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2016 Scientific Report

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Pathology Core services<br />

Biorepository Core services<br />

• Histology and diagnostic tissue services,<br />

including morphology, immunohistochemistry, in<br />

situ hybridization, and multiplex fluorescent IHC<br />

assays<br />

• Pathology review and annotation of clinical<br />

samples from VARI’s prospective and retrospective<br />

tissue collections<br />

• Design and construction of tissue microarrays<br />

• Digital imaging and spectral microscopy coupled<br />

with image analysis tools<br />

• Biobanking services for VARI investigators, the<br />

National Cancer Institute, the Multiple Myeloma<br />

Research Foundation, and the Tuberous Sclerosis<br />

Alliance<br />

• Biospecimen kit construction, shipping, and<br />

tracking<br />

• Clinical trials biobanking coordination<br />

• Quality management program<br />

• Cell fractionation and biospecimen processing<br />

• Laser capture microdissection<br />

• Cytogenetics<br />

• Ion Torrent genomic technology<br />

RECENT PUBLICATIONS<br />

The GTEx Consortium. 2015. The Genotype-Tissue Expression (GTEx) analysis: multitissue gene regulation in humans. Science<br />

348(6235): 648–660.<br />

Melé, Marta, Pedro G. Ferreira, Ferran Reverter, David S. DeLuca, Jean Monlong, Michael Sammeth, Taylor R. Young, Jakob M<br />

Goldmann, et al. 2015. The human transcriptome across tissues and individuals. Science 348(6235): 660–665.<br />

Rivas, Manuel A,. Matti Pirinen, Donald F. Conrad, Monkol Lek, Emily K. Tsang, Konrad J. Karczewski, Julian B. Maller, Kimberly<br />

R. Kukurba, et al. 2015. Effect of predicted protein-truncating genetic variants on the human transcriptome. Science 348(6235):<br />

666-669.<br />

66 Van Andel Research Institute | <strong>Scientific</strong> <strong>Report</strong>

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