The 10 Most Recommended Pharma & Life Sciences Solution providers in 2019
This month, Insights Success has come up with a very contemporary topic and has dealt under the issue of “The 10 Most Recommended Pharma & Life Sciences Solution providers in 2019”. Here we have tried to focus on the different business portfolios with unique service solutions
This month, Insights Success has come up with a very contemporary topic and has dealt under the issue of “The 10 Most Recommended Pharma & Life Sciences Solution providers in 2019”. Here we have tried to focus on the different business portfolios with unique service solutions
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VOL 04<br />
April <strong>2019</strong><br />
ISSUE 01<br />
<strong>The</strong><br />
<strong>10</strong> <strong>Most</strong><br />
<strong>Recommended</strong><br />
<strong>Pharma</strong><br />
&<br />
<strong>Life</strong> <strong>Sciences</strong><br />
<strong>Solution</strong><br />
<strong>providers</strong> <strong>in</strong> <strong>2019</strong><br />
Sarjen<br />
Systems<br />
Promot<strong>in</strong>g Indian <strong>Pharma</strong><br />
Research on Global Scene<br />
Nikur Mody<br />
Founder
From <strong>The</strong><br />
Editor<br />
RAPIDLY<br />
EVOLVING<br />
INDUSTRY<br />
PHARMA<br />
&<br />
LIFE<br />
SCIENCE<br />
THE OUTLOOK
decade ago, the global <strong>in</strong>dustry of pharma and life<br />
Ascience, which was of 390 billion USD, has now crossed 1<br />
trillion USD and still it is march<strong>in</strong>g forward majestically.<br />
“One of the biggest challenges to medic<strong>in</strong>e is the <strong>in</strong>corporation of<br />
<strong>in</strong>formation technology <strong>in</strong> our practices” said Samuel Wilson.<br />
Today, to rema<strong>in</strong> competitive <strong>in</strong> this dynamic environment, the<br />
<strong>Pharma</strong> and <strong>Life</strong> <strong>Sciences</strong> organizations are quickly adapt<strong>in</strong>g<br />
and respond<strong>in</strong>g to the on-go<strong>in</strong>g changes <strong>in</strong> market conditions,<br />
customer requirements, and government and <strong>in</strong>dustry<br />
regulations. <strong>The</strong> giant companies are controll<strong>in</strong>g the one-third of<br />
the market and produc<strong>in</strong>g revenue around <strong>in</strong> billions of USD,<br />
while many large numbers of start-ups and SMBs are compet<strong>in</strong>g<br />
to get their share of pie, and benchmark their existence <strong>in</strong> this<br />
fiercely competitive doma<strong>in</strong>.<br />
Predict<strong>in</strong>g the future for better analysis of patient adherence and<br />
improv<strong>in</strong>g time to market rema<strong>in</strong>s the key element of success.<br />
Access<strong>in</strong>g, analys<strong>in</strong>g and manag<strong>in</strong>g the vast volumes of data<br />
have been a very critical task to pharma and life sciences<br />
companies, as they improve bus<strong>in</strong>ess efficiency and<br />
performance.<br />
And, this is where this ‘Next Generation’ architecture the Big Data<br />
and Analytics are help<strong>in</strong>g to improve the efficiency and the<br />
development processes.<br />
On the conclud<strong>in</strong>g note, today the world is leverag<strong>in</strong>g<br />
technology <strong>in</strong>telligently to ga<strong>in</strong> competitive advantage. <strong>The</strong><br />
profound market research is done <strong>in</strong> order to provide a plethora<br />
of solutions. With chang<strong>in</strong>g times, the <strong>in</strong>dustry is uncover<strong>in</strong>g<br />
<strong>in</strong>novations that are revolutioniz<strong>in</strong>g the current product l<strong>in</strong>es and<br />
unfold<strong>in</strong>g <strong>in</strong>f<strong>in</strong>ite opportunities for betterment of the mank<strong>in</strong>g.<br />
Shruti P. Jambhale<br />
Shruti P. Jambhale
C o n<br />
Cover Story <strong>10</strong><br />
Sarjen Systems<br />
Promot<strong>in</strong>g Indian <strong>Pharma</strong><br />
Research on Global Scene<br />
cxo<br />
24<br />
18<br />
Interview With Insights Success<br />
Accurex Biomedical<br />
Pioneer <strong>in</strong> Manufactur<strong>in</strong>g<br />
and Market<strong>in</strong>g of In-vitro<br />
Diagnostic Reagents<br />
32<br />
Digitaliz<strong>in</strong>g<br />
<strong>Pharma</strong><br />
5 ways <strong>in</strong> which Digitalization<br />
is Transform<strong>in</strong>g Healthcare<br />
and <strong>Pharma</strong> Industry<br />
Healthcare<br />
Predictions<br />
Future Predictions of<br />
Electronic Health Records,<br />
<strong>2019</strong> and Beyond
t e n s<br />
Ashish <strong>Life</strong> Science<br />
Deliver<strong>in</strong>g Highest Quality<br />
Veter<strong>in</strong>ary Medic<strong>in</strong>es<br />
at Economical Price<br />
22<br />
Fermenta Biotech Ltd<br />
Discover | Develop | Deliver<br />
30<br />
Nucleome Informatics<br />
Unravel<strong>in</strong>g the Genomes<br />
for a Better Future<br />
38<br />
Articles<br />
26<br />
34<br />
Medic<strong>in</strong>e<br />
World Insights<br />
<strong>10</strong> Medic<strong>in</strong>es that<br />
Changed the World<br />
<strong>Pharma</strong><br />
Trends<br />
Top <strong>Pharma</strong>ceutical Trends<br />
to Watch Out <strong>in</strong> <strong>2019</strong><br />
C o n t e n s
Editor-<strong>in</strong>-Chief Pooja M. Bansal<br />
Manag<strong>in</strong>g Editor Devasish Kanojiya<br />
Executive Editor<br />
Shruti P. Jambhale<br />
Art & Design Head Amol Kamble<br />
Associate Designer Poonam<br />
Art & Picture Editor Rahul Kavnekar<br />
Co-designer<br />
Mayur Koli<br />
Bus<strong>in</strong>ess Development Manager<br />
Akansha Garewal<br />
Sales Executives Rutuja, Kaustubh, Shraddha, Joan<br />
Technical Specialist<br />
Amar, Pratiksha<br />
Digital Market<strong>in</strong>g Manager Prashant Chevale<br />
SME-SMO Executives Swati, Manoj<br />
Circulation Manager<br />
Tanaji<br />
sales@<strong>in</strong>sightssuccess.com<br />
April, <strong>2019</strong><br />
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RNI NUMBER: MAHENG/2018/75953
1T<br />
HE<br />
MOST RECOMMENDED<br />
PHARMA &<br />
L FE SCIENCES<br />
SOLUTION PROVIDERS IN <strong>2019</strong>
harma and life sciences companies are tak<strong>in</strong>g important steps to<br />
Padvance their bus<strong>in</strong>ess processes and drive greater efficiencies.<br />
<strong>The</strong> <strong>in</strong>dustry will embrace transformation <strong>in</strong>itiatives at a faster<br />
pace <strong>in</strong> com<strong>in</strong>g years, across multiple functional areas, <strong>in</strong>clud<strong>in</strong>g<br />
commercial, cl<strong>in</strong>ical, regulatory, and quality.<br />
In product development, companies are focused on streaml<strong>in</strong><strong>in</strong>g<br />
end-to-end processes to speed time to market and ma<strong>in</strong>ta<strong>in</strong> compliance.<br />
For commercial teams, driv<strong>in</strong>g smarter engagement with customers<br />
rema<strong>in</strong>s a core focus as they launch more specialized products.<br />
This month, Insights Success has come up with a very contemporary topic<br />
and has dealt under the issue of “<strong>The</strong> <strong>10</strong> <strong>Most</strong> <strong>Recommended</strong> <strong>Pharma</strong><br />
& <strong>Life</strong> <strong>Sciences</strong> <strong>Solution</strong> <strong>providers</strong> <strong>in</strong> <strong>2019</strong>”. Here we have tried to<br />
focus on the different bus<strong>in</strong>ess portfolios with unique service solutions,<br />
and Sarjen Systems Pvt. Ltd. has grabbed our attention most to become<br />
the Cover story of this magaz<strong>in</strong>e. This brand is one of the best when<br />
comes to the <strong>Pharma</strong> and <strong>Life</strong> Science <strong>Solution</strong> Providers.<br />
A Look <strong>in</strong>to<br />
the <strong>Pharma</strong><br />
&<br />
<strong>Life</strong> Science<br />
Canvas<br />
We have also focused on different companies those have come up with<br />
unique solutions. Ashish <strong>Life</strong> Science Pvt Ltd offers a range of cutt<strong>in</strong>g<br />
–edge veter<strong>in</strong>ary products with the world-class manufactur<strong>in</strong>g<br />
<strong>in</strong>frastructure and relationship driven approach. Fermenta Biotech<br />
Limited is a multifaceted organization with a high degree of focus on<br />
research, development and product delivery <strong>in</strong> the field of biotechnology,<br />
pharmaceutical and environmental solutions. Nucleome Informatics<br />
Private Limited plays a major role by provid<strong>in</strong>g Genomics and<br />
Bio<strong>in</strong>formatics analysis support.<br />
Alongside, the companies like Avesthagen Limited, Global Calcium<br />
Private Limited, Infionic Inc., Kare4u Healthcare <strong>Solution</strong>s Pvt., Nec<strong>Life</strong>,<br />
Syngene have also been featured <strong>in</strong> the list<strong>in</strong>g of “<strong>The</strong> <strong>10</strong> <strong>Most</strong><br />
<strong>Recommended</strong> <strong>Pharma</strong> & <strong>Life</strong> <strong>Sciences</strong> <strong>Solution</strong> <strong>providers</strong> <strong>in</strong> <strong>2019</strong>”.<br />
<strong>The</strong> <strong>in</strong>terview with Insights Success, Abh<strong>in</strong>av Thakur gave us glimpses<br />
on his brand Accurex Biomedical Pvt. Ltd. It is one of the top 3<br />
manufacturers of quality Cl<strong>in</strong>ical Chemistry Reagents and Ur<strong>in</strong>analysis<br />
Test Strips with over 34 years of expertise <strong>in</strong> this area.<br />
This magaz<strong>in</strong>e also <strong>in</strong>cludes leaders’ thoughts as well. Sudip Chhatui,<br />
the VP- Bus<strong>in</strong>ess and Operations discuss on the “5 ways <strong>in</strong> which digital<br />
is transform<strong>in</strong>g healthcare and <strong>Pharma</strong> <strong>in</strong>dustry” and Kumar<br />
Subramaniam, the Founder & CEO of 75Health highlights on the<br />
“Future Predictions of Electronic Health Records, <strong>2019</strong> and Beyond”.<br />
<strong>The</strong> editor’s thoughts are also part of this magaz<strong>in</strong>e where they have<br />
researched on contemporary topics like Top <strong>Pharma</strong>ceutical Trends to<br />
Watch Out <strong>in</strong> <strong>2019</strong> and <strong>10</strong> Medic<strong>in</strong>es that Changed the World.<br />
So have a look at the magaz<strong>in</strong>e and get the Insights of the <strong>Pharma</strong> and<br />
<strong>Life</strong> Science <strong>Solution</strong>s!
