmental <strong>Solution</strong>s bus<strong>in</strong>ess<br />

vertical focus<strong>in</strong>g on waste management through a blend of<br />

biotechnology and eng<strong>in</strong>eer<strong>in</strong>g acumen.<br />

Vitam<strong>in</strong> D3<br />

FBL pioneered the use of proprietary technology to<br />

manufacture Vitam<strong>in</strong> D3 <strong>in</strong> India. It addressed the grow<strong>in</strong>g<br />

need for its products across a wider range of applications <strong>in</strong><br />

the food, pharmaceuticals, dietary & nutritional<br />

supplements, feed, veter<strong>in</strong>ary and rodenticide segments.<br />

Biotechnology<br />

As a pioneer of Penicill<strong>in</strong> G Amidase (PGA), FBL has<br />

commercialized next generation PGA enzyme technologies<br />

for Amoxicill<strong>in</strong>, Ampicill<strong>in</strong>, Cephalex<strong>in</strong>, and Cefadroxil.<br />

<strong>The</strong> company offers improved CAL B Lipase catalysts that<br />

can be used for a plethora of applications.<br />

FBL has evolved as a dependable technology-driven partner<br />

enjoy<strong>in</strong>g customer trust irrespective of project size, phase,<br />

and complexity. Embrac<strong>in</strong>g <strong>in</strong>novative technologies have<br />

enabled FBL to <strong>in</strong>corporate the latest, eco-friendly<br />

manufactur<strong>in</strong>g practices, along with address<strong>in</strong>g sectors<br />

compris<strong>in</strong>g the pharmaceutical <strong>in</strong>dustry, f<strong>in</strong>e chemicals,<br />

bio-plastics and cosmetics.<br />

30 | | APRIL <strong>2019</strong>


MOST RECOMMENDED<br />

PHARMA &<br />

L FE SCIENCES<br />

SOLUTION PROVIDERS IN <strong>2019</strong><br />

1T<br />

HE<br />

Environmental <strong>Solution</strong>s<br />

FBL, a pioneer <strong>in</strong> enzyme technologies, offers <strong>in</strong>tegrated<br />

biotech as well as eng<strong>in</strong>eer<strong>in</strong>g solutions that address<br />

environmental issues. FBL’s tailor-made platform<br />

technologies provide unique waste water management and<br />

treatment advantages.<br />

Apart from its proprietary bio-product, Fermsept, FBL also<br />

offers Eng<strong>in</strong>eer<strong>in</strong>g Procurement and Construction solutions<br />

for a range of applications: encompass<strong>in</strong>g <strong>in</strong>tegrated<br />

solutions for sewage treatment plants and effluent treatment<br />

plants.<br />

Steer<strong>in</strong>g the Ship Ahead<br />

Prashant Nagre, CEO, has been associated with FBL for<br />

almost a decade, lead<strong>in</strong>g strategy and oversee<strong>in</strong>g day to day<br />

operations of all three bus<strong>in</strong>ess verticals viz. Biotechnology,<br />

<strong>Pharma</strong>ceuticals and Environmental <strong>Solution</strong>s. He also<br />

focuses on further build<strong>in</strong>g and develop<strong>in</strong>g the various<br />

strengths of FBL i.e. Manufactur<strong>in</strong>g, R&D and allied<br />

activities. He forms a core member of the product<br />

development team and is also responsible for creat<strong>in</strong>g and<br />

nurtur<strong>in</strong>g large bus<strong>in</strong>ess account relationships. Known for<br />

his meticulous plann<strong>in</strong>g skills, Prashant adds impetus to<br />

timely deliveries of products, quality orientation and human<br />

resource development with<strong>in</strong> the company.<br />

Awards and Accolades<br />

In its endeavor to deliver excellence <strong>in</strong> services, FBL has<br />

been bestowed with numerous awards and recognitions that<br />

exemplify its presence as a significant player <strong>in</strong> the<br />

<strong>in</strong>dustry. Few of the prized achievements are listed below:<br />

• India <strong>Pharma</strong> Awards 2018<br />

o Excellence <strong>in</strong> CSR for companies with turnover<br />

less than INR 500 Cr.<br />

o <strong>Pharma</strong> International Excellence<br />

o Excellence <strong>in</strong> Export Promotion<br />

• H<strong>in</strong>dustan Times Thane Ratna Award <strong>2019</strong> – Healthcare,<br />

<strong>Pharma</strong> and Biotech Manufactur<strong>in</strong>g<br />

• World HRD Congress Awards 2018<br />

o National Best Employer Brands<br />

o Bus<strong>in</strong>ess Leader of the Year – Mr. Prashant Nagre<br />

o Top <strong>10</strong>1 HR M<strong>in</strong>ds – Mr. V.K. Raveendranath,<br />

General Manager – Human Resources<br />

• Pride of Maharashtra Award <strong>2019</strong> for Best CEO of the<br />

Year <strong>in</strong> Manufactur<strong>in</strong>g – <strong>Pharma</strong>ceuticals – Mr. Prashant<br />

