2016 Scientific Report
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STEPHEN B. BAYLIN, M.D.<br />
Dr. Baylin joined VARI as a Professor in the Center for Epigenetics<br />
in January 2015 and is co-leader of the VARI-SU2C Epigenetics<br />
Dream Team. He devotes a portion of his time to VARI. His primary<br />
appointment is with Johns Hopkins University as the Virginia and D.K.<br />
Ludwig Professor of Oncology and Medicine and co-head of Cancer<br />
Biology at the Sidney Kimmel Comprehensive Cancer Center.<br />
RESEARCH INTERESTS<br />
The Van Andel Research Institute–Stand Up To Cancer (VARI-SU2C) Epigenetics Dream<br />
Team is a multi-institutional effort to develop new epigenetic therapies against cancer<br />
and to move promising therapies to clinical trials. As co-leader, Dr. Baylin oversees the<br />
team’s research, which leverages the combined expertise of its members.<br />
Epigenetics is the study of how the packaging and modification of DNA influences the<br />
genes that are active or kept silent in a particular cell, and it holds untold potential for<br />
treating cancer and other diseases. Through a detailed understanding of how normal<br />
epigenetic processes work, scientists can identify erroneous epigenetic modifications<br />
that may contribute to the development and progression of cancer. Epigenetic<br />
therapies, which work by correcting these errors, have the potential to directly treat<br />
cancer and to sensitize patients to traditional treatments such as chemotherapy and<br />
radiation and to promising new immunotherapy approaches.<br />
The VARI-SU2C Epigenetics Dream Team is headquartered at VARI in Grand Rapids,<br />
Michigan, and it includes members from Johns Hopkins University, Memorial Sloan<br />
Kettering Cancer Center, Fox Chase Cancer Center/Temple University, University of<br />
Southern California, and Rigshospitalet/University of Copenhagen. The American<br />
Association for Cancer Research (AACR), as SU2C’s scientific partner, reviews<br />
projects and provides objective scientific oversight.<br />
RECENT PUBLICATIONS<br />
Chaiappinelli, Katherine B., Pamela L. Strissel, Alexis Desrichard, Huili Li, Christine Henke, Benjamin Akman, Alexander Hein, Neal<br />
S. Rote, Leslie M. Cope, et al. 2015. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including<br />
endogenous retroviruses. Cell 162(5): 961–973.<br />
32 Van Andel Research Institute | <strong>Scientific</strong> <strong>Report</strong>