2016 Scientific Report

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2015 Summer Interns Kneeling, left to right: Cavacece, Versluis, Gillespie, Morgan, Meadows, Dunwoodie, Shepard, Cutler. Standing, left to right: Lensing, DeBruin, Hanrahan, DeMeester, Bohner, Kretowicz, Goodspeed, Li, Sundaram, Klein, Pfeiffer, Rietsema, Schmidtmann, Blanchett, Spahr, Cooper, Buikema, Schaar, VanBaren, Jeltema, Bessey, Donoghue, Thompson, Hollowell, Franklin Academy of Modern Engineering The Academy of Modern Engineering (AME) is one of four specialized programs within Innovation Central High School administered by Grand Rapids Public Schools. It provides selected high school students who plan to major in science or engineering the opportunity to work in a research laboratory. Since 2000, VARI has mentored 55 students in this program and its predecessor, GRAPCEP. The 2015 AME interns, Vanessa Baraza and Yesenia Barnel. 78 Van Andel Research Institute | <strong>Scientific</strong> <strong>Report</strong>
VARI AND JAY VAN ANDEL SEMINAR SERIES January 2015 Tiago Fleming Outeiro, University Medical Center, Göttingen, Germany “From the baker to the bedside: unraveling the molecular basis of neurodegeneration” February Steven Finkbeiner, Gladstone Institute of Neurological Disease, University of California, San Francisco “Unraveling mechanisms of neurodegeneration with genomics, single-cell analysis, and human iPSCs models” March Nora M. Navone, M.D. Anderson Cancer Center, Houston, Texas “Prostate cancer cell–stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases” Jie Shen, Harvard Medical School, Boston, Massachusetts “Insights into Alzheimer's and Parkinson's diseases from genetic approaches” April Robert Stroud, University of California, San Francisco “Wiggle wiggle, not a trickle: how do transmembrane transporters work” Gerry Coetzee, USC Norris Comprehensive Cancer Center, Los Angeles “Unlocking the secrets of enhancer biology with GWAS” May Michael F. Clarke, Stanford Institute, Stanford, California “Degenerative diseases and cancer: the yin and yang of stem cells” Matthew J. Farrer, University of British Columbia, Vancouver “Parkinson's disease: pathology, ontology, and etiology” June Douglas R. Spitz, University of Iowa, Iowa City “Metabolic oxidative stress in cancer biology and therapy: from the bench to the bedside” August Amy Manning-Bog, Sangamo BioSciences, Inc., Richmond, California “Unsuspected pathogenetic interactions in parkinsonism” September Chuan He, University of Chicago “Reversible RNA and DNA methylation in gene expression regulation” October Yifan Cheng, Howard Hughes Medical Institute, University of California, San Francisco “Structures of TRP ion channels by single particle cryo-EM: from blob-ology to atomic structures” Anne C. Ferguson-Smith, University of Cambridge, England “Parental origin effects and the epigenetic control of genome function” November Li-Huei Tsai, Picower Institute for Learning and Memory, Cambridge, Massachusetts “Epigenetic mechanisms of neuronal gene expression and memory” December Yang Shi, Harvard Medical School, Boston Children’s Hospital “Histone methylation regulation, recognition, and link to human disease” Ali Shilatifard, Northwestern University, Evanston, Illinois “Enhancer malfunction in cancer” 79
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Published June 2016. Cover design b
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ii Van Andel Research Institute | S
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Laboratory Reports continued Center
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PETER A. JONES, Ph.D., D.SC. CHIEF
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EVENTS AND AWARDS FUNDING Research!
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ARTHUR S. ALBERTS, PH.D. Dr. Albert
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Subsequently, our work has focused
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Other research is aimed at further
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XIAOHONG LI, PH.D. Dr. Li received
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JEFFREY P. MACKEIGAN, PH.D. Dr. Mac
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KARSTEN MELCHER, PH.D. Dr. Melcher
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LORENZO F. SEMPERE, PH.D. Dr. Sempe
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Prostate epithelial cells expressin
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GEORGE F. VANDE WOUDE, PH.D. STAFF
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BART O. WILLIAMS, PH.D. Dr. William
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NING WU, PH.D. Dr. Wu received her
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Page 40 and 41: STEPHEN B. BAYLIN, M.D. Dr. Baylin
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Page 44 and 45: PETER W. LAIRD, PH.D. Dr. Laird ear
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Page 48 and 49: SCOTT ROTHBART, PH.D. Dr. Rothbart
Page 50 and 51: Mapping of the mammalian 5-methylcy
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Page 62 and 63: GERHARD A. COETZEE, PH.D. Dr. Coetz
Page 64 and 65: Double calcein-labeled bone cross s
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