1T<br />
HE<br />
MOST RECOMMENDED<br />
PHARMA &<br />
L FE SCIENCES<br />
SOLUTION PROVIDERS IN <strong>2019</strong><br />
Sarjen<br />
Systems<br />
Promot<strong>in</strong>g Indian <strong>Pharma</strong><br />
Research on Global Scene<br />
COVER STORY
Nikur Mody<br />
Founder
Today, everyone is well aware<br />
that <strong>Pharma</strong> Research is the<br />
sector where there are only a<br />
few predom<strong>in</strong>ant players. <strong>The</strong>re are<br />
many companies, which are embrac<strong>in</strong>g<br />
the changes and creat<strong>in</strong>g a niche <strong>in</strong> the<br />
pharma & life science sector. Sarjen<br />
Systems is one such company which is<br />
provid<strong>in</strong>g affordable solutions by<br />
support<strong>in</strong>g and promot<strong>in</strong>g pharma<br />
research – a small step to br<strong>in</strong>g Indian<br />
pharma and pharma research on the<br />
global scene.<br />
With the Vision of “Hav<strong>in</strong>g a<br />
world-class organization with<br />
operational excellence and global<br />
reach”, Sarjen Systems has always<br />
ma<strong>in</strong>ta<strong>in</strong>ed standards to excel with<br />
m<strong>in</strong>imum fuss follow<strong>in</strong>g on the<br />
Mission of “Spread<strong>in</strong>g the power of<br />
bus<strong>in</strong>ess technology solutions to<br />
customers across the globe; add<strong>in</strong>g<br />
value to their bus<strong>in</strong>esses. And,<br />
encourag<strong>in</strong>g support for our employees<br />
who <strong>in</strong> turn would provide exceptional<br />
service to the customers”.<br />
‘<br />
DEVELOPING<br />
SOLUTIONS<br />
USING CUTTING-EDGE<br />
TECHNOLOGY<br />
&<br />
STRETCHING<br />
THE LIMITS TO<br />
GET THE BEST<br />
<strong>The</strong> Outset of the Sarjen Systems<br />
Nikur Mody is the Founder of Sarjen<br />
Systems and ever s<strong>in</strong>ce, he has always<br />
been <strong>in</strong>terested to strike out, pursu<strong>in</strong>g<br />
that seed of an idea with a zealous<br />
rage. Com<strong>in</strong>g from an IT background,<br />
his <strong>in</strong>terests led him to th<strong>in</strong>k of<br />
<strong>in</strong>troduc<strong>in</strong>g simplified approach to<br />
software development.<br />
In 90s, a lot of bus<strong>in</strong>ess software were<br />
enter<strong>in</strong>g <strong>in</strong>to the market and ga<strong>in</strong><strong>in</strong>g<br />
momentum to get recognized. By the<br />
time, Mody realized that there were<br />
ongo<strong>in</strong>g gaps between bus<strong>in</strong>ess<br />
expectations and technology<br />
enthusiasts who would understand<br />
those expectations very differently.<br />
And, amaz<strong>in</strong>gly, Sarjen Systems was a<br />
result of this ideology and was founded<br />
<strong>in</strong> the late 90s to offer technology<br />
solutions understand<strong>in</strong>g and serv<strong>in</strong>g<br />
precise bus<strong>in</strong>ess expectations.<br />
It became easier for Sarjen Systems, to<br />
meticulously study customer processes,<br />
variations <strong>in</strong> them from customer-tocustomer,<br />
and employ a dedicated team<br />
of bus<strong>in</strong>ess technology consultants. Its<br />
primary function is to fulfill customer<br />
expectations and deliver that last-mile<br />
customization to achieve significant<br />
improvement <strong>in</strong> work efficiency.<br />
Leader, Motivator, and a Mentor<br />
Nikur Mody is a visionary, at the<br />
nucleus of the team of brilliant experts,<br />
guid<strong>in</strong>g and provid<strong>in</strong>g directions to the<br />
organization through the emerg<strong>in</strong>g<br />
<strong>in</strong>dustry and technology changes and<br />
evolv<strong>in</strong>g methodologies. This has<br />
helped Sarjen Systems start the next<br />
“great big” walk, play<strong>in</strong>g a key role <strong>in</strong><br />
shap<strong>in</strong>g the corporate functions of<br />
bus<strong>in</strong>ess development as well as<br />
f<strong>in</strong>ance.<br />
Nikur has completed an MBA <strong>in</strong><br />
International Bus<strong>in</strong>ess and F<strong>in</strong>ance<br />
after f<strong>in</strong>ish<strong>in</strong>g his Bachelor’s <strong>in</strong><br />
Eng<strong>in</strong>eer<strong>in</strong>g with specialization <strong>in</strong><br />
Computer Technology. His <strong>in</strong>novative<br />
but practical approach has helped<br />
Sarjen Systems’ customers to realize<br />
value proposition through software<br />
solutions. Hav<strong>in</strong>g worked with all<br />
functional areas at grass root level, has<br />
helped <strong>in</strong> envision<strong>in</strong>g <strong>in</strong>novative<br />
projects with great detail. Prior to<br />
Sarjen Systems, he has worked with IT<br />
companies like L&T Information<br />
Technology and Mastek Ltd. <strong>in</strong>
strategic plann<strong>in</strong>g where he engaged<br />
his technology and eng<strong>in</strong>eer<strong>in</strong>g skills<br />
to solve significant corporate<br />
challenges.<br />
Notable Software <strong>Solution</strong>s<br />
S<strong>in</strong>ce its found<strong>in</strong>g, Sarjen Systems has<br />
stood out through its own unique<br />
bus<strong>in</strong>ess style. And, has been known to<br />
architect, design and develop<br />
proprietary technology stack with<br />
enormous careful thought and<br />
consideration.<br />
<strong>The</strong> product story <strong>in</strong>cludes three<br />
flagship products which are an<br />
evolution of solutions progress<strong>in</strong>g to<br />
address client demands. It starts with<br />
Sarjen Systems develop<strong>in</strong>g<br />
<strong>Pharma</strong>NET for supply cha<strong>in</strong> and sales<br />
‘n distribution, for sales force<br />
automation – FFReport<strong>in</strong>g, and then<br />
FForce – a Field Sales Excellence<br />
platform.<br />
Some other unique solutions are:<br />
KnowledgeNET - a global Drug dossier<br />
publish<strong>in</strong>g and lifecycle management;<br />
RIMS for regulatory <strong>in</strong>formation<br />
management.<br />
ProcessXE - an MES <strong>in</strong> the form of<br />
pharmaceutical manufactur<strong>in</strong>g<br />
automation with eBMR, Dispens<strong>in</strong>g<br />
and logbooks.<br />
QEdge - an automated enterprise-wide<br />
quality management (eQMS) for<br />
quality processes to ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g<br />
tra<strong>in</strong><strong>in</strong>g records and eLearn<strong>in</strong>g to<br />
document control and management for<br />
controlled processes and practices.<br />
PvEdge - Drug safety database for<br />
pharmacovigilance of drugs, vacc<strong>in</strong>es,<br />
devices, cl<strong>in</strong>ical trials, veter<strong>in</strong>ary<br />
vigilance – <strong>in</strong>corporated with signal<br />
detection and literature automation.<br />
BizNET - Paperless cl<strong>in</strong>ical trial<br />
management which can cover several<br />
different types of trial protocols, study<br />
types.<br />
Whereas consult<strong>in</strong>g on SAP<br />
deployment, Computer System<br />
Validations (CSV), Data analytics and<br />
AI & Mach<strong>in</strong>e Learn<strong>in</strong>g (ML),<br />
extend<strong>in</strong>g applications as Mobility<br />
solutions are Sarjen Systems’ forte.<br />
<strong>The</strong> Plus Po<strong>in</strong>ts<br />
Start<strong>in</strong>g with the sales and distribution<br />
solution, <strong>Pharma</strong>NET and then<br />
<strong>in</strong>tegrated it with ERP to give a robust<br />
boost to have some vital complexities<br />
outside of ERP, Sarjen Systems kept on<br />
add<strong>in</strong>g one solution after another <strong>in</strong> its<br />
‘<br />
SARJEN<br />
SYSTEMS<br />
HAS AN<br />
AMALGAMATION<br />
OF TECHNOLOGY<br />
AND INDUSTRY<br />
KNOWLEDGE<br />
CATERING<br />
SOLUTIONS WITH<br />
SIMPLICITY, EFFICIENCY<br />
&<br />
VISIBILITY TO<br />
AN ENTERPRISE
solution list. In this broad spectrum,<br />
mobility solutions on one end and on<br />
the other end, develop<strong>in</strong>g and<br />
implement<strong>in</strong>g solutions for digital<br />
transformation of cl<strong>in</strong>ical research<br />
organizations, drug safety database,<br />
enterprise-wide quality management<br />
and many more. At the core of Sarjen<br />
Systems’ solution implementation<br />
success, there is a flexible delivery<br />
approach where it efficiently merges its<br />
doma<strong>in</strong> expertise with the proprietary<br />
technology stack. All the products can<br />
be<br />
‘<br />
easily <strong>in</strong>tegrated with <strong>in</strong>dustry<br />
CONSTANT<br />
GREATER<br />
GOALS<br />
ARE THE WAY<br />
TO KEEP<br />
MOMENTUM<br />
GOING AND<br />
SUCCEED<br />
standard enterprise applications. Also,<br />
the project management and consult<strong>in</strong>g<br />
teams seamlessly execute <strong>in</strong>tegrat<strong>in</strong>g<br />
of projects ensur<strong>in</strong>g high throughput.<br />
<strong>The</strong> solution<strong>in</strong>g for pharma and life<br />
science doma<strong>in</strong>s was the precursor of<br />
implement<strong>in</strong>g processes and<br />
ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g high quality standards<br />
with cont<strong>in</strong>ued improvements. This<br />
would help <strong>in</strong> ensur<strong>in</strong>g that there were<br />
no defects or bugs <strong>in</strong> delivery,<br />
documentation and ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g<br />
all-around quality standards. Sarjen<br />
Systems provides solutions and<br />
services across several <strong>in</strong>dustry<br />
doma<strong>in</strong>s <strong>in</strong>clud<strong>in</strong>g <strong>Pharma</strong>ceutical,<br />
Healthcare, <strong>Life</strong> sciences, FMCG, and<br />
few others; comply<strong>in</strong>g with global<br />
regulatory guidel<strong>in</strong>es.<br />
Sarjen Systems’ USP<br />
· Expertise <strong>in</strong> <strong>Pharma</strong> and <strong>Life</strong> science<br />
doma<strong>in</strong>s<br />
· Proprietary Technology Stack ·<br />
Global Exposure/Presence<br />
· Complete solution basket – from<br />
Drug Development to Sales<br />
· Expert on cGxP and Regulatory<br />
guidel<strong>in</strong>es<br />
· <strong>Solution</strong>s compliant with Part 11<br />
(Annex 11, EMA and 21 CFR Part<br />
11, US FDA) and global guidel<strong>in</strong>es<br />
· Multiple Licens<strong>in</strong>g models to suit<br />
enterprise needs<br />
Unlocked Milestones<br />
Gett<strong>in</strong>g ISO 9001:2008 certification<br />
was the natural progression and it gave<br />
way to very structured quality<br />
management <strong>in</strong>tegrated with Sarjen<br />
Systems’ SDLC. <strong>The</strong>n, upgrad<strong>in</strong>g to<br />
risk and opportunity based ISO<br />
9001:2015 standards to achieve and<br />
ma<strong>in</strong>ta<strong>in</strong> control, and cont<strong>in</strong>ual<br />
improvement for processes, products<br />
and services. Cont<strong>in</strong>u<strong>in</strong>g them forward<br />
ensures structure, process-driven<br />
approach for seamless quality. Also,<br />
implement<strong>in</strong>g compliant GxP<br />
computerized systems us<strong>in</strong>g GAMP5<br />
driven risk-based validation for part 11<br />
compliance.<br />
Dynamic project management with the<br />
right set of people to develop solutions<br />
us<strong>in</strong>g cutt<strong>in</strong>g-edge technology,<br />
stretch<strong>in</strong>g the limits to get the best,<br />
achiev<strong>in</strong>g timel<strong>in</strong>es <strong>in</strong> the budget,<br />
ris<strong>in</strong>g to the challenge of def<strong>in</strong><strong>in</strong>g<br />
milestones, planned commitments and<br />
deliverables, ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g quality,<br />
track<strong>in</strong>g progress and overall<br />
strategiz<strong>in</strong>g the various stages of<br />
software development is Sarjen<br />
Systems’ highlight<strong>in</strong>g forte.<br />
Rewards and Recognitions<br />
Sarjen Systems was recently shortlisted<br />
as “Best Software Company” @<br />
Vibrant Gujarat Technology Summit.<br />
Sarjen Systems is a Microsoft Gold<br />
partner. Also, NASSCOM and Gesia<br />
member. <strong>The</strong>ir core team members<br />
have been <strong>in</strong>vited to speak at numerous<br />
events on various topics. <strong>The</strong>y have<br />
recently hosted a NASSCOM event.<br />
A Piece of Advice<br />
“One must focus on deep doma<strong>in</strong><br />
expertise and user-centric design with<br />
persistence to adapt, adopt and<br />
<strong>in</strong>novate. Small and mean<strong>in</strong>gful<br />
improvements will lead to hugely<br />
differentiat<strong>in</strong>g product <strong>in</strong> the long<br />
run.” – states Nikur Mody.<br />
Explor<strong>in</strong>g Market Leadership<br />
Sarjen Systems’ ongo<strong>in</strong>g adaptation of<br />
AI, ML, Blockcha<strong>in</strong> and Deep<br />
Learn<strong>in</strong>g has brought impactful change<br />
across its solutions. <strong>The</strong>se<br />
technological advancements of now<br />
and tomorrow, would not only improve<br />
overall efficiency and <strong>in</strong>culcate good<br />
practices but also <strong>in</strong>directly contribute<br />
to better and greater patient safety.<br />
Sarjen Systems is all set to cont<strong>in</strong>ue its<br />
habit of <strong>in</strong>novations by embedd<strong>in</strong>g<br />
new technologies and achieve a higher<br />
position as a lead<strong>in</strong>g software solutions<br />
provider, globally.