Nagre<br />

Roadmap to Future<br />

As the global biotech <strong>in</strong>dustry is witness<strong>in</strong>g a surge <strong>in</strong><br />

| 31<br />

players, competitive<br />

markets, and<br />

technological<br />

In the com<strong>in</strong>g<br />

advancements, FBL<br />

years, FBL aims to<br />

has identified the<br />

become a holistic<br />

milestones that it<br />

<strong>in</strong>tends to achieve over nutraceutical<br />

the next few years. It <strong>in</strong>gredient<br />

has broadly classified manufacturer,<br />

the goals <strong>in</strong> three through develop<strong>in</strong>g,<br />

directions:<br />

manufactur<strong>in</strong>g and<br />

commercializ<strong>in</strong>g<br />

Product Portfolio micronutrients<br />

Expansion: FBL required for human<br />

<strong>in</strong>tends to diversify its and animal nutrition<br />

portfolio to <strong>in</strong>clude a<br />

wide range of<br />

nutraceutical<br />

<strong>in</strong>gredients such as antioxidants and smart m<strong>in</strong>erals that are<br />

microencapsulated for added benefits.<br />

International Collaborations: It cont<strong>in</strong>ues to make<br />

determ<strong>in</strong>ed efforts to widen its footpr<strong>in</strong>t of Vitam<strong>in</strong> D3<br />

across geographies through engagements established across<br />

six cont<strong>in</strong>ents. To evolve as a key player <strong>in</strong> the<br />

nutraceuticals space, FBL has designed the roadmap to<br />

expand its portfolio through distribution agreements, jo<strong>in</strong>t<br />

ventures, and acquisitions.<br />

Micronutrient Space: FBL has envisaged various<br />

synergistic opportunities to create a formidable range of<br />

value-added nutritional <strong>in</strong>gredients, thus widen<strong>in</strong>g overall<br />

product offer<strong>in</strong>gs to cater to the press<strong>in</strong>g issue of<br />

micronutrient deficiency across the globe.<br />

FBL’s Associations<br />

Vitam<strong>in</strong> D Guru: FBL’s public awareness <strong>in</strong>itiative is a<br />

digital platform to enhance knowledge about the<br />

significance of Vitam<strong>in</strong> D for health and wellness.<br />

Vitam<strong>in</strong> Angels: FBL contributes towards Vitam<strong>in</strong> Angels’<br />

activities <strong>in</strong> the field of micronutrient deficiency <strong>in</strong> women<br />

and children <strong>in</strong> develop<strong>in</strong>g countries.<br />

National Association for the Bl<strong>in</strong>d (NAB): FBL not only<br />

contributes towards corneal transplants, squ<strong>in</strong>t correction<br />

surgeries, educational Braille kits and grant for Diploma <strong>in</strong><br />

Special Education course, but also <strong>in</strong>tegrates NAB’s<br />

members with its <strong>in</strong>ternal activities for employee<br />

engagement.<br />

APRIL <strong>2019</strong> |


Healthcare Predictions<br />

FUTURE<br />

PREDICTIONS<br />

Of<br />

ELECTRONIC<br />

HEALTH<br />

RECORDS,<br />

<strong>2019</strong><br />

&<br />

BEYOND<br />

About the Author<br />

Kumar Subramaniam, Founder & CEO at<br />

75Health<br />

Kumar Subramaniam has always believed<br />

and used technology as the means to<br />

improve the quality of bus<strong>in</strong>ess<br />

processes and enhance people's life. He<br />

conceptualized the <strong>in</strong>novative EMR<br />

Software with the objective of digitaliz<strong>in</strong>g<br />

crucial medical records and empower<strong>in</strong>g<br />

medical practices to achieve the best<br />

care delivery. He leverages technology to<br />

achieve bus<strong>in</strong>ess objectives while serv<strong>in</strong>g<br />

