Experience the Elekta Differ - Institute of Physics and Engineering in ...
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P06 IMPACT OF TECHNOLOGY<br />
An <strong>in</strong>stitutional experience <strong>of</strong><br />
new technology <strong>in</strong> radio<strong>the</strong>rapy<br />
P07 DETECTOR DENSITY<br />
Impacts on small-field<br />
dosimetric measurements<br />
P07 RANGE UNCERTAINTY<br />
Proton range uncerta<strong>in</strong>ty <strong>in</strong><br />
patient stopp<strong>in</strong>g power ratios<br />
SCOPE<br />
INSTITUTE OF PHYSICS AND ENGINEERING IN MEDICINE | www.ipem.ac.uk | Volume 21 Issue 3 | SEPTEMBER 2012<br />
A work <strong>of</strong><br />
fiction?<br />
Alice through <strong>the</strong><br />
archive cupboard<br />
Radiat<strong>in</strong>g<br />
enthusiasm<br />
IPEM at <strong>the</strong> 2012 Big<br />
Bang Science Fair<br />
Call for engagement<br />
Science <strong>and</strong> Parliament
DOSIMETRY<br />
SOLUTIONS<br />
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A WIDER PERSPECTIVE<br />
Recently, it was my<br />
privilege to attend <strong>the</strong><br />
World Congress on<br />
Medical <strong>Physics</strong> <strong>and</strong><br />
Biomedical <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong><br />
<strong>in</strong> Beij<strong>in</strong>g, Ch<strong>in</strong>a, which<br />
was held under <strong>the</strong> banner <strong>of</strong><br />
‘Promot<strong>in</strong>g Health through<br />
Technology’. Spread over 5 days <strong>and</strong><br />
with at least 17 parallel sessions, this<br />
was clearly <strong>the</strong> challenge that came<br />
through those elements that I was able<br />
to experience directly!<br />
This congress occurs every 3 years<br />
<strong>and</strong> is held under <strong>the</strong> auspices <strong>of</strong> <strong>the</strong><br />
International Union <strong>of</strong> Physical <strong>and</strong><br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> Sciences <strong>in</strong> Medic<strong>in</strong>e<br />
(IUPESM). It br<strong>in</strong>gs toge<strong>the</strong>r <strong>the</strong><br />
International Federation for Medical<br />
<strong>and</strong> Biological <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> (IFMBE)<br />
<strong>and</strong> <strong>the</strong> International Organisation for<br />
Medical <strong>Physics</strong> (IOMP), <strong>and</strong> <strong>the</strong>se<br />
societies were fur<strong>the</strong>r supported by<br />
<strong>the</strong> World Health Organization<br />
(WHO) <strong>and</strong> <strong>the</strong> International Atomic<br />
Energy Agency (IAEA) as global<br />
organisations with specific objectives<br />
<strong>in</strong> health.<br />
The world congress can seem a<br />
little remote from <strong>the</strong> issues <strong>in</strong><br />
healthcare science <strong>in</strong> <strong>the</strong> UK, or even<br />
<strong>in</strong> Europe, especially as this was <strong>the</strong><br />
third time <strong>in</strong> 9 years that it has been<br />
held <strong>in</strong> Asia. Although this perhaps<br />
reflects <strong>the</strong> changes <strong>in</strong> <strong>the</strong> global<br />
economic l<strong>and</strong>scape, it soon became<br />
clear to me that it is important not to<br />
lose sight <strong>of</strong> <strong>the</strong> global health<br />
challenges <strong>and</strong> <strong>the</strong> role that we could<br />
<strong>and</strong> should fulfil both <strong>in</strong>dividually<br />
<strong>and</strong> as IPEM.<br />
INTERNATIONAL<br />
RELATIONSHIPS<br />
IFMBE is directly l<strong>in</strong>ked to <strong>the</strong> WHO<br />
<strong>and</strong> <strong>the</strong> United Nations as a nongovernmental<br />
organisation<br />
(NGO). It is a position to<br />
which IOMP aspires <strong>and</strong><br />
hopes to achieve with<strong>in</strong><br />
<strong>the</strong> next 3 years. This<br />
relationship provides a<br />
route to <strong>in</strong>fluence <strong>the</strong> delivery<br />
<strong>of</strong> healthcare worldwide through<br />
physics <strong>and</strong> eng<strong>in</strong>eer<strong>in</strong>g <strong>and</strong> is<br />
already recognised <strong>in</strong> a programme<br />
with<strong>in</strong> <strong>the</strong> WHO which is seek<strong>in</strong>g to<br />
promote <strong>the</strong> development <strong>of</strong><br />
appropriate medical devices for<br />
Peter Jarritt<br />
President<br />
▼<br />
Be<strong>in</strong>g part <strong>of</strong><br />
<strong>the</strong> global<br />
medical physics<br />
community.<br />
develop<strong>in</strong>g countries. This challenge<br />
was powerfully delivered <strong>in</strong> a<br />
plenary lecture given by Adriana<br />
Velazquez Berumen who is coord<strong>in</strong>ator<br />
<strong>of</strong> <strong>the</strong> Medical Devices Unit<br />
at <strong>the</strong> WHO <strong>in</strong> Geneva. The<br />
availability <strong>and</strong> access to appropriate<br />
medical products <strong>and</strong> technologies is<br />
one <strong>of</strong> <strong>the</strong> WHO strategic objectives<br />
for its member states. It is not difficult<br />
to underst<strong>and</strong> such an objective <strong>in</strong><br />
relation to <strong>the</strong> develop<strong>in</strong>g world, yet<br />
to me, <strong>the</strong> challenge was identical to<br />
that fac<strong>in</strong>g <strong>the</strong> developed world. The<br />
healthcare agenda <strong>in</strong> <strong>the</strong> UK is to<br />
develop <strong>in</strong>novative, affordable <strong>and</strong><br />
appropriate healthcare technology to<br />
address <strong>the</strong> health needs <strong>of</strong> <strong>the</strong><br />
population. The develop<strong>in</strong>g world<br />
needs simple, low-powered, low-cost,<br />
robust <strong>and</strong> accurate diagnostic tools<br />
to solve <strong>the</strong>ir issues. Does this sound<br />
familiar?<br />
The congress had many <strong>the</strong>mes,<br />
some less familiar than o<strong>the</strong>rs,<br />
<strong>in</strong>clud<strong>in</strong>g education <strong>and</strong> tra<strong>in</strong><strong>in</strong>g,<br />
radiation safety, safety <strong>of</strong> medical<br />
devices, developments <strong>in</strong> photon <strong>and</strong><br />
ion <strong>the</strong>rapy <strong>and</strong> x-ray CT, biochipenabled<br />
translational medic<strong>in</strong>e, signal<br />
process<strong>in</strong>g <strong>and</strong> bio-magnetism <strong>and</strong><br />
physiology modell<strong>in</strong>g. It is good to<br />
know that research <strong>and</strong> development<br />
is alive <strong>and</strong> well.<br />
IPEM INVOLVEMENT<br />
IPEM will re-engage with<br />
<strong>the</strong> worldwide<br />
physics <strong>and</strong><br />
eng<strong>in</strong>eer<strong>in</strong>g<br />
community<br />
through <strong>the</strong><br />
International<br />
Conference<br />
on Medical<br />
<strong>Physics</strong> to be<br />
held <strong>in</strong><br />
Brighton,<br />
1st–4th<br />
September<br />
2013. The<br />
programme will<br />
address <strong>the</strong><br />
<strong>in</strong>ternational agenda as well<br />
as showcase <strong>the</strong> latest scientific<br />
research. Our response to <strong>and</strong><br />
<strong>in</strong>volvement <strong>in</strong> <strong>the</strong>se wider<br />
agendas is important.<br />
IPEM is formally l<strong>in</strong>ked as a<br />
PRESIDENT’S LETTER | SCOPE<br />
National Member Organisation to<br />
<strong>the</strong> European Federation <strong>of</strong><br />
Medical <strong>Physics</strong> (EFOMP) <strong>and</strong> <strong>the</strong><br />
IOMP. IPEM is able to nom<strong>in</strong>ate<br />
<strong>and</strong> support <strong>in</strong>dividuals who are<br />
will<strong>in</strong>g to st<strong>and</strong> as <strong>of</strong>ficers <strong>in</strong> <strong>the</strong>se<br />
organisations. Individuals do not<br />
represent IPEM but st<strong>and</strong> to<br />
develop <strong>and</strong> support <strong>the</strong> aims <strong>and</strong><br />
objectives <strong>of</strong> <strong>the</strong>ir respective<br />
organisation. IPEM supports <strong>and</strong><br />
benefits from <strong>the</strong>se activities<br />
<strong>in</strong>clud<strong>in</strong>g <strong>the</strong> formal recognition<br />
<strong>of</strong> <strong>the</strong> medical physicist as a<br />
healthcare pr<strong>of</strong>essional, <strong>the</strong><br />
specification <strong>of</strong> European<br />
st<strong>and</strong>ards for <strong>the</strong> medical physics<br />
expert, <strong>and</strong> <strong>the</strong> harmonisation <strong>and</strong><br />
recognition <strong>of</strong> tra<strong>in</strong><strong>in</strong>g<br />
programmes.<br />
If you have a passion for<br />
physics <strong>and</strong> eng<strong>in</strong>eer<strong>in</strong>g <strong>in</strong><br />
healthcare, I would encourage you<br />
to consider if <strong>the</strong>re is a role you<br />
would be prepared to undertake to<br />
support <strong>the</strong>se wider agendas. This<br />
might be through direct<br />
<strong>in</strong>volvement <strong>in</strong> programmes <strong>in</strong><br />
develop<strong>in</strong>g countries or through<br />
an <strong>in</strong>ternational organisation. The<br />
websites <strong>of</strong> EFOMP<br />
(www.efomp.org) <strong>and</strong> IOMP<br />
(www.iomp.org) provide an<br />
<strong>in</strong>dication <strong>of</strong> <strong>the</strong>ir respective<br />
activities. The IPEM VP<br />
International, Dr Manivannan<br />
(a.mani@adn.ac.uk), can provide<br />
fur<strong>the</strong>r <strong>in</strong>formation <strong>and</strong> advice.<br />
In conclusion we should not<br />
lose sight <strong>of</strong> <strong>the</strong> immediate needs<br />
<strong>of</strong> <strong>the</strong> pr<strong>of</strong>ession <strong>in</strong> <strong>the</strong> UK <strong>and</strong><br />
<strong>the</strong> contribution it can <strong>and</strong> does<br />
make to <strong>the</strong> delivery <strong>of</strong> healthcare.<br />
I would refer you to <strong>the</strong> article<br />
from Andrew Miller MP <strong>in</strong> this<br />
edition <strong>of</strong> Scope. Parliament<br />
represents <strong>the</strong> voice <strong>of</strong> <strong>the</strong> people<br />
<strong>and</strong> we should equally heed his<br />
encouragement to lobby <strong>and</strong><br />
<strong>in</strong>form our MPs, whe<strong>the</strong>r <strong>in</strong><br />
devolved governments or<br />
Westm<strong>in</strong>ster, to ensure that our<br />
contribution is recognised <strong>and</strong><br />
supported appropriately. This is a<br />
role we can all undertake. If you<br />
feel you would like support <strong>the</strong>n I<br />
would encourage you to talk to<br />
Steve Keevil (President Elect) or<br />
Carl Rowbottom (VP External).<br />
SCOPE | SEPTEMBER 2012 | 03
SCOPE | CONTENTS<br />
THIS ISSUE<br />
09<br />
13<br />
17<br />
26<br />
36<br />
COVER FEATURE<br />
ENGAGEMENT CALL<br />
The l<strong>in</strong>ks between<br />
science <strong>and</strong><br />
Parliament, <strong>and</strong> a<br />
challenge for all<br />
members<br />
04 | SEPTEMBER 2012 | SCOPE<br />
13 ALICE THROUGH THE ARCHIVE CUPBOARD<br />
A short story about what medical physicists get up to <strong>in</strong> <strong>the</strong>ir spare time.<br />
Can you f<strong>in</strong>d yourself?<br />
17 RADIATING ENTHUSIASM: IPEM AT THE 2012 BIG BANG SCIENCE FAIR<br />
How do you expla<strong>in</strong> radioactivity to a 6-year-old? Celebrat<strong>in</strong>g science,<br />
technology, eng<strong>in</strong>eer<strong>in</strong>g <strong>and</strong> maths with <strong>the</strong> next generation<br />
18 THE LAUNCH OF IPEM OUTREACH STRATEGY<br />
Help<strong>in</strong>g members to communicate science <strong>and</strong> eng<strong>in</strong>eer<strong>in</strong>g to students to<br />
encourage <strong>the</strong>m to study <strong>the</strong> subjects fur<strong>the</strong>r<br />
TRAVEL AWARD<br />
19 AAPM–IPEM MEDICAL PHYSICS TRAVEL GRANT REPORT<br />
Jun Deng<br />
MEETING REPORTS<br />
23 BESPOKE SOFTWARE IN MEDICAL PHYSICS AND CLINICAL ENGINEERING<br />
Andrew Rob<strong>in</strong>son<br />
26 2012 ESTRO 31/WORLD CONGRESS OF BRACHYTHERAPY<br />
Ahamed Badusha Mohamed Yoosuf<br />
30 REPORT ON NPL CLINICAL TEMPERATURE MEASUREMENT MEETING<br />
Rosie Richards <strong>and</strong> Jason Britton<br />
HISTORICAL FEATURE<br />
46 A HISTORY OF MEDICAL PHYSICS<br />
Francis Duck<br />
REGULARS<br />
03 PRESIDENT’S LETTER A wider perspective<br />
05 EDITORIAL Farewell Marc<br />
06 NEWS Recent discoveries <strong>in</strong> radio<strong>the</strong>rapy research<br />
33 INTERNATIONAL NEWS International conferences <strong>in</strong> 2012 <strong>and</strong> 2013<br />
35 MEMBERS’ NEWS Accolades for current <strong>and</strong> retir<strong>in</strong>g members<br />
40 BOOK REVIEWS Medical physics <strong>and</strong> popular science textbooks<br />
© r.nagy / Shutterstock
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<strong>and</strong><br />
Richard A. Amos<br />
Department <strong>of</strong> Radiation<br />
<strong>Physics</strong>, The University <strong>of</strong><br />
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Cancer Research UK<br />
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(Develop<strong>in</strong>g countries)<br />
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INTERNATIONAL EDITOR<br />
(North America)<br />
Richard A. Amos<br />
Department <strong>of</strong> Radiation<br />
<strong>Physics</strong>, The University <strong>of</strong><br />
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Cancer Center, 1840 Old<br />
Spanish Trail,Houston,<br />
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Department <strong>of</strong> Medical<br />
<strong>Physics</strong> <strong>and</strong> Cl<strong>in</strong>ical<br />
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© IPEM 2012<br />
ISSN 0964-9565<br />
“<br />
Please<br />
contact me if<br />
you wish to<br />
contribute to or<br />
comment on<br />
our magaz<strong>in</strong>e<br />
GEMMA WHITELAW<br />
”<br />
GEMMA WHITELAW EDITOR-IN-CHIEF<br />
COMMENT | SCOPE<br />
AFAREWELL MARC<br />
fter 5 years our Editor Marc<br />
Miquel is stepp<strong>in</strong>g down. I<br />
want to thank Marc for all his<br />
hard work; he has achieved<br />
many th<strong>in</strong>gs whilst Editor,<br />
<strong>in</strong>clud<strong>in</strong>g <strong>the</strong> launch <strong>of</strong> Scope<br />
Onl<strong>in</strong>e (www.scopeonl<strong>in</strong>e.co.<br />
uk), several changes to <strong>the</strong> editorial board <strong>and</strong><br />
launch<strong>in</strong>g <strong>the</strong> Keith Boddy prize for best<br />
educational article. It’ll be a tough act for me to<br />
follow, a daunt<strong>in</strong>g but excit<strong>in</strong>g challenge, <strong>and</strong> I<br />
shall keenly miss <strong>the</strong> guidance <strong>and</strong> direction<br />
Marc has given me whilst I was his deputy.<br />
Thankfully his <strong>of</strong>fice is just across <strong>the</strong> road<br />
from m<strong>in</strong>e, so his unseen h<strong>and</strong> may be visible<br />
until I f<strong>in</strong>d my feet.<br />
This edition <strong>of</strong> Scope <strong>in</strong>cludes a fasc<strong>in</strong>at<strong>in</strong>g<br />
article k<strong>in</strong>dly written for us by Andrew Miller<br />
MP. Here he discusses <strong>the</strong> l<strong>in</strong>ks between<br />
science <strong>and</strong> politics <strong>and</strong> presents all IPEM<br />
members with a challenge, which will<br />
hopefully improve <strong>the</strong> pr<strong>of</strong>ile <strong>of</strong> our field <strong>in</strong><br />
Parliament. Of course what goes for<br />
Westm<strong>in</strong>ster MPs also applies to MSPs <strong>and</strong><br />
representatives <strong>in</strong> <strong>the</strong> o<strong>the</strong>r devolved<br />
assemblies.<br />
If you ever wondered what was lurk<strong>in</strong>g <strong>in</strong><br />
<strong>the</strong> back <strong>of</strong> your department’s archive<br />
cupboard or what your colleagues do outside<br />
<strong>the</strong> <strong>of</strong>fice, <strong>the</strong>n look no fur<strong>the</strong>r than Henry<br />
Lawrence <strong>and</strong> Lynn Mart<strong>in</strong>ez’s article ‘Alice<br />
through <strong>the</strong> archive cupboard’. Who would<br />
have thought extreme iron<strong>in</strong>g <strong>and</strong> free div<strong>in</strong>g<br />
were <strong>in</strong> our collective skill-set?<br />
This issue also heralds o<strong>the</strong>r changes: Robert<br />
Nielson, IPEM’s General Secretary, <strong>and</strong> Peter<br />
Sharp OBE, <strong>the</strong> second President <strong>of</strong> IPEM, are<br />
both retir<strong>in</strong>g. I am sure <strong>the</strong>y will both be<br />
missed by all who have worked with <strong>the</strong>m.<br />
This issue also <strong>in</strong>cludes all <strong>the</strong> regulars such<br />
as news from Richard <strong>and</strong> Usman, a very full<br />
book review section <strong>and</strong> ano<strong>the</strong>r absorb<strong>in</strong>g<br />
chapter <strong>in</strong> Francis Duck’s tales on <strong>the</strong> history<br />
<strong>of</strong> medical physics. This one focuses on<br />
statistical th<strong>in</strong>ker <strong>and</strong> physician Jules Gavarret.<br />
Scope is a magaz<strong>in</strong>e written by <strong>and</strong> for <strong>the</strong><br />
membership <strong>of</strong> IPEM. If you are a member<br />
<strong>the</strong>n it is your magaz<strong>in</strong>e! If you know<br />
someth<strong>in</strong>g that no-one else does or want to<br />
share your po<strong>in</strong>t <strong>of</strong> view more widely amongst<br />
your colleagues <strong>the</strong>n this is <strong>the</strong> forum to jo<strong>in</strong><br />
<strong>in</strong>. So, please contact me if you wish to<br />
contribute to or comment on our magaz<strong>in</strong>e.<br />
SCOPE | SEPTEMBER 2012 | 05
SCOPE | NEWS BY USMAN I. LULA AND RICHARD AMOS<br />
IN BRIEF<br />
HIFU REDUCES<br />
SIDE EFFECTS<br />
Accord<strong>in</strong>g to a study from<br />
UCL UK, 42 patients<br />
received focal HIFU<br />
delivered to cl<strong>in</strong>ically<br />
significant cancer lesions.<br />
Twelve months after<br />
treatment, ur<strong>in</strong>ary <strong>and</strong><br />
erectile function returned to<br />
pre-treatment levels<br />
(Lancet Oncol; doi:<br />
10.1016/S1470-<br />
2045(12)70121-3). Early<br />
evidence on cancer control<br />
was also encourag<strong>in</strong>g.<br />
BRAIN MINI<br />
MAGNETOMETER<br />
In experiments performed at<br />
<strong>the</strong> Physikalisch-Technische<br />
Bundesanstalt <strong>in</strong> Germany,<br />
<strong>the</strong> sensor was used for<br />
magnetoencephalography<br />
(MEG) to measure alpha<br />
waves associated with a<br />
subject open<strong>in</strong>g <strong>and</strong> clos<strong>in</strong>g<br />
<strong>the</strong>ir eyes, <strong>and</strong> signals<br />
result<strong>in</strong>g from h<strong>and</strong><br />
stimulation (Biomed Opt;<br />
doi: 10.1364/BOE.3.000981).<br />
COILS MODULATE<br />
ACTIVITY<br />
Investigators from<br />
Massachusetts have shown<br />
that magnetic stimulation<br />
can generate similar neural<br />
activity to that elicited by <strong>the</strong><br />
electrical impulses used for<br />
DBS. They demonstrated<br />
that a magnetic coil could<br />
elicit neuronal signals <strong>in</strong><br />
ret<strong>in</strong>al cells when implanted<br />
<strong>in</strong>to <strong>the</strong> bra<strong>in</strong> directly above<br />
ret<strong>in</strong>al tissue (Nat Commun;<br />
doi: 10.1038/ncomms1914).<br />
ENGINEERED<br />
MICROVESSELS<br />
Bioeng<strong>in</strong>eers at <strong>the</strong><br />
University <strong>of</strong> Wash<strong>in</strong>gton,<br />
Seattle, have developed a<br />
means to grow small<br />
human blood vessels,<br />
creat<strong>in</strong>g a 3D test bed with<br />
which to study vascular<br />
phenomena such as<br />
angiogenesis <strong>and</strong><br />
thrombosis. The eng<strong>in</strong>eered<br />
vessels could transport<br />
human blood smoothly, even<br />
around corners.<br />
06 | SEPTEMBER 2012 | SCOPE<br />
Institutional experience <strong>of</strong> new<br />
technologies <strong>in</strong> radio<strong>the</strong>rapy<br />
TABLE 1<br />
Category Selections<br />
Demographics<br />
Process step<br />
<strong>of</strong> orig<strong>in</strong>ation<br />
Event type<br />
Simulation<br />
Treatment<br />
plann<strong>in</strong>g<br />
Accord<strong>in</strong>g to <strong>the</strong> Radio<strong>the</strong>rapy Risk<br />
Pr<strong>of</strong>ile report, published by <strong>the</strong><br />
World Health Organization, it is<br />
estimated that treatments for<br />
approximately 3,000 patients were<br />
affected by radio<strong>the</strong>rapy errors<br />
between 1976 <strong>and</strong> 2007. Analysis,<br />
even <strong>of</strong> cl<strong>in</strong>ically <strong>in</strong>significant<br />
events, can uncover QA<br />
deficiencies whilst also provid<strong>in</strong>g a<br />
method to study <strong>the</strong> impact <strong>of</strong><br />
patient safety enhancements.<br />
Date <strong>of</strong> event<br />
Time <strong>of</strong> event (May 2007 onwards)<br />
Number <strong>of</strong> treatment sessions for course<br />
Treatment site<br />
Treatment mach<strong>in</strong>e<br />
Simulation<br />
Treatment plann<strong>in</strong>g<br />
Data entry/transfer<br />
Treatment delivery<br />
Patient measurement<br />
Simulation documentation<br />
Incorrect manual application <strong>of</strong> transmission factor<br />
Calculation error – <strong>in</strong>verse square<br />
Calculation error – o<strong>the</strong>r parameters<br />
MD prescription/planner prescription mis<strong>in</strong>terpretation<br />
Transcription error<br />
O<strong>the</strong>r plann<strong>in</strong>g error<br />
Incorrect manual entry <strong>of</strong> treatment parameters<br />
Data entry Incorrect schedul<strong>in</strong>g <strong>of</strong> treatment fields or treatment<br />
sessions<br />
Incorrect/omitted block, bolus, compensator<br />
Incorrect/omitted wedge<br />
Incorrect/omitted static MLC shape<br />
Incorrect/omitted dynamic MLC shape (IMRT)<br />
Treatment<br />
Incorrect treatment record (chart<strong>in</strong>g)<br />
Incorrect use <strong>of</strong> field parameters or R&V override<br />
Incorrect treatment distance<br />
Incorrect field position (o<strong>the</strong>r than distance)<br />
2.5 mm 3%/3 mm<br />
Event impact<br />
Dosimetric magnitude per treatment session<br />
Dosimetric magnitude over treatment course<br />
Number <strong>of</strong> treatment sessions for which event occurred<br />
Table 1: Patient event demographic <strong>and</strong> event type classification.<br />
Thanks to Margie A. Hunt for supply<strong>in</strong>g <strong>the</strong> image. Figure © Elsevier,<br />
'The impact <strong>of</strong> new technologies on radiation oncology events <strong>and</strong><br />
trends <strong>in</strong> <strong>the</strong> past decade: an <strong>in</strong>stitutional experience’, Margie A. Hunt,<br />
Gerri Pastrana, Howard I. Amols, Aileen Killen, Kaled Alektiar, Int J<br />
Radiat Oncol 2012; article <strong>in</strong> press.<br />
Some previous studies have<br />
shown that new technologies such<br />
as record-<strong>and</strong>-verify (R&V) systems<br />
can both decrease certa<strong>in</strong> event<br />
types <strong>and</strong> <strong>in</strong>crease <strong>the</strong> potential for<br />
o<strong>the</strong>rs, e.g. field parameter/R&V<br />
override <strong>and</strong> chart<strong>in</strong>g events.<br />
The purpose <strong>of</strong> this study, from<br />
<strong>the</strong> Memorial Sloan-Ketter<strong>in</strong>g<br />
Cancer Center <strong>in</strong> New York, was to<br />
review <strong>the</strong> type <strong>and</strong> frequency <strong>of</strong><br />
patient events from external beam<br />
radio<strong>the</strong>rapy over a 10-year period.<br />
This was a period which<br />
encompassed significant<br />
technology change. The study would<br />
allow <strong>the</strong> group to identify trends,<br />
achievements <strong>and</strong> areas for<br />
improvement.<br />
Four radiation oncology process<br />
steps were classified <strong>and</strong> fur<strong>the</strong>r<br />
sub-classified accord<strong>in</strong>g to event<br />
type (table 1): simulation, treatment<br />
plann<strong>in</strong>g, data entry/transfer <strong>and</strong><br />
treatment delivery. Events were<br />
segregated accord<strong>in</strong>g to <strong>the</strong> most<br />
frequently observed types.<br />
There was generally a downward<br />
trend over time <strong>in</strong> <strong>the</strong> event rate<br />
ma<strong>in</strong>ly due to technological<br />
changes, e.g. replacement <strong>of</strong> R&V<br />
system <strong>and</strong> widespread<br />
implementation <strong>of</strong> IMRT. A total <strong>of</strong><br />
284 events were recorded between<br />
2001 <strong>and</strong> 2010. Dur<strong>in</strong>g this time,<br />
approximately 30,600 new<br />
treatment courses <strong>and</strong> 597,000<br />
treatments were delivered, yield<strong>in</strong>g<br />
an event rate <strong>of</strong> 0.93 per cent per<br />
course <strong>and</strong> 0.05 per cent per<br />
treatment session. Frequency <strong>of</strong><br />
event types particularly <strong>in</strong> plann<strong>in</strong>g<br />
<strong>and</strong> treatment delivery changed<br />
significantly over <strong>the</strong> course <strong>of</strong> <strong>the</strong><br />
study. Treatments <strong>in</strong>volv<strong>in</strong>g manual<br />
<strong>in</strong>tervention carried an event risk<br />
four times greater than those<br />
rely<strong>in</strong>g heavily on computer-aided<br />
design <strong>and</strong> delivery.<br />
Areas for improvement <strong>in</strong>clude<br />
manual calculation <strong>and</strong> data entry,<br />
late-day treatments <strong>and</strong> staff<br />
overreliance on computer systems.<br />
The chang<strong>in</strong>g roles <strong>of</strong> R&V systems<br />
<strong>in</strong>herent <strong>in</strong> an electronic medical<br />
record environment, <strong>the</strong><br />
<strong>in</strong>troduction <strong>of</strong> even more complex<br />
technology <strong>and</strong> <strong>the</strong> emergence <strong>of</strong><br />
hyp<strong>of</strong>ractionated treatment<br />
paradigms may all lead to new types<br />
<strong>of</strong> errors.<br />
Fur<strong>the</strong>r improvements <strong>in</strong> patient<br />
safety are imperative, given <strong>the</strong><br />
severe consequences that can arise<br />
from radio<strong>the</strong>rapy errors.<br />
MORE INFORMATION<br />
This work was recently published <strong>in</strong> Int<br />
J Radiat Oncol 2012; article <strong>in</strong> press,<br />
http://dx.doi.org/10.1016/j.ijrobp.<br />
2012.01.042
Detector density impacts<br />
small-field dosimetry<br />
A group <strong>of</strong> researchers at <strong>the</strong><br />
Clatterbridge Cancer Centre are<br />
<strong>in</strong>vestigat<strong>in</strong>g how physical<br />
characteristics <strong>of</strong> detectors<br />
affect small-field dosimetric<br />
measurements. The group<br />
recently published <strong>the</strong>ir report<br />
on <strong>the</strong> impact <strong>of</strong> density <strong>and</strong><br />
atomic composition on <strong>the</strong><br />
response <strong>of</strong> various detectors <strong>in</strong><br />
small fields.<br />