KNOW US BETTER<br />
• Founded Year:<br />
1998<br />
• Headquarter <strong>in</strong>:<br />
Ahmedabad, India<br />
• Major Operation Centers:<br />
Support offices <strong>in</strong> Mumbai,<br />
India; London, UK and<br />
Durham, USA<br />
• Total Number of Clients<br />
Served & Countries<br />
Served:<br />
<strong>10</strong>0+ clients <strong>in</strong> 50+<br />
countries<br />
• Our Tagl<strong>in</strong>e: Pioneer<strong>in</strong>g<br />
digital transformation for<br />
Indian <strong>Pharma</strong> research<br />
• URL: www.sarjen.com<br />
‘<br />
WE ARE<br />
A WORK CULTURE<br />
CREATING<br />
IDEA FLOWS MIND VERY EASILY<br />
OUT OF<br />
WHERE
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Interview with Insights Success<br />
Accurex<br />
Biomedical<br />
In today’s fast paced world, disease is<br />
not taken care of until body shows<br />
symptoms. Can high quality healthcare<br />
be delivered if patient’s physician is<br />
hurried, cold or uncar<strong>in</strong>g? That’s why<br />
many of the companies are <strong>in</strong>novat<strong>in</strong>g new<br />
technologies, new processes for timely<br />
diagnosis and treatment of diseases.<br />
Pioneer <strong>in</strong> Manufactur<strong>in</strong>g and<br />
Market<strong>in</strong>g of In-vitro<br />
Diagnostic Reagents<br />
In an <strong>in</strong>terview with Insights Success, Abh<strong>in</strong>av Thakur,<br />
Manag<strong>in</strong>g Director at Accurex Biomedical Pvt. Ltd. has<br />
shared some <strong>in</strong>sightful views and highlighted the <strong>in</strong>fluences made<br />
by their company. <strong>The</strong> company is one of the top 3 manufacturers<br />
of quality Cl<strong>in</strong>ical Chemistry Reagents and Ur<strong>in</strong>analysis Test<br />
Strips with over 34 years of expertise <strong>in</strong> this area.<br />
INTERVIEW WITH INSIGHTS SUCCESS<br />
1. Share with us the motivat<strong>in</strong>g factors that led towards the <strong>in</strong>ception of company?<br />
I was study<strong>in</strong>g <strong>in</strong> the USA when unfortunately, my father passed away prematurely. I came back to<br />
India to run the company for my family.<br />
At that po<strong>in</strong>t of time motivation for me was survival of the family bus<strong>in</strong>ess.<br />
Now the motivation for me is to grow the company so I can have an impact on the economic<br />
development of our country. I strongly believe that strong economic development is the antidote the<br />
poverty.<br />
2. Brief us about the goal, vision and mission of the company; it has set to mark its exceptionality <strong>in</strong><br />
future.<br />
We are <strong>in</strong> the medical diagnostics <strong>in</strong>dustry and impact the lives of humans. 70% of medical<br />
decisions are made based on medical diagnostic reports. Hence our mission is to help save lives by<br />
provid<strong>in</strong>g accurate and precise medical diagnostic solutions to pathology laboratories.<br />
Our vision is to be one of the Top medical diagnostic companies of India by 2025.<br />
3. Which is you flagship product? Tell us someth<strong>in</strong>g about that. It would be great if you provide us 2-3<br />
notable feedbacks from of renowned clients/bus<strong>in</strong>ess leaders regard<strong>in</strong>g your products/services.<br />
<strong>The</strong> most common test <strong>in</strong> any pathology lab is blood glucose. Diabetic patients are aware about their<br />
blood sugar levels and blood glucose is also checked at home by many diabetics.<br />
If there is an error I the blood glucose report the chances of the patient question<strong>in</strong>g the report are<br />
very high when compared to other tests.<br />
If the patient f<strong>in</strong>ds out the results provided by the lab are <strong>in</strong>accurate by test<strong>in</strong>g <strong>in</strong> another lab or at<br />
home, then the lab loses a customer and its reputation.<br />
Consequently, blood glucose is one of the test on which the reputation of a lab depends.<br />
18 | | APRIL <strong>2019</strong>
Abh<strong>in</strong>av Thakur<br />
MD<br />
APRIL <strong>2019</strong> |<br />
| 19
Accurex today is the largest supplier of blood glucose<br />
reagents <strong>in</strong> the country because of the quality of our<br />
reagents.<br />
This proves that our quality of reagents is the best <strong>in</strong> the<br />
country.<br />
4. Tell us about the services you provide through your<br />
venture (apart from your flag-ship one).<br />
We also provide medical diagnostic <strong>in</strong>struments.<br />
5. What is the uniqueness of your products and services as<br />
compare to your competitors? K<strong>in</strong>dly elaborate <strong>in</strong><br />
detail.<br />
Our company was established <strong>in</strong> 1984. S<strong>in</strong>ce we have<br />
been <strong>in</strong> the market for over 34 years we have build a<br />
strong brand <strong>in</strong> the market. If it was not for the quality<br />
of our products it would not have been possible for us<br />
to survive <strong>in</strong> the market for over 34 years.<br />
Hence quality of our reagents and result<strong>in</strong>g brand for<br />
the last 34 years is our competitive advantage.<br />
6. Brief us about the Founder/CEO of the company and<br />
the major contribution of him/her towards the<br />
development of the company.<br />
My father, Mr. Anil Thakur was the Founder &<br />
Ex-Manag<strong>in</strong>g Director of Accurex Biomedical Pvt.<br />
Ltd. He was an excellent visionary. Under his<br />
leadership, Accurex had launched various <strong>in</strong>novative<br />
products and marketed them with <strong>in</strong>novative strategies.<br />
He established Accurex as a Customer-Oriented<br />
organization, and launched the 24 x 7 module for all<br />
Accurex customers to log on their compla<strong>in</strong>ts/queries<br />
24 hours a day; 7 days a week - the first-of-its-k<strong>in</strong>d <strong>in</strong><br />
India.<br />
Mr. Thakur took Accurex to <strong>in</strong>ternational platforms<br />
through Medica, APCCB and various other<br />
International exhibitions and conferences. His<br />
contribution towards Accurex for the last 20 years was<br />
enormous. Unfortunately, Mr. Thakur passed away on<br />
25 January, 2004. However Accurex will cont<strong>in</strong>ue to be<br />
guided by his ideals and vision. In the near future,<br />
Accurex will achieve a leadership position <strong>in</strong> the<br />
Asia-Pacific region which was his dream.<br />
7. What are the positive developments go<strong>in</strong>g on <strong>in</strong> the<br />
<strong>Pharma</strong> & <strong>Life</strong> <strong>Sciences</strong> <strong>Solution</strong> provider company?<br />
Po<strong>in</strong>t-of-care test<strong>in</strong>g (POCT), or bedside test<strong>in</strong>g is<br />
def<strong>in</strong>ed as medical diagnostic test<strong>in</strong>g at or near the<br />
po<strong>in</strong>t of care—that is, at the time and place of patient<br />
care. This contrasts with the historical pattern <strong>in</strong> which<br />
test<strong>in</strong>g was wholly or mostly conf<strong>in</strong>ed to the medical<br />
laboratory, which entailed send<strong>in</strong>g off specimens away<br />
from the po<strong>in</strong>t of care and then wait<strong>in</strong>g hours or days to<br />
learn the results, dur<strong>in</strong>g which time care must cont<strong>in</strong>ue<br />
without the desired <strong>in</strong>formation.<br />
POC test<strong>in</strong>g is gett<strong>in</strong>g popular <strong>in</strong> the medical<br />
diagnostic <strong>in</strong>dustry.<br />
Through POC test<strong>in</strong>g the lab tests are available at the<br />
doctors and patients at home. This is convenient to the<br />
patient.<br />
8. Your advice to budd<strong>in</strong>g entrepreneurs?<br />
Four mantras:<br />
1. Good Governance: Never compromise on your<br />
ethics. Sooner or later you will have to pay the<br />
price. Reputation built over years can be<br />
destroyed <strong>in</strong> hours if you compromise on ethics.<br />
2. Empower your team. Don’<br />
t dictate your terms to<br />
the team but <strong>in</strong>volve your team <strong>in</strong> the decision<br />
mak<strong>in</strong>g process to get ownership.<br />
3. Build a competitive advantage <strong>in</strong> your bus<strong>in</strong>ess<br />
or you will become a commodity soon and loose<br />
your market share. You need to keep <strong>in</strong>novat<strong>in</strong>g<br />
to build your competitive advantage.<br />
4. Purpose: You need to build a strong purpose for<br />
your bus<strong>in</strong>ess. If you don’<br />
t have a strong<br />
purpose then you will give up <strong>in</strong> the difficult<br />
times. Money cannot be the only purpose<br />
because if money is the only purpose then it will<br />
be short lived and you may end up tak<strong>in</strong>g<br />
short cuts.<br />
9. What the company desperately wants to achieve <strong>in</strong> the<br />
next few years?<br />
In the next few years we want to build our foundation<br />
strong so we can raise funds and grow to achieve our<br />
mission and vision.<br />
20 | | APRIL <strong>2019</strong>
Ashish <strong>Life</strong> Science<br />
Deliver<strong>in</strong>g Highest Quality Veter<strong>in</strong>ary Medic<strong>in</strong>es at Economical Price<br />
Meet the Profound Founder<br />
Raujesh Agarrwal, the Founder of Ashish <strong>Life</strong> Science<br />
Pvt. Limited, has completed PG <strong>in</strong> Family Managed<br />
Bus<strong>in</strong>ess. He is responsible for deploy<strong>in</strong>g the company’s<br />
strategic vision and develop<strong>in</strong>g bus<strong>in</strong>ess alliances as well<br />
as build<strong>in</strong>g the management team. He has been actively<br />
<strong>in</strong>volved <strong>in</strong> sales & market<strong>in</strong>g of the company products<br />
all over the world. Over the period of time, he appo<strong>in</strong>ted<br />
distribution & market<strong>in</strong>g channel <strong>in</strong> over 60 countries.<br />
Idea beh<strong>in</strong>d ‘ALS’<br />
After travell<strong>in</strong>g to many countries, Raujesh realized the<br />
potential of Indian veter<strong>in</strong>ary medic<strong>in</strong>e. He recognized<br />
the huge bus<strong>in</strong>ess prospective for Animal health products<br />
<strong>in</strong> International markets. See<strong>in</strong>g the vision and growth of<br />
the <strong>in</strong>dustry he decided to start manufactur<strong>in</strong>g and<br />
export<strong>in</strong>g veter<strong>in</strong>ary products.<br />
Raujesh Agarrwal, Founder<br />
Ashish <strong>Life</strong> Science Pvt. Ltd. (ALS) is<br />
established s<strong>in</strong>ce 2002. S<strong>in</strong>ce <strong>in</strong>ception, it is<br />
tak<strong>in</strong>g efforts to deliver significant value to its<br />
customers by understand<strong>in</strong>g their needs and <strong>in</strong>novat<strong>in</strong>g<br />
to offer the right choice of products. Over the years, it<br />
has built up a reputation for reliability and trust between<br />
company and its customers.<br />