the community better.<br />

Alot of changes and<br />

<strong>in</strong>novations have been<br />

occurr<strong>in</strong>g <strong>in</strong> the<br />

healthcare sector s<strong>in</strong>ce the recent<br />

decades. Increased<br />

personalization <strong>in</strong> healthcare and<br />

<strong>in</strong>creased understand<strong>in</strong>g of<br />

patients’ role <strong>in</strong> achiev<strong>in</strong>g<br />

success of their own well-be<strong>in</strong>g<br />

is headed to a tipp<strong>in</strong>g po<strong>in</strong>t.<br />

Today, <strong>in</strong> addition to patient<br />

care, management of patient<br />

experience plays a vital role <strong>in</strong><br />

the healthcare ecosystem.<br />

With the advent of medical<br />

<strong>in</strong>formation systems such as the<br />

electronic health record software<br />

and practice management<br />

software, a lot of unprecedented<br />

changes have taken place <strong>in</strong><br />

cl<strong>in</strong>ical and adm<strong>in</strong>istrative<br />

32 | | APRIL <strong>2019</strong>


aspects of modern healthcare<br />

facilities and physician practices.<br />

<strong>The</strong> Transition to Electronic<br />

Health Records<br />

Globally, there has been a wide<br />

understand<strong>in</strong>g about the virtues of<br />

the electronic health record and<br />

how it transforms the way<br />

healthcare is provided. Increas<strong>in</strong>g<br />

adoption of the EHR is proof<br />

enough to emphasize the fact that it<br />

has become an <strong>in</strong>tegral part of the<br />

healthcare sett<strong>in</strong>g.<br />

<strong>The</strong> EHR landscape has had<br />

tremendous impact, thanks to the<br />

str<strong>in</strong>gent <strong>in</strong>dustry standards and<br />

regulatory requirements such as<br />

HIPAA. Moreover, <strong>in</strong>centives to<br />

<strong>providers</strong> have also augured well<br />

with the <strong>in</strong>crease <strong>in</strong> EHR adoption.<br />

What Does the Future Hold for<br />

the EHR Software?<br />

Although EHRs have been around<br />

s<strong>in</strong>ce long, they are seen to have<br />

still a long way to go. As the<br />

medical <strong>in</strong>dustry switches over<br />

from the traditional volume-based<br />

reimbursement model to<br />

quality-based model, EHRs will be<br />

focus<strong>in</strong>g more on value-based care,<br />

assist<strong>in</strong>g <strong>providers</strong> to skillfully<br />

manage their patients’ health <strong>in</strong> the<br />

most optimal way.<br />

Understand<strong>in</strong>g the follow<strong>in</strong>g EHR<br />

trends <strong>in</strong> the com<strong>in</strong>g years will<br />

enable practices to be prepared for<br />

fac<strong>in</strong>g unique needs and deliver<strong>in</strong>g<br />

the best possible care:<br />

• Ease of use and searchability<br />

o EHRs will be more easily<br />

searched, organized, and used –<br />

enabl<strong>in</strong>g full <strong>in</strong>teraction with<br />

patients<br />

• Interoperability and Integration<br />

o <strong>The</strong> ability of EHR Systems to<br />

<strong>in</strong>tegrate with other health<br />

<strong>in</strong>formation systems will <strong>in</strong>crease<br />

• Accessibility<br />

o Vendors will ensure that EHRs<br />

are more accessible to not only<br />

multi-facility networks and<br />

hospitals but also to all types of<br />

cl<strong>in</strong>ical practices regardless of<br />

size<br />

• Standardization<br />

o With stricter regulations and<br />

standardization of the EHR<br />

features and data, overall<br />

accuracy and reliability of the<br />

EHR System will <strong>in</strong>crease<br />

manifold<br />

• Chang<strong>in</strong>g Dynamics<br />

o AI and virtual assistants will<br />

become more powerful and<br />

accessible, mak<strong>in</strong>g their entry<br />

<strong>in</strong>to health IT – this will help<br />

mitigate issues, if any, with the<br />

EHR Software<br />

<strong>The</strong> EHR System and Healthcare<br />

Delivery Connect<br />

Manag<strong>in</strong>g patient health records is<br />

rendered smooth and effective, thanks<br />

to the <strong>in</strong>novative EHR Software. Us<strong>in</strong>g<br />

computer software and hardware for<br />

the application of data process<strong>in</strong>g<br />

ensures easy and accurate stor<strong>in</strong>g,<br />

shar<strong>in</strong>g, and retrieval of medical<br />

<strong>in</strong>formation. It also makes it possible<br />

to utilize this <strong>in</strong>formation for effective<br />

communication and <strong>in</strong>formation-based<br />

decision mak<strong>in</strong>g.<br />

Network<strong>in</strong>g the computers and<br />

communication attributes effectively<br />

facilitates efficiently mov<strong>in</strong>g critical<br />

health <strong>in</strong>formation. This results <strong>in</strong><br />

<strong>in</strong>creased ability to deliver efficient,<br />

better care.<br />

Choos<strong>in</strong>g the Right Fit for Your<br />

Practice<br />

EHR Software has atta<strong>in</strong>ed an<br />

<strong>in</strong>dispensable position <strong>in</strong> the<br />

healthcare sector. While choos<strong>in</strong>g<br />

the EHR solution diligently and<br />

perfectly results <strong>in</strong> <strong>providers</strong> be<strong>in</strong>g<br />