Monte Carlo modell<strong>in</strong>g was<br />
used to exam<strong>in</strong>e variations <strong>of</strong> a<br />
correction factor, F detector ,<br />
with field size. F detector is<br />
def<strong>in</strong>ed as <strong>the</strong> ratio <strong>of</strong> dose to a<br />
water voxel <strong>and</strong> dose to <strong>the</strong><br />
same voxel with <strong>the</strong> density <strong>of</strong><br />
<strong>the</strong> detector.<br />
In total, three detector types<br />
were studied: PTW diamond<br />
detector (density 3.5 g/cm 3 );<br />
PTW 31016 P<strong>in</strong>po<strong>in</strong>t chamber<br />
(0.0012 g/cm 3 ) <strong>and</strong> Sc<strong>and</strong>itronix<br />
unshielded electron diode (2.3<br />
g/cm 3 ). Monte Carlo simulations<br />
modelled a 15 MV beam <strong>in</strong>cident<br />
upon a water phantom with<br />
source-to-surface distance<br />
(SSD) <strong>of</strong> 100 cm. Detector voxels<br />
were located at 5 cm depth with<br />
volumes roughly equal to each<br />
detector’s active volume.<br />
The specific impact <strong>of</strong><br />
detector density on response<br />
was isolated through two sets <strong>of</strong><br />
calculated values for F detector .<br />
The group first calculated<br />
F detector us<strong>in</strong>g <strong>the</strong> density <strong>and</strong><br />
mass radiological properties <strong>of</strong><br />
<strong>the</strong> modelled detectors, <strong>and</strong><br />
<strong>the</strong>n repeated <strong>the</strong> calculations<br />
us<strong>in</strong>g <strong>the</strong> densities <strong>of</strong> diamond,<br />
silicon <strong>and</strong> air, but with mass<br />
radiological properties fixed at<br />
those <strong>of</strong> unit density.<br />
Simulations us<strong>in</strong>g field sizes<br />
rang<strong>in</strong>g from 0.25 to 10 cm<br />
showed that F detector varied<br />
significantly as a function <strong>of</strong> field<br />
size for all three detector types.<br />
The high-density diamond <strong>and</strong><br />
silicon detectors over-read at<br />
small field sizes, relative to<br />
wide-field read<strong>in</strong>gs, whereas<br />
<strong>the</strong> low-density air-filled<br />
detector under-read at small<br />
field sizes. Similar patterns<br />
were observed for <strong>the</strong> densitymodified<br />
water voxels, although<br />
values for F detector converged<br />
to unity for large fields. This<br />
behaviour suggests that <strong>the</strong><br />
variation <strong>of</strong> F detector at small<br />
field sizes arises from<br />
differences <strong>in</strong> detector density,<br />
ra<strong>the</strong>r than atomic composition.<br />
The researchers <strong>the</strong>n<br />
studied <strong>in</strong>tegral doses <strong>of</strong> slit<br />
fields us<strong>in</strong>g <strong>the</strong> silicon diode<br />
<strong>and</strong> P<strong>in</strong>po<strong>in</strong>t detectors. It was<br />
observed that doses measured<br />
along a pr<strong>of</strong>ile varied far less<br />
than central axis doses,<br />
suggest<strong>in</strong>g that, while doses at<br />
<strong>the</strong> centres <strong>of</strong> <strong>in</strong>dividual small<br />
fields would conta<strong>in</strong> errors if left<br />
uncorrected, <strong>in</strong>tegral doses<br />
calculated for VMAT or IMRT<br />
plans (which conta<strong>in</strong> many<br />
overlapp<strong>in</strong>g small fields) would<br />
be approximately correct. This<br />
implies that correct<strong>in</strong>g<br />
measured small-field dose<br />
distributions simply by scal<strong>in</strong>g<br />
<strong>the</strong>m us<strong>in</strong>g central axis<br />
F detector values may lead to<br />
erroneous estimates <strong>of</strong> <strong>the</strong><br />
<strong>in</strong>tegral doses delivered by<br />
techniques us<strong>in</strong>g multiple small<br />
fields. As such, <strong>the</strong> authors<br />
describe <strong>the</strong> ideal small-field<br />
dosimeter as hav<strong>in</strong>g a small<br />
active volume <strong>and</strong> water-like<br />
density.<br />
Work is ongo<strong>in</strong>g to develop a<br />
cavity <strong>the</strong>ory that describes this<br />
density dependence.<br />
A closer look at proton range uncerta<strong>in</strong>ties<br />
The major challenge for<br />
accurate range calculations for<br />
<strong>the</strong>rapeutic proton beams is <strong>the</strong><br />
uncerta<strong>in</strong>ty <strong>in</strong> patient stopp<strong>in</strong>g<br />
power ratios (SPRs). Marg<strong>in</strong>s<br />
along <strong>the</strong> beam axis, both distal<br />
<strong>and</strong> proximal to <strong>the</strong> cl<strong>in</strong>ical<br />
target volume, are used dur<strong>in</strong>g<br />
<strong>the</strong> treatment plann<strong>in</strong>g stage to<br />
account for this uncerta<strong>in</strong>ty <strong>and</strong><br />
ensure target coverage. A value<br />
<strong>of</strong> 3.5 per cent has been<br />
commonly used <strong>in</strong> <strong>the</strong> design <strong>of</strong><br />
<strong>the</strong>se marg<strong>in</strong>s for many years,<br />
but recently a group <strong>of</strong><br />
researchers at <strong>the</strong> University <strong>of</strong><br />
Texas MD Anderson Cancer<br />
Center took a closer look at this<br />
uncerta<strong>in</strong>ty.<br />
Us<strong>in</strong>g a comb<strong>in</strong>ation <strong>of</strong><br />
previously published data <strong>and</strong><br />
new, measured data, <strong>the</strong><br />
researchers assessed five<br />
contributions to SPR<br />
uncerta<strong>in</strong>ty <strong>in</strong> three<br />
representative tissue types:<br />
low-density lung, <strong>in</strong>termediatedensity<br />
s<strong>of</strong>t tissue <strong>and</strong> highdensity<br />
bone. Four <strong>of</strong> <strong>the</strong><br />
contribut<strong>in</strong>g factors correspond<br />
to steps <strong>in</strong> <strong>the</strong> stoichiometric<br />
calibration method, <strong>the</strong> most<br />
commonly used method for<br />
deriv<strong>in</strong>g SPRs for different<br />
tissue types. The fifth orig<strong>in</strong>ates<br />
from <strong>the</strong> dose calculation<br />
algorithm used <strong>in</strong> a treatment<br />
plann<strong>in</strong>g system. Stopp<strong>in</strong>g<br />
NEWS BY USMAN I. LULA AND RICHARD AMOS | SCOPE<br />
F detector as a function <strong>of</strong> field size.<br />
power ratios vary with proton<br />
energy <strong>and</strong> consequently vary<br />
along <strong>the</strong> proton beam path,<br />
whereas common algorithms<br />
ignore this effect.<br />
The researchers used <strong>the</strong><br />
uncerta<strong>in</strong>ties for each tissue<br />
type to estimate <strong>the</strong> composite<br />
range uncerta<strong>in</strong>ty for each<br />
beam <strong>in</strong> <strong>the</strong> treatment plans <strong>of</strong><br />
15 patients who were<br />
undergo<strong>in</strong>g proton <strong>the</strong>rapy for<br />
lung, prostate <strong>and</strong> head <strong>and</strong><br />
neck cancers.<br />
Uncerta<strong>in</strong>ty <strong>in</strong> <strong>in</strong>dividual<br />
tissue types, expressed to one<br />
st<strong>and</strong>ard deviation, ranged from<br />
1.6 per cent for s<strong>of</strong>t tissue to 5.0<br />
per cent for lung. Expressed<br />
MORE INFORMATION<br />
This story was first reported on Medical<br />
<strong>Physics</strong> Web on 11th July:<br />
http://medicalphysicsweb.org/cws/art<br />
icle/research/50234<br />
us<strong>in</strong>g <strong>the</strong> 95th percentile,<br />
beams used to treat lung<br />
tumours exhibited <strong>the</strong> greatest<br />
composite uncerta<strong>in</strong>ty <strong>of</strong> 3.4<br />
per cent. Beams treat<strong>in</strong>g<br />
prostate <strong>and</strong> head <strong>and</strong> neck<br />
cancer both resulted <strong>in</strong> an<br />
uncerta<strong>in</strong>ty <strong>of</strong> 3.0 per cent.<br />
This study highlighted that<br />
<strong>the</strong> currently used value <strong>of</strong> 3.5<br />
per cent is appropriate as a<br />
general recommendation to<br />
account for SPR uncerta<strong>in</strong>ties,<br />
<strong>and</strong> <strong>the</strong> group have no<br />
immediate plans to change<br />
<strong>the</strong>ir cl<strong>in</strong>ical practice.<br />
MORE INFORMATION<br />
This paper was published <strong>in</strong> Phys Med<br />
Biol 2012; 57: 4095–115.<br />
SCOPE | SEPTEMBER 2012 | 07
FEATURE | SCOPE<br />
SCIENCE AND<br />
PARLIAMENT:<br />
A CALL FOR ENGAGEMENT<br />
© r.nagy / Shutterstock<br />
Andrew Miller MP discusses <strong>the</strong> l<strong>in</strong>ks between<br />
science <strong>and</strong> politics, outl<strong>in</strong><strong>in</strong>g a challenge that<br />
all members can be <strong>in</strong>volved with <strong>in</strong> order to<br />
benefit not only <strong>the</strong> pr<strong>of</strong>ession but also<br />
healthcare <strong>and</strong> <strong>the</strong> whole science community<br />
Irecently spent a weekend at<br />
Ditchley Park <strong>in</strong> Oxfordshire,<br />
a house that has not only been<br />
graced with great names like<br />
W<strong>in</strong>ston Churchill among its<br />
visitors, but has been <strong>the</strong><br />
home <strong>of</strong> high-level bra<strong>in</strong> storm<strong>in</strong>g<br />
sessions amongst experts on many<br />
subjects over <strong>the</strong> last 60 years.<br />
Initially Sir David Wills, who<br />
conceived <strong>the</strong> idea <strong>and</strong> at that time<br />
owned <strong>the</strong> house, saw it as a venue<br />
for improv<strong>in</strong>g relations across <strong>the</strong><br />
Atlantic, especially between our<br />
respective governments here <strong>and</strong> <strong>in</strong><br />
<strong>the</strong> US.<br />
Today <strong>the</strong> transatlantic dimension<br />
is just as strong but many o<strong>the</strong>r<br />
nations participate <strong>in</strong> try<strong>in</strong>g to f<strong>in</strong>d<br />
solutions to problems that face us<br />
all. That is why I leapt at <strong>the</strong><br />
opportunity when I was <strong>in</strong>vited to<br />
attend a sem<strong>in</strong>ar entitled ‘Putt<strong>in</strong>g<br />
Science, Government, Bus<strong>in</strong>ess <strong>and</strong><br />
Innovation Toge<strong>the</strong>r’. All <strong>of</strong> my<br />
adult life I have been fasc<strong>in</strong>ated with<br />
<strong>the</strong> challenge <strong>of</strong> how to use science<br />
<strong>in</strong> a way that benefits people, <strong>and</strong><br />
also <strong>the</strong> vexed question <strong>of</strong> engag<strong>in</strong>g<br />
our society <strong>in</strong> <strong>the</strong> scientific<br />
challenges <strong>of</strong> today <strong>and</strong> help<strong>in</strong>g<br />
people without a science<br />
background to underst<strong>and</strong> <strong>the</strong><br />
relevance <strong>of</strong> research that is<br />
undertaken. Those challenges exist<br />
throughout our society but are<br />
especially acute <strong>in</strong> Parliament. MPs<br />
are expected to take important<br />
decisions not just about <strong>the</strong> science<br />
budget but about <strong>the</strong> application <strong>of</strong><br />
science throughout <strong>the</strong> country we<br />
seek to represent, dabbl<strong>in</strong>g <strong>in</strong> areas<br />
rang<strong>in</strong>g from education through to<br />
why we should <strong>in</strong>vest <strong>in</strong> CERN or<br />
<strong>the</strong> next generation <strong>of</strong> astronomy.<br />
You do not need to know much<br />
about <strong>the</strong> political process to realise<br />
that this presents a challenge;<br />
politics is all about priorities. But as<br />
only about 10 per cent <strong>of</strong> <strong>the</strong> House<br />
<strong>of</strong> Commons (a figure that has<br />
stayed relatively stable for some<br />
time) have ever worked <strong>in</strong> an STEM<br />
discipl<strong>in</strong>e, engag<strong>in</strong>g with MPs is<br />
essential.<br />
At <strong>the</strong> end <strong>of</strong> <strong>the</strong> Ditchley Park<br />
weekend we were each asked to sum<br />
up <strong>in</strong> one sentence what we got out<br />
<strong>of</strong> <strong>the</strong> event. In my case I learnt a<br />
tremendous amount but it<br />
conv<strong>in</strong>ced me more than ever <strong>of</strong> <strong>the</strong><br />
importance <strong>of</strong> cont<strong>in</strong>u<strong>in</strong>g <strong>the</strong><br />
longst<strong>and</strong><strong>in</strong>g work I am <strong>in</strong>volved <strong>in</strong><br />
with<strong>in</strong> Parliament to help build a<br />
bridge between science <strong>and</strong> politics.<br />
SCIENCE IN PARLIAMENT<br />
There are some stunn<strong>in</strong>gly good<br />
arrangements <strong>in</strong> place, such as <strong>the</strong><br />
Royal Society’s pair<strong>in</strong>g scheme,<br />
which <strong>of</strong>fers Fellows an opportunity<br />
to pair with an MP or civil servant<br />
▼<br />
SCOPE | SEPTEMBER 2012 | 09
▼<br />
SCOPE | FEATURE<br />
<strong>and</strong> both spend time toge<strong>the</strong>r <strong>in</strong> <strong>the</strong>ir<br />
respective environments. My limited<br />
knowledge <strong>of</strong> nanotechnology came<br />
from such an experience. There are<br />
also schemes like Newton’s Apple,<br />
devised <strong>and</strong> run passionately by<br />
Michael Elves, a man with a<br />
dist<strong>in</strong>guished <strong>in</strong>dustrial <strong>and</strong><br />
academic record who br<strong>in</strong>gs young<br />
scientists <strong>in</strong>to <strong>the</strong> House.<br />
Similarly <strong>the</strong>re are events like <strong>the</strong><br />
Parliamentary L<strong>in</strong>ks Day, now<br />
organised by <strong>the</strong> Society <strong>of</strong> Biology<br />
on behalf <strong>of</strong> <strong>the</strong> science <strong>and</strong><br />
eng<strong>in</strong>eer<strong>in</strong>g community, <strong>and</strong><br />
supported by <strong>the</strong> <strong>Institute</strong> <strong>of</strong> <strong>Physics</strong>,<br />
<strong>the</strong> Royal Society, <strong>the</strong> Royal Society<br />
<strong>of</strong> Ed<strong>in</strong>burgh, <strong>the</strong> Royal Academy <strong>of</strong><br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong>, <strong>the</strong> Biochemical Society,<br />
<strong>the</strong> Society for Experimental Biology,<br />
<strong>the</strong> Society for Applied Microbiology,<br />
<strong>the</strong> British Pharmacological Society,<br />
<strong>the</strong> Astronomical Society, <strong>the</strong><br />
Geological Society, <strong>the</strong> Council for<br />
<strong>the</strong> Ma<strong>the</strong>matical Sciences, <strong>the</strong> New<br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> Foundation, <strong>the</strong> Royal<br />
Society <strong>of</strong> Chemistry, <strong>the</strong> Campaign<br />
for Science <strong>and</strong> <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> <strong>and</strong> <strong>the</strong><br />
Parliamentary <strong>and</strong> Scientific<br />
Committee. This year more than 120<br />
people came to <strong>the</strong> House to focus on<br />
a series <strong>of</strong> discussions around science<br />
<strong>and</strong> sport; <strong>the</strong> subject was obviously<br />
not chosen by accident!<br />
The Speaker <strong>of</strong> <strong>the</strong> House <strong>of</strong><br />
Commons, Rt Hon John Bercow MP,<br />
opened <strong>the</strong> meet<strong>in</strong>g. He is quoted on<br />
<strong>the</strong> Society <strong>of</strong> Biology’s website as<br />
say<strong>in</strong>g: ‘I know, from my unique<br />
vantage po<strong>in</strong>t <strong>in</strong> <strong>the</strong> House, that<br />
Members on all sides cont<strong>in</strong>ue to<br />
raise issues that have a scientific<br />
aspect to <strong>the</strong>m.<br />
‘It is all <strong>the</strong> more important that<br />
every Member <strong>of</strong> Parliament should<br />
be able to benefit from non-partisan<br />
assistance <strong>of</strong> <strong>the</strong> k<strong>in</strong>d <strong>of</strong>fered by<br />
pr<strong>of</strong>essional scientific bodies like <strong>the</strong><br />
Society <strong>of</strong> Biology, <strong>the</strong> <strong>Institute</strong> <strong>of</strong><br />
<strong>Physics</strong>, <strong>the</strong> Royal Society <strong>of</strong><br />
Chemistry <strong>and</strong> many o<strong>the</strong>rs with<br />
<strong>the</strong>ir proven commitment to public<br />
<strong>in</strong>terest.’<br />
The first All Party Parliamentary<br />
Group was <strong>the</strong> Parliamentary <strong>and</strong><br />
Scientific Committee (P&SC). All<br />
Party Groups are made up <strong>of</strong> MPs<br />
<strong>and</strong> peers work<strong>in</strong>g toge<strong>the</strong>r across<br />
parties on areas <strong>of</strong> common <strong>in</strong>terest.<br />
The P&SC engages regularly with <strong>the</strong><br />
science community <strong>and</strong> publishes its<br />
quarterly magaz<strong>in</strong>e entitled Science<br />
<strong>in</strong> Parliament.<br />
One <strong>of</strong> <strong>the</strong> more recent<br />
<strong>in</strong>novations is ‘SET for Brita<strong>in</strong>’,<br />
10 | SEPTEMBER 2012 | SCOPE<br />
orig<strong>in</strong>ated by <strong>the</strong> late Dr Eric<br />
Wharton <strong>and</strong> cont<strong>in</strong>ued by <strong>the</strong><br />
former MP for Bristol Dr Doug<br />
Naysmith. The event is organised<br />
<strong>and</strong> run by staff <strong>of</strong> <strong>the</strong> P&SC with a<br />
tremendous amount <strong>of</strong> help from<br />
learned societies <strong>and</strong> private<br />
companies. This successfully br<strong>in</strong>gs<br />
a great poster competition to <strong>the</strong><br />
House, ga<strong>the</strong>r<strong>in</strong>g early career<br />
researchers toge<strong>the</strong>r from a number<br />
<strong>of</strong> discipl<strong>in</strong>es <strong>and</strong> most importantly<br />
gett<strong>in</strong>g <strong>the</strong>m engaged with MPs.<br />
Both Houses have a Science <strong>and</strong><br />
Technology Select Committee<br />
work<strong>in</strong>g on a range <strong>of</strong> topics. The<br />
Commons Committee that I chair is<br />
currently work<strong>in</strong>g on a number <strong>of</strong><br />
projects <strong>in</strong>clud<strong>in</strong>g, for example, a<br />
report on medical implants. We are<br />
supported by a team <strong>of</strong> extremely<br />
well qualified science specialists <strong>and</strong><br />
clerks. (The name clerk <strong>in</strong> Parliament<br />
applies to a highly qualified advisor<br />
not simply a scribe.)<br />
Parliament is also served by<br />
brilliant librarians <strong>and</strong> <strong>the</strong><br />
Parliamentary Office <strong>of</strong> Science <strong>and</strong><br />
Technology (POST). The latter is<br />
Parliament’s <strong>in</strong>-house source <strong>of</strong><br />
<strong>in</strong>dependent, balanced <strong>and</strong><br />
accessible analysis <strong>of</strong> public policy<br />
issues related to science <strong>and</strong><br />
technology. The organisation has<br />
some permanent staff as well as a<br />
network <strong>of</strong> seconded extremely<br />
bright young scientists.<br />
WHAT ELSE IS NEEDED?<br />
That all sounds like a long list but it<br />
does not alter <strong>the</strong> fact that MPs are<br />
under permanent pressure to be<br />
do<strong>in</strong>g o<strong>the</strong>r th<strong>in</strong>gs <strong>and</strong> <strong>the</strong> degree <strong>of</strong><br />
engagement with science <strong>and</strong> science<br />
policy is somewhat limited. So this is<br />
where you come <strong>in</strong>!<br />
IPEM members are work<strong>in</strong>g <strong>in</strong> a<br />
discipl<strong>in</strong>e that every politician,<br />
irrespective <strong>of</strong> <strong>the</strong>ir orig<strong>in</strong>al tra<strong>in</strong><strong>in</strong>g,<br />
will see as relevant to <strong>the</strong> society<br />
with<strong>in</strong> which we live. Whilst <strong>the</strong><br />
scientists <strong>and</strong> technicians with<strong>in</strong> <strong>the</strong><br />
<strong>Institute</strong> rarely get a mention <strong>in</strong> <strong>the</strong><br />
popular press compared with, say,<br />
doctors <strong>and</strong> nurses, anyone who<br />
has ever visited a hospital<br />
ei<strong>the</strong>r pr<strong>of</strong>essionally or as a<br />
patient will readily see <strong>the</strong><br />
importance <strong>of</strong> <strong>the</strong><br />
underly<strong>in</strong>g science that<br />
supports our health system.<br />
So each <strong>and</strong> every one <strong>of</strong> you<br />
are <strong>in</strong> a strong position to<br />
help address <strong>the</strong> challenge I<br />
have described. Whe<strong>the</strong>r you<br />
ABOVE LEFT<br />
Ditchley Park<br />
<strong>in</strong> Oxfordshire.<br />
▼<br />
ABOVE RIGHT<br />
Parliamentary<br />
L<strong>in</strong>ks Day:<br />
Julian Huppert<br />
MP, Rt Hon John<br />
Bercow MP,<br />
Andrew Miller<br />
MP <strong>and</strong> Dame<br />
Nancy Rothwell.<br />
▼<br />
work <strong>in</strong> a hospital or are <strong>in</strong>volved <strong>in</strong><br />
design<strong>in</strong>g or manufactur<strong>in</strong>g tools for<br />
<strong>the</strong> health service I simply <strong>in</strong>vite you<br />
to engage with your own local MP<br />
<strong>and</strong> make sure that he or she<br />
underst<strong>and</strong>s <strong>the</strong> importance <strong>of</strong> <strong>the</strong><br />
underly<strong>in</strong>g science that supports <strong>the</strong><br />
great <strong>in</strong>novations that are go<strong>in</strong>g on <strong>in</strong><br />
healthcare on a daily basis. Don’t just<br />
talk to MPs about healthcare but<br />
about how modern science today<br />
crosses discipl<strong>in</strong>es. Without people<br />
like Alan Tur<strong>in</strong>g would we have<br />
mapped <strong>the</strong> genome so quickly? In<br />
<strong>the</strong> great advances we have seen <strong>in</strong><br />
scann<strong>in</strong>g <strong>and</strong> x-ray tools <strong>the</strong><br />
crossover between <strong>the</strong> needs <strong>of</strong> highend<br />
eng<strong>in</strong>eer<strong>in</strong>g companies work<strong>in</strong>g<br />
<strong>in</strong> a whole range <strong>of</strong> <strong>in</strong>dustrial<br />
discipl<strong>in</strong>es <strong>and</strong> <strong>the</strong> application <strong>of</strong> <strong>the</strong><br />
technologies for <strong>the</strong> benefit <strong>of</strong> human<br />
health are issues that each <strong>of</strong> you can<br />
wax considerably more lyrically than<br />
I, for example on how 3D pr<strong>in</strong>t<strong>in</strong>g is<br />
go<strong>in</strong>g to have a significant role <strong>in</strong><br />
orthopaedics. But <strong>the</strong> key<br />
message to get over is that<br />
medic<strong>in</strong>e does not exist <strong>in</strong><br />
isolation from <strong>the</strong> rest <strong>of</strong> <strong>the</strong><br />
science base <strong>and</strong> <strong>in</strong>deed<br />
could not.<br />
This is not just a challenge I<br />
am lay<strong>in</strong>g down to IPEM<br />
members. I th<strong>in</strong>k that it should be
© Ralph Loch 2010<br />
<strong>the</strong> responsibility <strong>of</strong> every scientist to<br />
engage with <strong>the</strong> political community<br />
so that MPs get directly from <strong>the</strong><br />
people <strong>the</strong>y are represent<strong>in</strong>g <strong>the</strong><br />
importance <strong>of</strong> work that has been<br />
undertaken under <strong>the</strong>ir very noses <strong>in</strong><br />
<strong>the</strong>ir own constituencies. The more<br />
we can make this happen <strong>the</strong> more<br />
optimistic I would be that this<br />
government <strong>and</strong> future governments<br />
will take <strong>the</strong> science budget seriously.<br />
The o<strong>the</strong>r end <strong>of</strong> <strong>the</strong> telescope is <strong>of</strong><br />
course what <strong>the</strong> <strong>Institute</strong> can do to<br />
match <strong>the</strong> work that has been<br />
undertaken by o<strong>the</strong>r learned societies<br />
directly with<strong>in</strong> Parliament.<br />
Stephen Keevil <strong>and</strong> o<strong>the</strong>rs are<br />
frequently knock<strong>in</strong>g on my door <strong>and</strong><br />
those <strong>of</strong> my colleagues to press <strong>the</strong><br />
case for <strong>the</strong> <strong>Institute</strong>. Many <strong>of</strong> <strong>the</strong><br />
larger or perhaps more well-<strong>of</strong>f<br />
societies have pr<strong>of</strong>essionalised that<br />
process; some hire <strong>in</strong> external<br />
government affairs specialists, some<br />
employ <strong>the</strong>ir own. Some societies<br />
collaborate toge<strong>the</strong>r <strong>and</strong> share <strong>the</strong><br />
costs <strong>of</strong> a person to front <strong>the</strong>ir<br />
activities <strong>in</strong> Parliament. And <strong>the</strong>re is<br />
a high degree <strong>of</strong> co-operation<br />
between various organisations, for<br />
example <strong>the</strong> L<strong>in</strong>ks Day that I<br />
mentioned earlier <strong>in</strong>volves people<br />
from earth sciences, biology, physics,<br />
eng<strong>in</strong>eer<strong>in</strong>g <strong>and</strong> chemistry, etc.<br />
“<br />
They<br />
have sp<strong>in</strong><strong>of</strong>f<br />
benefits to<br />
<strong>the</strong> whole<br />
<strong>of</strong> <strong>the</strong><br />
health<br />
mach<strong>in</strong>e<br />
”<br />
So my second challenge to <strong>the</strong><br />
<strong>Institute</strong> is to <strong>in</strong>vite you to ask <strong>the</strong><br />
question: how do you get a better<br />
voice <strong>in</strong> Parliament?<br />
Both <strong>of</strong> <strong>the</strong> challenges I am sett<strong>in</strong>g<br />
out for you are clearly not just good<br />
for your own pr<strong>of</strong>ession but <strong>the</strong>y<br />
have sp<strong>in</strong>-<strong>of</strong>f benefits to <strong>the</strong> whole <strong>of</strong><br />
<strong>the</strong> health mach<strong>in</strong>e, as well as much<br />
more broadly across <strong>the</strong> science<br />
community.<br />
F<strong>in</strong>ally, some <strong>of</strong> you will come<br />
across difficult cases (I mean <strong>the</strong> MPs<br />
not <strong>the</strong> patients) but each <strong>of</strong> you will<br />
have anecdotes that will help get <strong>the</strong><br />
message across. For example, when I<br />
was be<strong>in</strong>g treated by a consultant<br />
who has now retired I went to one<br />
appo<strong>in</strong>tment <strong>and</strong> found him <strong>in</strong> a<br />
very excited mood.<br />
He said, ‘Andrew, you’re<br />
<strong>in</strong>terested <strong>in</strong> technology; come <strong>and</strong><br />
have a look at my new system’.<br />
Picture archiv<strong>in</strong>g had just been<br />
switched on <strong>in</strong> his hospital <strong>and</strong> for<br />
<strong>the</strong> first time he was able to send me<br />
for an x-ray, hav<strong>in</strong>g just read my<br />
notes, <strong>and</strong> to have it <strong>in</strong> front <strong>of</strong> him<br />