ALS’s entire team is consistently evolv<strong>in</strong>g to meet its<br />
customers’ needs across the Globe. It offers a range of<br />
cutt<strong>in</strong>g –edge veter<strong>in</strong>ary products with the world-class<br />
manufactur<strong>in</strong>g <strong>in</strong>frastructure and relationship driven<br />
approach.<br />
“We pride ourselves on personal service, good work<strong>in</strong>g<br />
relationships, and satisfy<strong>in</strong>g our customers wherever<br />
they may be.” says Raujesh Agarrwal, the Founder.<br />
“We believe animals have been cater<strong>in</strong>g to service of<br />
mank<strong>in</strong>d and it is our duty to reciprocate back.” –states<br />
Raujesh.<br />
World-Class Quality Products<br />
<strong>The</strong> company has therefore, developed a strong focus on<br />
‘Animal Healthcare’. <strong>The</strong> provided quality is beyond the<br />
horizon of any negotiation. <strong>The</strong>refore, world-class<br />
manufactur<strong>in</strong>g facility has been set up that could meet<br />
str<strong>in</strong>gent cGMP Guidel<strong>in</strong>es of any regulatory body<br />
<strong>in</strong>clud<strong>in</strong>g World Health Organization. <strong>The</strong> company<br />
strictly follows cGMP <strong>in</strong> all aspects of production and<br />
distribution activities. Also, the manufactur<strong>in</strong>g facility is<br />
approved by various health authorities for supply of<br />
veter<strong>in</strong>ary medic<strong>in</strong>es.<br />
Inclusive Services<br />
ALS exhibits high diligence at every level and function.<br />
22 | | APRIL <strong>2019</strong>
MOST RECOMMENDED<br />
PHARMA &<br />
L FE SCIENCES<br />
SOLUTION PROVIDERS IN <strong>2019</strong><br />
Adherence to quality, best-<strong>in</strong>-class manufactur<strong>in</strong>g<br />
practices, highest level of laboratory certification and<br />
high service standards have enabled it to build last<strong>in</strong>g<br />
relationship across the globe.<br />
“As India is strong on human pharmaceuticals;<br />
therefore, we saw an opportunity for pharmaceutical <strong>in</strong><br />
the Animal space and decided to totally focus on animal<br />
products.” states Raujesh.<br />
Ris<strong>in</strong>g above the Horizon<br />
Beh<strong>in</strong>d the meteoric rise of ALS, there is a team of<br />
committed <strong>in</strong>dividuals. <strong>The</strong> team of ALS comprises of<br />
dedicated professionals who believe <strong>in</strong> learn<strong>in</strong>g, empathy<br />
and <strong>in</strong>novation. <strong>The</strong> entire team is relentlessly and<br />
passionately work<strong>in</strong>g towards the advancement of<br />
animal care.<br />
ALS operates across the entire spectrum of therapeutic<br />
segments – Antiparasitics, Ecoparasiticides, NSAIDs,<br />
Antibiotics, Antifungal, Antiprotozoal, Tonics and<br />
Neutraceuticals to name a few. Besides, it also offer all<br />
dosage forms – bolus, tablets, powder, suspensions,<br />
solutions, oral paste, <strong>in</strong>jectable and spray & o<strong>in</strong>tments<br />
ensur<strong>in</strong>g that its clients also have an ease and<br />
effectiveness of adm<strong>in</strong>istrations.<br />
Notable Achievements<br />
Ashish <strong>Life</strong> Science has won the “SME Bus<strong>in</strong>ess<br />
Excellence Awards 2014”, presented by D&B, <strong>The</strong><br />
Times Group and Federal Bank. Also, it has been<br />
recognized as “India’s small Giants” by India SME <strong>in</strong><br />
2014. Furthermore, Raujesh was <strong>in</strong>terviewed by ET now<br />
after ALS was recognized as an emerg<strong>in</strong>g “<strong>Pharma</strong><br />
Company <strong>in</strong> micro segment”.<br />
Additionally, ALS has won the prestigious “Top <strong>10</strong>0<br />
SMEBOI Awards” (achievers of 2012), the “Top <strong>10</strong>0<br />
SMEBOI Awards” (Achievers of 2013) and the “ECGC-<br />
D&B- Indian Exporters Excellence Awards 2015 – Best<br />
manufactur<strong>in</strong>g Exporters” Award along with the Golden<br />
Maharashtra MSME’s “Manufactur<strong>in</strong>g Summit 2015<br />
Award”. And, it has been featured <strong>in</strong> the well-known<br />
“Dollar Bus<strong>in</strong>ess magaz<strong>in</strong>e” <strong>in</strong> 2016.<br />
1T<br />
HE<br />
We believe that our<br />
customer's customer<br />
is our customer<br />
and satisfaction<br />
of these customers<br />
is our responsibility<br />
as well, and,<br />
we believe <strong>in</strong><br />
deliver<strong>in</strong>g Value<br />
Founder’s Piece of Advice<br />
“Today, there is strong awareness by people about<br />
generics. People have started question<strong>in</strong>g the cost of the<br />
product. Thus, this is forc<strong>in</strong>g companies to reasonably<br />
price their products.” says Raujesh. Furthermore, he said<br />
“It’s all about Vision – Passion – Commitment”.<br />
Rock-solid Future<br />
<strong>The</strong> company is hav<strong>in</strong>g crystal-clear vision and thus,<br />
gear<strong>in</strong>g up to adopt the future trends. It has established<br />
its name <strong>in</strong> the <strong>in</strong>ternational market and will cont<strong>in</strong>ue to<br />
surpass the expectations of the customer and always<br />
improve and deliver highest quality at economical price<br />
on timely basis.<br />
| 23<br />
APRIL <strong>2019</strong> |
Digitaliz<strong>in</strong>g <strong>Pharma</strong><br />
Author<br />
ABOUT THE<br />
Sudip Chhatui –VP,<br />
Bus<strong>in</strong>ess and Operations at<br />
Curofy<br />
Sudip hails from Kolkata<br />
NSIT, Delhi Alumni. He was<br />
the first person <strong>in</strong> the<br />
Curofy Market<strong>in</strong>g team,<br />
who jo<strong>in</strong>ed before the<br />
launch of the Curofy app.<br />
Initially set up and led the<br />
growth team and is now<br />
lead<strong>in</strong>g the Bus<strong>in</strong>ess<br />
development team Curofy.<br />
He is a startup enthusiast.<br />
And, he is one who loves<br />
travel<strong>in</strong>g. Also, a Real<br />
Madrid fan.<br />
24 | | APRIL <strong>2019</strong>
5<br />
PHARMA<br />
echnology is chang<strong>in</strong>g every <strong>in</strong>dustry <strong>in</strong> significant<br />
Tways. No one can dispute technology’s ability to<br />
enable us all to live longer and healthier lives.<br />
From surgical robots to “smart hospitals,” the digital<br />
transformation is revolutioniz<strong>in</strong>g pharma and healthcare<br />
<strong>in</strong>dustry.<br />
While talk<strong>in</strong>g about digitalization, a po<strong>in</strong>t which needs to<br />
be clarified is that it isn’t just about automation of process<br />
or job or even new technology. It is much bigger and more<br />
fundamental than that. Digital transformation is about us<strong>in</strong>g<br />
digital technologies and data to fulfil the need of the<br />
consumer.<br />
Data visualization to <strong>in</strong>crease accessibility<br />
WAYS IN WHICH<br />
DIGITALIZATION<br />
IS TRANSFORMING<br />
HEALTHCARE AND<br />
INDUSTRY<br />
F<strong>in</strong>ancial transparency:<br />
Technology helps people <strong>in</strong> gett<strong>in</strong>g <strong>in</strong>formation about<br />
healthcare expenses. Till now, if the patient was gett<strong>in</strong>g<br />
treated, it was often unclear whether the procedures be<strong>in</strong>g<br />
done are actually necessary or not. But, now the patients<br />
and their family are well aware of the treatments. <strong>The</strong>re’s<br />
also a lack of consistency for health care treatments, the<br />
same services and procedures vary <strong>in</strong> cost from state to<br />
state, sometimes even from one hospital to the next. In<br />
many cases, patients don’t know how much a procedure<br />
costs until it’s done and they’ve received the bill.<br />
Healthcare cost sometimes leads to personal bankruptcy.<br />
Digital transformation is help<strong>in</strong>g the system to improve the<br />
overall patient experience.<br />
Data visualization isn’t just any art, it’s grounded <strong>in</strong> real<br />
results and <strong>in</strong>dustry f<strong>in</strong>d<strong>in</strong>gs. With the new technology, the<br />
way people access and process <strong>in</strong>formation are chang<strong>in</strong>g.<br />
For example, smart health monitors that can collect<br />
personalized, real-time data, encourag<strong>in</strong>g healthier<br />
lifestyles help <strong>in</strong> gather<strong>in</strong>g more lifestyle data, and medical<br />
records. Compar<strong>in</strong>g the responses of patients with<br />
similarities <strong>in</strong> DNA, medical histories and lifestyle can<br />
allow us to understand health risks and the impact of<br />
different treatments. This shar<strong>in</strong>g of data-based <strong>in</strong>telligence<br />
if done <strong>in</strong> a tangible and accessible way, not just helps the<br />
scientifically-m<strong>in</strong>ded people but also helps the border<br />
audience.<br />
Access to a wide range of medical products<br />
<strong>The</strong> medical product <strong>in</strong>formation is easily accessiable<br />
nowadays, it is no more limited to pathways of pharma<br />
companies and the secrecy no longer exists. Information<br />
about every medic<strong>in</strong>al product is available on the <strong>in</strong>ternet.<br />
Patients and consumers can easily f<strong>in</strong>d various ways to cure<br />
there condition through the <strong>in</strong>ternet. <strong>The</strong>y can even f<strong>in</strong>d the<br />
alternatives to drugs without spend<strong>in</strong>g a penny.<br />
Digitalization streaml<strong>in</strong>es the process for efficiency:<br />
Future-forward technologies like AI that can make some of<br />
the major complex k<strong>in</strong>d of decisions us<strong>in</strong>g <strong>in</strong>-depth data<br />
and analytical calculations are transform<strong>in</strong>g strategic<br />
processes as we know them.<br />
Increas<strong>in</strong>g channel of communication:<br />
Earlier if a patient had any healthcare concerns they used to<br />
rush to the hospital. However, with a grow<strong>in</strong>g digital<br />
presence, patients now explore the <strong>in</strong>ternet for hospital<br />
sites, e-mailers to connect to the doctor. Other than this,<br />
patients have onl<strong>in</strong>e access to medical records which they<br />
can share with their doctors.<br />
Digital transformation is an ongo<strong>in</strong>g journey that requires<br />
putt<strong>in</strong>g the consumer at the centre of your bus<strong>in</strong>ess. It has<br />
created a whole new realm of possibility for the consumer,<br />
specifically with the advent of smartphones and their<br />
applications (apps). Smartphone apps are now considered<br />
helpful <strong>in</strong> enhanc<strong>in</strong>g patient education, facilitat<strong>in</strong>g<br />
communication and patient engagement.<br />
APRIL <strong>2019</strong> |<br />
| 25
Medic<strong>in</strong>e World Insights<br />
Penicill<strong>in</strong><br />
01<br />
<strong>10</strong> Medic<strong>in</strong>es<br />
that Changed<br />
the World<br />