facilitated to deliver better care<br />

quality and enhance practice<br />

efficiency, a wrong selection would<br />

lead to significant disruption to<br />

regular practice activities and<br />

cont<strong>in</strong>ued difficulty all along the<br />

course of use of the software.<br />

As EHRs lend themselves to be<br />

customized accord<strong>in</strong>g to specific<br />

practice needs, it is essential to first<br />

go through the various features and<br />

get complete demo of each solution<br />

prior to decid<strong>in</strong>g which one to buy.<br />

With cloud be<strong>in</strong>g considered the<br />

future of comput<strong>in</strong>g and as today’s<br />

consumers are more <strong>in</strong>cl<strong>in</strong>ed<br />

toward us<strong>in</strong>g mobile devices,<br />

cloud-based mobile EHR is set to<br />

become more dom<strong>in</strong>ant among<br />

EHR Software service <strong>providers</strong><br />

and practitioners <strong>in</strong> the future.<br />

In the chang<strong>in</strong>g healthcare<br />

scenario, EHRs will certa<strong>in</strong>ly<br />

cont<strong>in</strong>ue to play the role of the<br />

driv<strong>in</strong>g force <strong>in</strong> its evolution. Our<br />

goal is transform<strong>in</strong>g the healthcare<br />

sector us<strong>in</strong>g digital technologies<br />

and empower<strong>in</strong>g the healthcare<br />

fraternity to raise the bar of quality<br />

and efficiency several notches up.<br />

APRIL <strong>2019</strong> |<br />

| 33


<strong>Pharma</strong> Trends<br />

<strong>Pharma</strong>ceutical<br />

Top<br />

Trends to Watch Out <strong>in</strong><br />

<strong>2019</strong><br />

34 | | APRIL <strong>2019</strong>


Indian pharmaceutical <strong>in</strong>dustry is grow<strong>in</strong>g with an impressive pace for last couple of years and is expected to be <strong>in</strong><br />

the top <strong>10</strong> global markets <strong>in</strong> value terms by 2020. <strong>The</strong> <strong>in</strong>dustry is progress<strong>in</strong>g with a compounded annual growth<br />

rate (CAGR) of 15 percent over the last ve years and is adopt<strong>in</strong>g new bus<strong>in</strong>ess models to serve its targeted audience<br />

faster, and better. Good economic growth, high burden of diseases, improvement <strong>in</strong> healthcare <strong>in</strong>frastructure and<br />

<strong>in</strong>creased awareness have tipped to be the reasons beh<strong>in</strong>d such optimistic projections.<br />

However, there are many areas on which any pharmaceutical company should look <strong>in</strong>to- such as organ-on-chip, 3D<br />

Bio-pr<strong>in</strong>t<strong>in</strong>g, AI, and Antibiotics Discovery. Ignor<strong>in</strong>g such vital areas can otherwise can h<strong>in</strong>der the growth prospects of<br />

pharmaceutical <strong>in</strong>dustry.<br />

APRIL <strong>2019</strong> |<br />

| 35


3D Bio-pr<strong>in</strong>t<strong>in</strong>g<br />

Every year thousands of people lose their life due to<br />

organ failure. Many times even after be<strong>in</strong>g nancially<br />

capable, people do not receive organs at the right<br />

time as there is a wide gap between the grow<strong>in</strong>g<br />

demand of organs v/s number of registered donors<br />

<strong>in</strong> the <strong>in</strong>dustry. Usage 3D bio-pr<strong>in</strong>t<strong>in</strong>g thus many see<br />

as a solution for tackl<strong>in</strong>g this critical problem. In biopr<strong>in</strong>t<strong>in</strong>g,<br />

experts use patients own liv<strong>in</strong>g cells to<br />

reproduce organs to reduce the risk of reject<strong>in</strong>g cells.<br />

T h i s f u r t h e r l o w e r t h e r i s k o f t a k i n g<br />

immunosuppressant drugs which are needed after<br />

organ transplant and many times causes trouble for<br />

the patients <strong>in</strong> terms of loss of appetite, nausea,<br />

vomit<strong>in</strong>g, <strong>in</strong>creased hair growth, and hand<br />

trembl<strong>in</strong>g. Moreover, transplantation us<strong>in</strong>g biopr<strong>in</strong>t<strong>in</strong>g<br />

only <strong>in</strong>volves only one <strong>in</strong>dividual that needs<br />

to be operated on and hence, lowers the number of<br />

people need to be hospitalized dur<strong>in</strong>g critical<br />

procedures.<br />

Many believe that organs made form bio-pr<strong>in</strong>t<strong>in</strong>g<br />

can also be used for drug discovery and test<strong>in</strong>g, tissue<br />

eng<strong>in</strong>eer<strong>in</strong>g, research and study. <strong>The</strong>se are the<br />

reasons why pharmaceuticals companies and<br />

hospitals are look<strong>in</strong>g towards 3D bio-pr<strong>in</strong>t<strong>in</strong>g with an<br />

array of hope. It is ma<strong>in</strong>ly used for the creation and<br />

transplantation of several tissues <strong>in</strong>clud<strong>in</strong>g multilayered<br />

sk<strong>in</strong>, heart tissue, cartilag<strong>in</strong>ous structures,<br />