as I came up through <strong>the</strong> queue <strong>of</strong><br />
patients. He played with his<br />
computer <strong>and</strong> showed me how he<br />
could enlarge <strong>the</strong>se shots <strong>of</strong> various<br />
bits <strong>of</strong> me <strong>and</strong> alter <strong>the</strong> contrasts to<br />
hone <strong>in</strong> <strong>in</strong> more detail. The net result<br />
FEATURE | SCOPE<br />
was a more satisfactory outcome<br />
because he could better <strong>in</strong>terpret <strong>the</strong><br />
data <strong>and</strong> equally importantly, as a<br />
result <strong>of</strong> <strong>the</strong> fact that he no longer has<br />
to re-read <strong>the</strong> patient’s file due to <strong>the</strong><br />
long gap between be<strong>in</strong>g sent <strong>of</strong>f for<br />
an x-ray <strong>and</strong> <strong>the</strong> <strong>in</strong>formation gett<strong>in</strong>g<br />
back to him, he saw real productivity<br />
improvements <strong>and</strong> was able, he<br />
guessed, to see at least one more<br />
patient <strong>in</strong> each cl<strong>in</strong>ic session. There<br />
was a consultant who understood <strong>the</strong><br />
relevance <strong>of</strong> technology <strong>and</strong> here is a<br />
patient who was grateful for its<br />
application.<br />
There are hundreds more such<br />
anecdotes that are directly related to<br />
health improvement <strong>in</strong> every s<strong>in</strong>gle<br />
constituency. MPs need to know<br />
about <strong>the</strong>m <strong>and</strong> <strong>the</strong> best people to<br />
talk to MPs about technologies like<br />
this are people like you. n<br />
FURTHER READING<br />
Science <strong>in</strong> Parliament<br />
www.vm<strong>in</strong>e.net/science<strong>in</strong>parliament<br />
SET for Brita<strong>in</strong><br />
www.setforbrita<strong>in</strong>.org.uk<br />
House <strong>of</strong> Commons Select<br />
Committee <strong>of</strong> Science <strong>and</strong> Technology<br />
www.parliament.uk/science<br />
Parliamentary <strong>of</strong>fice <strong>of</strong><br />
Science <strong>and</strong> Technology (POST)<br />
www.parliament.uk/post<br />
SCOPE | SEPTEMBER 2012 | 11
4513 371 0993 03:12<br />
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All images © Henry Lawrence <strong>and</strong> Lynn Mart<strong>in</strong>ez, 2012<br />
o<strong>the</strong>r’, said Alice, ‘I’ll<br />
never get this tra<strong>in</strong><strong>in</strong>g<br />
portfolio f<strong>in</strong>ished until<br />
I can f<strong>in</strong>d that ion<br />
recomb<strong>in</strong>ation paper<br />
by Havercr<strong>of</strong>t’. 1 B‘<br />
She had looked everywhere,<br />
Medl<strong>in</strong>e, Scopus, <strong>and</strong> worst <strong>of</strong> all she<br />
remembered see<strong>in</strong>g a dog-eared copy<br />
ly<strong>in</strong>g somewhere around <strong>the</strong><br />
department.<br />
Her eyes drifted to <strong>the</strong> archive<br />
cupboard. Nobody ever used it;<br />
maybe once a year th<strong>in</strong>gs no-one had<br />
<strong>the</strong> courage to throw away got<br />
dumped <strong>the</strong>re. It was worth a try.<br />
She opened <strong>the</strong> door. Slowly, <strong>the</strong>n<br />
with an unstoppable momentum,<br />
generations <strong>of</strong> reports, graphs <strong>and</strong><br />
FIGURE 1.<br />
Was that <strong>the</strong><br />
sound <strong>of</strong> music <strong>in</strong><br />
<strong>the</strong> distance?<br />
▼<br />
charts stirred, <strong>and</strong> <strong>in</strong> one long, slow<br />
movement avalanched over her.<br />
She was completely covered, <strong>and</strong><br />
all went dark. Frantically she waved<br />
her arms around, push<strong>in</strong>g papers<br />
hi<strong>the</strong>r <strong>and</strong> thi<strong>the</strong>r. At last she saw<br />
light, <strong>and</strong> looked up.<br />
She turned around. There was no<br />
sign <strong>of</strong> <strong>the</strong> cupboard! Or her <strong>of</strong>fice.<br />
The whole medical physics<br />
department <strong>of</strong> Lymeswold Hospital<br />
had been transformed <strong>in</strong>to a vast,<br />
brood<strong>in</strong>g forest.<br />
She stra<strong>in</strong>ed her ears. Was that<br />
music <strong>in</strong> <strong>the</strong> distance? It sounded like<br />
some sort <strong>of</strong> barn dance b<strong>and</strong>,<br />
banjos, 42 m<strong>and</strong>ol<strong>in</strong>s, 19,27 a flute, 37<br />
highl<strong>and</strong> pipes, 71 a ukulele 72 <strong>and</strong> a<br />
fiddle. 2,58<br />
FEATURE | SCOPE<br />
Alice through <strong>the</strong><br />
archive cupboard<br />
Henry Lawrence (Ipswich Hospital) reveals what your colleagues really get up to <strong>in</strong><br />
<strong>the</strong>ir spare time! Illustrated by Lynn Mart<strong>in</strong>ez (Royal Free Hospital, London)<br />
‘Golly’, thought Alice, ‘that<br />
sounds fun!’. I like to do a little<br />
Appalachian clog danc<strong>in</strong>g65 myself.<br />
I’ll go <strong>and</strong> ask <strong>the</strong>m where I am. As<br />
she came to <strong>the</strong> brow <strong>of</strong> a hill she<br />
looked down at a full-blown barn<br />
dance27 <strong>in</strong> operation. Her experienced<br />
ear told her straightaway… ‘That’s<br />
North West Morris, 6 I can’t dance<br />
that! Maybe if <strong>the</strong>y did some Welsh<br />
folk dance7 I might st<strong>and</strong> a chance’.<br />
No sooner did that thought cross<br />
her m<strong>in</strong>d when <strong>the</strong> b<strong>and</strong> stopped,<br />
<strong>and</strong> a woman <strong>in</strong> full seventeenthcentury<br />
costume brought her lute15 out from with<strong>in</strong> <strong>the</strong> flow<strong>in</strong>g folds <strong>of</strong><br />
her woven17 gown <strong>and</strong> <strong>the</strong> lilt<strong>in</strong>g<br />
notes <strong>of</strong> Greensleeves filled <strong>the</strong> air,<br />
jo<strong>in</strong>ed by tenor <strong>and</strong> bass recorders. 66<br />
▼<br />
SCOPE | SEPTEMBER 2012 | 13
▼<br />
And when <strong>the</strong> choirs 5,11,16,20,23,33,64 jo<strong>in</strong>ed<br />
<strong>in</strong>, Alice was <strong>in</strong> seventh heaven. ‘But<br />
she shouldn’t have been do<strong>in</strong>g<br />
Regency dance ‘, 6 thought Alice.<br />
‘That’s all wrong.’<br />
‘What is this place?’, she<br />
wondered. ‘And who are all <strong>the</strong>se<br />
people? Such a change from all those<br />
bor<strong>in</strong>g people at work.’<br />
The whirr <strong>of</strong> a Super-8 movie<br />
camera brought her round. 30 ‘It’s an<br />
arty film’, <strong>the</strong> operator said, ‘<strong>and</strong><br />
we’re record<strong>in</strong>g <strong>the</strong> soundtrack’. She<br />
beckoned, <strong>and</strong> toge<strong>the</strong>r <strong>the</strong>y peeped<br />
through a w<strong>in</strong>dow.<br />
Inside was a complete record<strong>in</strong>g<br />
studio, 71 <strong>and</strong> a jazz b<strong>and</strong> 12 was hitt<strong>in</strong>g<br />
a groove with a long solo. A bunch <strong>of</strong><br />
14 | SEPTEMBER 2012 | SCOPE<br />
hangers-on sat beh<strong>in</strong>d <strong>the</strong> record<strong>in</strong>g<br />
desk. Some were do<strong>in</strong>g crosswords, 11<br />
o<strong>the</strong>rs origami, 53 balloon modell<strong>in</strong>g 52<br />
or play<strong>in</strong>g board games; 3 that solo<br />
must have been go<strong>in</strong>g on a long time!<br />
The film-maker panned her<br />
camera round; a well honed<br />
muscleman 31 was bounc<strong>in</strong>g up <strong>and</strong><br />
down on a trampol<strong>in</strong>e. 5 Some actors 54<br />
were practic<strong>in</strong>g ice skat<strong>in</strong>g 35 on <strong>the</strong><br />
pond, throw<strong>in</strong>g Frisbees. 55 A girl was<br />
star<strong>in</strong>g <strong>in</strong>tently at a tra<strong>in</strong> set. 19,35<br />
‘Why is she play<strong>in</strong>g with that?’,<br />
asked Alice. ‘She’s secretly<br />
committed to sav<strong>in</strong>g <strong>the</strong><br />
environment‘, 10 replied <strong>the</strong> filmmaker.<br />
‘She believes <strong>in</strong> “Small is<br />
Beautiful”.’<br />
“<br />
‘Such<br />
a change<br />
from all<br />
those<br />
bor<strong>in</strong>g<br />
people at<br />
work’<br />
”<br />
There is someth<strong>in</strong>g about <strong>the</strong><br />
smell <strong>of</strong> homemade bread. 18,55 It was<br />
waft<strong>in</strong>g from beh<strong>in</strong>d <strong>the</strong> bushes.<br />
Alice was <strong>the</strong>re <strong>in</strong> a flash, <strong>in</strong> front <strong>of</strong><br />
a table laid out with cakes,<br />
wonderfully decorated, 41 show<strong>in</strong>g <strong>the</strong><br />
sugar craft artist’s 42 skills to<br />
perfection. And <strong>in</strong> <strong>the</strong> middle, an<br />
enormous jar <strong>of</strong> award-w<strong>in</strong>n<strong>in</strong>g<br />
marmalade! 52<br />
It was a market. Next to <strong>the</strong> cake<br />
stall were all sorts <strong>of</strong> people sell<strong>in</strong>g<br />
<strong>the</strong>ir wares. Someone was sell<strong>in</strong>g<br />
felt, 17 lovely crochet toys 37 <strong>and</strong> lea<strong>the</strong>r<br />
craft. 42 A gallery stall was show<strong>in</strong>g a<br />
mixed exhibition <strong>of</strong> photographs, 18,28<br />
pa<strong>in</strong>t<strong>in</strong>gs 40 <strong>and</strong> sketches. 17 Ano<strong>the</strong>r<br />
was piled high with pottery 39,42 that
would not have been out <strong>of</strong> place <strong>in</strong><br />
any Cornish seaside shop. And <strong>the</strong>re<br />
was even a detector calibration jig, all<br />
built out <strong>of</strong> Lego. 21<br />
But best <strong>of</strong> all was <strong>the</strong> beaded<br />
jewellery. 2 ‘Who makes that?’, she<br />
asked. ‘No-one knows’, replied <strong>the</strong><br />
cuckoo clockmaker. 56 ‘But I hear she<br />
is gett<strong>in</strong>g married on top <strong>of</strong> <strong>the</strong><br />
mounta<strong>in</strong>.‘ 2 ‘Oh goody’, giggled<br />
Alice. ‘I’d love to come.’<br />
So <strong>of</strong>f <strong>the</strong>y went, some<br />
hik<strong>in</strong>g, 19,47,61,66 some on mounta<strong>in</strong><br />
bikes, 28,51,62,69 some on horseback. 45,68 A<br />
sheep farmer seemed to be danc<strong>in</strong>g<br />
<strong>the</strong> Salsa. 67 When <strong>the</strong>y came to a<br />
clear<strong>in</strong>g some <strong>of</strong> <strong>the</strong> guys started<br />
kick<strong>in</strong>g a ball about. 8,60,63<br />
FIGURE 2.<br />
[ LEFT]<br />
And <strong>the</strong>re stood<br />
<strong>the</strong> vicar,<br />
vestments<br />
blow<strong>in</strong>g <strong>in</strong> <strong>the</strong><br />
w<strong>in</strong>d.<br />
▼<br />
FIGURE 3.<br />
[ RIGHT]<br />
A sweat<strong>in</strong>g<br />
woman was<br />
balanc<strong>in</strong>g on her<br />
head.<br />
▼<br />
‘I want to play’, shouted Alice, but<br />
ladies don’t play football. So<br />
everyone played Korfball 32 <strong>and</strong><br />
rounders 8,13 <strong>in</strong>stead.<br />
Suddenly, some characters who<br />
looked like <strong>the</strong>y came out <strong>of</strong> a roleplay<strong>in</strong>g<br />
game 3 stood on <strong>the</strong> path <strong>in</strong><br />
full armour, but one <strong>of</strong> <strong>the</strong> horsemen<br />
tucked his lance under his arm <strong>and</strong><br />
charged. 45 The Aikido warriors 16,43<br />
drew <strong>the</strong>ir swords, but it was <strong>the</strong><br />
kung fu fighters 2 who caused <strong>the</strong> role<br />
players to retreat, <strong>and</strong> recommence<br />
<strong>the</strong>ir Ars Magica game <strong>in</strong> <strong>the</strong> dark<br />
recesses <strong>of</strong> <strong>the</strong> palace.<br />
They came to a wide, slow flow<strong>in</strong>g<br />
river. Some kayaks <strong>and</strong> boats 9,14,19<br />
were head<strong>in</strong>g upstream; <strong>the</strong>y<br />
FEATURE | SCOPE<br />
shouted <strong>and</strong> a sail<strong>in</strong>g boat57 <strong>of</strong>fered<br />
to take <strong>the</strong>m across. But just as she<br />
stepped onboard, Alice slipped <strong>and</strong><br />
fell <strong>in</strong>to <strong>the</strong> dark, murky water. A<br />
scuba diver28 came straight to her<br />
aid, but it was <strong>the</strong> bog snorkell<strong>in</strong>g<br />
champion34 who found her. Toge<strong>the</strong>r<br />
<strong>the</strong>y brought her splutter<strong>in</strong>g to <strong>the</strong><br />
surface.<br />
‘Lucky I can do breath-hold free<br />
div<strong>in</strong>g‘, 34 thought Alice as she broke<br />
<strong>the</strong> surface.<br />
On <strong>the</strong> o<strong>the</strong>r side <strong>of</strong> <strong>the</strong> river,<br />
stretch<strong>in</strong>g high <strong>in</strong>to <strong>the</strong> sky, stood<br />
<strong>the</strong> mounta<strong>in</strong>s.<br />
‘Good that I’ve done a bit <strong>of</strong><br />
climb<strong>in</strong>g’, thought Alice. And so had<br />
<strong>the</strong> o<strong>the</strong>rs, 2 <strong>and</strong> <strong>the</strong>re were some<br />
scoutmasters too, 14,24,41 so everyone<br />
was under safe leadership. 24,40,59,70 The<br />
paths looked like a maze, 11 but<br />
someone had a map; a secret map <strong>of</strong><br />
all <strong>the</strong> footpaths2 that had been<br />
made cl<strong>and</strong>est<strong>in</strong>ely <strong>and</strong> h<strong>and</strong>ed<br />
down through generations.<br />
Thick clouds were form<strong>in</strong>g on <strong>the</strong><br />
top <strong>of</strong> <strong>the</strong> mounta<strong>in</strong>. ‘They’re not<br />
clouds’, said Alice. She had done<br />
research on extreme wea<strong>the</strong>r, 49 <strong>and</strong><br />
knew it was a volcano. But <strong>the</strong><br />
sound <strong>of</strong> church bells2,11,29 spurred<br />
<strong>the</strong>m on, <strong>and</strong> <strong>the</strong> orchestra, 2,22,26,36,37<br />
played <strong>the</strong> wedd<strong>in</strong>g march as <strong>the</strong>y<br />
neared <strong>the</strong> top. She had never seen<br />
so many church <strong>of</strong>ficials. 2,22,26,36 But<br />
which one was <strong>the</strong> vicar?<br />
Almost on cue <strong>the</strong> church doors<br />
opened to <strong>the</strong> <strong>in</strong>sistent riff <strong>of</strong><br />
Hawkw<strong>in</strong>d’s ‘Silver Mach<strong>in</strong>e’, <strong>the</strong><br />
b<strong>and</strong>27,53 led by a large moustachioed<br />
bass player. 8 And <strong>the</strong>re stood <strong>the</strong><br />
vicar, vestments blow<strong>in</strong>g <strong>in</strong> <strong>the</strong><br />
w<strong>in</strong>d, his Stratocaster pound<strong>in</strong>g out<br />
<strong>the</strong> chords. 50<br />
‘The groom should be along any<br />
moment’, someone hoped. There he<br />
is at <strong>the</strong> edge <strong>of</strong> <strong>the</strong> volcano crater.<br />
‘It looks as if he’s iron<strong>in</strong>g his<br />
shirt‘, 25 said Alice. ‘He must be very<br />
proud <strong>of</strong> his appearance.’<br />
‘It’s gett<strong>in</strong>g hot’, she thought as<br />
she went up to a build<strong>in</strong>g next to <strong>the</strong><br />
church. ‘It’s like a sauna!’ Steam was<br />
com<strong>in</strong>g out, <strong>and</strong> she peeped <strong>in</strong>side.<br />
A sweat<strong>in</strong>g woman was balanc<strong>in</strong>g<br />
on her head. 4,61 ‘Golly’, thought<br />
Alice. ‘That’s <strong>the</strong> yoga Sirsha Asana<br />
position. 4 I could never master that.‘<br />
‘Never m<strong>in</strong>d’, said <strong>the</strong> <strong>in</strong>verted<br />
practitioner. ‘You can always go<br />
home <strong>and</strong> practice Thulaikatchi*<br />
Asana.’<br />
A buzz turned her attention<br />
skywards. Were <strong>the</strong>y model aircraft<br />
close to, 38,46 or real ones48,63 far away?<br />
▼<br />
SCOPE | SEPTEMBER 2012 | 15
▼<br />
Some <strong>of</strong> <strong>the</strong> models were almost life<br />
size, 38 so it was hard to tell. But one<br />
was trail<strong>in</strong>g a long banner; <strong>the</strong><br />
writ<strong>in</strong>g too small to read.<br />
Just <strong>the</strong>n <strong>the</strong> volcano started<br />
rumbl<strong>in</strong>g, <strong>and</strong> great plumes <strong>of</strong><br />
smoke billowed skywards. Panic set<br />
<strong>in</strong>; everyone started runn<strong>in</strong>g down<br />
<strong>the</strong> mounta<strong>in</strong>. Great folds <strong>of</strong> lava,<br />
red hot, <strong>and</strong> sulphurous fumes<br />
chas<strong>in</strong>g <strong>the</strong>m.<br />
Alice could feel <strong>the</strong> lava lapp<strong>in</strong>g<br />
at her feet, her lungs were burst<strong>in</strong>g,<br />
<strong>the</strong> smoke envelop<strong>in</strong>g her. Just <strong>in</strong><br />
time, without a second to spare, <strong>the</strong><br />
plane with <strong>the</strong> banner swooped<br />
down low on Alice. A drown<strong>in</strong>g man<br />
REFERENCES<br />
1 Havercr<strong>of</strong>t, Klevenhagen.<br />
Phys Med Biol 1993; 38:<br />
25–38.<br />
2 Anon<br />
3 Adrian Lonsdale<br />
4 Agelos Saplaouros<br />
5 Alexis Moore<br />
6 Alison Scott<br />
7 Andrew Tyler<br />
8 Andy Beavis<br />
9 Andy Buckle<br />
10 Angela Cotton<br />
11 Angela New<strong>in</strong>g<br />
12 Arek Mazurek<br />
13 Bruce Walmsley<br />
16 | SEPTEMBER 2012 | SCOPE<br />
will grasp at a straw, <strong>and</strong> a tra<strong>in</strong>ee<br />
cl<strong>in</strong>ical scientist will do <strong>the</strong> same to<br />
a banner trail<strong>in</strong>g from a model<br />
aircraft when be<strong>in</strong>g chased down a<br />
mounta<strong>in</strong> by a stream <strong>of</strong> boil<strong>in</strong>g<br />
lava.<br />
‘Lucky I learned how to climb<br />
silks 34,36 when I was at juggl<strong>in</strong>g 27,52,72<br />
school’, thought Alice, as she<br />
performed her favourite double<br />
hocks climb. It was when she was<br />
safely near <strong>the</strong> top that she paused<br />
<strong>and</strong> looked down at <strong>the</strong> writ<strong>in</strong>g on<br />
<strong>the</strong> banner. It was Havercr<strong>of</strong>t’s<br />
paper on ion recomb<strong>in</strong>ation, <strong>the</strong><br />
very one she had been look<strong>in</strong>g for!<br />
Engrossed by <strong>the</strong> elegance <strong>of</strong><br />
14 Carol<strong>in</strong>e Rudl<strong>and</strong> (May)<br />
15 Carolyn Richardson<br />
16 Ca<strong>the</strong>r<strong>in</strong>e Eveleigh<br />
17 Clare Hadley<br />
18 Conor Heeney<br />
19 David Carpenter<br />
20 David Taylor<br />
21 Ed Hockaday<br />
22 Elizabeth Crawford<br />
23 Eve Sh<strong>in</strong><br />
24 Giles David Morrison<br />
25 Graham Freestone<br />
26 Hea<strong>the</strong>r Williams<br />
27 Henry Lawrence<br />
28 Ian Negus<br />
29 Jack Aylward<br />
30 Jacquel<strong>in</strong>e Roberts<br />
31 James Goracy<br />
32 James Weston<br />
33 Janet Droege (née<br />
Havercr<strong>of</strong>t)<br />
34 Jason Cashmore<br />
35 Joseph O'Brien<br />
36 Karen Chalmers<br />
37 Karen Fuller<br />
38 Keith Mitchell<br />
39 Lucy W<strong>in</strong>ch<br />
40 Lynn Mart<strong>in</strong>ez<br />
41 Lynsey Hamlett<br />
42 Maria Holstensson<br />
FIGURE 4.<br />
‘Lucky I learned<br />
how to climb silks<br />
when I was at<br />
juggl<strong>in</strong>g school.’<br />
▼<br />
*‘Thulaikatchi’ is<br />
Tamil for<br />
‘television’.<br />
Talekatchi Asana is<br />
sitt<strong>in</strong>g <strong>in</strong> front <strong>of</strong><br />
<strong>the</strong> telly.<br />
43 Mar<strong>in</strong>a Romanchikova<br />
44 Mark Powell<br />
45 Mark Rawson<br />
46 Ma<strong>the</strong>w James<br />
47 Matilda Nyekiova<br />
48 Mike Avison<br />
49 Neil S. Rob<strong>in</strong>son<br />
50 Paul Ganney<br />
51 Peter Cl<strong>in</strong>ch<br />
52 Peter Julyan<br />
53 Philip Orr<br />
54 Rachel Cooke<br />
55 Robert Fl<strong>in</strong>tham<br />
56 Robert Speller<br />
57 Rob<strong>in</strong> Laney<br />
Havercr<strong>of</strong>t’s analysis, she read on.<br />
Soon she had quite forgotten her<br />
plight, be<strong>in</strong>g towed beh<strong>in</strong>d a giant<br />
model aircraft escap<strong>in</strong>g from an<br />
explod<strong>in</strong>g volcano. And when she<br />
had f<strong>in</strong>ished <strong>the</strong> conclusion she<br />
looked up. Like a magic trick 44 she<br />
had recomb<strong>in</strong>ed with reality! She<br />
was back <strong>in</strong> her <strong>of</strong>fice at Lymeswold<br />
Hospital, surrounded by a pile <strong>of</strong><br />
debris from <strong>the</strong> archive cupboard.<br />
‘Golly, what an adventure!’,<br />
thought Alice. ‘If I wrote it up, noone<br />
would believe me. 2,27,47 I can’t<br />
wait until I f<strong>in</strong>ish my portfolio <strong>and</strong><br />
meet up with some normal people<br />
aga<strong>in</strong>.’ n<br />
58 Rosal<strong>in</strong>d Perr<strong>in</strong><br />
59 Rosemary Morton<br />
60 Ryan Lewis<br />
61 Samantha Eustace<br />
62 Sarah Naylor<br />
63 Sean Owen<br />
64 Sharan Packer<br />
65 Stephanie Wentworth<br />
66 Stephen Mason<br />
67 Steve Weston<br />
68 Teresa Clark<br />
69 Tom Jordan<br />
70 Usman Lula<br />
71 Wayne Gardner<br />
72 Yatigammana Dylan
Radiat<strong>in</strong>g enthusiasm: IPEM at<br />
<strong>the</strong> 2012 Big Bang Science Fair<br />
Lisa Parker-Gomm (External Relations Manager, IPEM)<br />
How do you expla<strong>in</strong><br />
radioactivity to a 6-yearold?<br />
This was just one <strong>of</strong><br />
<strong>the</strong> challenges IPEM’s<br />
team <strong>of</strong> outreach<br />
volunteers set<br />
<strong>the</strong>mselves at this year’s Big Bang Fair<br />
– a national event for young people<br />
which celebrates science, technology,<br />
eng<strong>in</strong>eer<strong>in</strong>g <strong>and</strong> maths.<br />
In March over 56,000 visitors<br />
flocked to <strong>the</strong> NEC <strong>in</strong> Birm<strong>in</strong>gham <strong>and</strong><br />
hundreds <strong>of</strong> <strong>the</strong>m visited IPEM’s st<strong>and</strong><br />
where <strong>the</strong>y had h<strong>and</strong>s-on experience <strong>of</strong><br />
how physics is used <strong>in</strong> healthcare. Matt<br />
Dunn, Head <strong>of</strong> Radiology <strong>Physics</strong> at<br />
Nott<strong>in</strong>gham University Hospitals NHS<br />
Trust, led <strong>the</strong> IPEM team: ‘Our st<strong>and</strong><br />
seemed relatively low-budget – no<br />
expensive plasma screens <strong>and</strong> suchlike.<br />
But our real strength was <strong>in</strong> allow<strong>in</strong>g<br />
<strong>the</strong> visitors to get <strong>the</strong>ir h<strong>and</strong>s on real<br />
equipment that is actually used <strong>in</strong><br />
hospitals. Hundreds <strong>of</strong> people came to<br />
our st<strong>and</strong>, <strong>and</strong> we were busy most <strong>of</strong><br />
<strong>the</strong> time’.<br />
DISCOVERING RADIOACTIVITY<br />
IPEM’s most attention-grabb<strong>in</strong>g<br />
<strong>of</strong>fer<strong>in</strong>g was a simulated hospital<br />
radioactivity <strong>in</strong>cident. Every 30<br />
m<strong>in</strong>utes <strong>the</strong> alarms went <strong>of</strong>f <strong>and</strong> it was<br />
time to don <strong>the</strong> big yellow CBRN<br />
protection suit, apron, gloves,<br />
overshoes, hat <strong>and</strong> o<strong>the</strong>r pretend<br />
‘protection’ gear <strong>and</strong> start search<strong>in</strong>g for<br />
radiation! No-one was <strong>in</strong> danger, <strong>of</strong><br />
course, but it gave visitors <strong>the</strong><br />
opportunity to scan unfortunate<br />
victims with a Geiger counter to f<strong>in</strong>d<br />
‘radiation’ (it was just alcohol vapour),<br />
<strong>and</strong> also to discover how everyday<br />
items such as bananas <strong>and</strong> potassium<br />
salt (Lo-Salt) are radioactive too. As<br />
well as be<strong>in</strong>g fun, <strong>the</strong> demonstrators<br />
had <strong>the</strong> opportunity to expla<strong>in</strong> <strong>the</strong><br />
many ways radiation is used <strong>in</strong><br />
medic<strong>in</strong>e for <strong>the</strong> benefit <strong>of</strong> patients.<br />
One parent asked a volunteer to<br />
expla<strong>in</strong> radioactivity to his 6-year-old<br />
daughter. Amaz<strong>in</strong>gly, <strong>the</strong> child claimed<br />
to know what atoms were, <strong>and</strong> <strong>the</strong>y<br />
were both happy with <strong>the</strong> impromptu,<br />
if perhaps non-PC, explanation that<br />
some atoms didn’t like <strong>the</strong> way <strong>the</strong>y<br />
looked, so <strong>the</strong>y threw <strong>of</strong>f bits <strong>of</strong><br />
<strong>the</strong>mselves until <strong>the</strong>y felt better!<br />
Ano<strong>the</strong>r activity on <strong>of</strong>fer was us<strong>in</strong>g<br />
an ultrasound scanner to identify<br />
sweets <strong>and</strong> fruit concealed <strong>in</strong> m<strong>in</strong>iphantoms.<br />
‘The children enjoyed <strong>the</strong><br />
game, <strong>and</strong> on a few occasions we<br />
scanned ourselves to show <strong>the</strong> very<br />
enthusiastic ones our kidneys, hearts<br />
<strong>and</strong> blood vessel <strong>in</strong> our wrists’,<br />
commented Matt Dunn. This proved<br />
to be a very engag<strong>in</strong>g demonstration<br />
when families would be guess<strong>in</strong>g <strong>the</strong><br />
fruit toge<strong>the</strong>r, <strong>and</strong> parents tell<strong>in</strong>g <strong>the</strong>ir<br />
children about <strong>the</strong>ir experience with<br />
ultrasound dur<strong>in</strong>g pregnancy.<br />
IPEM’s third <strong>of</strong>fer<strong>in</strong>g was blood<br />
pressure <strong>and</strong> pulse monitor<strong>in</strong>g. ‘My<br />
read<strong>in</strong>gs were sky high at <strong>the</strong> start<br />
due to <strong>the</strong> stress <strong>of</strong> organis<strong>in</strong>g <strong>the</strong><br />
event!’, said Matt Dunn. ‘We were a<br />
bit worried too <strong>in</strong> case some <strong>of</strong> <strong>the</strong><br />
visitors’ read<strong>in</strong>gs fell outside <strong>the</strong><br />
normal range, but fortunately that<br />
didn’t happen.’ Children approached<br />
<strong>the</strong> experience with anxiety, much<br />
giggl<strong>in</strong>g <strong>and</strong> a spirit <strong>of</strong> competition to<br />
see who had <strong>the</strong> best read<strong>in</strong>g.<br />
Volunteers agreed that although it<br />
could be tir<strong>in</strong>g to st<strong>and</strong> all day talk<strong>in</strong>g<br />
to people, when <strong>the</strong>y found someone<br />
who was genu<strong>in</strong>ely <strong>in</strong>terested <strong>in</strong> what<br />
<strong>the</strong>y were say<strong>in</strong>g it was a real joy. Matt<br />
said: ‘Many <strong>of</strong> <strong>the</strong> kids were really<br />
enthusiastic about science <strong>and</strong> it was<br />
really good to see that. We weren’t<br />
really try<strong>in</strong>g to recruit <strong>the</strong>m to be<br />
medical physicists, but just try<strong>in</strong>g to<br />
<strong>in</strong>spire <strong>the</strong>m to carry on <strong>the</strong>ir science<br />
education so that hopefully <strong>in</strong> years to<br />
come <strong>the</strong>re will be a better supply <strong>of</strong><br />
scientists contribut<strong>in</strong>g to <strong>the</strong> UK<br />
economy <strong>and</strong> society <strong>in</strong> general.’ Part<br />