It was discovered <strong>in</strong> 1928 by Scottish scientist<br />
Alexander Flem<strong>in</strong>g. Antibiotic, People began us<strong>in</strong>g<br />
<strong>in</strong> 1942 to treat <strong>in</strong>fections and it is used to treat<br />
<strong>in</strong>fections caused by certa<strong>in</strong> susceptible bacteria.<br />
Ether/General<br />
Anesthesia<br />
03<br />
<strong>The</strong> use of anaesthesia can be traced back to<br />
ancient civilizations when opium and other natural<br />
substances were used for the purpose. <strong>The</strong> first<br />
public demonstration of the use of Ether as an<br />
anaesthetic was done <strong>in</strong> 1846 by William T.G.<br />
Morton. Diethyl Ether or Ether is an organic<br />
compound hold<strong>in</strong>g anaesthetic properties and<br />
was widely used dur<strong>in</strong>g surgeries until 2005.<br />
02<br />
Insul<strong>in</strong><br />
A natural prote<strong>in</strong>, it needs to be adm<strong>in</strong>istered as<br />
medic<strong>in</strong>e for diabetic patients. First used <strong>in</strong> 1922<br />
by Frederick Bant<strong>in</strong>g, Charles Best and James<br />
Collip. It is used to treat diabetes and<br />
complications aris<strong>in</strong>g due to it and used along<br />
with glucose to treat high blood potassium levels.<br />
Oral<br />
Contraceptives<br />
04<br />
Oral Contraceptive pills are a method of hormonal<br />
contraception for birth control taken by women. In<br />
1950 Margaret Sanger jotted down her research<br />
f<strong>in</strong>d<strong>in</strong>gs to develop a birth control pill and <strong>in</strong> 1960,<br />
the first pill was approved. Some pills conta<strong>in</strong> both<br />
estrogen and progest<strong>in</strong> while some conta<strong>in</strong> only<br />
progest<strong>in</strong>. <strong>The</strong>y prevent fertilization by <strong>in</strong>hibit<strong>in</strong>g<br />
ovulation and thicken<strong>in</strong>g cervical mucus and<br />
depend on the user's adherence to the dosage.<br />
05<br />
Aspir<strong>in</strong><br />
A non-steroidal anti-<strong>in</strong>flammatory drug,<br />
acetylsalicylic acid (ASA) was first created <strong>in</strong> 1853<br />
by French Chemist Charles Frédéric Gerhardt and<br />
rechristened as Aspir<strong>in</strong> by Bayer for commercial<br />
use. It is used to treat pa<strong>in</strong>, fever and<br />
<strong>in</strong>flammation <strong>in</strong> general and used specifically <strong>in</strong><br />
case of heart attacks, and certa<strong>in</strong> types of cancer.<br />
26 | | APRIL <strong>2019</strong>
Mechloretham<strong>in</strong>e<br />
06<br />
Also known as Chlormeth<strong>in</strong>e and HN2 is a<br />
cytotoxic chemotherapy agent derived from<br />
mustard gas. Once used <strong>in</strong> warfare, their medical<br />
utility was first established by a team led by<br />
Cornelius P. Rhoads. Its derivatives are used to<br />
treat cancer and lymphoid malignancies like<br />
Hodgk<strong>in</strong>'s disease, prostate cancer and<br />
leukaemia.<br />
07<br />
Morph<strong>in</strong>e<br />
Chlorpromaz<strong>in</strong>e<br />
08<br />
A pa<strong>in</strong> medication extracted from plants which<br />
belong to the opiate family. First isolated dur<strong>in</strong>g<br />
the years 1803-1805 by Friedrich Serturner and<br />
commercially available <strong>in</strong> 1827. It acts on the<br />
central nervous system (CNS) to suppress the<br />
feel<strong>in</strong>g of pa<strong>in</strong> and is used to treat chronic, acute,<br />
myocardial and labour pa<strong>in</strong> and can be<br />
adm<strong>in</strong>istered orally or <strong>in</strong>jected.<br />
It was discovered <strong>in</strong> 1950 by chemist Paul<br />
Charpentier and was later produced as the first<br />
antipsychotic medic<strong>in</strong>e. Commonly marketed<br />
under the name of Thoraz<strong>in</strong>e it is used to treat<br />
psychotic disorders like schizophrenia, Bipolar<br />
disorder among others.<br />
09<br />
Stat<strong>in</strong>s<br />
Antiretroviral<br />
<strong>10</strong><br />
Stat<strong>in</strong>s are a class of lipid-lower<strong>in</strong>g medic<strong>in</strong>es<br />
that effectively reduce LDL cholesterol.<br />
Commonly sold as atorvastat<strong>in</strong> under the trade<br />
name Lipitor among others, it was first isolated by<br />
biochemist Akira Endo and approved for medical<br />
use <strong>in</strong> 1996. It is used to prevent cardiovascular<br />
diseases and abnormal lipid levels.<br />
Multiple Antiretroviral Medic<strong>in</strong>es are used to<br />
manage HIV/AIDS dur<strong>in</strong>g the Antiretroviral<br />
<strong>The</strong>rapy. Taken <strong>in</strong> comb<strong>in</strong>ation, these drugs<br />
prevent the growth of the virus to slow down and<br />
control the disease. <strong>The</strong> therapy first started as a<br />
solution to the dreaded disease <strong>in</strong> 1996.<br />
Sneha S<strong>in</strong>ha<br />
Editor<br />
APRIL <strong>2019</strong> |<br />
| 27
Fermenta Biotech Ltd<br />
Discover | Develop | Deliver<br />
Himachal Pradesh and was followed by another <strong>in</strong> 2011 at<br />
Dahej, Gujarat. Both the units are certificated by global<br />
accreditations. Align<strong>in</strong>g with world-class standards, a<br />
state-of-art R&D center is located at Thane that adds glory<br />
to FBL.<br />
Today, it is the only manufacturer and supplier of Vitam<strong>in</strong><br />
D3 (Cholecalciferol) <strong>in</strong> South-East Asia and shares the<br />
stage with a few manufacturers at the global platform.<br />
Hav<strong>in</strong>g a dom<strong>in</strong>ant presence over fifty countries and 300<br />
global customers, FBL exploits its experience to create a<br />
worldwide distribution network for pharmaceuticals, dietary<br />
and nutritional supplements, food, feed veter<strong>in</strong>ary and<br />
rodenticides.<br />
Prashant Nagre, CEO<br />
Nutrition and Preventive Health has taken gigantic<br />
leaps over the last decade. Emphasiz<strong>in</strong>g on<br />
creat<strong>in</strong>g an environment-friendly, susta<strong>in</strong>able<br />
world, the global nutraceutical <strong>in</strong>dustry is set to be a<br />
$578.23 billion <strong>in</strong>dustry by 2025 as per a report by<br />
ASSOCHAM.<br />
Conceptualized <strong>in</strong> 1986, Fermenta Biotech Ltd (FBL) is<br />
one of the lead<strong>in</strong>g entities with<strong>in</strong> the Indian sub-cont<strong>in</strong>ent<br />
that caters to this niche segment. This excerpt illustrates the<br />
successful voyage of FBL over the years, along with<br />
showcas<strong>in</strong>g the unique products and services while giv<strong>in</strong>g a<br />
glimpse of an adroit leader - Prashant Nagre, the CEO.<br />
Inception Saga – Go<strong>in</strong>g Down the Memory Lane!<br />
FBL, <strong>in</strong>cepted under the auspices of Duphar-Interfran Ltd<br />
(now known as DIL Ltd.), is the bra<strong>in</strong>child of late Mr.<br />
Vasant Kumar Datla. Start<strong>in</strong>g the journey from 1986, FBL<br />
has stamped its presence across the globe and created<br />
countless milestones and cont<strong>in</strong>ues to march forward. In<br />
1987, FBL’s first manufactur<strong>in</strong>g unit came up <strong>in</strong> Kullu,<br />
Marquee Products & Services<br />
Vitam<strong>in</strong> D3 is the flagship product of FBL and is also its<br />
largest portfolio <strong>in</strong> terms of bus<strong>in</strong>ess. Additionally, it has<br />
amassed expertise <strong>in</strong> <strong>in</strong>tegrated biotechnology solutions viz.<br />
enzymes as well as an Environmental <strong>Solution</strong>s bus<strong>in</strong>ess<br />
vertical focus<strong>in</strong>g on waste management through a blend of<br />
biotechnology and eng<strong>in</strong>eer<strong>in</strong>g acumen.<br />
Vitam<strong>in</strong> D3<br />
FBL pioneered the use of proprietary technology to<br />
manufacture Vitam<strong>in</strong> D3 <strong>in</strong> India. It addressed the grow<strong>in</strong>g<br />
need for its products across a wider range of applications <strong>in</strong><br />
the food, pharmaceuticals, dietary & nutritional<br />
supplements, feed, veter<strong>in</strong>ary and rodenticide segments.<br />
Biotechnology<br />
As a pioneer of Penicill<strong>in</strong> G Amidase (PGA), FBL has<br />
commercialized next generation PGA enzyme technologies<br />
for Amoxicill<strong>in</strong>, Ampicill<strong>in</strong>, Cephalex<strong>in</strong>, and Cefadroxil.<br />
<strong>The</strong> company offers improved CAL B Lipase catalysts that<br />
can be used for a plethora of applications.<br />
FBL has evolved as a dependable technology-driven partner<br />
enjoy<strong>in</strong>g customer trust irrespective of project size, phase,<br />
and complexity. Embrac<strong>in</strong>g <strong>in</strong>novative technologies have<br />
enabled FBL to <strong>in</strong>corporate the latest, eco-friendly<br />
manufactur<strong>in</strong>g practices, along with address<strong>in</strong>g sectors<br />
compris<strong>in</strong>g the pharmaceutical <strong>in</strong>dustry, f<strong>in</strong>e chemicals,<br />
bio-plastics and cosmetics.<br />
30 | | APRIL <strong>2019</strong>
MOST RECOMMENDED<br />
PHARMA &<br />
L FE SCIENCES<br />
SOLUTION PROVIDERS IN <strong>2019</strong><br />
1T<br />
HE<br />
Environmental <strong>Solution</strong>s<br />
FBL, a pioneer <strong>in</strong> enzyme technologies, offers <strong>in</strong>tegrated<br />
biotech as well as eng<strong>in</strong>eer<strong>in</strong>g solutions that address<br />
environmental issues. FBL’s tailor-made platform<br />
technologies provide unique waste water management and<br />
treatment advantages.<br />
Apart from its proprietary bio-product, Fermsept, FBL also<br />
offers Eng<strong>in</strong>eer<strong>in</strong>g Procurement and Construction solutions<br />
for a range of applications: encompass<strong>in</strong>g <strong>in</strong>tegrated<br />
solutions for sewage treatment plants and effluent treatment<br />
plants.<br />
Steer<strong>in</strong>g the Ship Ahead<br />
Prashant Nagre, CEO, has been associated with FBL for<br />
almost a decade, lead<strong>in</strong>g strategy and oversee<strong>in</strong>g day to day<br />
operations of all three bus<strong>in</strong>ess verticals viz. Biotechnology,<br />
<strong>Pharma</strong>ceuticals and Environmental <strong>Solution</strong>s. He also<br />
focuses on further build<strong>in</strong>g and develop<strong>in</strong>g the various<br />
strengths of FBL i.e. Manufactur<strong>in</strong>g, R&D and allied<br />
activities. He forms a core member of the product<br />
development team and is also responsible for creat<strong>in</strong>g and<br />
nurtur<strong>in</strong>g large bus<strong>in</strong>ess account relationships. Known for<br />
his meticulous plann<strong>in</strong>g skills, Prashant adds impetus to<br />
timely deliveries of products, quality orientation and human<br />
resource development with<strong>in</strong> the company.<br />
Awards and Accolades<br />
In its endeavor to deliver excellence <strong>in</strong> services, FBL has<br />
been bestowed with numerous awards and recognitions that<br />