bone, vascular grafts, and tracheal spl<strong>in</strong>ts.<br />

It can also help pharmaceutical companies <strong>in</strong><br />

reduc<strong>in</strong>g overall cost associated with drug<br />

manufactur<strong>in</strong>g once get transformed from an<br />

experimental stage to a fully functional mode.<br />

Increas<strong>in</strong>g R&D expenditure, availability of venture<br />

capital, and government grants are fuell<strong>in</strong>g the<br />

growth of 3D bio-pr<strong>in</strong>t<strong>in</strong>g. It is expected that 3D biopr<strong>in</strong>t<strong>in</strong>g<br />

market will reach USD 2.6 billion by 2024.<br />

Organs-on-chips<br />

Limitations of current planar, animal models and<br />

static cell culture system affect the drug discovery<br />

process to a larger extent. Many times it leads to<br />

<strong>in</strong>creased drug failure rates which even cost<br />

pharmaceuticals companies billions of dollars.<br />

Moreover, many human diseases are still not<br />

modelled accurately us<strong>in</strong>g '<strong>in</strong> vitro' process and thus<br />

h<strong>in</strong>der the growth <strong>in</strong> therapy development.<br />

Shortcom<strong>in</strong>gs of these models started a debate <strong>in</strong> the<br />

pharmaceutical vertical to develop a more<br />

physiological model relevant to human organs and<br />

thus lead to the growth of organs-on-chips.<br />

Organ-on-chip offers a wide range of applications<br />

such as phenotypic screen<strong>in</strong>g, diseases modell<strong>in</strong>g,<br />

and patient stratication. Scientists believe that<br />

organs-on-chips have huge potential to make the<br />

drug discovery process efcient and faster as its<br />

microchips conta<strong>in</strong> liv<strong>in</strong>g cells which can mimic<br />

processes <strong>in</strong> the body such as peristalsis, breath<strong>in</strong>g<br />

and <strong>in</strong>fection. Such chips are t<strong>in</strong>y devices that imitate<br />

the structure, physiology and function of human<br />

organs. Researchers have represented over two<br />

dozen organs <strong>in</strong> on-chip systems, famously <strong>in</strong>cludes-<br />

Lung, Heart, Kidney, Artery, Sk<strong>in</strong>. Some are even<br />

work<strong>in</strong>g to imitate a human-on-chip as well.<br />

While there is a lot of scepticism existed beh<strong>in</strong>d<br />

organs-on-chips some six to seven years ago, many<br />

pharmaceutical companies are now work<strong>in</strong>g towards<br />

it <strong>in</strong> a full-edged mode and embraced this concept<br />

<strong>in</strong>to their bus<strong>in</strong>ess model as well. Market researchers<br />

predicts that organs-on-chip eld which was valued<br />

only at $5 million <strong>in</strong> 2016 will witnessed a meteoric<br />

rise <strong>in</strong> com<strong>in</strong>g years and is expected to reach $170<br />

million by 2023. This <strong>in</strong>dustry will grow with a CAGR<br />

of 63.2% from 2017 to 2023, researchers predict.<br />

36 | | APRIL <strong>2019</strong>


New Antibiotics Discovery<br />

Antibiotic resistant bacteria- superbug led to the<br />

death of more than 700,000 people all across the<br />

world. And, if UK government is to be believed, this<br />

number will dramatically jump up to <strong>10</strong> million by<br />

2050; if necessary steps not taken <strong>in</strong> the arena of new<br />

antibiotic discovery. Experts believe irresponsible<br />

prescription of antibiotics even for the normal cases,<br />

and <strong>in</strong>creased usage of antibiotics <strong>in</strong> farm<strong>in</strong>g<br />

accelerat<strong>in</strong>g the rate of bacterial mutation, render<strong>in</strong>g<br />

them to resistant to drug with alarm<strong>in</strong>g pace.<br />

On the other hand, antibiotic discovery has been a<br />

much ignored area amongst the researchers. <strong>Most</strong> of<br />

the pharmaceutical companies are more <strong>in</strong>cl<strong>in</strong>ed<br />

towards research<strong>in</strong>g and develop<strong>in</strong>g drugs that are<br />

more “economically feasible”. This is the reason the<br />

last novel antibiotic classes was <strong>in</strong>troduced some<br />

thirty years ago.<br />

However, with the grow<strong>in</strong>g need to tackle the menace<br />

of superbug, beneciary reforms <strong>in</strong> the legislation<br />

and <strong>in</strong>creased <strong>in</strong>vestment <strong>in</strong> antibiotic researchmany<br />

organizations are now work<strong>in</strong>g day-<strong>in</strong> day-out<br />

to discover new antibiotics.<br />

In 2015, a group of scientists made a breakthrough<br />

<strong>in</strong> the antibiotics vertical with the discovery of<br />

Teixobact<strong>in</strong>, a powerful antibiotics class that has the<br />

potential to withstand the development of bacterial<br />

resistance aga<strong>in</strong>st it.<br />

Increased Adoption of AI<br />

Develop<strong>in</strong>g a drug is a time consum<strong>in</strong>g and<br />

