2016 Scientific Report
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
CENTER FOR<br />
CANCER AND CELL BIOLOGY<br />
Bart O. Williams, Ph.D.<br />
Director<br />
The Center’s scientists study the basic<br />
mechanisms and molecular biology of cancer and<br />
other diseases, with the goal of developing better<br />
diagnostics and therapies.<br />
A depiction of arrestin binding by a phosphorylated and active rhodopsin.<br />
The cell membrane lipids are shown as off-white, rhodopsin is blue, arrestin is red, and<br />
phosphorus molecules are orange. The phosphorylated C-terminal tail of rhodopsin<br />
binds to the N-domain (left) of the arrestin molecule. In the main contact region between<br />
the two molecules (central), arrestin accommodates the ICL2 helix of rhodopsin. In this<br />
fully activated state, the tip of arrestin’s C-domain contacts the membrane (right).<br />
(Model by Parker de Waal of the Xu lab)<br />
5
Change language