exemplify its presence as a significant player <strong>in</strong> the<br />
<strong>in</strong>dustry. Few of the prized achievements are listed below:<br />
• India <strong>Pharma</strong> Awards 2018<br />
o Excellence <strong>in</strong> CSR for companies with turnover<br />
less than INR 500 Cr.<br />
o <strong>Pharma</strong> International Excellence<br />
o Excellence <strong>in</strong> Export Promotion<br />
• H<strong>in</strong>dustan Times Thane Ratna Award <strong>2019</strong> – Healthcare,<br />
<strong>Pharma</strong> and Biotech Manufactur<strong>in</strong>g<br />
• World HRD Congress Awards 2018<br />
o National Best Employer Brands<br />
o Bus<strong>in</strong>ess Leader of the Year – Mr. Prashant Nagre<br />
o Top <strong>10</strong>1 HR M<strong>in</strong>ds – Mr. V.K. Raveendranath,<br />
General Manager – Human Resources<br />
• Pride of Maharashtra Award <strong>2019</strong> for Best CEO of the<br />
Year <strong>in</strong> Manufactur<strong>in</strong>g – <strong>Pharma</strong>ceuticals – Mr. Prashant<br />
Nagre<br />
Roadmap to Future<br />
As the global biotech <strong>in</strong>dustry is witness<strong>in</strong>g a surge <strong>in</strong><br />
| 31<br />
players, competitive<br />
markets, and<br />
technological<br />
In the com<strong>in</strong>g<br />
advancements, FBL<br />
years, FBL aims to<br />
has identified the<br />
become a holistic<br />
milestones that it<br />
<strong>in</strong>tends to achieve over nutraceutical<br />
the next few years. It <strong>in</strong>gredient<br />
has broadly classified manufacturer,<br />
the goals <strong>in</strong> three through develop<strong>in</strong>g,<br />
directions:<br />
manufactur<strong>in</strong>g and<br />
commercializ<strong>in</strong>g<br />
Product Portfolio micronutrients<br />
Expansion: FBL required for human<br />
<strong>in</strong>tends to diversify its and animal nutrition<br />
portfolio to <strong>in</strong>clude a<br />
wide range of<br />
nutraceutical<br />
<strong>in</strong>gredients such as antioxidants and smart m<strong>in</strong>erals that are<br />
microencapsulated for added benefits.<br />
International Collaborations: It cont<strong>in</strong>ues to make<br />
determ<strong>in</strong>ed efforts to widen its footpr<strong>in</strong>t of Vitam<strong>in</strong> D3<br />
across geographies through engagements established across<br />
six cont<strong>in</strong>ents. To evolve as a key player <strong>in</strong> the<br />
nutraceuticals space, FBL has designed the roadmap to<br />
expand its portfolio through distribution agreements, jo<strong>in</strong>t<br />
ventures, and acquisitions.<br />
Micronutrient Space: FBL has envisaged various<br />
synergistic opportunities to create a formidable range of<br />
value-added nutritional <strong>in</strong>gredients, thus widen<strong>in</strong>g overall<br />
product offer<strong>in</strong>gs to cater to the press<strong>in</strong>g issue of<br />
micronutrient deficiency across the globe.<br />
FBL’s Associations<br />
Vitam<strong>in</strong> D Guru: FBL’s public awareness <strong>in</strong>itiative is a<br />
digital platform to enhance knowledge about the<br />
significance of Vitam<strong>in</strong> D for health and wellness.<br />
Vitam<strong>in</strong> Angels: FBL contributes towards Vitam<strong>in</strong> Angels’<br />
activities <strong>in</strong> the field of micronutrient deficiency <strong>in</strong> women<br />
and children <strong>in</strong> develop<strong>in</strong>g countries.<br />
National Association for the Bl<strong>in</strong>d (NAB): FBL not only<br />
contributes towards corneal transplants, squ<strong>in</strong>t correction<br />
surgeries, educational Braille kits and grant for Diploma <strong>in</strong><br />
Special Education course, but also <strong>in</strong>tegrates NAB’s<br />
members with its <strong>in</strong>ternal activities for employee<br />
engagement.<br />
APRIL <strong>2019</strong> |
Healthcare Predictions<br />
FUTURE<br />
PREDICTIONS<br />
Of<br />
ELECTRONIC<br />
HEALTH<br />
RECORDS,<br />
<strong>2019</strong><br />
&<br />
BEYOND<br />
About the Author<br />
Kumar Subramaniam, Founder & CEO at<br />
75Health<br />
Kumar Subramaniam has always believed<br />
and used technology as the means to<br />
improve the quality of bus<strong>in</strong>ess<br />
processes and enhance people's life. He<br />
conceptualized the <strong>in</strong>novative EMR<br />
Software with the objective of digitaliz<strong>in</strong>g<br />
crucial medical records and empower<strong>in</strong>g<br />
medical practices to achieve the best<br />
care delivery. He leverages technology to<br />
achieve bus<strong>in</strong>ess objectives while serv<strong>in</strong>g<br />
the community better.<br />
Alot of changes and<br />
<strong>in</strong>novations have been<br />
occurr<strong>in</strong>g <strong>in</strong> the<br />
healthcare sector s<strong>in</strong>ce the recent<br />
decades. Increased<br />
personalization <strong>in</strong> healthcare and<br />
<strong>in</strong>creased understand<strong>in</strong>g of<br />
patients’ role <strong>in</strong> achiev<strong>in</strong>g<br />
success of their own well-be<strong>in</strong>g<br />
is headed to a tipp<strong>in</strong>g po<strong>in</strong>t.<br />
Today, <strong>in</strong> addition to patient<br />
care, management of patient<br />
experience plays a vital role <strong>in</strong><br />
the healthcare ecosystem.<br />
With the advent of medical<br />
<strong>in</strong>formation systems such as the<br />
electronic health record software<br />
and practice management<br />
software, a lot of unprecedented<br />
changes have taken place <strong>in</strong><br />
cl<strong>in</strong>ical and adm<strong>in</strong>istrative<br />
32 | | APRIL <strong>2019</strong>
aspects of modern healthcare<br />
facilities and physician practices.<br />
<strong>The</strong> Transition to Electronic<br />
Health Records<br />
Globally, there has been a wide<br />
understand<strong>in</strong>g about the virtues of<br />
the electronic health record and<br />
how it transforms the way<br />
healthcare is provided. Increas<strong>in</strong>g<br />
adoption of the EHR is proof<br />
enough to emphasize the fact that it<br />
has become an <strong>in</strong>tegral part of the<br />
healthcare sett<strong>in</strong>g.<br />
<strong>The</strong> EHR landscape has had<br />
tremendous impact, thanks to the<br />
str<strong>in</strong>gent <strong>in</strong>dustry standards and<br />
regulatory requirements such as<br />
HIPAA. Moreover, <strong>in</strong>centives to<br />
<strong>providers</strong> have also augured well<br />
with the <strong>in</strong>crease <strong>in</strong> EHR adoption.<br />
What Does the Future Hold for<br />
the EHR Software?<br />
Although EHRs have been around<br />
s<strong>in</strong>ce long, they are seen to have<br />
still a long way to go. As the<br />
medical <strong>in</strong>dustry switches over<br />
from the traditional volume-based<br />
reimbursement model to<br />
quality-based model, EHRs will be<br />
focus<strong>in</strong>g more on value-based care,<br />
assist<strong>in</strong>g <strong>providers</strong> to skillfully<br />
manage their patients’ health <strong>in</strong> the<br />
most optimal way.<br />
Understand<strong>in</strong>g the follow<strong>in</strong>g EHR<br />
trends <strong>in</strong> the com<strong>in</strong>g years will<br />
enable practices to be prepared for<br />
fac<strong>in</strong>g unique needs and deliver<strong>in</strong>g<br />
the best possible care:<br />
• Ease of use and searchability<br />
o EHRs will be more easily<br />
searched, organized, and used –<br />
enabl<strong>in</strong>g full <strong>in</strong>teraction with<br />
patients<br />
• Interoperability and Integration<br />
o <strong>The</strong> ability of EHR Systems to<br />
<strong>in</strong>tegrate with other health<br />
<strong>in</strong>formation systems will <strong>in</strong>crease<br />
• Accessibility<br />
o Vendors will ensure that EHRs<br />
are more accessible to not only<br />
multi-facility networks and<br />
hospitals but also to all types of<br />
cl<strong>in</strong>ical practices regardless of<br />
size<br />
• Standardization<br />
o With stricter regulations and<br />
standardization of the EHR<br />
features and data, overall<br />
accuracy and reliability of the<br />
EHR System will <strong>in</strong>crease<br />
manifold<br />
• Chang<strong>in</strong>g Dynamics<br />
o AI and virtual assistants will<br />
become more powerful and<br />
accessible, mak<strong>in</strong>g their entry<br />
<strong>in</strong>to health IT – this will help<br />
mitigate issues, if any, with the<br />
EHR Software<br />
<strong>The</strong> EHR System and Healthcare<br />
Delivery Connect<br />
Manag<strong>in</strong>g patient health records is<br />
rendered smooth and effective, thanks<br />
to the <strong>in</strong>novative EHR Software. Us<strong>in</strong>g<br />
computer software and hardware for<br />
the application of data process<strong>in</strong>g<br />
ensures easy and accurate stor<strong>in</strong>g,<br />
shar<strong>in</strong>g, and retrieval of medical<br />
<strong>in</strong>formation. It also makes it possible<br />
to utilize this <strong>in</strong>formation for effective<br />
communication and <strong>in</strong>formation-based<br />
decision mak<strong>in</strong>g.<br />
Network<strong>in</strong>g the computers and<br />
communication attributes effectively<br />
facilitates efficiently mov<strong>in</strong>g critical<br />
health <strong>in</strong>formation. This results <strong>in</strong><br />
<strong>in</strong>creased ability to deliver efficient,<br />
better care.<br />
Choos<strong>in</strong>g the Right Fit for Your<br />
Practice<br />
EHR Software has atta<strong>in</strong>ed an<br />
<strong>in</strong>dispensable position <strong>in</strong> the<br />
healthcare sector. While choos<strong>in</strong>g<br />
the EHR solution diligently and<br />
perfectly results <strong>in</strong> <strong>providers</strong> be<strong>in</strong>g<br />
facilitated to deliver better care<br />
quality and enhance practice<br />
efficiency, a wrong selection would<br />
lead to significant disruption to<br />
regular practice activities and<br />
cont<strong>in</strong>ued difficulty all along the<br />
course of use of the software.<br />
As EHRs lend themselves to be<br />
customized accord<strong>in</strong>g to specific<br />
practice needs, it is essential to first<br />
go through the various features and<br />
get complete demo of each solution<br />
prior to decid<strong>in</strong>g which one to buy.<br />
With cloud be<strong>in</strong>g considered the<br />
future of comput<strong>in</strong>g and as today’s<br />
consumers are more <strong>in</strong>cl<strong>in</strong>ed<br />
toward us<strong>in</strong>g mobile devices,<br />
cloud-based mobile EHR is set to<br />
become more dom<strong>in</strong>ant among<br />
EHR Software service <strong>providers</strong><br />
and practitioners <strong>in</strong> the future.<br />
In the chang<strong>in</strong>g healthcare<br />
scenario, EHRs will certa<strong>in</strong>ly<br />
cont<strong>in</strong>ue to play the role of the<br />
driv<strong>in</strong>g force <strong>in</strong> its evolution. Our<br />