e x p e n s i v e t a s k . T h e c u r r e n t p r o b l e m o f<br />

pharmaceutical <strong>in</strong>dustry is that n<strong>in</strong>e out of <strong>10</strong> drugs<br />

fail to make it to pre-registration stage due to their<br />

poor absorption, distribution, metabolism, or<br />

excretion (ADME).<br />

In silico (on a computer) drug design, an <strong>in</strong>novative<br />

technique based on AI can help pharmaceutical<br />

companies to reduce such a shock<strong>in</strong>g drug failure<br />

ratio. Such techniques allow the mapp<strong>in</strong>g of drugs<br />

structures and targets that can lead to a more<br />

successful drug development without costly scientic<br />

development.<br />

Another area of AI which is widely becom<strong>in</strong>g popular<br />

is- advanced analytics. Every day thousands of<br />

journals and research paper get published on<br />

various prom<strong>in</strong>ent research <strong>in</strong>stitutes. Genius m<strong>in</strong>ds<br />

from across the globe sweat all through the years to<br />

create someth<strong>in</strong>g concrete but unable to ga<strong>in</strong> any<br />

<strong>in</strong>sights form others research concern<strong>in</strong>g to similar<br />

set of problems. Analytics has solved such problem. It<br />

process vast amount of scientic data and help<br />

pharmaceutical companies to develop drug at much<br />

faster pace by predict<strong>in</strong>g the properties of new drug<br />

candidate <strong>in</strong> advance. This is the reason many<br />

companies now-a-days us<strong>in</strong>g AI to predict risks and<br />

their drivers to enable preventive ma<strong>in</strong>tenance and<br />

remediation of the drugs.<br />

In 2018, malacid<strong>in</strong>s, a new family of antibiotics were<br />

discovered. However it is currently be<strong>in</strong>g <strong>in</strong> its nascent<br />

stage, but one can witness an <strong>in</strong>creas<strong>in</strong>g trend<br />

towards discover<strong>in</strong>g new antibiotic class among the<br />

scientists community.<br />

- Shruti Jambhale<br />

APRIL <strong>2019</strong> |<br />

| 37


Nucleome Informatics<br />

Unravel<strong>in</strong>g the Genomes for a Better Future<br />

been regularly work<strong>in</strong>g on sequenc<strong>in</strong>g of cancer genomes<br />

and human exomes. Wildlife and plant genome sequenc<strong>in</strong>g<br />

and populations genomics is another area of <strong>in</strong>terest where<br />

it provides NGS services regularly. <strong>The</strong> last six years have<br />

seen the company assemble 18 plants, 9 animals, 5 <strong>in</strong>sects,<br />

and over <strong>10</strong>0 microbial genomes and analyzed human<br />

genome and exome sequenc<strong>in</strong>g data (4580 samples by Jan<br />

<strong>2019</strong>). It was also <strong>in</strong>volved <strong>in</strong> prestigious sequenc<strong>in</strong>g<br />

projects like Mango, Pomegranate, Tiger, Indian Wild Dog,<br />

Leopard and Insect genome sequenc<strong>in</strong>g programs. It also<br />

offers cfDNA Sequenc<strong>in</strong>g and Cell l<strong>in</strong>e genome sequenc<strong>in</strong>g<br />

services.<br />

<strong>The</strong> Insightful M<strong>in</strong>ds<br />

<strong>The</strong> company is a resultant of three genius m<strong>in</strong>ds com<strong>in</strong>g<br />

together.<br />

(From Left to Right)<br />

Dushyant S<strong>in</strong>gh Baghel, MD & CEO<br />

Bip<strong>in</strong> Kumar, Co-founder & VP<br />

Abhishek Tripathi, Co-founder & VP<br />

Nucleome Informatics is well regarded <strong>in</strong> the <strong>Life</strong><br />

sciences <strong>in</strong>dustry for its expertise <strong>in</strong> de novo<br />

genome sequenc<strong>in</strong>g of larger genomes us<strong>in</strong>g<br />

hybrid assembly approach. <strong>Pharma</strong> companies and hospitals<br />

have been us<strong>in</strong>g Nucleome’s genome resequenc<strong>in</strong>g, exome<br />

sequenc<strong>in</strong>g and targeted resequenc<strong>in</strong>g services quite often.<br />

Nucleome plays a major role by provid<strong>in</strong>g Genomics and<br />

Bio<strong>in</strong>formatics analysis support for scientists work<strong>in</strong>g <strong>in</strong><br />

the field of genomes, transcriptomes, metagenomes, and<br />

epigenomes research. Nucleome’s flagship product <strong>in</strong>cludes<br />

software DrSeq for RNA sequence analysis software, DrSeq<br />

Genome Survey and Big Data Decoder server specially<br />

designed for NGS analysis. Nucleome also has pipel<strong>in</strong>es for<br />