II tra<strong>in</strong>ee Kirsty Hodgson commented:<br />
‘It was great to talk to so many<br />
<strong>in</strong>terest<strong>in</strong>g people, not only <strong>the</strong><br />
children <strong>and</strong> teachers, but members <strong>of</strong><br />
<strong>the</strong> Science Council, <strong>the</strong> STEM<br />
ambassador scheme <strong>and</strong> many o<strong>the</strong>rs.<br />
It will be a good experience to put <strong>in</strong>to<br />
my portfolio <strong>and</strong> it was nice to<br />
promote physics <strong>in</strong> healthcare as<br />
many people had not come across it<br />
before.’<br />
BENEFITS OF VOLUNTEERING<br />
The Big Bang Fair is delivered by over<br />
170 organisations from <strong>the</strong> public,<br />
private <strong>and</strong> voluntary sectors. Led by<br />
▼ Scann<strong>in</strong>g<br />
victims to<br />
detect<br />
‘radiation’.<br />
FEATURE | SCOPE<br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong>UK <strong>in</strong> partnership with<br />
<strong>the</strong> British Science Association, <strong>the</strong><br />
<strong>Institute</strong> <strong>of</strong> <strong>Physics</strong>, <strong>the</strong> Science<br />
Council, <strong>the</strong> Royal Academy <strong>of</strong><br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> <strong>and</strong> Young Eng<strong>in</strong>eers, <strong>the</strong><br />
event is supported by <strong>the</strong> Department<br />
for Bus<strong>in</strong>ess, Innovation <strong>and</strong> Skills as<br />
well as numerous sponsors from<br />
<strong>in</strong>dustry. IPEM has taken part <strong>in</strong> each<br />
<strong>of</strong> <strong>the</strong> 4 years <strong>the</strong> event has been<br />
staged. For more <strong>in</strong>formation see:<br />
www.<strong>the</strong>bigbangfair.co.uk.<br />
Next year’s national event will be<br />
<strong>in</strong> London on 24th–26th March <strong>and</strong><br />
IPEM will once aga<strong>in</strong> be tak<strong>in</strong>g part. If<br />
you’re passionate about your<br />
pr<strong>of</strong>ession <strong>and</strong> want to share this with<br />
young people, why not give it a go?<br />
IPEM has a range <strong>of</strong> pre-prepared<br />
activities, support<strong>in</strong>g materials for<br />
teachers, <strong>and</strong> will deal with all <strong>the</strong><br />
logistics – all we need is a little <strong>of</strong><br />
your time <strong>and</strong> enthusiasm. To f<strong>in</strong>d out<br />
more, contact outreach@ipem.ac.uk.<br />
As Evelyn Sh<strong>in</strong>, ano<strong>the</strong>r volunteer<br />
from Nott<strong>in</strong>gham University<br />
Hospitals, enthused: ‘If <strong>of</strong>fered aga<strong>in</strong>,<br />
I’d volunteer <strong>in</strong> a heartbeat. It was a<br />
really great experience.’ n<br />
ACKNOWLEDGEMENTS<br />
Thanks to <strong>the</strong> follow<strong>in</strong>g for <strong>the</strong>ir contribution<br />
to this report: Mat<strong>the</strong>w Dunn, Head <strong>of</strong><br />
Radiology <strong>Physics</strong>, Nott<strong>in</strong>gham University<br />
Hospitals NHS Trust; Evelyn Sh<strong>in</strong>, Nott<strong>in</strong>gham<br />
University Hospitals NHS Trust; Kirsty<br />
Hodgson, University Hospitals Birm<strong>in</strong>gham<br />
NHS Foundation Trust; Eva McClean,<br />
Development <strong>and</strong> Communications Manager,<br />
IPEM, <strong>and</strong> to all <strong>the</strong> o<strong>the</strong>r volunteers who<br />
helped on <strong>the</strong> st<strong>and</strong> or loaned equipment for<br />
<strong>the</strong> demonstrations.<br />
SCOPE | SEPTEMBER 2012 | 17
SCOPE | FEATURE<br />
The launch <strong>of</strong> IPEM outreach<br />
strategy to connect with students<br />
Mat<strong>the</strong>w Dunn (Nott<strong>in</strong>gham University Hospitals NHS Trust)<br />
The new IPEM outreach<br />
strategy was recently<br />
launched at <strong>the</strong><br />
communicat<strong>in</strong>g<br />
science session at<br />
MPEC 2012 <strong>in</strong> Oxford.<br />
The outreach strategy aims to help<br />
members communicate science <strong>and</strong><br />
eng<strong>in</strong>eer<strong>in</strong>g to students to encourage<br />
<strong>the</strong>m to study <strong>the</strong>se subjects fur<strong>the</strong>r.<br />
It is vital that students underst<strong>and</strong><br />
<strong>the</strong> excitement <strong>and</strong> importance <strong>of</strong><br />
science, technology <strong>and</strong> eng<strong>in</strong>eer<strong>in</strong>g<br />
<strong>in</strong> medic<strong>in</strong>e. The NHS alone is by far<br />
<strong>the</strong> largest employer <strong>of</strong> scientists <strong>in</strong><br />
<strong>the</strong> UK yet students are <strong>of</strong>ten<br />
unaware <strong>of</strong> <strong>the</strong> career opportunities<br />
<strong>in</strong> healthcare science <strong>and</strong><br />
eng<strong>in</strong>eer<strong>in</strong>g. The types <strong>of</strong> events that<br />
members currently support is widerang<strong>in</strong>g.<br />
Examples <strong>in</strong>clude:<br />
n school careers fairs,<br />
n classroom experiments <strong>and</strong><br />
demonstrations,<br />
n hospital open days,<br />
n departmental visits or tours,<br />
n teacher-focussed events.<br />
IPEM <strong>and</strong> <strong>the</strong> membership have<br />
supported 35 such events throughout<br />
2011 <strong>and</strong> 2012.<br />
Every event has a different<br />
audience so it is important that <strong>the</strong><br />
right type <strong>of</strong> activity is matched to<br />
<strong>the</strong> event <strong>in</strong> order to maximise<br />
impact. The purpose is to encourage<br />
<strong>the</strong> study <strong>of</strong> general science GCSE<br />
<strong>and</strong> A-level subjects <strong>and</strong> to <strong>in</strong>troduce<br />
<strong>the</strong> concept <strong>of</strong> scientists <strong>and</strong><br />
eng<strong>in</strong>eers work<strong>in</strong>g <strong>in</strong> medic<strong>in</strong>e.<br />
Students are generally surprised to<br />
learn that physics <strong>and</strong> eng<strong>in</strong>eer<strong>in</strong>g<br />
degrees can lead to jobs <strong>in</strong> <strong>the</strong><br />
medical <strong>in</strong>dustry <strong>and</strong> healthcare.<br />
IPEM’S OUTREACH ACTIVITIES<br />
IPEM’s outreach activities have<br />
traditionally been delivered <strong>and</strong><br />
supported by <strong>in</strong>dividual members on<br />
a local level, <strong>of</strong>ten <strong>in</strong> <strong>the</strong>ir own time.<br />
As a result efforts were <strong>of</strong>ten<br />
duplicated <strong>and</strong> experiences not<br />
shared. The impact was sometimes<br />
limited as <strong>the</strong> activities were not<br />
always targeted at <strong>the</strong> appropriate<br />
18 | SEPTEMBER 2012 | SCOPE<br />
Work<strong>in</strong>g with<br />
school children to<br />
stimulate <strong>the</strong>ir<br />
<strong>in</strong>terest can be<br />
hugely reward<strong>in</strong>g.<br />
▼<br />
“<br />
The<br />
types <strong>of</strong><br />
events that<br />
members<br />
currently<br />
support is<br />
widerang<strong>in</strong>g<br />
”<br />
group <strong>and</strong> were costly <strong>in</strong> terms <strong>of</strong><br />
time to develop <strong>and</strong> adm<strong>in</strong>ister. In<br />
<strong>the</strong> last few years more <strong>of</strong>fice support<br />
has been requested by members <strong>and</strong><br />
<strong>the</strong> result<strong>in</strong>g <strong>in</strong>crease <strong>in</strong> outreach<br />
activities requires a more strategic<br />
approach to IPEM’s outreach efforts.<br />
IPEM Council has allocated fund<strong>in</strong>g<br />
to deliver this strategy over 2 years.<br />
IPEM will also cont<strong>in</strong>ue to directly<br />
support a limited number <strong>of</strong> events<br />
such as <strong>the</strong> national Big Bang Fair<br />
(www.<strong>the</strong>bigbangfair.co.uk, see<br />
page 17).<br />
The vast majority <strong>of</strong> outreach<br />
activity is best delivered by volunteer<br />
IPEM members; however, <strong>the</strong> effort<br />
<strong>in</strong>volved <strong>in</strong> deliver<strong>in</strong>g outreach<br />
activities can be substantially<br />
reduced by hav<strong>in</strong>g a range <strong>of</strong> ‘readymade’<br />
activities <strong>and</strong> resources which<br />
can be downloaded from <strong>the</strong> website<br />
or sent out to members from <strong>the</strong><br />
<strong>of</strong>fice. When developed <strong>the</strong>se<br />
materials will allow members to<br />
concentrate on <strong>the</strong> delivery <strong>of</strong><br />
outreach.<br />
IPEM members at all stages <strong>of</strong><br />
<strong>the</strong>ir careers are encouraged to<br />
support <strong>the</strong> <strong>in</strong>itiative <strong>and</strong> get<br />
<strong>in</strong>volved <strong>in</strong> outreach activities from<br />
talk<strong>in</strong>g to students to develop<strong>in</strong>g<br />
activities or experiments. Although<br />
work<strong>in</strong>g with school children may<br />
<strong>in</strong>itially be daunt<strong>in</strong>g, most members<br />
f<strong>in</strong>d <strong>the</strong> experience hugely reward<strong>in</strong>g<br />
<strong>and</strong> also a great way <strong>of</strong> improv<strong>in</strong>g<br />
communication skills. n<br />
GET INVOLVED<br />
To f<strong>in</strong>d out more or volunteer please<br />
contact <strong>the</strong> outreach team:<br />
outreach@ipem.ac.uk
2011 AAPM–IPEM MEDICAL PHYSICS<br />
TRAVEL GRANT REPORT<br />
JUN DENG Yale New Haven Hospital, New Haven, CT, USA<br />
I<br />
n April 2012 I visited <strong>the</strong> UK<br />
after receiv<strong>in</strong>g an<br />
AAPM–IPEM Medical<br />
<strong>Physics</strong> Travel Grant. Here I<br />
outl<strong>in</strong>e my experiences at<br />
each <strong>of</strong> <strong>the</strong> centres that I went<br />
to <strong>and</strong> <strong>the</strong> people that I met.<br />
16TH APRIL: CASTLE<br />
HILL HOSPITAL<br />
After a long tra<strong>in</strong> ride from London to<br />
Hull, I f<strong>in</strong>ally arrived at <strong>the</strong> Castle<br />
Hill Hospital where Dr Andy Beavis,<br />
Head <strong>of</strong> <strong>the</strong> Radiation <strong>Physics</strong><br />
Department, was <strong>the</strong> host for my first<br />
stop dur<strong>in</strong>g this trip to <strong>the</strong> UK. My<br />
visit started with a tour <strong>of</strong> <strong>the</strong><br />
department led by Dr Beavis. The<br />
whole oncology centre is very new<br />
with eco- <strong>and</strong> patient-friendly designs<br />
everywhere, which to me makes it<br />
seem ra<strong>the</strong>r more like a hotel than a<br />
cancer centre for radio<strong>the</strong>rapy. Then I<br />
gave a lecture talk<strong>in</strong>g about <strong>the</strong><br />
kVCBCT imag<strong>in</strong>g doses <strong>and</strong> <strong>the</strong><br />
associated cancer risks, after which<br />
we had a round-table meet<strong>in</strong>g for<br />
physics staff so that everyone could<br />
get <strong>in</strong>volved <strong>in</strong> a more <strong>in</strong>teractive<br />
discussion. The primary concerns<br />
were about <strong>the</strong> imag<strong>in</strong>g doses <strong>and</strong><br />
why CT manufacturers did a better<br />
job than <strong>the</strong> l<strong>in</strong>ac manufacturers for<br />
CBCT <strong>in</strong> terms <strong>of</strong> imag<strong>in</strong>g dose<br />
reduction, protocol optimisation <strong>and</strong><br />
patient safety. I also learnt that a<br />
virtual CT reconstructor has been<br />
developed by this group so that<br />
virtual CT scans can be simulated to<br />
study <strong>the</strong> correlation between <strong>the</strong><br />
imag<strong>in</strong>g doses <strong>and</strong> <strong>the</strong> image quality<br />
without actually perform<strong>in</strong>g a scan<br />
on a patient. I was very <strong>in</strong>terested <strong>in</strong><br />
this project <strong>and</strong> <strong>in</strong>dicated that our<br />
group was develop<strong>in</strong>g a similar tool<br />
dedicated to CBCT virtual simulation<br />
<strong>and</strong> reconstruction. F<strong>in</strong>ally, I was<br />
lucky enough to experience a state-<strong>of</strong><strong>the</strong>-art<br />
technology named VERT<br />
developed <strong>and</strong> co-founded by Dr<br />
Beavis. VERT (virtual environment<br />
for radio<strong>the</strong>rapy <strong>and</strong> tra<strong>in</strong><strong>in</strong>g) is a<br />
l<strong>in</strong>ac simulator set <strong>in</strong> a 3D virtual<br />
environment, which can help users<br />
tra<strong>in</strong> with full access to <strong>the</strong> l<strong>in</strong>ac<br />
functionality without <strong>in</strong>terfer<strong>in</strong>g with<br />
<strong>the</strong> cl<strong>in</strong>ical workflow. We actually<br />
took a picture as shown <strong>in</strong> figure 1<br />
with VERT displayed <strong>in</strong> <strong>the</strong><br />
background.<br />
FIGURE 1.<br />
Dr Andy Beavis<br />
<strong>and</strong> Jun at<br />
Castle Hill<br />
Hospital.<br />
▼<br />
TRAVEL AWARD | SCOPE<br />
17TH APRIL: CLATTERBRIDGE<br />
CENTRE FOR ONCOLOGY<br />
The follow<strong>in</strong>g day I visited <strong>the</strong><br />
Clatterbridge Centre for Oncology<br />
where Dr Alan Nahum was my<br />
host. We actually started our<br />
conversion with our fond memories<br />
<strong>of</strong> <strong>the</strong> past. I was fasc<strong>in</strong>ated by all<br />
sorts <strong>of</strong> legendary stories told by<br />
Alan about our common friends.<br />
Alan’s postdoc Dr Julien Uzan gave<br />
me a brief <strong>in</strong>troduction to <strong>the</strong>ir latest<br />
research tool called Biosuite, aim<strong>in</strong>g<br />
to facilitate biologically based<br />
treatment plann<strong>in</strong>g <strong>and</strong><br />
optimisation. The s<strong>of</strong>tware analysed<br />
<strong>the</strong> DVH data exported from<br />
conventional treatment plann<strong>in</strong>g<br />
systems <strong>and</strong> computed TCP <strong>and</strong><br />
NTCP based on published Marsden<br />
<strong>and</strong> LKB models. In addition, <strong>the</strong><br />
s<strong>of</strong>tware was able to optimise <strong>the</strong><br />
plan with a fixed NTCP value, <strong>the</strong><br />
so-called isotoxic plann<strong>in</strong>g scheme,<br />
<strong>and</strong> generate a series <strong>of</strong> plans with<br />
different TCP values correspond<strong>in</strong>g<br />
to different fractionations. Later on,<br />
I gave a lecture on kVCBCT <strong>and</strong> was<br />
engaged <strong>in</strong> a very <strong>in</strong>teractive<br />
discussion with dozens <strong>of</strong> physicists<br />
<strong>and</strong> research staff. I enjoyed some<br />
tough questions raised by Alan <strong>and</strong><br />
Dr Ge<strong>of</strong>f Lawrence. F<strong>in</strong>ally, I was<br />
k<strong>in</strong>dly given a tour <strong>of</strong> <strong>the</strong> only<br />
proton radio<strong>the</strong>rapy facility <strong>in</strong> <strong>the</strong><br />
UK, Douglas Cyclotron (figure 2), by<br />
Dr Andrzej Kacperek. It produced a<br />
s<strong>in</strong>gle energy <strong>of</strong> 62 MeV proton<br />
beams dedicated to radio<strong>the</strong>rapy <strong>of</strong><br />
eye tumours due to its limited<br />
treatment depth <strong>in</strong> tissue <strong>of</strong> 3 cm.<br />
The highly acclaimed<br />
pr<strong>of</strong>essionalism <strong>and</strong> rigorous efforts<br />
to quality control <strong>the</strong> cl<strong>in</strong>ical<br />
practices at every step made it a<br />
highly successful facility, which<br />
treated one-third <strong>of</strong> eye patients <strong>in</strong><br />
<strong>the</strong> UK <strong>and</strong> dozens <strong>of</strong> patients<br />
across <strong>the</strong> world. It was a busy day<br />
for me. In fact, I was so <strong>in</strong>volved<br />
with <strong>the</strong> <strong>in</strong>tensive discussions that I<br />
forgot my room number when I got<br />
back to my hotel. Luckily I did not<br />
forget which hotel I was stay<strong>in</strong>g <strong>in</strong>!<br />
▼<br />
SCOPE | SEPTEMBER 2012 | 19
▼<br />
SCOPE | TRAVEL AWARD<br />
20 | SEPTEMBER 2012 | SCOPE<br />
FIGURE 2.<br />
Dr Andrzej<br />
Kacperek, Dr<br />
Alan Nahum <strong>and</strong><br />
Jun at<br />
Clatterbridge<br />
Centre for<br />
Oncology.<br />
▼<br />
FIGURE 3.<br />
Dr Jonathan<br />
Sykes, Dr Vivian<br />
Consgrove <strong>and</strong><br />
Jun at St James's<br />
<strong>Institute</strong> for<br />
Oncology.<br />
▼<br />
FIGURE 4.<br />
Jun, Dr Jim<br />
Warr<strong>in</strong>gton, Dr<br />
Margaret<br />
Bidmead, Dr<br />
Ellen Donovan<br />
<strong>and</strong> Dr Phil Evans<br />
at Royal Marsden<br />
Hospital.<br />
▼<br />
FIGURE 5.<br />
Dr Elizabeth<br />
Macaulay <strong>and</strong><br />
Jun at Churchill<br />
Hospital.<br />
▼<br />
18TH APRIL: ST JAMES’S<br />
INSTITUTE FOR ONCOLOGY<br />
My third visit took place at St James’s<br />
<strong>Institute</strong> for Oncology <strong>in</strong> Leeds where<br />
Dr Vivian Consgrove, Head <strong>of</strong><br />
Radio<strong>the</strong>rapy <strong>Physics</strong>, was my host<br />
(figure 3). The centre has ten <strong>Elekta</strong><br />
l<strong>in</strong>acs for cl<strong>in</strong>ical treatments <strong>and</strong> two<br />
for research. With about 6,500 patients<br />
treated annually, it is quite a challenge<br />
to manage <strong>the</strong> whole cl<strong>in</strong>ical workflow<br />
seamlessly without errors. I noticed<br />
three major factors contribut<strong>in</strong>g to <strong>the</strong>ir<br />
high efficiency: (1) a well thought-out<br />
design <strong>of</strong> <strong>the</strong> cl<strong>in</strong>ic such that patients<br />
received pr<strong>of</strong>essional care from a<br />
dedicated group <strong>of</strong> cl<strong>in</strong>icians while<br />
ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g a high degree <strong>of</strong> privacy;<br />
(2) a clear structure <strong>of</strong> management <strong>and</strong><br />
easy-to-follow guidel<strong>in</strong>es <strong>and</strong> policies,<br />
<strong>and</strong> (3) all <strong>the</strong> photon beams are<br />
matched throughout <strong>the</strong> department.<br />
Later on, I gave a lecture on imag<strong>in</strong>g<br />
doses from kVCBCT <strong>and</strong> <strong>the</strong>ir<br />
associated cancer risks. Although my<br />
study <strong>in</strong>dicated large imag<strong>in</strong>g doses<br />
from CBCT procedures, I emphasised<br />
more than once that people should not<br />
be scared by <strong>the</strong> potential cancer risks<br />
associated with <strong>the</strong> medical imag<strong>in</strong>g<br />
procedures as long as those procedures<br />
are adm<strong>in</strong>istrated <strong>in</strong> a prudent way <strong>and</strong><br />
are cl<strong>in</strong>ically justified. The risk <strong>of</strong> not<br />
hav<strong>in</strong>g those procedures done would<br />
be much greater for most <strong>of</strong> <strong>the</strong> cancer<br />
patients. Dr Jonathan Sykes, one <strong>of</strong> <strong>the</strong><br />
physicists do<strong>in</strong>g research work on IGRT<br />
<strong>and</strong> kVCBCT, exchanged his ideas with<br />
me on how to correlate CBCT with CT<br />
as plann<strong>in</strong>g CT has always been<br />
considered as reference to <strong>the</strong> CBCT<br />
images <strong>in</strong> determ<strong>in</strong><strong>in</strong>g <strong>the</strong> shifts. I<br />
po<strong>in</strong>ted out that ano<strong>the</strong>r possible<br />
approach would be to use onl<strong>in</strong>e CBCT<br />
image datasets as <strong>the</strong> reference <strong>in</strong>stead<br />
<strong>of</strong> plann<strong>in</strong>g CT as long as <strong>the</strong><br />
Hounsfield number <strong>in</strong> CBCT images is<br />
accurately determ<strong>in</strong>ed.<br />
19TH APRIL: ROYAL<br />
MARSDEN HOSPITAL<br />
I visited Royal Marsden Hospital<br />
(RMH) <strong>in</strong> Sutton <strong>the</strong> next day. My host<br />
was Dr Phil Evans, Head <strong>of</strong> <strong>the</strong><br />
Radiation <strong>Physics</strong> Department, who<br />
gave me a detailed <strong>in</strong>troduction to <strong>the</strong><br />
organisation <strong>of</strong> RMH (figure 4). He<br />
showed me a copy <strong>of</strong> <strong>the</strong> RMH’s 2010<br />
annual report <strong>and</strong> discussed some <strong>of</strong><br />
<strong>the</strong> fasc<strong>in</strong>at<strong>in</strong>g projects that were<br />
conducted dur<strong>in</strong>g 2010. I delivered my<br />
oral presentation to a large audience<br />
<strong>in</strong>clud<strong>in</strong>g <strong>the</strong> staff members from <strong>the</strong><br />
Chelsea site. My lecture generated quite<br />
a few questions regard<strong>in</strong>g <strong>the</strong> CBCT
applications <strong>in</strong> <strong>the</strong> cl<strong>in</strong>ic. I also<br />
emphasised <strong>in</strong> my talk that prudent<br />
medical imag<strong>in</strong>g procedures always<br />
outweighed <strong>the</strong> potential cancer risks,<br />
because miss<strong>in</strong>g <strong>the</strong> tumour target<br />
would lead to greater cancer risks <strong>in</strong><br />
<strong>the</strong> future if necessary medical imag<strong>in</strong>g<br />
procedures were not performed. Later<br />
on I had <strong>the</strong> opportunity to have a oneon-one<br />
discussion with some <strong>of</strong> <strong>the</strong><br />
research fellows, postdocs <strong>and</strong> PhD<br />
students at RMH. The topics were very<br />
<strong>in</strong>terest<strong>in</strong>g <strong>and</strong> significant, cover<strong>in</strong>g<br />
imag<strong>in</strong>g dose, toxicity <strong>and</strong> marg<strong>in</strong><br />
reduction correlations <strong>in</strong> breast cancer<br />
radio<strong>the</strong>rapy with CBCT, patient<br />
fatigue study <strong>in</strong> IMRT treatments <strong>of</strong><br />
head <strong>and</strong> neck cancer, a CT x-ray<br />
energy spectrum simulator, breast<br />
tissue segmentation for better <strong>and</strong><br />
more accurate contour<strong>in</strong>g <strong>and</strong> dose<br />
pa<strong>in</strong>t<strong>in</strong>g, dynamic leaf track<strong>in</strong>g for<br />
<strong>Elekta</strong> MLC, as well as a new CMOS<br />
technology developed to replace<br />
current EPID for better <strong>and</strong> quicker<br />
responses to high-dose radiation. I had<br />
a pleasant <strong>and</strong> <strong>in</strong>-depth discussion<br />
with each one <strong>of</strong> <strong>the</strong>m <strong>and</strong> caught a<br />
glimpse <strong>of</strong> what was go<strong>in</strong>g on <strong>in</strong> each<br />
project. In fact, it was an unforgettable<br />
experience for me as I was exposed to<br />
so many different projects with<strong>in</strong> such<br />
a short period <strong>of</strong> time.<br />
20TH APRIL: CHURCHILL<br />
HOSPITAL<br />
My last stop was <strong>the</strong> Churchill<br />
Hospital <strong>in</strong> Oxford, a beautiful college<br />
town <strong>and</strong> host to <strong>the</strong> University <strong>of</strong><br />
Oxford. Dr Elizabeth Macaulay, Head<br />
<strong>of</strong> Radiation <strong>Physics</strong>, was my host <strong>in</strong><br />
this visit <strong>and</strong> gave me a quick tour <strong>of</strong><br />
<strong>the</strong> facility (figure 5). My talk on<br />
kVCBCT was well received <strong>and</strong><br />
generated a lot <strong>of</strong> discussions on<br />
CBCT applications <strong>and</strong> imag<strong>in</strong>g<br />
doses. Three research scientists from<br />
diagnostic imag<strong>in</strong>g rema<strong>in</strong>ed after my<br />
talk <strong>and</strong> we had fur<strong>the</strong>r discussions<br />
on <strong>the</strong> status <strong>and</strong> future directions <strong>of</strong><br />
CBCT as compared to <strong>the</strong> CT<br />
technology. I acknowledged that our<br />
current CBCT technology was still not<br />
mature yet, <strong>and</strong> more research work<br />
would be needed from both academia<br />
<strong>and</strong> <strong>in</strong>dustry to fur<strong>the</strong>r improve it to<br />
be more efficient <strong>and</strong> safer for <strong>the</strong><br />
patients. As our colleagues <strong>in</strong> CT are<br />
I had a<br />
pleasant<br />
<strong>and</strong> <strong>in</strong>depth<br />
discussion<br />
with each<br />
one <strong>of</strong><br />
<strong>the</strong>m<br />
“<br />
”<br />
TRAVEL AWARD | SCOPE<br />
do<strong>in</strong>g everyth<strong>in</strong>g <strong>the</strong>y can to optimise<br />
<strong>the</strong> scan protocol <strong>and</strong> reduce <strong>the</strong> dose<br />
to patients, we should also be engaged<br />
<strong>in</strong> efforts to optimise our cl<strong>in</strong>ical<br />
rout<strong>in</strong>es so that low-dose CBCT can be<br />
adm<strong>in</strong>istered to patients <strong>in</strong> an optimal<br />
<strong>and</strong> <strong>in</strong>dividual way.<br />
This concluded my 10-day visit to<br />
five great <strong>in</strong>stitutions <strong>in</strong> <strong>the</strong> UK.<br />
Dur<strong>in</strong>g this trip, I not only met many<br />
wonderful colleagues <strong>in</strong> <strong>the</strong> UK <strong>and</strong><br />
learnt a lot about <strong>the</strong>ir research<br />
projects <strong>and</strong> cl<strong>in</strong>ical practices, but also<br />
shared my experiences with <strong>the</strong>m on<br />
some mutually <strong>in</strong>terest<strong>in</strong>g topics,<br />
which was <strong>in</strong>deed an <strong>in</strong>valuable<br />
experience to me <strong>and</strong> my future career<br />
development. I would like to take this<br />
opportunity to express my s<strong>in</strong>cere<br />
gratitude to Drs Andy Beavis, Alan<br />
Nahum, Vivian Consgrove, Phil Evans<br />
<strong>and</strong> Elizabeth Macaulay for <strong>the</strong>ir<br />
valuable time <strong>and</strong> genu<strong>in</strong>e hospitality.<br />
F<strong>in</strong>ally, I’d like to thank both AAPM<br />
<strong>and</strong> IPEM for this wonderful travel<br />
grant that allowed me to visit <strong>the</strong> UK<br />
<strong>and</strong> exchange ideas <strong>and</strong> share my<br />
research work with my fellow<br />
physicists <strong>in</strong> <strong>the</strong> UK.<br />
SCOPE | SEPTEMBER 2012 | 21
Austrian Medical Center Upgrades Cancer Treatment System to Accelerate<br />
Patient Care with <strong>Elekta</strong>’s Ultra-fast Agility Austrian<br />
ustrian Medical Center Upg<br />
rades Cancer T<br />
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patients<br />
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li lity-equipped<br />
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treat<br />
m ment<br />
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patients<br />
per<br />
day.<br />
.<br />
An<br />
MLC,<br />
a device<br />
m ade u up<br />
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numerous,<br />
<strong>in</strong>dividua<br />
l t tungsten<br />
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Us<strong>in</strong><br />
g 160 hig high-resolution<br />
leav<br />
ves,<br />
Agility<br />
precise<br />
l ly<br />
sculpts<br />
delivered<br />
radiation<br />
t o t <strong>the</strong><br />
dist<strong>in</strong>ctive<br />
contours<br />
<strong>of</strong><br />
<strong>the</strong><br />