goal is transform<strong>in</strong>g the healthcare<br />
sector us<strong>in</strong>g digital technologies<br />
and empower<strong>in</strong>g the healthcare<br />
fraternity to raise the bar of quality<br />
and efficiency several notches up.<br />
APRIL <strong>2019</strong> |<br />
| 33
<strong>Pharma</strong> Trends<br />
<strong>Pharma</strong>ceutical<br />
Top<br />
Trends to Watch Out <strong>in</strong><br />
<strong>2019</strong><br />
34 | | APRIL <strong>2019</strong>
Indian pharmaceutical <strong>in</strong>dustry is grow<strong>in</strong>g with an impressive pace for last couple of years and is expected to be <strong>in</strong><br />
the top <strong>10</strong> global markets <strong>in</strong> value terms by 2020. <strong>The</strong> <strong>in</strong>dustry is progress<strong>in</strong>g with a compounded annual growth<br />
rate (CAGR) of 15 percent over the last ve years and is adopt<strong>in</strong>g new bus<strong>in</strong>ess models to serve its targeted audience<br />
faster, and better. Good economic growth, high burden of diseases, improvement <strong>in</strong> healthcare <strong>in</strong>frastructure and<br />
<strong>in</strong>creased awareness have tipped to be the reasons beh<strong>in</strong>d such optimistic projections.<br />
However, there are many areas on which any pharmaceutical company should look <strong>in</strong>to- such as organ-on-chip, 3D<br />
Bio-pr<strong>in</strong>t<strong>in</strong>g, AI, and Antibiotics Discovery. Ignor<strong>in</strong>g such vital areas can otherwise can h<strong>in</strong>der the growth prospects of<br />
pharmaceutical <strong>in</strong>dustry.<br />
APRIL <strong>2019</strong> |<br />
| 35
3D Bio-pr<strong>in</strong>t<strong>in</strong>g<br />
Every year thousands of people lose their life due to<br />
organ failure. Many times even after be<strong>in</strong>g nancially<br />
capable, people do not receive organs at the right<br />
time as there is a wide gap between the grow<strong>in</strong>g<br />
demand of organs v/s number of registered donors<br />
<strong>in</strong> the <strong>in</strong>dustry. Usage 3D bio-pr<strong>in</strong>t<strong>in</strong>g thus many see<br />
as a solution for tackl<strong>in</strong>g this critical problem. In biopr<strong>in</strong>t<strong>in</strong>g,<br />
experts use patients own liv<strong>in</strong>g cells to<br />
reproduce organs to reduce the risk of reject<strong>in</strong>g cells.<br />
T h i s f u r t h e r l o w e r t h e r i s k o f t a k i n g<br />
immunosuppressant drugs which are needed after<br />
organ transplant and many times causes trouble for<br />
the patients <strong>in</strong> terms of loss of appetite, nausea,<br />
vomit<strong>in</strong>g, <strong>in</strong>creased hair growth, and hand<br />
trembl<strong>in</strong>g. Moreover, transplantation us<strong>in</strong>g biopr<strong>in</strong>t<strong>in</strong>g<br />
only <strong>in</strong>volves only one <strong>in</strong>dividual that needs<br />
to be operated on and hence, lowers the number of<br />
people need to be hospitalized dur<strong>in</strong>g critical<br />
procedures.<br />
Many believe that organs made form bio-pr<strong>in</strong>t<strong>in</strong>g<br />
can also be used for drug discovery and test<strong>in</strong>g, tissue<br />
eng<strong>in</strong>eer<strong>in</strong>g, research and study. <strong>The</strong>se are the<br />
reasons why pharmaceuticals companies and<br />
hospitals are look<strong>in</strong>g towards 3D bio-pr<strong>in</strong>t<strong>in</strong>g with an<br />
array of hope. It is ma<strong>in</strong>ly used for the creation and<br />
transplantation of several tissues <strong>in</strong>clud<strong>in</strong>g multilayered<br />
sk<strong>in</strong>, heart tissue, cartilag<strong>in</strong>ous structures,<br />
bone, vascular grafts, and tracheal spl<strong>in</strong>ts.<br />
It can also help pharmaceutical companies <strong>in</strong><br />
reduc<strong>in</strong>g overall cost associated with drug<br />
manufactur<strong>in</strong>g once get transformed from an<br />
experimental stage to a fully functional mode.<br />
Increas<strong>in</strong>g R&D expenditure, availability of venture<br />
capital, and government grants are fuell<strong>in</strong>g the<br />
growth of 3D bio-pr<strong>in</strong>t<strong>in</strong>g. It is expected that 3D biopr<strong>in</strong>t<strong>in</strong>g<br />
market will reach USD 2.6 billion by 2024.<br />
Organs-on-chips<br />
Limitations of current planar, animal models and<br />
static cell culture system affect the drug discovery<br />
process to a larger extent. Many times it leads to<br />
<strong>in</strong>creased drug failure rates which even cost<br />
pharmaceuticals companies billions of dollars.<br />
Moreover, many human diseases are still not<br />
modelled accurately us<strong>in</strong>g '<strong>in</strong> vitro' process and thus<br />
h<strong>in</strong>der the growth <strong>in</strong> therapy development.<br />
Shortcom<strong>in</strong>gs of these models started a debate <strong>in</strong> the<br />
pharmaceutical vertical to develop a more<br />
physiological model relevant to human organs and<br />
thus lead to the growth of organs-on-chips.<br />
Organ-on-chip offers a wide range of applications<br />
such as phenotypic screen<strong>in</strong>g, diseases modell<strong>in</strong>g,<br />
and patient stratication. Scientists believe that<br />
organs-on-chips have huge potential to make the<br />
drug discovery process efcient and faster as its<br />
microchips conta<strong>in</strong> liv<strong>in</strong>g cells which can mimic<br />
processes <strong>in</strong> the body such as peristalsis, breath<strong>in</strong>g<br />
and <strong>in</strong>fection. Such chips are t<strong>in</strong>y devices that imitate<br />
the structure, physiology and function of human<br />
organs. Researchers have represented over two<br />
dozen organs <strong>in</strong> on-chip systems, famously <strong>in</strong>cludes-<br />
Lung, Heart, Kidney, Artery, Sk<strong>in</strong>. Some are even<br />
work<strong>in</strong>g to imitate a human-on-chip as well.<br />
While there is a lot of scepticism existed beh<strong>in</strong>d<br />
organs-on-chips some six to seven years ago, many<br />
pharmaceutical companies are now work<strong>in</strong>g towards<br />
it <strong>in</strong> a full-edged mode and embraced this concept<br />
<strong>in</strong>to their bus<strong>in</strong>ess model as well. Market researchers<br />
predicts that organs-on-chip eld which was valued<br />
only at $5 million <strong>in</strong> 2016 will witnessed a meteoric<br />
rise <strong>in</strong> com<strong>in</strong>g years and is expected to reach $170<br />
million by 2023. This <strong>in</strong>dustry will grow with a CAGR<br />
of 63.2% from 2017 to 2023, researchers predict.<br />
36 | | APRIL <strong>2019</strong>
New Antibiotics Discovery<br />
Antibiotic resistant bacteria- superbug led to the<br />
death of more than 700,000 people all across the<br />
world. And, if UK government is to be believed, this<br />
number will dramatically jump up to <strong>10</strong> million by<br />
2050; if necessary steps not taken <strong>in</strong> the arena of new<br />
antibiotic discovery. Experts believe irresponsible<br />
prescription of antibiotics even for the normal cases,<br />
and <strong>in</strong>creased usage of antibiotics <strong>in</strong> farm<strong>in</strong>g<br />
accelerat<strong>in</strong>g the rate of bacterial mutation, render<strong>in</strong>g<br />
them to resistant to drug with alarm<strong>in</strong>g pace.<br />
On the other hand, antibiotic discovery has been a<br />
much ignored area amongst the researchers. <strong>Most</strong> of<br />
the pharmaceutical companies are more <strong>in</strong>cl<strong>in</strong>ed<br />
towards research<strong>in</strong>g and develop<strong>in</strong>g drugs that are<br />
more “economically feasible”. This is the reason the<br />
last novel antibiotic classes was <strong>in</strong>troduced some<br />
thirty years ago.<br />
However, with the grow<strong>in</strong>g need to tackle the menace<br />
of superbug, beneciary reforms <strong>in</strong> the legislation<br />
and <strong>in</strong>creased <strong>in</strong>vestment <strong>in</strong> antibiotic researchmany<br />
organizations are now work<strong>in</strong>g day-<strong>in</strong> day-out<br />
to discover new antibiotics.<br />
In 2015, a group of scientists made a breakthrough<br />
<strong>in</strong> the antibiotics vertical with the discovery of<br />
Teixobact<strong>in</strong>, a powerful antibiotics class that has the<br />
potential to withstand the development of bacterial<br />
resistance aga<strong>in</strong>st it.<br />
Increased Adoption of AI<br />
Develop<strong>in</strong>g a drug is a time consum<strong>in</strong>g and<br />
e x p e n s i v e t a s k . T h e c u r r e n t p r o b l e m o f<br />
pharmaceutical <strong>in</strong>dustry is that n<strong>in</strong>e out of <strong>10</strong> drugs<br />
fail to make it to pre-registration stage due to their<br />
poor absorption, distribution, metabolism, or<br />
excretion (ADME).<br />
In silico (on a computer) drug design, an <strong>in</strong>novative<br />
technique based on AI can help pharmaceutical<br />
companies to reduce such a shock<strong>in</strong>g drug failure<br />
ratio. Such techniques allow the mapp<strong>in</strong>g of drugs<br />
structures and targets that can lead to a more<br />
successful drug development without costly scientic<br />
development.<br />
Another area of AI which is widely becom<strong>in</strong>g popular<br />
is- advanced analytics. Every day thousands of<br />
journals and research paper get published on<br />
various prom<strong>in</strong>ent research <strong>in</strong>stitutes. Genius m<strong>in</strong>ds<br />
from across the globe sweat all through the years to<br />
create someth<strong>in</strong>g concrete but unable to ga<strong>in</strong> any<br />
<strong>in</strong>sights form others research concern<strong>in</strong>g to similar<br />
set of problems. Analytics has solved such problem. It<br />
process vast amount of scientic data and help<br />
pharmaceutical companies to develop drug at much<br />
faster pace by predict<strong>in</strong>g the properties of new drug<br />
candidate <strong>in</strong> advance. This is the reason many<br />
companies now-a-days us<strong>in</strong>g AI to predict risks and<br />
their drivers to enable preventive ma<strong>in</strong>tenance and<br />
remediation of the drugs.<br />
In 2018, malacid<strong>in</strong>s, a new family of antibiotics were<br />
discovered. However it is currently be<strong>in</strong>g <strong>in</strong> its nascent<br />
stage, but one can witness an <strong>in</strong>creas<strong>in</strong>g trend<br />
towards discover<strong>in</strong>g new antibiotic class among the<br />
scientists community.<br />
- Shruti Jambhale<br />
APRIL <strong>2019</strong> |<br />
| 37
Nucleome Informatics<br />
Unravel<strong>in</strong>g the Genomes for a Better Future<br />
been regularly work<strong>in</strong>g on sequenc<strong>in</strong>g of cancer genomes<br />
and human exomes. Wildlife and plant genome sequenc<strong>in</strong>g<br />