Exome, Metagenome, transcriptome and amplicon datasets<br />

developed <strong>in</strong>-house. It has a variety of projects <strong>in</strong>volv<strong>in</strong>g<br />

discovery of SNP markers by resequenc<strong>in</strong>g of human<br />

samples and identify<strong>in</strong>g the complete Genetic makeup of<br />

the follow<strong>in</strong>g organisms like, Buffalo, Pomegranate,<br />

Mango, Pigeon Pea, Mosquito, Dhole, Rice varieties, Indian<br />

Bengal Tiger, Great Indian Bustard, Eggplant Borer, etc.<br />

Dist<strong>in</strong>guished Services<br />

Nucleome has successfully completed many significant<br />

plants, animals and microbial de novo genomes and has<br />

Dushyant S<strong>in</strong>gh Baghel, Founder, MD and CEO hold an<br />

MS <strong>in</strong> Biotechnology from Bharathiar University and<br />

executive education <strong>in</strong> management from Indian School of<br />

Bus<strong>in</strong>ess, Hyderabad. He carries twelve years of experience<br />

<strong>in</strong> sequenc<strong>in</strong>g and assembly of genomes. A self-motivated<br />

person with true qualities of entrepreneurship and<br />

leadership, he started the company <strong>in</strong> the year 2012 with his<br />

partners and Co-founders Abhishek Tripathi and Bip<strong>in</strong><br />

Kumar.<br />

Abhishek Tripathi, VP - R&D and Operations with an MS<br />

<strong>in</strong> Biotechnology has an experience of twelve years <strong>in</strong><br />

Genomics Industry.<br />

Bip<strong>in</strong> Kumar, VP - Corporate Sales with an MS <strong>in</strong><br />

Biotechnology has an experience of thirteen years <strong>in</strong><br />

Genomics and diagnostics Industry.<br />

With a good understand<strong>in</strong>g of Genomics market <strong>in</strong> India<br />

and their experience, they laid the foundation for<br />

Nucleome. Under the leadership of the founders Dushyant<br />

S<strong>in</strong>gh Baghel, Bip<strong>in</strong> Kumar and Abhishek Tripathi, the<br />

team has designed and developed software for data<br />

analysis, assembled various genomes, completed more than<br />

500 Genome and Transcriptome projects <strong>in</strong> a span of 6<br />

years. Currently Nucleome is be<strong>in</strong>g considered as India’s<br />

fastest grow<strong>in</strong>g genomics and bio<strong>in</strong>formatics solution<br />

provider.<br />

38 | | APRIL <strong>2019</strong>


1T<br />

HE<br />

MOST RECOMMENDED<br />

PHARMA &<br />

L FE SCIENCES<br />

SOLUTION PROVIDERS IN <strong>2019</strong><br />

Hard Work is all it takes to Succeed<br />

Nucleome has <strong>in</strong>vested its entire seed fund<strong>in</strong>g <strong>in</strong> build<strong>in</strong>g a<br />

well-equipped laboratory with sophisticated wet lab<br />

<strong>in</strong>struments and servers like BigData Decoder which are<br />

specially designed for next generation sequenc<strong>in</strong>g data<br />

analysis along with NGS analysis pipel<strong>in</strong>es on onl<strong>in</strong>e cloud<br />

servers like Google genomics, Amazon Web Server and<br />

DNA nexus.<br />

It has successfully completed various projects <strong>in</strong> association<br />

with various International organizations like CNRGV<br />

(France), Fasteris SA (Switzerland), Koppert Biological<br />

Systems (<strong>The</strong> Netherlands), Cold Spr<strong>in</strong>g Harbor Laboratory<br />

(USA), McDonnell Genome Institute, (USA), University of<br />

California (USA), Yale University (USA), New York<br />

Genome Center (USA), Wash<strong>in</strong>gton University(USA), <strong>The</strong><br />

Queensland Alliance for Agriculture and Food<br />

Innovation(Australia) and Indian <strong>in</strong>stitutes like CCMB,<br />

CIBA, IHBT, NRCP, NRCPB, ILS and NDDB. Nucleome<br />

has also built a sound association with all the major<br />

<strong>in</strong>stitutes under ICAR, CSIR, DBT and various hospitals<br />

<strong>in</strong>clud<strong>in</strong>g Tata Memorial Hospital Mumbai and private<br />

organisations like ITC and Beej Sheetal Seeds.<br />

Nucleome was awarded ‘India’s 20 <strong>Most</strong> Promis<strong>in</strong>g<br />

<strong>Pharma</strong> & <strong>Life</strong> Science Technology <strong>Solution</strong> Provider<br />