tumo<br />
r r,<br />
while<br />
reduc<strong>in</strong>g<br />
exposure<br />
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tissues.<br />
Beam-shap<strong>in</strong>g<br />
spee<br />
d i is<br />
provided<br />
by<br />
<strong>the</strong><br />
MLC’<br />
s ultra-fas<br />
t le leaf<br />
movements<br />
– twice<br />
as<br />
fast<br />
as<br />
oth<br />
er ML MLCs<br />
commonly<br />
used<br />
<strong>in</strong> th<br />
e <strong>in</strong> <strong>in</strong>dustry<br />
–<br />
enabl<strong>in</strong>g<br />
physicians<br />
t<strong>of</strong>u<br />
o fur<strong>the</strong>r<br />
exploit<br />
th<br />
h e most<br />
t ad<br />
vanced<br />
d c<br />
a ancer<br />
th<br />
h erapies<br />
ies<br />
such<br />
as<br />
stereotact<br />
ic radios radiosurgery<br />
(SRS),<br />
stereotact<br />
ic radi radiation<br />
<strong>the</strong>rapy<br />
(SRTT)<br />
<strong>and</strong>Voo<br />
lumetr<br />
ic M Modulated<br />
Arc<br />
Therapy<br />
(VMATT).<br />
Fur<strong>the</strong>r,<br />
with<br />
a ne<br />
w lo lower<br />
radiation<br />
transmission<br />
desig n, r research<br />
has<br />
shown<br />
Agility<br />
can<br />
sig nific nificantly<br />
r<br />
e<br />
d<br />
uce t<br />
h<br />
e p<br />
a<br />
t<br />
ien<br />
t<br />
’ s n<br />
o<br />
on-t<br />
n-t h<br />
era<br />
p<br />
eu<br />
t<br />
ic<br />
radiation<br />
exposure<br />
a s co compared<br />
to<br />
1<br />
o<strong>the</strong>r<br />
conventiona<br />
l ML MLC’<br />
s.<br />
<strong>Experience</strong> <strong>the</strong> <strong>Elekta</strong> lekta <strong>Differ</strong>ence <strong>Differ</strong> <strong>Differ</strong>e ence<br />
Speed with Precision Pr Precision<br />
Base<br />
d o on<br />
<strong>the</strong>ir<br />
experience,<br />
cl<strong>in</strong>ician<br />
n s<br />
at<br />
th<br />
e Sa Salzburg<br />
center<br />
report<br />
that<br />
th<br />
h e<br />
Agilit<br />
y ML MLC’<br />
s new<br />
design<br />
provides<br />
<strong>the</strong>m<br />
n o ot<br />
only<br />
with<br />
additional<br />
speed<br />
d ,<br />
but<br />
als<br />
o m more<br />
precise<br />
dose<br />
sculpt<strong>in</strong>g<br />
g<br />
capabi<br />
li lities<br />
<strong>and</strong><br />
remarkably<br />
lower<br />
non-th<br />
era erapeutic<br />
radiation<br />
dose<br />
de<br />
li<br />
v<br />
er<br />
e<br />
e<br />
d t<br />
o t<br />
h<br />
e p<br />
a<br />
t<br />
ien<br />
t.<br />
“ Look<br />
<strong>in</strong> <strong>in</strong>g<br />
closely<br />
at<br />
several<br />
cancer<br />
cas<br />
es, w we’<br />
ve<br />
calculated<br />
a measurable<br />
le<br />
improvement<br />
<strong>in</strong> dose<br />
shap<strong>in</strong>g<br />
preci<br />
sio sion<br />
with<br />
Agility’ss<br />
high<br />
resolut<br />
io ion,<br />
five<br />
millimeter<br />
leavv<br />
es, ”<br />
say<br />
ys Fe<br />
lix S Sedlmayy<br />
er,<br />
M.D.,<br />
Pr<strong>of</strong>eesso<br />
o r<br />
<strong>and</strong><br />
Chairman,<br />
Department<br />
<strong>of</strong><br />
Radiot<br />
h herapy<br />
<strong>and</strong><br />
Radio-Oncology,<br />
,<br />
SALK a<br />
nd<br />
Paracelsus<br />
Medical<br />
Universi<br />
si ty.<br />
. “ This<br />
greater<br />
precision<br />
improves<br />
our<br />
ability<br />
to<br />
foo<br />
cus<br />
radiat<br />
io ion<br />
to<br />
<strong>the</strong><br />
t um umor,<br />
while<br />
strictly<br />
limit<strong>in</strong>g<br />
expos<br />
ur ure<br />
to<br />
surround<strong>in</strong>g<br />
critical<br />
struct<br />
ur ures.<br />
”<br />
“ Wee<br />
w er ere<br />
astonished<br />
at<br />
<strong>the</strong><br />
amount<br />
<strong>of</strong><br />
heal<br />
t thy<br />
tissue<br />
dose<br />
reduction<br />
we<br />
cou<br />
ld ac<br />
hie<br />
ve,<br />
” h<br />
e add<br />
s. “<br />
Thi<br />
s cap<br />
aci acity<br />
<strong>the</strong>oretically<br />
enables<br />
us<br />
to<br />
improve<br />
outco<br />
m mes<br />
<strong>and</strong><br />
reduce<br />
<strong>the</strong><br />
potential<br />
ffo<br />
or<br />
comp<br />
lic lications.<br />
”<br />
Harness<strong>in</strong>g<br />
Agility’s<br />
s unique<br />
ability<br />
to<br />
deli<br />
v ver<br />
high-resolution<br />
beam<br />
shap<strong>in</strong><br />
g o over<br />
a large<br />
40cm x 40cm<br />
field,<br />
t h he<br />
medical<br />
center<br />
has<br />
used<br />
t hi his<br />
n<br />
e<br />
w t<br />
e<br />
c<br />
chn<br />
hn o<br />
log<br />
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l<br />
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y a<br />
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l<br />
l<br />
<strong>in</strong>dicatio<br />
io ns,<br />
<strong>in</strong>clud<strong>in</strong>g<br />
stereotactic<br />
(SBRT<br />
T/ T/SRTT)<br />
cases<br />
<strong>and</strong><br />
o<strong>the</strong>r<br />
advan<br />
ce ced<br />
IMRT T t <strong>the</strong>rapies.<br />
WWorld’s<br />
orld’<br />
s F FFirst<br />
irst<br />
FField<br />
ield Upgrade Upg rade to Agility<br />
TTakes<br />
ak es Only Two T Two<br />
Weeks<br />
Whi<br />
le t <strong>the</strong><br />
cl<strong>in</strong>ical<br />
perfoo<br />
rmance<br />
<strong>of</strong><br />
Agilit<br />
y i is<br />
now<br />
fo oremost<br />
<strong>in</strong> <strong>the</strong><br />
m<strong>in</strong> d ds<br />
<strong>of</strong><br />
th<br />
e Sa Salzburg<br />
physicians<br />
<strong>and</strong><br />
physici<br />
s sts,<br />
<strong>the</strong><br />
speed<br />
<strong>of</strong><br />
<strong>the</strong><br />
Agility<br />
upg<br />
rade a also<br />
made<br />
an<br />
impression.<br />
“ Our<br />
ma<strong>in</strong><br />
<strong>in</strong>teres<br />
t wa was<br />
<strong>in</strong> limit<strong>in</strong>g<br />
downtime,<br />
s<strong>in</strong>ce<br />
w e a are<br />
operat<strong>in</strong>g<br />
only<br />
three<br />
l<strong>in</strong>acs<br />
an<br />
d co could<br />
hardly<br />
compensate<br />
foo<br />
r on<br />
e l<strong>in</strong> l<strong>in</strong>ac<br />
be<strong>in</strong>g<br />
down<br />
foo<br />
r a long<br />
per<br />
io iod<br />
<strong>of</strong><br />
time,<br />
” says<br />
Peter<br />
Kopp,<br />
Ph.D.,<br />
D ep eputy<br />
Head<br />
<strong>of</strong><br />
Medical<br />
<strong>Physics</strong>.<br />
“ Tw w wo<br />
weeks<br />
seemed<br />
extremely<br />
ambitiou<br />
s t to<br />
accomplish<br />
a<br />
co<br />
m<br />
p<br />
let<br />
e swa<br />
p o<br />
u<br />
t o<br />
f f t<br />
t<br />
h<br />
e ML<br />
C h<br />
e<br />
ad<br />
s<br />
<strong>and</strong><br />
to<br />
perfoo<br />
rm<br />
th<br />
e m measurements.<br />
But<br />
we<br />
all<br />
worked<br />
t og oge<strong>the</strong>r<br />
– <strong>the</strong><br />
Elektt<br />
a personnel,<br />
o ur lo local<br />
service<br />
eng<strong>in</strong>eer,<br />
Georg<br />
Schr<br />
ö öcker,<br />
<strong>in</strong><br />
addition<br />
to<br />
<strong>the</strong><br />
medical<br />
center<br />
physics<br />
staff<br />
<strong>and</strong><br />
IT eng<strong>in</strong>eer<br />
s – t to<br />
makee<br />
it<br />
a success.<br />
”<br />
Agility is <strong>of</strong>fer ed <strong>in</strong> ne new<br />
systems or<br />
as an upg rade to exist<strong>in</strong>g tr treatment<br />
systems. For<br />
more<br />
<strong>in</strong>formation,<br />
visit<br />
www.elekta.com/agility<br />
www .elekta.com/agility<br />
*Agility *Agg<br />
ility<br />
iis<br />
s not<br />
licensed<br />
for foo<br />
r sale s<br />
ale<br />
<strong>in</strong><br />
all<br />
markets.<br />
Approval Apppp<br />
roval<strong>of</strong><br />
<strong>of</strong> f i<strong>in</strong>dications<br />
ndications<br />
may<br />
ay<br />
vary<br />
y between<br />
different diffffe<br />
ereent<br />
ccountries.<br />
ountries.<br />
AAdditional<br />
dditio<br />
o nalre<br />
regulatory egg<br />
ulatory<br />
y<br />
clearances cleara<br />
ances<br />
may<br />
y bbe<br />
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d i<strong>in</strong><br />
n ssome<br />
ome<br />
ma markets rkkets<br />
1 Cosgrove, Cosgg<br />
rove,<br />
VP,<br />
, ThThompson,<br />
omp<br />
pson,<br />
n, C, Chrisophides, Ch<br />
risopp<br />
hides,<br />
D<br />
et<br />
aal.<br />
l. (2009) Physical Phy<br />
ysical<br />
ccharacterization<br />
hara<br />
a acterization<strong>of</strong><br />
<strong>of</strong> f a new<br />
concept concep<br />
pt<br />
design dess<br />
igg<br />
n<strong>of</strong> <strong>of</strong> f aan<br />
n E<strong>Elekta</strong><br />
lekta<br />
a R<br />
Radiation adiationHe<br />
Head ead<br />
with<br />
<strong>in</strong>tegrated <strong>in</strong>tegg<br />
raa<br />
ted<br />
160-l 160-leaf eaf<br />
f multi-leaf multi-leaff<br />
ccollimator.<br />
ollimator.<br />
.<br />
PPoster<br />
oster<br />
ppresented<br />
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ented<br />
aat<br />
t AASTRO<br />
STR<br />
O 2009.<br />
4513 371 1012 08:12
FIGURE 1.<br />
A slide from<br />
David Willis’ talk.<br />
▼<br />
MEETING REPORTS | SCOPE<br />
BESPOKE SOFTWARE IN MEDICAL PHYSICS<br />
AND CLINICAL ENGINEERING CONFERENCE<br />
ANDREW ROBINSON The Harley Street Cl<strong>in</strong>ic, London<br />
UCLH INSTITUTE FOR CHILD HEALTH 28th May 2012<br />
IT WAS A WONDERFULLY SUNNY DAY IN MAY<br />
when nearly 90 delegates descended on London for this<br />
conference organised by IPEM’s Informatics <strong>and</strong><br />
Comput<strong>in</strong>g Special Interest Group (ICSIG). The Special<br />
Interest Group was keen to highlight <strong>the</strong> key work that<br />
is performed by medical physicists <strong>and</strong> cl<strong>in</strong>ical<br />
eng<strong>in</strong>eers <strong>in</strong> design<strong>in</strong>g, develop<strong>in</strong>g <strong>and</strong> ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g<br />
bespoke s<strong>of</strong>tware that is used <strong>in</strong> <strong>the</strong>ir departments.<br />
Presentations on a variety <strong>of</strong> applications across all<br />
medical physics <strong>and</strong> cl<strong>in</strong>ical eng<strong>in</strong>eer<strong>in</strong>g specialities<br />
were delivered, as well as a large collection <strong>of</strong> scientific<br />
posters that delegates could peruse at <strong>the</strong>ir leisure<br />
dur<strong>in</strong>g <strong>the</strong> breaks.<br />
PRESENTATIONS<br />
David Willis (Norfolk <strong>and</strong> Norwich University<br />
Hospital, Norwich) opened <strong>the</strong> conference with an<br />
<strong>in</strong>formative presentation entitled ‘Bespoke s<strong>of</strong>tware:<br />
concept to cl<strong>in</strong>ical’, where he went through his<br />
experience <strong>of</strong> s<strong>of</strong>tware development from a<br />
commercial, research <strong>and</strong> cl<strong>in</strong>ical perspective (figure 1).<br />
His presentation summed up <strong>the</strong> role <strong>of</strong> <strong>the</strong> bespoke<br />
s<strong>of</strong>tware/<strong>in</strong>-house developer well. He also hit <strong>the</strong> nail<br />
on <strong>the</strong> head with <strong>the</strong> <strong>of</strong>ten found problem <strong>in</strong><br />
departments that rely on one or two people to make<br />
bespoke s<strong>of</strong>tware: ‘Couldn’t write<br />
us a program to do that?’, a statement that may<br />
resonate with some readers! It was also <strong>in</strong>terest<strong>in</strong>g to<br />
hear about some <strong>of</strong> <strong>the</strong> radio<strong>the</strong>rapy-related s<strong>of</strong>tware<br />
that he has developed, <strong>in</strong>clud<strong>in</strong>g s<strong>of</strong>tware to perform<br />
transit EPID dosimetry, an area where <strong>the</strong>re are few<br />
commercial alternatives.<br />
A highly enjoyable talk was given by <strong>the</strong><br />
conference’s <strong>in</strong>vited speaker Ian Wells (University <strong>of</strong><br />
Surrey, Guildford). In his talk ‘In-house s<strong>of</strong>tware<br />
development: a retrospective view’, he gave an<br />
overview <strong>of</strong> how comput<strong>in</strong>g had changed dur<strong>in</strong>g his<br />
career, as well as highlight<strong>in</strong>g <strong>the</strong> importance <strong>of</strong><br />
ensur<strong>in</strong>g that s<strong>of</strong>tware meets appropriate st<strong>and</strong>ards<br />
from both a patient safety <strong>and</strong> pr<strong>of</strong>essional po<strong>in</strong>t <strong>of</strong><br />
view. He had four questions for <strong>in</strong>-house s<strong>of</strong>tware<br />
developers to take away with <strong>the</strong>m: is your s<strong>of</strong>tware<br />
durable? Are your systems safe? Is your methodology<br />
appropriate? Are your qualifications suitable, <strong>and</strong> does<br />
SCOPE | SEPTEMBER 2012 | 23<br />
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24 | SEPTEMBER 2012 | SCOPE<br />
FIGURE 2.<br />
A slide from Ian<br />
Well’s talks.<br />
▼<br />
FIGURE 3.<br />
Overview slide for<br />
Ed McDonagh <strong>and</strong><br />
Laurence K<strong>in</strong>g’s<br />
presentation.<br />
▼
FIGURE 4.<br />
Delegates<br />
enjoy<strong>in</strong>g a c<strong>of</strong>fee<br />
break.<br />
▼<br />
this really matter? Pr<strong>of</strong>essor Wells also talked about <strong>the</strong><br />
use <strong>of</strong> s<strong>of</strong>tware as a medical device <strong>and</strong> <strong>the</strong> importance<br />
<strong>of</strong> know<strong>in</strong>g what any s<strong>of</strong>tware that you develop will be<br />
used for once you have released it, cit<strong>in</strong>g an example<br />
where he was asked to be an expert witness <strong>in</strong> a<br />
crim<strong>in</strong>al trial follow<strong>in</strong>g <strong>the</strong> analysis <strong>of</strong> data us<strong>in</strong>g<br />
s<strong>of</strong>tware that he had developed (figure 2).<br />
By far <strong>the</strong> most animated presentation <strong>of</strong> <strong>the</strong> day<br />
was by Ed McDonagh <strong>and</strong> Laurence K<strong>in</strong>g (Royal<br />
Marsden Hospital, London), whose presentation<br />
dazzled <strong>the</strong> audience with <strong>the</strong>ir work on automat<strong>in</strong>g<br />
dose audits <strong>in</strong> diagnostic radiology through a variety<br />
<strong>of</strong> techniques, <strong>in</strong>clud<strong>in</strong>g optical character recognition<br />
s<strong>of</strong>tware (figure 3). As dose audits can be particularly<br />
time consum<strong>in</strong>g <strong>and</strong> span multiple equipment<br />
manufacturers, <strong>the</strong>ir work to automate this process<br />
across multiple manufacturers has a significant impact<br />
on reduc<strong>in</strong>g <strong>the</strong>ir workload, <strong>and</strong> is someth<strong>in</strong>g that<br />
o<strong>the</strong>r centres may wish to look <strong>in</strong>to.<br />
There were a couple <strong>of</strong> talks from scientists Marc<br />
White (National Hospital for Neurology <strong>and</strong><br />
Neurosurgery, London) <strong>and</strong> Peter Wright (University<br />
Hospital <strong>of</strong> North Staffordshire, Stoke on Trent) about<br />
applications <strong>of</strong> bespoke s<strong>of</strong>tware <strong>in</strong> MRI. One th<strong>in</strong>g<br />
that I learned was how vast <strong>the</strong> DICOM st<strong>and</strong>ard<br />
actually is, <strong>and</strong> that it even has a ‘tag’ for how many<br />
legs a patient has. An <strong>in</strong>terest<strong>in</strong>g po<strong>in</strong>t that was<br />
discussed dur<strong>in</strong>g <strong>the</strong> MRI talks was that QA <strong>of</strong><br />
MEETING REPORTS | SCOPE<br />
diffusion techniques <strong>in</strong> MRI will be <strong>of</strong> vast importance<br />
soon as neurosurgeons heavily rely on <strong>the</strong> <strong>in</strong>formation<br />
yielded by this type <strong>of</strong> scan.<br />
At lunchtime delegates took <strong>the</strong> opportunity to look<br />
at <strong>the</strong> large collection <strong>of</strong> posters that were on show, as<br />
well as speak with <strong>the</strong> authors about <strong>the</strong> work on<br />
display. One author even bought an <strong>in</strong>teractive<br />
demonstration to accompany <strong>the</strong>ir poster on<br />
applications <strong>of</strong> MatSOAP (Rasam Teymouri). The<br />
poster session was a good opportunity to network,<br />
<strong>and</strong> also for delegates to discuss ideas with each o<strong>the</strong>r<br />
about implement<strong>in</strong>g different s<strong>of</strong>tware solutions back<br />
<strong>in</strong> <strong>the</strong>ir respective hospitals.<br />
DISCUSSION<br />
At <strong>the</strong> end <strong>of</strong> <strong>the</strong> meet<strong>in</strong>g <strong>the</strong>re was time for a<br />
discussion about various topics that had come up <strong>in</strong><br />
<strong>the</strong> day. One area that was highlighted was <strong>the</strong> need to<br />
have an appropriate amount <strong>of</strong> comput<strong>in</strong>g covered <strong>in</strong><br />
<strong>the</strong> new Modernis<strong>in</strong>g Scientific Careers curriculum for<br />
medical physics <strong>and</strong> cl<strong>in</strong>ical eng<strong>in</strong>eers. Ano<strong>the</strong>r was<br />
<strong>the</strong> desire for more <strong>of</strong> a ‘community’ for pr<strong>of</strong>essionals<br />
work<strong>in</strong>g <strong>in</strong> medical physics <strong>and</strong> cl<strong>in</strong>ical eng<strong>in</strong>eer<strong>in</strong>g,<br />
where comput<strong>in</strong>g advice could be sought <strong>and</strong><br />
resources shared. All <strong>in</strong> all <strong>the</strong> conference seemed to be<br />
well received, with <strong>the</strong> potential for similar meet<strong>in</strong>gs<br />
<strong>in</strong> <strong>the</strong> future a dist<strong>in</strong>ct possibility given <strong>the</strong> <strong>in</strong>terest<br />
shown <strong>in</strong> this meet<strong>in</strong>g (figure 4). n<br />
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SCOPE | MEETING REPORTS<br />
IPEM TRAVEL BURSARY: 2012 ESTRO 31/<br />
WORLD CONGRESS OF BRACHYTHERAPY<br />
AHAMED BADUSHA MOHAMED YOOSUF Nor<strong>the</strong>rn Irel<strong>and</strong> Cancer Centre, Belfast<br />
BARCELONA 9th–13th May 2012<br />
THE EUROPEAN SOCIETY OF RADIOTHERAPY AND<br />
Oncology (ESTRO) is an <strong>in</strong>terdiscipl<strong>in</strong>ary society with<br />
an aim to advance all aspects <strong>of</strong> radiation oncology.<br />
Events are organised to facilitate <strong>the</strong> meet<strong>in</strong>g <strong>of</strong><br />
pr<strong>of</strong>essionals to share <strong>the</strong>ir ideas <strong>and</strong> work. This year<br />
ESTRO 31 <strong>and</strong> <strong>the</strong> World Congress <strong>of</strong> Brachy<strong>the</strong>rapy<br />
(WCB) were organised as a jo<strong>in</strong>t conference. Be<strong>in</strong>g an<br />
Indian medical physicist work<strong>in</strong>g <strong>in</strong> <strong>the</strong> UK, <strong>the</strong>re is so<br />
much that I wanted to learn <strong>and</strong> experience for myself<br />
about radio<strong>the</strong>rapy practice <strong>in</strong> Europe. As a recipient <strong>of</strong><br />
an IPEM bursary award, I had <strong>the</strong> opportunity to attend<br />
<strong>the</strong> ESTRO 31/WCB conference from 9th–13th May<br />
2012, held <strong>in</strong> <strong>the</strong> International Convention Centre <strong>in</strong><br />
Barcelona. The city <strong>of</strong>fers a feast <strong>of</strong> sculptures, pa<strong>in</strong>t<strong>in</strong>gs,<br />
mosaics, impressive architecture <strong>and</strong> fashion. Especially<br />
remarkable is <strong>the</strong> work <strong>of</strong> architect Antoni Gaudí<br />
(figures 1 <strong>and</strong> 2), which can be seen throughout <strong>the</strong> city.<br />
GLOBAL CONFERENCE<br />
This year’s conference was a huge success with almost<br />
4,000 delegates from 50 different countries <strong>in</strong><br />
attendance. Eighty exhibitors <strong>in</strong> <strong>the</strong> 10,000 m² exhibition<br />
area provided <strong>the</strong> opportunity to discover <strong>the</strong> latest<br />
products <strong>and</strong> services with<strong>in</strong> radiation oncology. There<br />
were 300 <strong>in</strong>vited speakers, 188 oral presentations, 241<br />
oral posters <strong>and</strong> 662 e-posters. At any one time <strong>the</strong>re<br />
were eight parallel streams spread across different<br />
auditoriums <strong>of</strong> <strong>the</strong> International Convention Centre<br />
(figure 3), allow<strong>in</strong>g delegates <strong>the</strong> ability to attend<br />
relevant sessions throughout <strong>the</strong> conference.<br />
I predom<strong>in</strong>antly attended World Congress <strong>of</strong><br />
Brachy<strong>the</strong>rapy sessions. This is a 4-yearly conference<br />
<strong>and</strong> is attended by physicians, physicists, biologists,<br />
technicians <strong>and</strong> company reps from all over <strong>the</strong> world<br />
with a keen <strong>in</strong>terest <strong>in</strong> brachy<strong>the</strong>rapy. This is <strong>the</strong> fifth<br />
edition <strong>of</strong> this jo<strong>in</strong>t meet<strong>in</strong>g <strong>and</strong> <strong>the</strong> programme took<br />
place over 4 days, <strong>in</strong>clud<strong>in</strong>g a pre-meet<strong>in</strong>g course<br />
cover<strong>in</strong>g many aspects <strong>of</strong> brachy<strong>the</strong>rapy.<br />
The scientific programme was organised by Groupe<br />
Européen de Curiethérapie <strong>and</strong> The European Society for<br />
Therapeutic Radiology <strong>and</strong> Oncology (GEC-ESTRO), <strong>in</strong><br />
co-operation with <strong>the</strong> American Brachy<strong>the</strong>rapy Society<br />
(ABS), Asociacion Lat<strong>in</strong>o-americana de Terapia Radiante<br />
Oncologica (ALATRO), Indian Brachy<strong>the</strong>rapy Society<br />
(IBS) <strong>and</strong> Australian Brachy<strong>the</strong>rapy Group (ABG). My<br />
goal on attend<strong>in</strong>g this conference was to exp<strong>and</strong> my<br />
current knowledge <strong>of</strong> brachy<strong>the</strong>rapy physics <strong>and</strong> ga<strong>the</strong>r<br />
useful <strong>in</strong>formation which could be adopted <strong>in</strong> our<br />
centre’s practice to improve our service.<br />
The first day <strong>of</strong> WCB (9th May) started with a premeet<strong>in</strong>g<br />
workshop on ‘Recent advances <strong>in</strong><br />
brachy<strong>the</strong>rapy physics’ that brought toge<strong>the</strong>r em<strong>in</strong>ent<br />
speakers from a variety <strong>of</strong> backgrounds, both medical<br />
<strong>and</strong> scientific, from Europe <strong>and</strong> <strong>the</strong> USA. The workshop<br />
demonstrated <strong>the</strong> most recent advances <strong>in</strong> high dose<br />
26 | SEPTEMBER 2012 | SCOPE<br />
rate (HDR) <strong>and</strong> low dose rate (LDR) brachy<strong>the</strong>rapy.<br />
Topics <strong>in</strong>cluded source calibration, quality assurance,<br />
3D conformal imag<strong>in</strong>g, advanced treatment plann<strong>in</strong>g<br />
us<strong>in</strong>g model-based algorithms, <strong>in</strong> vivo dosimetry,<br />
uncerta<strong>in</strong>ties <strong>in</strong> brachy<strong>the</strong>rapy <strong>and</strong> pr<strong>of</strong>essional society<br />
recommendations.<br />
The use <strong>of</strong> model-based algorithms <strong>in</strong> brachy<strong>the</strong>rapy<br />
treatment plann<strong>in</strong>g was reported by Luc Beaulieu<br />
(Laval University Cancer Research Centre, Québec,<br />
Canada) <strong>and</strong> a review <strong>of</strong> current developments <strong>in</strong><br />
plann<strong>in</strong>g systems was discussed. In current practice, all<br />
dose calculations <strong>in</strong> brachy<strong>the</strong>rapy treatment plann<strong>in</strong>g<br />
are based on AAPM Task Group (TG) Report 43 which<br />
utilises a factor-based algorithm. In a recent study<br />
published by Mark Rivard et al. (United States), <strong>the</strong><br />
limitations <strong>of</strong> TG 43 were described <strong>and</strong> it was found<br />
that <strong>in</strong> lower photon energies, as used <strong>in</strong> brachy<strong>the</strong>rapy,<br />
<strong>the</strong> absorbed dose <strong>in</strong> water to tissue differs due to<br />
higher photoelectric effect cross-sections <strong>of</strong> tissue<br />
compared to water. Similarly, <strong>the</strong> mass attenuation<br />
coefficient <strong>of</strong> tissues differs at low photon energies.<br />
Dose calculation algorithms are be<strong>in</strong>g developed based<br />
on Monte Carlo methods, collapsed cone <strong>and</strong> solv<strong>in</strong>g<br />
<strong>the</strong> l<strong>in</strong>ear Boltzmann transport equation. Also reported<br />
was <strong>the</strong> recommendation that rout<strong>in</strong>e <strong>in</strong> vivo dosimetry<br />
should be <strong>in</strong>troduced <strong>in</strong> brachy<strong>the</strong>rapy procedures, as at<br />
present <strong>the</strong>se are performed without any record <strong>and</strong><br />
verify systems.<br />
INTRODUCTORY SESSIONS<br />
The <strong>of</strong>ficial open<strong>in</strong>g ceremony took place at 6pm <strong>in</strong> <strong>the</strong><br />
ma<strong>in</strong> auditorium with a special lecture by <strong>the</strong> keynote<br />
speaker Manel Esteller (IDIBELL – Bellvitge Biomedical<br />
Research <strong>Institute</strong>, Barcelona, Spa<strong>in</strong>), about medical<br />
applications <strong>of</strong> epigenetics, a study <strong>of</strong> heritable changes<br />
<strong>in</strong> gene expression caused by mechanisms o<strong>the</strong>r than<br />
changes <strong>in</strong> <strong>the</strong> underly<strong>in</strong>g DNA sequence, <strong>in</strong> health <strong>and</strong><br />
disease. After <strong>the</strong> lecture we were enterta<strong>in</strong>ed by <strong>the</strong><br />
<strong>in</strong>novative music show <strong>of</strong> Pagagn<strong>in</strong>i (figure 4), who<br />
brought to life some <strong>of</strong> <strong>the</strong> most treasured musical<br />
pieces <strong>in</strong> <strong>the</strong> key <strong>of</strong> comedy. The day was rounded <strong>of</strong>f<br />
by a special open<strong>in</strong>g reception <strong>in</strong> <strong>the</strong> exhibition area<br />
where <strong>the</strong> technical exhibition was formally opened.<br />
With such a massive exhibition <strong>and</strong> hundreds <strong>of</strong><br />
scientific posters, <strong>the</strong> conference had an extremely<br />
vivacious atmosphere.<br />
Thursday began with <strong>the</strong> symposium on ‘Modern<br />
brachy<strong>the</strong>rapy: role <strong>of</strong> new image modalities’ with six<br />
presentations discuss<strong>in</strong>g <strong>the</strong> latest imag<strong>in</strong>g <strong>in</strong>novations,<br />
from orthogonal radiograph to functional imag<strong>in</strong>g, <strong>and</strong><br />
<strong>the</strong>ir impact <strong>in</strong> brachy<strong>the</strong>rapy. Although every<br />
presentation was <strong>in</strong>formative, <strong>the</strong> topic I found most<br />
appeal<strong>in</strong>g was <strong>the</strong> role <strong>of</strong> ultrasound <strong>in</strong> modern<br />
brachy<strong>the</strong>rapy. In brachy<strong>the</strong>rapy, ultrasound has a role<br />
<strong>in</strong> prostate, gynaecological <strong>and</strong> <strong>in</strong>terstitial applications.