and populations genomics is another area of <strong>in</strong>terest where<br />
it provides NGS services regularly. <strong>The</strong> last six years have<br />
seen the company assemble 18 plants, 9 animals, 5 <strong>in</strong>sects,<br />
and over <strong>10</strong>0 microbial genomes and analyzed human<br />
genome and exome sequenc<strong>in</strong>g data (4580 samples by Jan<br />
<strong>2019</strong>). It was also <strong>in</strong>volved <strong>in</strong> prestigious sequenc<strong>in</strong>g<br />
projects like Mango, Pomegranate, Tiger, Indian Wild Dog,<br />
Leopard and Insect genome sequenc<strong>in</strong>g programs. It also<br />
offers cfDNA Sequenc<strong>in</strong>g and Cell l<strong>in</strong>e genome sequenc<strong>in</strong>g<br />
services.<br />
<strong>The</strong> Insightful M<strong>in</strong>ds<br />
<strong>The</strong> company is a resultant of three genius m<strong>in</strong>ds com<strong>in</strong>g<br />
together.<br />
(From Left to Right)<br />
Dushyant S<strong>in</strong>gh Baghel, MD & CEO<br />
Bip<strong>in</strong> Kumar, Co-founder & VP<br />
Abhishek Tripathi, Co-founder & VP<br />
Nucleome Informatics is well regarded <strong>in</strong> the <strong>Life</strong><br />
sciences <strong>in</strong>dustry for its expertise <strong>in</strong> de novo<br />
genome sequenc<strong>in</strong>g of larger genomes us<strong>in</strong>g<br />
hybrid assembly approach. <strong>Pharma</strong> companies and hospitals<br />
have been us<strong>in</strong>g Nucleome’s genome resequenc<strong>in</strong>g, exome<br />
sequenc<strong>in</strong>g and targeted resequenc<strong>in</strong>g services quite often.<br />
Nucleome plays a major role by provid<strong>in</strong>g Genomics and<br />
Bio<strong>in</strong>formatics analysis support for scientists work<strong>in</strong>g <strong>in</strong><br />
the field of genomes, transcriptomes, metagenomes, and<br />
epigenomes research. Nucleome’s flagship product <strong>in</strong>cludes<br />
software DrSeq for RNA sequence analysis software, DrSeq<br />
Genome Survey and Big Data Decoder server specially<br />
designed for NGS analysis. Nucleome also has pipel<strong>in</strong>es for<br />
Exome, Metagenome, transcriptome and amplicon datasets<br />
developed <strong>in</strong>-house. It has a variety of projects <strong>in</strong>volv<strong>in</strong>g<br />
discovery of SNP markers by resequenc<strong>in</strong>g of human<br />
samples and identify<strong>in</strong>g the complete Genetic makeup of<br />
the follow<strong>in</strong>g organisms like, Buffalo, Pomegranate,<br />
Mango, Pigeon Pea, Mosquito, Dhole, Rice varieties, Indian<br />
Bengal Tiger, Great Indian Bustard, Eggplant Borer, etc.<br />
Dist<strong>in</strong>guished Services<br />
Nucleome has successfully completed many significant<br />
plants, animals and microbial de novo genomes and has<br />
Dushyant S<strong>in</strong>gh Baghel, Founder, MD and CEO hold an<br />
MS <strong>in</strong> Biotechnology from Bharathiar University and<br />
executive education <strong>in</strong> management from Indian School of<br />
Bus<strong>in</strong>ess, Hyderabad. He carries twelve years of experience<br />
<strong>in</strong> sequenc<strong>in</strong>g and assembly of genomes. A self-motivated<br />
person with true qualities of entrepreneurship and<br />
leadership, he started the company <strong>in</strong> the year 2012 with his<br />
partners and Co-founders Abhishek Tripathi and Bip<strong>in</strong><br />
Kumar.<br />
Abhishek Tripathi, VP - R&D and Operations with an MS<br />
<strong>in</strong> Biotechnology has an experience of twelve years <strong>in</strong><br />
Genomics Industry.<br />
Bip<strong>in</strong> Kumar, VP - Corporate Sales with an MS <strong>in</strong><br />
Biotechnology has an experience of thirteen years <strong>in</strong><br />
Genomics and diagnostics Industry.<br />
With a good understand<strong>in</strong>g of Genomics market <strong>in</strong> India<br />
and their experience, they laid the foundation for<br />
Nucleome. Under the leadership of the founders Dushyant<br />
S<strong>in</strong>gh Baghel, Bip<strong>in</strong> Kumar and Abhishek Tripathi, the<br />
team has designed and developed software for data<br />
analysis, assembled various genomes, completed more than<br />
500 Genome and Transcriptome projects <strong>in</strong> a span of 6<br />
years. Currently Nucleome is be<strong>in</strong>g considered as India’s<br />
fastest grow<strong>in</strong>g genomics and bio<strong>in</strong>formatics solution<br />
provider.<br />
38 | | APRIL <strong>2019</strong>
1T<br />
HE<br />
MOST RECOMMENDED<br />
PHARMA &<br />
L FE SCIENCES<br />
SOLUTION PROVIDERS IN <strong>2019</strong><br />
Hard Work is all it takes to Succeed<br />
Nucleome has <strong>in</strong>vested its entire seed fund<strong>in</strong>g <strong>in</strong> build<strong>in</strong>g a<br />
well-equipped laboratory with sophisticated wet lab<br />
<strong>in</strong>struments and servers like BigData Decoder which are<br />
specially designed for next generation sequenc<strong>in</strong>g data<br />
analysis along with NGS analysis pipel<strong>in</strong>es on onl<strong>in</strong>e cloud<br />
servers like Google genomics, Amazon Web Server and<br />
DNA nexus.<br />
It has successfully completed various projects <strong>in</strong> association<br />
with various International organizations like CNRGV<br />
(France), Fasteris SA (Switzerland), Koppert Biological<br />
Systems (<strong>The</strong> Netherlands), Cold Spr<strong>in</strong>g Harbor Laboratory<br />
(USA), McDonnell Genome Institute, (USA), University of<br />
California (USA), Yale University (USA), New York<br />
Genome Center (USA), Wash<strong>in</strong>gton University(USA), <strong>The</strong><br />
Queensland Alliance for Agriculture and Food<br />
Innovation(Australia) and Indian <strong>in</strong>stitutes like CCMB,<br />
CIBA, IHBT, NRCP, NRCPB, ILS and NDDB. Nucleome<br />
has also built a sound association with all the major<br />
<strong>in</strong>stitutes under ICAR, CSIR, DBT and various hospitals<br />
<strong>in</strong>clud<strong>in</strong>g Tata Memorial Hospital Mumbai and private<br />
organisations like ITC and Beej Sheetal Seeds.<br />
Nucleome was awarded ‘India’s 20 <strong>Most</strong> Promis<strong>in</strong>g<br />
<strong>Pharma</strong> & <strong>Life</strong> Science Technology <strong>Solution</strong> Provider<br />
Companies 2016’ by a lead<strong>in</strong>g magaz<strong>in</strong>e.<br />
Us<strong>in</strong>g Nucleome’s services researchers have published<br />
several Research Papers.<br />
Paper <strong>in</strong> the field of Animal Genomics:<br />
• <strong>The</strong> Cuon Enigma: Genome survey and comparative<br />
genomics of the endangered Dhole 1 (Cuon alp<strong>in</strong>us) <strong>in</strong><br />
bioRxiv<br />
• High coverage genome sequenc<strong>in</strong>g and identification of<br />
genomic variants <strong>in</strong> Bengal tiger (Panthera tigris tigris)<br />
<strong>in</strong> bioRxiv<br />
• Genome Plasticity <strong>in</strong> Cultured Leishmania donovani:<br />
Comparison of Early and Late Passages <strong>in</strong> Frontiers <strong>in</strong><br />
Microbiology<br />
• RNA-Seq Revealed Expression of Many Novel Genes<br />
Associated With Leishmania do no vani Persistence and<br />
clearance <strong>in</strong> the Host Macrophage <strong>in</strong> Frontiers <strong>in</strong><br />
Cellular and Infection Microbiology<br />
Papers <strong>in</strong> the field of Agri Genomics:<br />
• Analysis of DNA methylome and transcriptome<br />
profil<strong>in</strong>g follow<strong>in</strong>g Gibberell<strong>in</strong> A3 (GA3) foliar<br />
application <strong>in</strong> Nicotiana tabacum L. <strong>in</strong> Indian Journal<br />
of Plant Physiology<br />
• Identification of candidate pathogenicity determ<strong>in</strong>ants of<br />
Rhizoctonia<br />
solani AG1-IA,<br />
which causes<br />
sheath blight<br />
disease <strong>in</strong> rice <strong>in</strong><br />
Current Genetics<br />
of Spr<strong>in</strong>ger<br />
Nature<br />
• Alterations <strong>in</strong> rice<br />
chloroplast<br />
<strong>in</strong>tegrity,<br />
photosynthesis<br />
Company’s expertise<br />
lies <strong>in</strong> Sequenc<strong>in</strong>g<br />
and Analysis of de<br />
novo genome us<strong>in</strong>g<br />
hybrid assembly<br />
approach,<br />
Transcriptome,<br />
and genome<br />
resequenc<strong>in</strong>g data<br />
and metabolome associated with pathogenesis of<br />
Rhizoctonia solani <strong>in</strong> Scientific Reports<br />
• Sequenc<strong>in</strong>g, Denovo Assembly, Functional Annotation<br />
and Analysis of Phyllanthus amarus Leaf Transcriptome<br />
Us<strong>in</strong>g the Illum<strong>in</strong>a Platform <strong>in</strong> Frontiers <strong>in</strong> Plant<br />
Science<br />
• Analysis of high iron rice l<strong>in</strong>es reveals new miRNAs<br />
that target iron transporters <strong>in</strong> roots <strong>in</strong> Journal of<br />
Experimental Botany<br />
Lapp<strong>in</strong>g up the Opportunities<br />
<strong>The</strong> <strong>Pharma</strong> and life science <strong>in</strong>dustry is bustl<strong>in</strong>g with ideas<br />
and applications. <strong>The</strong> <strong>in</strong>creas<strong>in</strong>g application of genomics <strong>in</strong><br />
biotech and pharmaceutical research and development has<br />
created a huge commercial market for sequenc<strong>in</strong>g and<br />
bio<strong>in</strong>formatics worldwide. <strong>The</strong> explosive growth of<br />
biological techniques necessitates the acquisition,<br />
process<strong>in</strong>g, analysis, and <strong>in</strong>tegration of the data. <strong>The</strong>se<br />
immense amounts of data are generated by the experiments<br />
as diverse as genomics, clon<strong>in</strong>g, expression analysis,<br />
genotyp<strong>in</strong>g, cellular analysis and others. Many young<br />
entrepreneurs are look<strong>in</strong>g at it as an opportunity for new<br />
startups. <strong>The</strong> founders advise them say<strong>in</strong>g “Dare to<br />
dream…..Follow your dream….Live your dream…..Strive<br />
hard to achieve your dream.”<br />
For a Better Future<br />
Nucleome aims at a healthier future through revolutionary<br />
genetic analysis solutions. It is committed to generat<strong>in</strong>g<br />
rapid, appropriate and high-quality results which can create<br />
a great difference <strong>in</strong> research projects.<br />
Nucleome’s focus has always been <strong>in</strong> the field of Plant,<br />
Animal and Human Genomics and is plann<strong>in</strong>g to strengthen<br />
its position <strong>in</strong> this field. It has planned to raise its SeriesA<br />
fund<strong>in</strong>g to expand its <strong>in</strong>frastructure by build<strong>in</strong>g India’s<br />
largest genomics and supercomput<strong>in</strong>g bio<strong>in</strong>formatics<br />
facility. It aims to fund and propel its Population genomics<br />
program to sequence <strong>10</strong>,000 human genomes and <strong>10</strong>0,000<br />
exomes of various cancer and diabetics patients <strong>in</strong> India.<br />
APRIL <strong>2019</strong> |<br />
| 39