Companies 2016’ by a lead<strong>in</strong>g magaz<strong>in</strong>e.<br />

Us<strong>in</strong>g Nucleome’s services researchers have published<br />

several Research Papers.<br />

Paper <strong>in</strong> the field of Animal Genomics:<br />

• <strong>The</strong> Cuon Enigma: Genome survey and comparative<br />

genomics of the endangered Dhole 1 (Cuon alp<strong>in</strong>us) <strong>in</strong><br />

bioRxiv<br />

• High coverage genome sequenc<strong>in</strong>g and identification of<br />

genomic variants <strong>in</strong> Bengal tiger (Panthera tigris tigris)<br />

<strong>in</strong> bioRxiv<br />

• Genome Plasticity <strong>in</strong> Cultured Leishmania donovani:<br />

Comparison of Early and Late Passages <strong>in</strong> Frontiers <strong>in</strong><br />

Microbiology<br />

• RNA-Seq Revealed Expression of Many Novel Genes<br />

Associated With Leishmania do no vani Persistence and<br />

clearance <strong>in</strong> the Host Macrophage <strong>in</strong> Frontiers <strong>in</strong><br />

Cellular and Infection Microbiology<br />

Papers <strong>in</strong> the field of Agri Genomics:<br />

• Analysis of DNA methylome and transcriptome<br />

profil<strong>in</strong>g follow<strong>in</strong>g Gibberell<strong>in</strong> A3 (GA3) foliar<br />

application <strong>in</strong> Nicotiana tabacum L. <strong>in</strong> Indian Journal<br />

of Plant Physiology<br />

• Identification of candidate pathogenicity determ<strong>in</strong>ants of<br />

Rhizoctonia<br />

solani AG1-IA,<br />

which causes<br />

sheath blight<br />

disease <strong>in</strong> rice <strong>in</strong><br />

Current Genetics<br />

of Spr<strong>in</strong>ger<br />

Nature<br />

• Alterations <strong>in</strong> rice<br />

chloroplast<br />

<strong>in</strong>tegrity,<br />

photosynthesis<br />

Company’s expertise<br />

lies <strong>in</strong> Sequenc<strong>in</strong>g<br />

and Analysis of de<br />

novo genome us<strong>in</strong>g<br />

hybrid assembly<br />

approach,<br />

Transcriptome,<br />

and genome<br />

resequenc<strong>in</strong>g data<br />

and metabolome associated with pathogenesis of<br />

Rhizoctonia solani <strong>in</strong> Scientific Reports<br />

• Sequenc<strong>in</strong>g, Denovo Assembly, Functional Annotation<br />

and Analysis of Phyllanthus amarus Leaf Transcriptome<br />

Us<strong>in</strong>g the Illum<strong>in</strong>a Platform <strong>in</strong> Frontiers <strong>in</strong> Plant<br />

Science<br />

• Analysis of high iron rice l<strong>in</strong>es reveals new miRNAs<br />

that target iron transporters <strong>in</strong> roots <strong>in</strong> Journal of<br />

Experimental Botany<br />

Lapp<strong>in</strong>g up the Opportunities<br />

<strong>The</strong> <strong>Pharma</strong> and life science <strong>in</strong>dustry is bustl<strong>in</strong>g with ideas<br />

and applications. <strong>The</strong> <strong>in</strong>creas<strong>in</strong>g application of genomics <strong>in</strong><br />

biotech and pharmaceutical research and development has<br />

created a huge commercial market for sequenc<strong>in</strong>g and<br />

bio<strong>in</strong>formatics worldwide. <strong>The</strong> explosive growth of<br />

biological techniques necessitates the acquisition,<br />

process<strong>in</strong>g, analysis, and <strong>in</strong>tegration of the data. <strong>The</strong>se<br />

immense amounts of data are generated by the experiments<br />

as diverse as genomics, clon<strong>in</strong>g, expression analysis,<br />

genotyp<strong>in</strong>g, cellular analysis and others. Many young<br />

entrepreneurs are look<strong>in</strong>g at it as an opportunity for new<br />

startups. <strong>The</strong> founders advise them say<strong>in</strong>g “Dare to<br />

dream…..Follow your dream….Live your dream…..Strive<br />

hard to achieve your dream.”<br />

For a Better Future<br />

Nucleome aims at a healthier future through revolutionary<br />

genetic analysis solutions. It is committed to generat<strong>in</strong>g<br />

rapid, appropriate and high-quality results which can create<br />

a great difference <strong>in</strong> research projects.<br />

Nucleome’s focus has always been <strong>in</strong> the field of Plant,<br />

Animal and Human Genomics and is plann<strong>in</strong>g to strengthen<br />

its position <strong>in</strong> this field. It has planned to raise its SeriesA<br />

fund<strong>in</strong>g to expand its <strong>in</strong>frastructure by build<strong>in</strong>g India’s<br />

largest genomics and supercomput<strong>in</strong>g bio<strong>in</strong>formatics<br />

facility. It aims to fund and propel its Population genomics<br />

program to sequence <strong>10</strong>,000 human genomes and <strong>10</strong>0,000<br />

exomes of various cancer and diabetics patients <strong>in</strong> India.<br />

APRIL <strong>2019</strong> |<br />

| 39

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