FIGURE 1<br />
[TOP LEFT]<br />
Casa Batlló,<br />
Barcelona.<br />
▼<br />
FIGURE 2<br />
[TOP RIGHT]<br />
La Sagrada<br />
Familia,<br />
Barcelona.<br />
▼<br />
FIGURE 3<br />
Barcelona’s<br />
International<br />
Convention<br />
Centre (CCIB).<br />
▼<br />
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▼<br />
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28 | SEPTEMBER 2012 | SCOPE<br />
FIGURE 4.<br />
Pagagn<strong>in</strong>i music<br />
show.<br />
▼<br />
FIGURE 5.<br />
[LEFT]<br />
Discussion <strong>in</strong> <strong>the</strong><br />
poster area<br />
dur<strong>in</strong>g a c<strong>of</strong>fee<br />
break.<br />
▼<br />
FIGURE 6.<br />
[RIGHT]<br />
Poster<br />
presentation.<br />
▼
Developments <strong>in</strong> ultrasound were fundamental to <strong>the</strong><br />
rise <strong>in</strong> activity <strong>in</strong> prostate brachy<strong>the</strong>rapy <strong>in</strong> recent years<br />
based on <strong>the</strong> transrectal ultrasound-guided transper<strong>in</strong>eal<br />
implant technique.<br />
Ultrasound techniques have matured with fur<strong>the</strong>r<br />
scientific developments <strong>and</strong> are <strong>in</strong>tegrated with modern<br />
dosimetry algorithms; image fusion techniques enable<br />
ultrasound to be comb<strong>in</strong>ed with computed tomography<br />
(CT) <strong>and</strong> magnetic resonance imag<strong>in</strong>g (MRI) <strong>in</strong> prostate<br />
brachy<strong>the</strong>rapy which can result <strong>in</strong> accurate real-time<br />
imag<strong>in</strong>g <strong>and</strong> may translate <strong>in</strong>to better patient dosimetry.<br />
The use <strong>of</strong> ultrasound images <strong>in</strong> gynaecological<br />
brachy<strong>the</strong>rapy was presented by Sylvia Van Dyk (Peter<br />
MacCallum Cancer Centre, East Melbourne, Victoria,<br />
Australia). With <strong>the</strong> advent <strong>of</strong> high-quality threedimensional<br />
imag<strong>in</strong>g, ultrasound can provide an<br />
excellent representation <strong>of</strong> <strong>the</strong> cervix <strong>and</strong> uterus<br />
enabl<strong>in</strong>g <strong>the</strong> def<strong>in</strong>ition <strong>of</strong> cl<strong>in</strong>ical target volume (CTV) as<br />
per <strong>the</strong> GEC-ESTRO requirements. It was demonstrated<br />
that <strong>the</strong> size <strong>and</strong> shape <strong>of</strong> <strong>the</strong> cervix measured <strong>in</strong><br />
ultrasound <strong>and</strong> MRI images correlate well. For those<br />
centres with limited or no MRI facility, ultrasound<br />
provides a more readily available tool to def<strong>in</strong>e CTV for<br />
conformal plann<strong>in</strong>g.<br />
POSTER PRESENTATION<br />
Throughout <strong>the</strong> duration <strong>of</strong> conference, <strong>the</strong> poster area<br />
<strong>and</strong> manufacturer’s stalls kept us occupied dur<strong>in</strong>g c<strong>of</strong>fee<br />
breaks (figure 5).<br />
MEETING REPORTS | SCOPE<br />
I felt honoured that my abstract was accepted for<br />
poster presentation <strong>and</strong> to be displayed amongst <strong>the</strong> sea<br />
<strong>of</strong> posters (figure 6). On Thursday even<strong>in</strong>g <strong>the</strong>re was a<br />
poster reception at 6.30pm so I te<strong>the</strong>red myself to my<br />
poster dur<strong>in</strong>g this time. The poster is entitled ‘Sector<br />
analysis <strong>of</strong> I-125 prostate implants provides an effective<br />
method compar<strong>in</strong>g pre- <strong>and</strong> post-implant dosimetry’. In<br />
this study, a sector analysis treatment plann<strong>in</strong>g tool was<br />
used as a scientific method <strong>of</strong> exam<strong>in</strong><strong>in</strong>g <strong>the</strong> distribution<br />
<strong>of</strong> dose with<strong>in</strong> 12 separate sub-volumes or ‘sectors’ <strong>of</strong><br />
<strong>the</strong> prostate <strong>and</strong> compared pre- <strong>and</strong> post-implant<br />
dosimetry.<br />
The next two days also consisted <strong>of</strong> an <strong>in</strong>tense<br />
programme <strong>of</strong> educational courses, lunchtime<br />
symposiums, debates <strong>and</strong> scientific sessions. The<br />
conference covered many areas <strong>of</strong> ‘state-<strong>of</strong>-<strong>the</strong>-art’<br />
brachy<strong>the</strong>rapy <strong>and</strong> was very <strong>in</strong>formative. The meet<strong>in</strong>g<br />
was an exceptional educational opportunity <strong>and</strong> a great<br />
forum for discussion. I ga<strong>in</strong>ed an essential <strong>in</strong>sight <strong>in</strong>to<br />
<strong>the</strong> current status <strong>and</strong> future development <strong>of</strong><br />
brachy<strong>the</strong>rapy physics <strong>and</strong> found this ESTRO 31/WCB a<br />
valuable experience.<br />
I am grateful to IPEM for giv<strong>in</strong>g me <strong>the</strong> chance to<br />
attend this very useful conference. I would also like to<br />
thank colleagues <strong>in</strong> Radio<strong>the</strong>rapy <strong>Physics</strong>, Nor<strong>the</strong>rn<br />
Irel<strong>and</strong> Cancer Centre, for <strong>the</strong>ir support <strong>and</strong><br />
encouragement, especially Gerald<strong>in</strong>e Workman <strong>and</strong> Dr<br />
Darren M. Mitchell who supported me <strong>in</strong> <strong>the</strong> research<br />
work reported <strong>in</strong> <strong>the</strong> poster presentation. n<br />
SCOPE | SEPTEMBER 2012 | 29
SCOPE | MEETING REPORTS<br />
REPORT ON NPL CLINICAL TEMPERATURE<br />
MEASUREMENT MEETING<br />
ROSIE RICHARDS North London Consortium<br />
JASON BRITTON Leeds Teach<strong>in</strong>g Hospitals NHS Trust<br />
NATIONAL PHYSICAL LABORATORY 30th January 2012<br />
THE NATIONAL PHYSICS LABORATORY (NPL), AT<br />
<strong>the</strong>ir premises <strong>in</strong> Tedd<strong>in</strong>gton, hosted a one-day<br />
scientific meet<strong>in</strong>g on cl<strong>in</strong>ical temperature measurement<br />
with some excellent speakers <strong>and</strong> <strong>in</strong>terest<strong>in</strong>g<br />
discussions on <strong>the</strong> research <strong>and</strong> development<br />
presented. The meet<strong>in</strong>g was jo<strong>in</strong>tly organised by <strong>the</strong><br />
National Physical Laboratory <strong>and</strong> <strong>the</strong> IPEM<br />
Physiological Measurement Special Interest Group.<br />
The morn<strong>in</strong>g keynote speaker was Helen McEvoy<br />
(NPL, Tedd<strong>in</strong>gton), who talked about cl<strong>in</strong>ical<br />
<strong>the</strong>rmometry us<strong>in</strong>g tympanic <strong>the</strong>rmometers. Helen has<br />
been <strong>in</strong>vestigat<strong>in</strong>g different approaches to <strong>the</strong> tra<strong>in</strong><strong>in</strong>g<br />
<strong>of</strong> cl<strong>in</strong>ical staff <strong>in</strong> <strong>the</strong> appropriate use <strong>of</strong> <strong>the</strong> devices,<br />
such that <strong>the</strong> uncerta<strong>in</strong>ty associated with <strong>the</strong> technique<br />
may be reduced. She covered <strong>the</strong> factors to consider<br />
when measur<strong>in</strong>g temperature <strong>and</strong> <strong>the</strong> risks to consider<br />
when us<strong>in</strong>g such a device. The risks <strong>in</strong>clude: (1)<br />
misdiagnosis due to an <strong>in</strong>accurate read<strong>in</strong>g which could<br />
be due to poor calibration, h<strong>and</strong>l<strong>in</strong>g or storage, or (2)<br />
<strong>in</strong>jury due to <strong>the</strong> probe be<strong>in</strong>g pushed too far <strong>in</strong>to <strong>the</strong><br />
ear or cross-contam<strong>in</strong>ation. A focussed 1-hour tra<strong>in</strong><strong>in</strong>g<br />
programme has now been developed work<strong>in</strong>g with<br />
Oxford Radcliffe Hospitals NHS Trust which can now<br />
be purchased <strong>and</strong> is delivered by NPL.<br />
TIME FOR A CHANGE<br />
The second speaker was Martha Sund-Lev<strong>and</strong>er<br />
(Hoegl<strong>and</strong> Hospital, Eksjo, Sweden), whose<br />
presentation entitled ‘Time for a change when<br />
assess<strong>in</strong>g <strong>and</strong> evaluat<strong>in</strong>g body temperature <strong>in</strong> cl<strong>in</strong>ical<br />
practice’ looked at <strong>the</strong> variability <strong>of</strong> cl<strong>in</strong>ical<br />
temperature measurement <strong>and</strong> <strong>the</strong> factors that may<br />
affect <strong>the</strong> read<strong>in</strong>gs <strong>in</strong> different healthcare sett<strong>in</strong>gs. She<br />
discussed a literature review carried out by her <strong>and</strong><br />
colleagues review<strong>in</strong>g <strong>the</strong> variability <strong>of</strong> temperature<br />
measurements made at different body sites <strong>and</strong> how<br />
this could impact on <strong>the</strong> cl<strong>in</strong>ical management <strong>of</strong><br />
patients. Her work also looked at <strong>the</strong> effects <strong>of</strong> age<strong>in</strong>g<br />
on normal body temperature ranges. It has been<br />
identified that elderly patients with dementia may be<br />
at risk <strong>of</strong> hypo<strong>the</strong>rmia as slightly lower than normal<br />
temperature read<strong>in</strong>gs <strong>in</strong> this patient cohort may not be<br />
seen as cl<strong>in</strong>ically significant. The discussions follow<strong>in</strong>g<br />
prompted Francis R<strong>in</strong>g (University <strong>of</strong> Glamorgan,<br />
Pontypridd) to comment that paracetamol (which<br />
Martha had discussed <strong>in</strong> relation to its effect on<br />
temperature) was not an anti-<strong>in</strong>flammatory drug,<br />
hav<strong>in</strong>g only analgesic effects, <strong>and</strong> was not now<br />
rout<strong>in</strong>ely used <strong>in</strong> cl<strong>in</strong>ical practice.<br />
Follow<strong>in</strong>g this, <strong>the</strong> programme moved onto an<br />
<strong>in</strong>terest<strong>in</strong>g presentation by Sheera Su<strong>the</strong>rl<strong>and</strong><br />
(Churchill Hospital, Oxford) who has researched <strong>the</strong><br />
potential <strong>of</strong> monitor<strong>in</strong>g <strong>the</strong> core temperature <strong>of</strong><br />
patients (with established renal failure) dur<strong>in</strong>g<br />
30 | SEPTEMBER 2012 | SCOPE<br />
haemodialysis with a <strong>the</strong>rmal imag<strong>in</strong>g camera <strong>and</strong><br />
establish<strong>in</strong>g if this can have a positive impact on <strong>the</strong>ir<br />
overall cl<strong>in</strong>ical management. The research<br />
<strong>in</strong>vestigated <strong>the</strong> affects <strong>of</strong> lower<strong>in</strong>g <strong>the</strong> dialysate<br />
temperature to less than 37°C (which is traditionally<br />
used <strong>in</strong> haemodialysis treatments). There is some<br />
evidence that this may be actively warm<strong>in</strong>g <strong>the</strong><br />
patient with a statistically significant difference <strong>in</strong> pre<strong>and</strong><br />
post-dialysis temperatures shown at a level <strong>of</strong> p =<br />
0.001. However, it has been found that some patients<br />
do not tolerate cooler dialysate. Thermal imag<strong>in</strong>g was<br />
also used to <strong>in</strong>vestigate <strong>the</strong> possibility that changes <strong>in</strong><br />
measured core body temperature could be correlated<br />
with a ‘crash’ or hypovolemic event that commonly<br />
occurs. Kev<strong>in</strong> Howell (Royal Free Hospital, London)<br />
commented that hypovolemia may be <strong>the</strong> ma<strong>in</strong> issue<br />
to consider.<br />
DENTAL THERMOGRAPHIC IMAGING<br />
The next speaker, Paula Lancaster (Leeds Dental<br />
<strong>Institute</strong>), showed her work on vital dental<br />
<strong>the</strong>rmographic imag<strong>in</strong>g. The aim <strong>of</strong> <strong>the</strong> work was to<br />
<strong>in</strong>vestigate <strong>the</strong> temperature <strong>of</strong> <strong>the</strong> tooth <strong>in</strong> <strong>the</strong> hope <strong>of</strong><br />
us<strong>in</strong>g this as an objective method to measure <strong>the</strong><br />
vitality <strong>of</strong> <strong>the</strong> tooth.<br />
Currently sensitivity tests are performed to<br />
subjectively assess <strong>the</strong> neural supply to <strong>the</strong> tooth but<br />
this does not tell <strong>the</strong> dentist anyth<strong>in</strong>g about <strong>the</strong> blood<br />
supply. Alternatively an x-ray may be taken <strong>of</strong> <strong>the</strong><br />
patient’s mouth; however, this carries concerns <strong>of</strong> <strong>the</strong><br />
use <strong>of</strong> ionis<strong>in</strong>g radiation (albeit <strong>in</strong> very low doses). A<br />
dental x-ray will only provide anatomical ra<strong>the</strong>r than<br />
physiological <strong>in</strong>formation. The researchers tested <strong>the</strong><br />
<strong>the</strong>ory that <strong>the</strong> central core <strong>of</strong> <strong>the</strong> tooth is warmer<br />
than <strong>the</strong> rest <strong>of</strong> <strong>the</strong> crown by us<strong>in</strong>g a skeletal model.<br />
They found that a <strong>the</strong>rmal gradient could be detected,<br />
when <strong>the</strong> tooth is subjected to external cool<strong>in</strong>g. This<br />
may be promis<strong>in</strong>g for us<strong>in</strong>g a similar model <strong>in</strong> vivo<br />
once ethical approval is obta<strong>in</strong>ed. Paula suggested<br />
that possible applications <strong>of</strong> <strong>the</strong>rmography may<br />
<strong>in</strong>clude:<br />
n assessment <strong>of</strong> vitality <strong>of</strong> <strong>the</strong> tooth <strong>in</strong> people with<br />
toothache <strong>and</strong> <strong>the</strong> provision <strong>of</strong> <strong>in</strong>formation on<br />
which to base treatment decisions,<br />
n assessment <strong>of</strong> <strong>the</strong> extent <strong>of</strong> trauma to <strong>the</strong> teeth,<br />
n assessment <strong>of</strong> <strong>the</strong> development <strong>of</strong> <strong>the</strong> root <strong>in</strong> tooth<br />
transplant (this is currently done us<strong>in</strong>g<br />
radiographs).<br />
Any methods developed need to be simple <strong>and</strong><br />
need to give consistent results. The discussions that<br />
followed this talk brought up issues such as how to<br />
f<strong>in</strong>d <strong>the</strong> emissivity <strong>of</strong> enamel. S<strong>in</strong>ce <strong>the</strong> tests are<br />
look<strong>in</strong>g for relative differences <strong>in</strong> temperature, it was<br />
suggested that this may not be too important.
