2016 Scientific Report
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Pathology Core services<br />
Biorepository Core services<br />
• Histology and diagnostic tissue services,<br />
including morphology, immunohistochemistry, in<br />
situ hybridization, and multiplex fluorescent IHC<br />
assays<br />
• Pathology review and annotation of clinical<br />
samples from VARI’s prospective and retrospective<br />
tissue collections<br />
• Design and construction of tissue microarrays<br />
• Digital imaging and spectral microscopy coupled<br />
with image analysis tools<br />
• Biobanking services for VARI investigators, the<br />
National Cancer Institute, the Multiple Myeloma<br />
Research Foundation, and the Tuberous Sclerosis<br />
Alliance<br />
• Biospecimen kit construction, shipping, and<br />
tracking<br />
• Clinical trials biobanking coordination<br />
• Quality management program<br />
• Cell fractionation and biospecimen processing<br />
• Laser capture microdissection<br />
• Cytogenetics<br />
• Ion Torrent genomic technology<br />
RECENT PUBLICATIONS<br />
The GTEx Consortium. 2015. The Genotype-Tissue Expression (GTEx) analysis: multitissue gene regulation in humans. Science<br />
348(6235): 648–660.<br />
Melé, Marta, Pedro G. Ferreira, Ferran Reverter, David S. DeLuca, Jean Monlong, Michael Sammeth, Taylor R. Young, Jakob M<br />
Goldmann, et al. 2015. The human transcriptome across tissues and individuals. Science 348(6235): 660–665.<br />
Rivas, Manuel A,. Matti Pirinen, Donald F. Conrad, Monkol Lek, Emily K. Tsang, Konrad J. Karczewski, Julian B. Maller, Kimberly<br />
R. Kukurba, et al. 2015. Effect of predicted protein-truncating genetic variants on the human transcriptome. Science 348(6235):<br />
666-669.<br />
66 Van Andel Research Institute | <strong>Scientific</strong> <strong>Report</strong>