The day’s presentations <strong>the</strong>n moved on to research<br />
<strong>in</strong>to <strong>the</strong>rmal symmetry on <strong>the</strong> upper <strong>and</strong> lower<br />
extremities on normal healthy volunteers carried out at<br />
Glamorgan University by Ricardo Vardasca<br />
(University <strong>of</strong> M<strong>in</strong>ho, Braga, Portugal). For this work<br />
high-resolution <strong>the</strong>rmal imag<strong>in</strong>g cameras were used to<br />
capture a large number <strong>of</strong> images <strong>of</strong> <strong>the</strong> upper <strong>and</strong><br />
lower extremities. Unlike previous work <strong>in</strong> <strong>the</strong> area,<br />
<strong>the</strong> images were captured <strong>in</strong> a controlled environment<br />
<strong>and</strong> <strong>the</strong> analysis was not based on s<strong>in</strong>gle po<strong>in</strong>ts. The<br />
images were <strong>the</strong>n collated <strong>and</strong> st<strong>and</strong>ardised us<strong>in</strong>g<br />
geometric models. The models were used to scale <strong>the</strong><br />
images to <strong>the</strong> same shape <strong>and</strong> size for each subject. The<br />
f<strong>in</strong>al outcome showed a small difference <strong>of</strong> 0.5°C ±<br />
0.3°C between left <strong>and</strong> right regions. A difference <strong>of</strong><br />
0.1°C was also found between ventral <strong>and</strong> dorsal<br />
regions. Francis R<strong>in</strong>g commented after <strong>the</strong> presentation<br />
that <strong>the</strong>re is a measurement uncerta<strong>in</strong>ty associated<br />
with <strong>the</strong> cameras which must be accounted for when<br />
review<strong>in</strong>g <strong>the</strong> results. It was also unclear how <strong>the</strong><br />
results could be used <strong>in</strong> <strong>the</strong> management <strong>of</strong> patients<br />
<strong>and</strong> where this may be used <strong>in</strong> <strong>the</strong> care pathway.<br />
The next speaker, Ismael Fern<strong>and</strong>ez Cuevas<br />
(Universidad Politecnica de Madrid), presented results<br />
<strong>of</strong> a pilot study look<strong>in</strong>g at <strong>the</strong> effects <strong>of</strong> <strong>the</strong> circadian<br />
cycle on sk<strong>in</strong> surface temperature. The measurements<br />
were conducted <strong>in</strong> a controlled <strong>the</strong>rmal environment<br />
<strong>and</strong> were taken periodically over a 13-hour day with<br />
The H<strong>and</strong>hound voice-operated<br />
‘h<strong>and</strong>s-free’ h<strong>and</strong> monitor<br />
Designed for use <strong>in</strong> radioisotope h<strong>and</strong>l<strong>in</strong>g<br />
situations where h<strong>and</strong>s could be contam<strong>in</strong>ated.<br />
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Sta<strong>in</strong>less steel hous<strong>in</strong>g for ease <strong>of</strong><br />
clean<strong>in</strong>g <strong>and</strong> decontam<strong>in</strong>ation.<br />
Tel: 01273 497600<br />
MEETING REPORTS | SCOPE<br />
<strong>the</strong> subject st<strong>and</strong><strong>in</strong>g <strong>in</strong> <strong>the</strong> same position. Although<br />
<strong>the</strong>re was no obvious pattern result<strong>in</strong>g from <strong>the</strong><br />
measurements at different times, <strong>the</strong> temperature<br />
fluctuations were fairly constant for all areas <strong>of</strong> <strong>the</strong><br />
body that were analysed. After correct<strong>in</strong>g <strong>the</strong><br />
temperature us<strong>in</strong>g <strong>the</strong> calibration area, <strong>the</strong> data<br />
showed similarities with exist<strong>in</strong>g results <strong>in</strong> this field<br />
by Pr<strong>of</strong>essor R<strong>in</strong>g et al. S<strong>in</strong>ce observations showed that<br />
when <strong>the</strong> body was expect<strong>in</strong>g food <strong>in</strong>take <strong>the</strong><br />
temperature <strong>in</strong>creased, a member <strong>of</strong> <strong>the</strong> audience<br />
suggested that <strong>the</strong> glucose level could be monitored if<br />
<strong>the</strong> experiment was repeated. Discussion also took<br />
place about <strong>the</strong> ‘constant core-variable shell’ <strong>the</strong>ory<br />
that is <strong>of</strong>ten applied to <strong>the</strong>rmal regulation <strong>of</strong> <strong>the</strong><br />
human body.<br />
THYROID-ASSOCIATED EYE DISEASE<br />
John Allen (Freeman Hospital, Newcastle upon Tyne)<br />
was <strong>the</strong> next speaker, present<strong>in</strong>g work on ‘Detect<strong>in</strong>g<br />
<strong>in</strong>flammatory disease <strong>in</strong> patients with active (Graves)<br />
thyroid eye disease’. The treatment regimen used for<br />
thyroid-associated orbitopathy depends on <strong>the</strong><br />
outcomes <strong>of</strong> subjective cl<strong>in</strong>ical assessment. John’s pilot<br />
<strong>in</strong>vestigation was aim<strong>in</strong>g to develop a work<strong>in</strong>g<br />
protocol for <strong>the</strong>rmal imag<strong>in</strong>g <strong>of</strong> <strong>the</strong> eye <strong>and</strong> use it to<br />
explore a range <strong>of</strong> characteristics <strong>in</strong> patients with this<br />
pathology. Complications <strong>in</strong>volved bl<strong>in</strong>k<strong>in</strong>g, sweat<strong>in</strong>g<br />
<strong>and</strong> tear<strong>in</strong>g which may be asymmetric. Before <strong>the</strong><br />
Web: www.sou<strong>the</strong>rnscientific.co.uk<br />
SCOPE | SEPTEMBER 2012 | 31<br />
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SCOPE | MEETING REPORTS<br />
images were obta<strong>in</strong>ed <strong>the</strong> environment was cooled to<br />
allow <strong>in</strong>flammatory areas (deeper vessels) to become<br />
dom<strong>in</strong>ant. The <strong>in</strong>itial results were quite encourag<strong>in</strong>g<br />
<strong>and</strong> <strong>the</strong> <strong>the</strong>rmal imag<strong>in</strong>g results demonstrated elevated<br />
temperature <strong>in</strong> <strong>the</strong> eyes <strong>in</strong> patients where <strong>the</strong> disease<br />
was active compared to <strong>in</strong>active. John presented some<br />
statistical analysis to show that a probability graph or<br />
contour plot may be <strong>the</strong> way forward to classify <strong>the</strong>se<br />
patients <strong>in</strong> <strong>the</strong> future. However, this was only based on<br />
a cohort <strong>of</strong> 15 patients <strong>and</strong> <strong>the</strong>refore its statistical<br />
validity is equivocal.<br />
ISO STANDARDS<br />
The second keynote speaker <strong>of</strong> <strong>the</strong> day was Francis<br />
R<strong>in</strong>g, whose presentation was entitled ‘ISO st<strong>and</strong>ards<br />
for fever screen<strong>in</strong>g <strong>and</strong> <strong>the</strong>ir implications’. This<br />
presentation raised questions about <strong>the</strong> feasibility <strong>of</strong><br />
fever screen<strong>in</strong>g on a large scale.<br />
The reason for cont<strong>in</strong>ued <strong>in</strong>vestigations <strong>in</strong>to fever<br />
screen<strong>in</strong>g is that <strong>the</strong>re is always a risk <strong>of</strong> a new<br />
<strong>in</strong>fluenza virus emerg<strong>in</strong>g <strong>and</strong> spread<strong>in</strong>g. This would<br />
cause disruption to society <strong>and</strong> fatalities, especially <strong>in</strong><br />
vulnerable groups such as <strong>the</strong> elderly <strong>and</strong> children.<br />
Francis described <strong>the</strong> various stages <strong>of</strong> an <strong>in</strong>fluenza<br />
p<strong>and</strong>emic before mov<strong>in</strong>g on to speak about fever<br />
screen<strong>in</strong>g requirements. F<strong>in</strong>ally, he presented some<br />
results <strong>of</strong> <strong>the</strong> research <strong>in</strong>vestigat<strong>in</strong>g <strong>the</strong> mean <strong>in</strong>ner<br />
canthus temperature <strong>in</strong> febrile <strong>and</strong> afebrile children<br />
present<strong>in</strong>g at an A&E department <strong>in</strong> Warsaw. It was<br />
unclear from <strong>the</strong> presentation as to why <strong>the</strong> research<br />
could not have been undertaken <strong>in</strong> <strong>the</strong> UK <strong>and</strong> if all <strong>the</strong><br />
possible variables had been sufficiently well controlled<br />
or properly <strong>in</strong>vestigated.<br />
The penultimate speaker, Kev<strong>in</strong> Howell, reviewed<br />
his work on <strong>the</strong> use <strong>of</strong> a low-cost (£2,500), low <strong>the</strong>rmal<br />
<strong>and</strong> spatial resolution (160 × 120 pixels) <strong>the</strong>rmal imager<br />
<strong>in</strong> <strong>the</strong> cl<strong>in</strong>ical assessment <strong>of</strong> patients with Raynaud’s<br />
phenomenon. The aim <strong>of</strong> <strong>the</strong> work was to determ<strong>in</strong>e<br />
whe<strong>the</strong>r <strong>the</strong> low-cost portable <strong>the</strong>rmal camera would<br />
give comparable results to a more expensive device<br />
(£10,000–£11,000) with higher resolution <strong>and</strong> better<br />
<strong>the</strong>rmal resolution which has been used to assess this<br />
cohort <strong>of</strong> patients at <strong>the</strong> Royal Free Hospital. Despite<br />
small differences <strong>in</strong> <strong>the</strong> measured f<strong>in</strong>ger temperatures,<br />
<strong>the</strong> results demonstrated that <strong>the</strong> cheaper <strong>the</strong>rmal<br />
imager can be used <strong>in</strong> assess<strong>in</strong>g patients with<br />
Raynaud’s phenomenon <strong>and</strong> when compared to <strong>the</strong><br />
more expensive device cl<strong>in</strong>ically it would have no<br />
32 | SEPTEMBER 2012 | SCOPE<br />
impact on cl<strong>in</strong>ical management. It was <strong>the</strong>refore<br />
concluded that low spatial resolution is not a limitation<br />
for Raynaud’s phenomenon work (see figure 1).<br />
THERMAL IMAGING APPLICATIONS IN<br />
CRYOTHERAPY<br />
The f<strong>in</strong>al speaker <strong>of</strong> <strong>the</strong> day, Arm<strong>and</strong> Cholewka<br />
(University <strong>of</strong> Silesia, Katowice, Pol<strong>and</strong>), presented on<br />
<strong>the</strong>rmal imag<strong>in</strong>g applications <strong>in</strong> whole-body<br />
cryo<strong>the</strong>rapy. This was an <strong>in</strong>terest<strong>in</strong>g application <strong>of</strong><br />
<strong>the</strong>rmography us<strong>in</strong>g <strong>the</strong> cold environment to constrict<br />
surface vessels <strong>and</strong> detect <strong>and</strong> treat deeper areas <strong>of</strong><br />
<strong>in</strong>flammation. A typical cryosauna has a temperature <strong>of</strong><br />
−120°C <strong>and</strong> <strong>the</strong> patient is required to spend 2–3<br />
m<strong>in</strong>utes at a time <strong>in</strong> it. The aims <strong>of</strong> Arm<strong>and</strong>’s work<br />
were to evaluate <strong>the</strong> effects <strong>of</strong> cryo<strong>the</strong>rapy <strong>and</strong> to<br />
determ<strong>in</strong>e <strong>the</strong> sk<strong>in</strong> response due to <strong>the</strong> low<br />
temperature used <strong>in</strong> whole-body cryo<strong>the</strong>rapy. After <strong>the</strong><br />
patients had been <strong>in</strong> <strong>the</strong> chamber <strong>the</strong>rmal images were<br />
captured <strong>of</strong> different sk<strong>in</strong> segments. These showed a<br />
mean whole-body decrease <strong>in</strong> temperature <strong>of</strong> 5.8°C<br />
with a maximum <strong>of</strong> 8.7°C. After use patients reported a<br />
significant recovery after one to ten cryogenic sessions.<br />
There was also a slight improvement <strong>in</strong> <strong>the</strong> fitness <strong>of</strong><br />
<strong>the</strong> patients. In conclusion, Arm<strong>and</strong> claimed that <strong>the</strong>re<br />
was <strong>in</strong>creased diagnostic value <strong>of</strong> <strong>the</strong>rmal imag<strong>in</strong>g<br />
after body cool<strong>in</strong>g <strong>and</strong> that <strong>the</strong>rmal imag<strong>in</strong>g can be<br />
helpful <strong>in</strong> <strong>the</strong> monitor<strong>in</strong>g <strong>of</strong> <strong>the</strong>rapeutic effects <strong>of</strong><br />
whole-body cryo<strong>the</strong>rapy. However, very little evidence<br />
was presented to support this view <strong>and</strong> it was unclear<br />
from <strong>the</strong> presentation how <strong>the</strong>rmal imag<strong>in</strong>g<br />
contributed to patient care or overall management, <strong>and</strong><br />
where this would be used <strong>in</strong> <strong>the</strong> care <strong>and</strong> diagnostic<br />
pathway.<br />
It was clear from <strong>the</strong> presentations that outside <strong>the</strong><br />
use <strong>of</strong> <strong>the</strong>rmal imag<strong>in</strong>g for patients with Raynaud’s<br />
phenomenon a lot <strong>of</strong> possible cl<strong>in</strong>ical uses are <strong>in</strong> <strong>the</strong><br />
very early stages <strong>of</strong> development <strong>and</strong> have not really<br />
become established <strong>in</strong> ma<strong>in</strong>stream cl<strong>in</strong>ical practice.<br />
SUMMARY<br />
The meet<strong>in</strong>g was attended by about 25 delegates <strong>and</strong><br />
will hopefully become a regular event <strong>in</strong> <strong>the</strong> NPL<br />
calendar s<strong>in</strong>ce it proved to be a great success. n<br />
MORE INFORMATION<br />
All <strong>of</strong> <strong>the</strong> slides <strong>and</strong> talks can be accessed via YouTube at:<br />
http://www.youtube.com/playlist?list=PL08A8E92B0363DA68&fe<br />
ature=plcp<br />
FIGURE 1<br />
Images from <strong>the</strong><br />
more expensive<br />
<strong>the</strong>rmal imag<strong>in</strong>g<br />
camera (left)<br />
when compared<br />
to <strong>the</strong> less<br />
expensive device<br />
(right). As can be<br />
seen, very little<br />
cl<strong>in</strong>ical<br />
difference can be<br />
observed.<br />
▼
MEETINGS 2012/2013<br />
EUROPEAN MEETINGS<br />
Meet<strong>in</strong>g Venue <strong>and</strong> dates More <strong>in</strong>formation<br />
World Molecular Imag<strong>in</strong>g Congress<br />
6th European Conference on Medical<br />
<strong>Physics</strong><br />
IPEM Medical <strong>Physics</strong> <strong>and</strong> <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong><br />
Conference<br />
Ma<strong>the</strong>matics <strong>of</strong> Medical Devices <strong>and</strong><br />
Surgical Procedures<br />
7th IET International Conference on<br />
Appropriate Healthcare Technologies for<br />
Develop<strong>in</strong>g Countries (AHT2012 )<br />
Annual Meet<strong>in</strong>g <strong>of</strong> <strong>the</strong> German Society <strong>of</strong><br />
Medical <strong>Physics</strong> (DGMP)<br />
International Conference on Medical Image<br />
Comput<strong>in</strong>g <strong>and</strong> Computer Assisted<br />
Intervention<br />
3rd Newport 1-Day Update Course on<br />
Photo<strong>the</strong>rapy Dosimetry<br />
International Cancer Imag<strong>in</strong>g Society 12th<br />
Annual Teach<strong>in</strong>g Course<br />
International Symposium on Biomedical<br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> <strong>and</strong> Medical <strong>Physics</strong><br />
European Medical <strong>Physics</strong> <strong>and</strong> <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong><br />
Conference (EMPEC 2012)<br />
MR Safety Tra<strong>in</strong><strong>in</strong>g Course<br />
4th International Symposium on<br />
Radionuclide Targeted Radio<strong>the</strong>rapy <strong>and</strong><br />
Dosimetry (ISTARD)<br />
12th IEEE International Conference on<br />
BioInformatics <strong>and</strong> Bio<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong><br />
(BIBE 2012)<br />
2012 International Conference on<br />
NeuroRehabilitation<br />
IAEA International Conference on Radiation<br />
Protection <strong>in</strong> Medic<strong>in</strong>e – Sett<strong>in</strong>g <strong>the</strong> Scene<br />
for <strong>the</strong> Next Decade<br />
38th World Hospital Congress – Future<br />
Healthcare<br />
Dubl<strong>in</strong>, Irel<strong>and</strong><br />
5th–8th September<br />
Sibiu, Romania<br />
6th–9th September<br />
Oxford, UK<br />
10th–12th September<br />
London, UK<br />
17th–19th September<br />
London, UK<br />
18th–19th September<br />
Jena, Germany<br />
26th–29th September<br />
Nice, France<br />
1st–5th October<br />
Newport, Wales, UK<br />
2nd October<br />
Oxford, UK<br />
4th–6th October<br />
Riga, Latvia<br />
10th–12th October<br />
S<strong>of</strong>ia, Bulgaria<br />
18th–20th October<br />
Vienna, Austria<br />
18th–20th October<br />
Milan, Italy<br />
27th–31st October<br />
Larnaca, Cyprus<br />
11th–13th November<br />
Toledo, Spa<strong>in</strong><br />
14th–16th November<br />
Bonn, Germany<br />
3rd–7th December<br />
Oslo, Norway<br />
18th–20th June 2013<br />
INTERNATIONAL NEWS | SCOPE<br />
This is a non-exhaustive list <strong>of</strong> meet<strong>in</strong>gs <strong>of</strong> <strong>in</strong>terest. For IPEM workshops <strong>and</strong> meet<strong>in</strong>gs <strong>and</strong> a full list <strong>of</strong> meet<strong>in</strong>gs, please check <strong>the</strong> IPEM website:<br />
http://www.ipem.ac.uk/Conferences<strong>and</strong>events<br />
http://www.wmicmeet<strong>in</strong>g.org/<br />
http://www.ecmp2012.ro/<br />
http://www.ipem.ac.uk/Conferences<strong>and</strong>events/<br />
mpec/Pages/default.aspx<br />
http://www.ima.org.uk/conferences/conferences_cal<br />
endar/maths_<strong>of</strong>_medical_devices_&_surgical_proce<br />
dures.cfm<br />
http://www.<strong>the</strong>iet.org/aht2012<br />
http://www.conventus.de/dgmp2012/<br />
http://medical.rob.uni-luebeck.de/miccai2012rt/<br />
http://www.b<strong>in</strong>i.rtu.lv/isbemp<br />
http://www.bsbpe.org<br />
Contact ESMRMB Society<br />
http://bibe2012.cs.ucy.ac.cy/<br />
http://www.icnr2012.org<br />
http://www-pub.iaea.org/<br />
mtcd/meet<strong>in</strong>gs/Meet<strong>in</strong>gs2012.asp<br />
http://www.oslo2013.no<br />
SCOPE | SEPTEMBER 2012 | 33<br />
▼
SCOPE | INTERNATIONAL NEWS<br />
MEETINGS 2012/2013<br />
NORTH AMERICAN MEETINGS<br />
Meet<strong>in</strong>g Venue <strong>and</strong> dates More <strong>in</strong>formation<br />
Applied Health <strong>Physics</strong> (5-week course) Oak<br />
Ridge Associated Universities H<strong>and</strong>s-on<br />
Tra<strong>in</strong><strong>in</strong>g <strong>in</strong> <strong>the</strong> Radiological Sciences<br />
Computed Tomography H<strong>and</strong>s-on Workshop<br />
for Physicists<br />
Pr<strong>in</strong>ciples <strong>and</strong> Practices <strong>of</strong> Radiation Safety:<br />
Occupational <strong>and</strong> Environmental Radiation<br />
Protection<br />
ASTRO Annual Meet<strong>in</strong>g<br />
IEEE Nuclear Science Symposium, Medical<br />
Imag<strong>in</strong>g Conference <strong>and</strong> Workshop on<br />
Room-temperature Semiconductor X-ray<br />
<strong>and</strong> Gamma-ray Detectors<br />
Respiratory Motion Management for<br />
Radiation Therapy<br />
Radiological Society <strong>of</strong> North America<br />
(RSNA) Annual Meet<strong>in</strong>g 2012<br />
Practical Aspects <strong>of</strong> Stereotactic Body<br />
Radiation Therapy (SBRT)<br />
HPS Mid-year Topical Meet<strong>in</strong>g on Medical<br />
Health <strong>Physics</strong> <strong>and</strong> Accelerator Dosimetry<br />
7th International Conference on Ethical<br />
Issues <strong>in</strong> Biomedical <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong><br />
REST OF THE WORLD MEETINGS<br />
Thai International Workshop on New<br />
Technologies <strong>in</strong> Radio<strong>the</strong>rapy<br />
12th International Conference on Radiation<br />
Shield<strong>in</strong>g (ICRS-12) <strong>and</strong> 17th Topical Meet<strong>in</strong>g<br />
<strong>of</strong> <strong>the</strong> Radiation Protection <strong>and</strong> Shield<strong>in</strong>g<br />
Division <strong>of</strong> <strong>the</strong> American Nuclear Society<br />
IC3DDose: 7th International Conference on<br />
3D Radiation Dosimetry (formerly known as<br />
DOSGEL)<br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> & Physical Sciences <strong>in</strong> Medic<strong>in</strong>e<br />
Conference (EPSM2012)<br />
IEEE-EMBS – International Conference on<br />
Biomedical <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> <strong>and</strong> Sciences<br />
(IECBES 2012)<br />
17th International Conference on <strong>the</strong> Use <strong>of</strong><br />
Computers <strong>in</strong> Radiation Therapy (ICCR)<br />
34 | SEPTEMBER 2012 | SCOPE<br />
Oak Ridge, TN<br />
10th September–12th October<br />
Houston, TX<br />
14th–16th September<br />
Boston, MA<br />
23rd–27th September<br />
Boston, MA<br />
28th–31st October<br />
Anaheim, CA<br />
29th October–3rd November<br />
St Louis, MO<br />
16th–17th November<br />
Chicago, IL<br />
25th–30th November<br />
Stanford, CA<br />
30th November–1st December<br />
Scottsdale, AZ<br />
27th–30th January 2013<br />
New York, NY<br />
20th–21st April 2013<br />
Bangkok, Thail<strong>and</strong><br />
22nd–25th August<br />
Nara, Japan<br />
2nd–7th September<br />
Sydney, Australia<br />
4th–8th November<br />
Gold Coast, Queensl<strong>and</strong>, Australia<br />
2nd–6th December<br />
Langkawi, Malaysia<br />
17th–19th December<br />
Melbourne, Australia<br />
6th–9th May 2013<br />
http://www.orau.org/environmental-assessmentshealth-physics/capabilities/health-physicstra<strong>in</strong><strong>in</strong>g/course-descriptions-<strong>and</strong>-schedules.aspx<br />
http://www.md<strong>and</strong>erson.org/education-<strong>and</strong>research/departments-programs-<strong>and</strong>labs/departments-<strong>and</strong>-divisions/imag<strong>in</strong>gphysics/education/<strong>in</strong>dex.html<br />
https://ecpe.sph.harvard.edu/programs.cfm?CSID=<br />
OERP0913&pg=cluster&CLID=1<br />
https://www.astro.org/Meet<strong>in</strong>gs-<strong>and</strong>-Events/2012-<br />
Annual-Meet<strong>in</strong>g/Index.aspx<br />
http://www.nss-mic.org/2012/NSSMa<strong>in</strong>.asp<br />
http://radonc.wustl.edu/pdf/MMRTCourse.pdf<br />
http://www.rsna.org/Annual_Meet<strong>in</strong>g.aspx<br />
http://hps.org/meet<strong>in</strong>gs/meet<strong>in</strong>g33.html<br />
http://www.downstate.edu/orthopaedics/<br />
bioethicsconf2013/<br />
http://www.cccthai.org/en_/<br />
http://www.icrs12.org/<br />
http://www.ic3ddose.org<br />
http://www.epsmconference.org/<br />
http://iecbes2012.myembs.org/<br />
http://www.iccr2013.org<br />
Email: iccr2013@ar<strong>in</strong>ex.com.au
MEMBERS’ NEWS | SCOPE<br />
Röntgen Prize <strong>of</strong> <strong>the</strong> British Journal <strong>of</strong> Radiology<br />
One <strong>of</strong> our own, Peter Mountford,<br />
was recently awarded <strong>the</strong><br />
prestigious Röntgen Prize <strong>of</strong> <strong>the</strong><br />
British Journal <strong>of</strong> Radiology.<br />
Peter was formerly Director <strong>of</strong><br />
Medical <strong>Physics</strong> <strong>and</strong> Cl<strong>in</strong>ical<br />
Technology, University<br />
Hospital <strong>of</strong> North<br />
Staffordshire, Stoke-on-<br />
Trent, <strong>and</strong> also a Reader <strong>in</strong><br />
<strong>the</strong> School <strong>of</strong> Postgraduate<br />
Medic<strong>in</strong>e <strong>of</strong> Keele<br />
University.<br />
At a reception<br />
held at UKRC <strong>in</strong><br />
Manchester on<br />
Monday 25th<br />
June 2012,<br />
Peter was<br />
awarded <strong>the</strong><br />
2010 Röntgen<br />
Prize <strong>of</strong> <strong>the</strong><br />
British Journal<br />
<strong>of</strong> Radiology. Founded <strong>in</strong> 1924, <strong>in</strong><br />
memory <strong>of</strong> Pr<strong>of</strong>essor W.C.<br />
Röntgen, this prize is awarded<br />
annually to a member, or a team<br />
<strong>of</strong> workers <strong>in</strong>clud<strong>in</strong>g a member,<br />
whose contribution to <strong>the</strong> British<br />
Journal <strong>of</strong> Radiology has<br />
been <strong>of</strong> special merit.<br />
The subject <strong>of</strong> <strong>the</strong><br />
contribution must be<br />
related to radio<strong>the</strong>rapy,<br />
radiobiology or physics.<br />
The BIR stated <strong>in</strong><br />
<strong>the</strong>ir citation that:<br />
‘Throughout his NHS career Dr<br />
Mountford served <strong>the</strong> British<br />
<strong>Institute</strong> <strong>of</strong> Radiology with<br />
dist<strong>in</strong>ction. In 1994 he jo<strong>in</strong>ed <strong>the</strong><br />
Editorial Board <strong>of</strong><br />
<strong>the</strong> British<br />
Journal <strong>of</strong><br />
Radiology<br />
<strong>and</strong> later<br />
became<br />
Deputy<br />
Laser Position<strong>in</strong>g<br />
Innovative equipment for radio<strong>the</strong>rapy<br />
First laser position<strong>in</strong>g system designed<br />
with a double diode.<br />
Switch between red <strong>and</strong> green for each<br />
laser l<strong>in</strong>e at <strong>the</strong> touch <strong>of</strong> a button.<br />
No manual adjustment needed.<br />
Smart Phantom® calibrates to 0.1mm<br />
accuracy.<br />
Editor for physics <strong>and</strong><br />
technology. He additionally<br />
made scientific contributions to<br />
<strong>the</strong> BJR <strong>in</strong> numerous articles<br />
published between 1976 <strong>and</strong><br />
2009 <strong>and</strong>, for 6 years, was a<br />
member <strong>of</strong> <strong>the</strong> BIR Radiation<br />
Protection Committee.<br />
The BIR recognises with<br />
gratitude Peter Mountford's long<br />
<strong>and</strong> dist<strong>in</strong>guished association<br />
with its activities <strong>and</strong> is<br />
delighted to award him <strong>the</strong> 2010<br />
Röntgen Prize.’<br />
I th<strong>in</strong>k that our whole<br />
readership would wish to jo<strong>in</strong><br />
me <strong>in</strong> congratulat<strong>in</strong>g Peter on<br />
his achievement.<br />
Peter Mountford (right) <strong>and</strong><br />
Dr Stephen Davies, <strong>the</strong> President<br />
<strong>of</strong> <strong>the</strong> British <strong>Institute</strong> <strong>of</strong><br />
Radiology. Thank you to <strong>the</strong> BIR<br />
for provid<strong>in</strong>g <strong>the</strong> image.<br />
▼<br />
www.osl.uk.com<br />
enquiry@osl.uk.com<br />
+44 (0)1743 462694<br />
SCOPE | SEPTEMBER 2012 | 35<br />
▼
SCOPE | MEMBERS’ NEWS<br />
Robert Neilson<br />
Peter Sharp acknowledges <strong>the</strong> exceptional hard work <strong>of</strong> IPEM’s retir<strong>in</strong>g General Secretary<br />
One can argue as to<br />
who is <strong>the</strong> more<br />
important person <strong>in</strong><br />
<strong>the</strong> <strong>Institute</strong>, <strong>the</strong><br />
President or <strong>the</strong><br />
General Secretary. A President<br />
is ra<strong>the</strong>r like a pigeon, he (or<br />
she) flies <strong>in</strong>, makes a mess <strong>and</strong><br />
<strong>the</strong>n flies <strong>of</strong>f aga<strong>in</strong> after 2 years.<br />
The General Secretary has <strong>the</strong><br />
brush <strong>and</strong> pan <strong>and</strong> is<br />
responsible for clean<strong>in</strong>g up<br />
afterwards.<br />
MAJOR ACHIEVEMENTS<br />
As one <strong>of</strong> <strong>the</strong> first pigeons that<br />
Robert had to clean up after, I<br />
have no doubts about <strong>the</strong><br />
importance <strong>of</strong> <strong>the</strong> role <strong>of</strong> <strong>the</strong><br />
General Secretary. Of course he<br />
is now well supported by an<br />
adm<strong>in</strong>istrative team <strong>in</strong><br />
Fairmount House, but he<br />
carries <strong>the</strong> ultimate<br />
responsibility. I asked Robert<br />
what his greatest challenge had<br />
been <strong>and</strong> certa<strong>in</strong>ly well up <strong>the</strong><br />
top ten list was <strong>the</strong> <strong>in</strong>troduction<br />
<strong>of</strong> <strong>the</strong> new computer system.<br />
Those <strong>of</strong> you who are keen<br />
36 | SEPTEMBER 2012 | SCOPE<br />
subscribers to Private Eye will<br />
frequently read about <strong>the</strong><br />
disasters that befall many<br />
government departments when<br />
<strong>the</strong>y try to <strong>in</strong>troduce new<br />
computer systems <strong>and</strong> IPEM,<br />
while not (yet) featur<strong>in</strong>g <strong>in</strong> that<br />
august organ, was not immune<br />
from that. I have <strong>of</strong>ten said that a<br />
new President has two options;<br />
ei<strong>the</strong>r <strong>in</strong>troduce a new computer<br />
system for <strong>the</strong> <strong>of</strong>fice or<br />
undertake a reorganisation <strong>of</strong><br />
how IPEM works. Ei<strong>the</strong>r way<br />
he/she will have an excuse for<br />
putt<strong>in</strong>g <strong>of</strong>f any difficult decisions<br />
until after <strong>the</strong>ir term <strong>of</strong> <strong>of</strong>fice. But<br />
Robert is <strong>the</strong> man with <strong>the</strong> brush<br />
<strong>and</strong> pan.<br />
“<br />
The General<br />
Secretary has <strong>the</strong><br />
brush <strong>and</strong> pan <strong>and</strong><br />
is responsible for<br />
clean<strong>in</strong>g up<br />
”<br />
Like many lead<strong>in</strong>g lights <strong>in</strong><br />
IPEM Robert has Scottish roots.<br />
Be<strong>in</strong>g a keen amateur<br />
genealogist Robert has traced<br />
one part <strong>of</strong> his family back to St<br />
N<strong>in</strong>ians, near Stirl<strong>in</strong>g. However,<br />
<strong>in</strong> <strong>the</strong> middle <strong>of</strong> <strong>the</strong> n<strong>in</strong>eteenth<br />
century <strong>the</strong>y moved down to<br />
Yorkshire, first to <strong>the</strong> York area<br />
<strong>and</strong> <strong>the</strong>n, his sub-branch, to<br />
Knott<strong>in</strong>gley, where Robert<br />
himself was born. Robert is now<br />
a fully fledged Yorkshireman,<br />
hav<strong>in</strong>g lived <strong>in</strong> <strong>the</strong> county all<br />
his life. Not only does he<br />
love its moors <strong>and</strong><br />
dales but as a<br />
committed Christian<br />
Robert has many<br />
connections through<br />
his work with <strong>the</strong><br />
Congregational<br />
Church <strong>in</strong> Pontefract.<br />
Those <strong>of</strong> us who<br />
have had <strong>the</strong> privilege <strong>of</strong> work<strong>in</strong>g<br />
with Robert over <strong>the</strong> years<br />
appreciate his openness, honesty<br />
<strong>and</strong> full commitment to <strong>the</strong> aims<br />
<strong>of</strong> <strong>the</strong> <strong>Institute</strong>. When I suggested<br />
to Robert that perhaps not be<strong>in</strong>g<br />
a scientist would have been a<br />
disadvantage <strong>in</strong> his early days, he<br />
po<strong>in</strong>ted out that he had always<br />
been keen on science <strong>and</strong> it was<br />
only a quirk <strong>of</strong> <strong>the</strong> educational<br />
system that meant he had ended<br />
up on <strong>the</strong> arts side. Also, <strong>in</strong> his<br />
previous jobs <strong>in</strong> <strong>the</strong> power<br />
<strong>in</strong>dustry, he had worked with<br />
scientists <strong>and</strong> eng<strong>in</strong>eers <strong>and</strong><br />
needed a strong technical<br />
background to carry out audits<br />
<strong>and</strong> manage <strong>the</strong> functions for<br />
which he was responsible at a<br />
power station <strong>and</strong> <strong>in</strong> <strong>the</strong> fuel<br />
supply cha<strong>in</strong>.<br />
That devotion to <strong>the</strong><br />
pr<strong>of</strong>ession showed itself aga<strong>in</strong><br />
when I asked Robert <strong>of</strong> what<br />
achievement he was most proud.<br />
He said that it was <strong>the</strong> work he<br />
did with <strong>the</strong> Science Council, on<br />
behalf <strong>of</strong> <strong>the</strong> <strong>Institute</strong>. Dur<strong>in</strong>g<br />
that time <strong>the</strong> Chartered Scientist<br />
designation was developed <strong>and</strong><br />
he played an important role on<br />
<strong>the</strong> Registration Authority, act<strong>in</strong>g<br />
as its chair dur<strong>in</strong>g <strong>the</strong> crucial<br />
formative period when CSci<br />
st<strong>and</strong>ards were set <strong>and</strong> <strong>in</strong>itial<br />
licences were awarded. In <strong>the</strong><br />
last year he has been <strong>in</strong>volved <strong>in</strong><br />
<strong>in</strong>troduc<strong>in</strong>g <strong>the</strong> RSci <strong>and</strong><br />
RSciTech qualification for<br />
science technologists at different<br />
career stages, with IPEM be<strong>in</strong>g<br />
one <strong>of</strong> <strong>the</strong> first organisations to<br />
be able to award <strong>the</strong> new<br />
designations. There is someth<strong>in</strong>g<br />
<strong>in</strong> <strong>the</strong> genes <strong>of</strong> medical physicists<br />
that makes <strong>the</strong>m cynical about<br />
<strong>the</strong> value <strong>of</strong> qualifications but, <strong>in</strong><br />
a competitive world, marks <strong>of</strong><br />
pr<strong>of</strong>essional st<strong>and</strong><strong>in</strong>g are<br />
<strong>in</strong>creas<strong>in</strong>gly important <strong>and</strong><br />
Robert must be congratulated on<br />
his work.<br />
So how has <strong>the</strong> role <strong>of</strong> <strong>the</strong><br />
General Secretary developed over<br />
<strong>the</strong> time Robert has been <strong>in</strong><br />
<strong>of</strong>fice? He rem<strong>in</strong>ded me <strong>of</strong> a<br />
question that I had asked him at<br />
his <strong>in</strong>terview, ‘Do you feel that<br />
this job is really a full-time one?’<br />
His answer had been that no, it<br />
wasn’t, at least not as we had<br />
described it <strong>in</strong> <strong>the</strong> job<br />
specification, but it should be full<br />
time as <strong>the</strong>re was much more<br />
that needed to be done <strong>and</strong> he<br />
promptly listed all <strong>the</strong> extra<br />
tasks. Despite that he was<br />
appo<strong>in</strong>ted.<br />
CHALLENGES FACED<br />
The ma<strong>in</strong> change has been <strong>the</strong><br />
move from <strong>the</strong> post be<strong>in</strong>g<br />
primarily adm<strong>in</strong>istrative to one <strong>of</strong><br />
be<strong>in</strong>g <strong>the</strong> Chief Executive, <strong>the</strong><br />
person who makes a significant<br />
contribution to <strong>the</strong> strategic<br />
vision <strong>of</strong> <strong>the</strong> <strong>Institute</strong>. Now that<br />
<strong>the</strong> <strong>Institute</strong> has a well-organised<br />
<strong>of</strong>fice to take on <strong>the</strong> many tasks<br />
that an organisation <strong>of</strong> our size<br />
needs do<strong>in</strong>g, <strong>the</strong> role has been<br />
much more h<strong>and</strong>s-<strong>of</strong>f with<br />
Robert <strong>in</strong>creas<strong>in</strong>gly be<strong>in</strong>g asked<br />
to represent <strong>the</strong> <strong>Institute</strong> on<br />
external bodies, such as <strong>the</strong><br />
Science Council. I know that<br />
dur<strong>in</strong>g my time as President I<br />
found it very helpful to have<br />
Robert sitt<strong>in</strong>g next to me at<br />
committee meet<strong>in</strong>gs to provide<br />
wise advice <strong>and</strong> rem<strong>in</strong>d me when<br />
I was stray<strong>in</strong>g from <strong>the</strong> party l<strong>in</strong>e.<br />
Of course <strong>in</strong> <strong>the</strong> past few years<br />
<strong>the</strong> l<strong>and</strong>scape <strong>in</strong> which <strong>the</strong><br />
<strong>Institute</strong> operates has changed<br />
significantly. The <strong>Institute</strong> is faced<br />
with an adm<strong>in</strong>istration <strong>in</strong><br />
Westm<strong>in</strong>ster which does not<br />
always appreciate <strong>the</strong> value <strong>of</strong><br />
pr<strong>of</strong>essional societies <strong>and</strong> seems<br />
to prefer to take on much <strong>of</strong> <strong>the</strong>ir<br />
roles <strong>the</strong>mselves. Robert’s view<br />
<strong>of</strong> <strong>the</strong> challenges fac<strong>in</strong>g his<br />
successor is that <strong>the</strong>y need to<br />
create an organisation that gives
a strong pr<strong>of</strong>essional<br />
leadership. The old model <strong>of</strong> <strong>the</strong><br />
majority <strong>of</strong> work be<strong>in</strong>g carried<br />
out by volunteers is now not so<br />
appropriate with everyone<br />
under much more scrut<strong>in</strong>y as to<br />
how <strong>the</strong>y use <strong>the</strong>ir time. More<br />
reliance will need to be on paid<br />
staff with appropriate<br />
pr<strong>of</strong>essional backgrounds. He<br />
also has a typically trenchant<br />
view on who is <strong>the</strong> audience <strong>of</strong><br />
IPEM. Of course <strong>the</strong> NHS is a<br />
major customer (I can hear<br />
Robert mutter four devolved<br />
NHS organisations) but we need<br />
to service a far broader<br />
congregation; academia, biology<br />
<strong>and</strong> related <strong>in</strong>dustries, perhaps<br />
even agriculture.<br />
Robert has served <strong>the</strong><br />
<strong>Institute</strong> well for <strong>the</strong> past 16<br />
years <strong>and</strong> even <strong>in</strong> his f<strong>in</strong>al<br />
months his enthusiasm for <strong>the</strong><br />
‘<br />
RETIREMENT<br />
Eight IPEM Presidents <strong>and</strong> <strong>the</strong> President-Elect had lunch with Robert Neilson <strong>in</strong> York to mark his retirement as General Secretary.<br />
Back row (left to right): Peter Sharp OBE (1997–99); Steve Smye (2001–03); Peter Wells CBE (1995–97); Peter Jackson (2005–07); Keith Ison<br />
(2007–09); Peter Williams (2003–05). Front row: Chris Gibson (2009–11); Peter Jarritt (2011–13); Robert Neilson (General Secretary,<br />
1996–2012); Steve Keevil (President-Elect, 2011–13). Rod Smallwood (1999–2001) was unable to attend at <strong>the</strong> last m<strong>in</strong>ute.<br />
work <strong>of</strong> <strong>the</strong> <strong>Institute</strong> is strong.<br />
We will miss his wise guidance,<br />
his hard work <strong>and</strong> his strategic<br />
vision. We will also miss his<br />
many anecdotes from his<br />
previous jobs! We wish him a<br />
long <strong>and</strong> productive retirement<br />
which he says he will spend<br />
br<strong>in</strong>g<strong>in</strong>g to fruition five books<br />
<strong>and</strong> f<strong>in</strong>ally trac<strong>in</strong>g his Scottish<br />
ancestry beyond a blank period<br />
<strong>in</strong> records, which he believes<br />
was caused by a ‘disruption’ <strong>in</strong><br />
<strong>the</strong> established, Scottish<br />
Presbyterian Church <strong>in</strong> St<br />
N<strong>in</strong>ians. He is amused, as a<br />
member <strong>of</strong> a church that had its<br />
orig<strong>in</strong>s <strong>in</strong> similar pr<strong>in</strong>cipled<br />
dissent from <strong>the</strong> 1662 Act <strong>of</strong><br />
Uniformity <strong>in</strong> Engl<strong>and</strong>, that his<br />
Scottish ancestors may<br />
<strong>the</strong>mselves have been <strong>in</strong>volved<br />
<strong>in</strong> <strong>the</strong> Scottish version <strong>of</strong> dissent<br />
<strong>in</strong> <strong>the</strong> 1700s.<br />
SCOPE | SEPTEMBER 2012 | 37
SCOPE | MEMBERS’ NEWS<br />
Pr<strong>of</strong>essor Peter Sharp OBE, FRSE, FIPEM, CSci, FInstP<br />
Robert Neilson pays tribute to <strong>the</strong> <strong>in</strong>credible work achieved <strong>in</strong> a long career<br />
Pr<strong>of</strong>essor Peter<br />
Sharp retired from<br />
his tw<strong>in</strong><br />
appo<strong>in</strong>tments as<br />
Pr<strong>of</strong>essor <strong>of</strong><br />
Medical <strong>Physics</strong> at <strong>the</strong><br />
University <strong>of</strong> Aberdeen <strong>and</strong><br />
Cl<strong>in</strong>ical Director <strong>of</strong> Medical<br />
<strong>Physics</strong> for NHS Grampian at<br />
<strong>the</strong> end <strong>of</strong> August 2012. He is<br />
one <strong>of</strong> a decreas<strong>in</strong>g number <strong>of</strong><br />
people with truly dual<br />
appo<strong>in</strong>tments, whose salary is<br />
paid by both <strong>the</strong> university <strong>and</strong><br />
<strong>the</strong> hospital. He observes that<br />
this means both employers<br />
expect him to do a full-time job<br />
for <strong>the</strong>m! He actually has found<br />
<strong>the</strong> arrangement very useful, as<br />
work<strong>in</strong>g with medical staff <strong>in</strong><br />
his NHS role has given him<br />
opportunities for spott<strong>in</strong>g<br />
research projects that he could<br />
carry out <strong>in</strong> his university role.<br />
EARLY CAREER<br />
Born <strong>in</strong> L<strong>in</strong>colnshire, <strong>and</strong> after<br />
a grammar school education <strong>in</strong><br />
Spald<strong>in</strong>g, Peter read <strong>Physics</strong> at<br />
Durham University <strong>and</strong> was<br />
awarded <strong>the</strong> degree <strong>of</strong> BSc<br />
(Hons) <strong>in</strong> 1968. Dur<strong>in</strong>g his f<strong>in</strong>al<br />
year he applied to Aberdeen for<br />
a place on <strong>the</strong> MSc <strong>in</strong> Medical<br />
<strong>Physics</strong> course developed by<br />
John Mallard OBE, who was <strong>the</strong><br />
first Pr<strong>of</strong>essor <strong>of</strong> Medical<br />
<strong>Physics</strong> at Aberdeen, <strong>and</strong> whom<br />
Peter would later succeed as<br />
<strong>the</strong> second Pr<strong>of</strong>essor. Peter<br />
decided his <strong>in</strong>terests really<br />
were <strong>in</strong> go<strong>in</strong>g on to do a PhD,<br />
<strong>and</strong> gave this as <strong>the</strong> reason for<br />
withdraw<strong>in</strong>g his application.<br />
John Mallard countered by<br />
<strong>of</strong>fer<strong>in</strong>g Peter a place as a PhD<br />
student to undertake research<br />
<strong>in</strong>to <strong>the</strong> quality <strong>of</strong> nuclear<br />
medic<strong>in</strong>e images, <strong>and</strong> <strong>the</strong> rest,<br />
as <strong>the</strong>y say, is history.<br />
When Peter had completed<br />
his PhD, he obta<strong>in</strong>ed a<br />
permanent appo<strong>in</strong>tment <strong>and</strong><br />
38 | SEPTEMBER 2012 | SCOPE<br />
stayed for <strong>the</strong> whole <strong>of</strong> his<br />
work<strong>in</strong>g life, eventually<br />
succeed<strong>in</strong>g John Mallard as<br />
Pr<strong>of</strong>essor <strong>of</strong> Medical <strong>Physics</strong><br />
when he retired.<br />
When asked why he had spent<br />
his entire career <strong>in</strong> Aberdeen, he<br />
said simply that <strong>the</strong>re was a lot <strong>of</strong><br />
<strong>in</strong>terest<strong>in</strong>g scientific work go<strong>in</strong>g<br />
on <strong>the</strong>re <strong>and</strong> he wanted to be part<br />
<strong>of</strong> it. In <strong>the</strong> early 1970s two SPECT<br />
“<br />
This means<br />
both employers<br />
expect him to do a<br />
full-time job for<br />
<strong>the</strong>m!<br />
”<br />
scanners were built, <strong>the</strong> first <strong>in</strong><br />
<strong>the</strong> UK <strong>and</strong> predat<strong>in</strong>g <strong>the</strong> x-ray CT<br />
scanner. Later, a gamma camera<br />
was mounted on <strong>the</strong> st<strong>and</strong> from<br />
an old cobalt mach<strong>in</strong>e to produce<br />
an early SPECT camera. In <strong>the</strong><br />
early 1980s Aberdeen developed<br />
<strong>the</strong> first cl<strong>in</strong>ical whole-body MR<br />
imager <strong>and</strong> established a PET<br />
centre <strong>in</strong> Aberdeen, <strong>the</strong> first <strong>in</strong> <strong>the</strong><br />
UK apart from <strong>the</strong> MRC PET<br />
Centre at Hammersmith<br />
Hospital. This <strong>in</strong>volved<br />
dismantl<strong>in</strong>g a cyclotron that had<br />
been used <strong>in</strong> a radio<strong>the</strong>rapy<br />
project <strong>in</strong> Ed<strong>in</strong>burgh, shipp<strong>in</strong>g it<br />
up to Aberdeen (courtesy <strong>of</strong> <strong>the</strong><br />
Army) <strong>and</strong> <strong>the</strong>n reassembl<strong>in</strong>g it.<br />
The Aberdeen PET centre also<br />
used a second-h<strong>and</strong> PET scanner<br />
that had previously been at <strong>the</strong><br />
Hammersmith PET centre.<br />
Initially <strong>the</strong>re was nowhere to put<br />
<strong>the</strong> equipment, so money had to<br />
be raised to buy an old farm<br />
build<strong>in</strong>g which was <strong>the</strong>n<br />
converted <strong>in</strong>to a PET centre with a<br />
radiochemistry facility. Peter<br />
remembers it as fun to see so<br />
much be<strong>in</strong>g achieved on a<br />
shoestr<strong>in</strong>g budget, although it<br />
didn’t seem like it at <strong>the</strong> time.<br />
PROFESSIONAL WORK<br />
Peter has spent most <strong>of</strong> his<br />
career work<strong>in</strong>g <strong>in</strong> nuclear<br />
medic<strong>in</strong>e, but when he succeeded<br />
John Mallard as Chair <strong>and</strong> as<br />
Head <strong>of</strong> Department <strong>in</strong> 1992, he<br />
rel<strong>in</strong>quished his role as Head <strong>of</strong><br />
Nuclear Medic<strong>in</strong>e, whilst<br />
reta<strong>in</strong><strong>in</strong>g a pr<strong>of</strong>essional <strong>in</strong>terest<br />
<strong>in</strong> <strong>the</strong> area. His cont<strong>in</strong>u<strong>in</strong>g<br />
<strong>in</strong>terest resulted <strong>in</strong> him<br />
persuad<strong>in</strong>g <strong>the</strong> hospital to pay for<br />
a new build<strong>in</strong>g for <strong>the</strong> PET centre<br />
to br<strong>in</strong>g it on to <strong>the</strong> hospital site,<br />
rais<strong>in</strong>g money for a new cyclotron<br />
<strong>and</strong> radiochemistry facility <strong>and</strong><br />
purchas<strong>in</strong>g a new PET imager. A<br />
few years later <strong>the</strong> Scottish<br />
Government wanted to know if<br />
PET was likely to be <strong>of</strong> value <strong>in</strong> <strong>the</strong><br />
management <strong>of</strong> cancer, <strong>and</strong><br />
Peter was asked to chair an<br />
advisory group to formulate<br />
advice. A model was constructed<br />
show<strong>in</strong>g how PET would be used<br />
<strong>in</strong> <strong>the</strong> cl<strong>in</strong>ical sett<strong>in</strong>g, <strong>and</strong><br />
populated with measures <strong>of</strong> <strong>the</strong><br />
sensitivity <strong>and</strong> specificity <strong>of</strong> PET<br />
for various cancers, to work out<br />
<strong>the</strong> likely costs <strong>of</strong> a PET service<br />
<strong>and</strong> <strong>the</strong>n demonstrate that it<br />
would be cost effective. The<br />
Scottish Government was<br />
persuaded that <strong>the</strong>y should <strong>in</strong>vest<br />
<strong>in</strong> PET scanners, which by this<br />
time were PET/CT scanners, <strong>and</strong><br />
equip <strong>the</strong> four cancer centres <strong>in</strong><br />
Scotl<strong>and</strong>. Peter was awarded <strong>the</strong><br />
Norman Veal Medal <strong>of</strong> <strong>the</strong> British<br />
Nuclear Medic<strong>in</strong>e Society <strong>in</strong> 1999<br />
<strong>in</strong> recognition <strong>of</strong> his contribution<br />
to nuclear medic<strong>in</strong>e.<br />
Away from nuclear medic<strong>in</strong>e,<br />
Peter’s research <strong>in</strong>terests had<br />
developed <strong>in</strong>to <strong>the</strong> science<br />
underp<strong>in</strong>n<strong>in</strong>g ophthalmology.<br />
There was a strong research<br />
group at Aberdeen University<br />
<strong>in</strong>terested <strong>in</strong> <strong>the</strong> biology <strong>of</strong><br />
diabetic eye disease, which is <strong>the</strong><br />
most common cause <strong>of</strong> bl<strong>in</strong>dness<br />
<strong>in</strong> <strong>the</strong> work<strong>in</strong>g age population.<br />
This group approached Peter’s<br />
physics team to see if <strong>the</strong>y could<br />
develop a scann<strong>in</strong>g laser<br />
ophthalmoscope. This was a<br />
device that scanned a laser beam<br />
over <strong>the</strong> ret<strong>in</strong>a <strong>of</strong> <strong>the</strong> eye <strong>and</strong> built<br />
up a picture from <strong>the</strong> reflected<br />
light. The team went fur<strong>the</strong>r <strong>and</strong><br />
built a mach<strong>in</strong>e that used three<br />
lasers at different wavelengths, to<br />
give a full colour, ra<strong>the</strong>r than<br />
monochromatic, image. It also<br />
went on to modify <strong>the</strong> scanner so<br />
that it would image <strong>in</strong>dividual<br />
blood cells as <strong>the</strong>y flowed<br />
through <strong>the</strong> ret<strong>in</strong>al vasculature <strong>in</strong><br />
rats <strong>and</strong> genetically modified<br />
mice. This allowed measurement<br />
<strong>of</strong> <strong>the</strong>ir speed <strong>and</strong> number <strong>of</strong><br />
cells, thus provid<strong>in</strong>g tools to<br />
<strong>in</strong>vestigate vascular diseases<br />
where it was believed that <strong>the</strong><br />
blood cells would stick to <strong>the</strong><br />
walls <strong>of</strong> <strong>the</strong> vessels.<br />
Peter’s team was <strong>the</strong>n<br />
approached by a group <strong>of</strong><br />
ophthalmologists who were<br />
runn<strong>in</strong>g a diabetic ret<strong>in</strong>al<br />
screen<strong>in</strong>g service <strong>in</strong> Scotl<strong>and</strong>.<br />
Every person <strong>in</strong> Scotl<strong>and</strong> with<br />
diabetes has annual images <strong>of</strong><br />
<strong>the</strong>ir eyes taken to look for early<br />
signs <strong>of</strong> eye disease. They were<br />
tra<strong>in</strong><strong>in</strong>g ret<strong>in</strong>al screeners to<br />
exam<strong>in</strong>e <strong>the</strong> tens <strong>of</strong> thous<strong>and</strong>s <strong>of</strong><br />
images <strong>and</strong> clearly it was<br />
extremely time consum<strong>in</strong>g,<br />
expensive <strong>and</strong> not very reliable.<br />
The physics team’s task was to<br />
develop s<strong>of</strong>tware that would<br />
analyse <strong>the</strong> ret<strong>in</strong>al images for <strong>the</strong><br />
pathology that was <strong>in</strong>dicative <strong>of</strong><br />
early eye disease. If none was<br />
found <strong>the</strong>n <strong>the</strong> person would<br />
simply be told to return <strong>the</strong> next<br />
year for ano<strong>the</strong>r picture. If <strong>the</strong>re<br />
were some abnormal features<br />
<strong>the</strong>n <strong>the</strong> images would be passed<br />
on to a human screener for<br />
fur<strong>the</strong>r analysis. The required<br />
s<strong>of</strong>tware was developed <strong>and</strong><br />
trialled with thous<strong>and</strong>s <strong>of</strong><br />
patients. The trials showed that it<br />
was reliable, <strong>and</strong> cheaper than
employ<strong>in</strong>g human screeners for<br />
basic screen<strong>in</strong>g. A licence on<br />
<strong>the</strong> s<strong>of</strong>tware was taken up by a<br />
company <strong>and</strong> <strong>the</strong> system is now<br />
<strong>in</strong> rout<strong>in</strong>e use <strong>in</strong> <strong>the</strong> Scottish<br />
Screen<strong>in</strong>g Service.<br />
HONOURS RECEIVED<br />
Research support<strong>in</strong>g<br />
ophthalmology cont<strong>in</strong>ues.<br />
Ano<strong>the</strong>r cl<strong>in</strong>ical trial<br />
concern<strong>in</strong>g automat<strong>in</strong>g<br />
macular oedema detection has<br />
just been completed; ano<strong>the</strong>r<br />
project is look<strong>in</strong>g at whe<strong>the</strong>r<br />
diabetic eye disease is a<br />
predictor <strong>of</strong> cardiovascular<br />
disease, <strong>and</strong> ano<strong>the</strong>r is look<strong>in</strong>g<br />
at <strong>the</strong> <strong>in</strong>formation that can be<br />
derived from serial ret<strong>in</strong>al<br />
photographs.<br />
In 2000 Peter’s department<br />
was awarded <strong>the</strong> Queen's<br />
Anniversary Prize for Higher<br />
<strong>and</strong> Fur<strong>the</strong>r Education <strong>in</strong><br />
recognition <strong>of</strong> its ‘pre-em<strong>in</strong>ence<br />
<strong>in</strong> medical imag<strong>in</strong>g technology<br />
for over 30 years’. As Peter had<br />
been <strong>the</strong>re for <strong>the</strong> entire 30<br />
years (<strong>and</strong> now 12 years more),<br />
this was not only a recognition<br />
<strong>of</strong> <strong>the</strong> work that <strong>the</strong> department<br />
had been do<strong>in</strong>g, it also reflected<br />
his contribution to it.<br />
But Peter’s work <strong>and</strong><br />
achievements must also be set<br />
<strong>in</strong> <strong>the</strong> context <strong>of</strong> his wider<br />
pr<strong>of</strong>essional contribution <strong>in</strong><br />
Scotl<strong>and</strong>, <strong>in</strong> <strong>the</strong> UK <strong>and</strong>, more<br />
recently, <strong>in</strong> Europe.<br />
Even as a PhD student,<br />
Peter’s research <strong>in</strong>volved<br />
contact with <strong>the</strong> NHS<br />
department <strong>in</strong> Aberdeen <strong>and</strong><br />
John Mallard quickly persuaded<br />
him to jo<strong>in</strong> HPA/IPSM,<br />
predecessor organisations <strong>of</strong><br />
IPEM. He recalled that an early<br />
<strong>in</strong>volvement <strong>in</strong> pr<strong>of</strong>essional<br />
body ‘corridors <strong>of</strong> power’ was<br />
when he attended a meet<strong>in</strong>g <strong>of</strong><br />
<strong>the</strong> IPSM Pr<strong>of</strong>essional<br />
Committee at <strong>the</strong> <strong>Institute</strong> <strong>of</strong><br />
<strong>Physics</strong>’ former <strong>of</strong>fices <strong>in</strong><br />
Belgrave Square, where <strong>the</strong><br />
HPA/IPSM <strong>of</strong>fice was <strong>the</strong>n hosted.<br />
Keith Boddy, who was to attend<br />
<strong>the</strong> meet<strong>in</strong>g, was delayed<br />
because he had been asked to<br />
meet with IOP <strong>of</strong>ficers, to be given<br />
<strong>the</strong> news that HPA /IPSM were<br />
be<strong>in</strong>g asked to f<strong>in</strong>d alternative<br />
<strong>of</strong>fice accommodation. It was<br />
decided to move to York, where<br />
IPEM (as it now is) now occupies<br />
its third <strong>of</strong>fice premises.<br />
Peter was <strong>the</strong> second IPEM<br />
President (1997–99), hav<strong>in</strong>g<br />
previously served as <strong>the</strong> first<br />
IPEM Vice President (1995–97)<br />
<strong>and</strong> <strong>the</strong> last Honorary Secretary<br />
<strong>of</strong> IPSM (1992–95), prior to which<br />
he was IPSM’s Assistant<br />
Honorary Secretary (1990–92).<br />
His reward for such dedicated<br />
service, post Presidency, was to<br />
be nom<strong>in</strong>ated by IPEM to be Chair<br />
<strong>of</strong> <strong>the</strong> Association <strong>of</strong> Cl<strong>in</strong>ical<br />
Scientists, to chair RPA 2000<br />
(which certificates Radiation<br />
Protection Advisers on behalf <strong>of</strong><br />
<strong>the</strong> Health <strong>and</strong> Safety Executive),<br />
to chair IPEM’s Pr<strong>of</strong>essional<br />
Conduct Committee, to represent<br />
IPEM on <strong>the</strong> Executive <strong>of</strong> <strong>the</strong><br />
IOP–IPEM Medical <strong>Physics</strong><br />
Group, to be Company Secretary<br />
<strong>of</strong> Radiation <strong>and</strong> Oncology<br />
Congresses, to represent IPEM<br />
on <strong>the</strong> Scottish Forum for<br />
Healthcare Science (which he<br />
also chaired), to be Honorary<br />
Treasurer <strong>of</strong> <strong>the</strong> (UK) Federation<br />
for Healthcare Science, to be<br />
Honorary Treasurer <strong>of</strong> <strong>the</strong><br />
European Federation <strong>of</strong><br />
Organisations for <strong>Physics</strong> <strong>in</strong><br />
Medic<strong>in</strong>e (EFOMP) <strong>and</strong> to be a<br />
member <strong>of</strong> <strong>the</strong> Science Council’s<br />
Registration Authority. Peter was<br />
elected as a Fellow <strong>of</strong> <strong>the</strong><br />
Royal Society <strong>of</strong> Ed<strong>in</strong>burgh<br />
(FRSE) <strong>and</strong> has served on<br />
its Council <strong>and</strong> its<br />
Fellowship Appo<strong>in</strong>tments<br />
Committee.<br />
‘<br />
OTHER INTERESTS<br />
As retirement (from employment,<br />
at least!) has drawn closer, Peter<br />
has managed to h<strong>and</strong> over most<br />
<strong>of</strong> his roles that had not already<br />
come to <strong>the</strong> end <strong>of</strong> a def<strong>in</strong>ed term<br />
<strong>of</strong> <strong>of</strong>fice. He rema<strong>in</strong>s a member <strong>of</strong><br />
<strong>the</strong> Science Council’s<br />
Registration Authority <strong>and</strong> <strong>in</strong><br />
January 2011 stood down after 5<br />
years as Honorary Treasurer to<br />
become Vice President <strong>of</strong> EFOMP,<br />
<strong>in</strong> <strong>the</strong> knowledge that he would<br />
succeed to <strong>the</strong> Presidency <strong>of</strong><br />
EFOMP from January 2012 for a<br />
term <strong>of</strong> 3 years.<br />
He confesses that he has ‘lived<br />
to work ra<strong>the</strong>r than worked to<br />
live’, but does f<strong>in</strong>d time for some<br />
<strong>in</strong>terests that are not workrelated.<br />
He chairs <strong>the</strong><br />
Adm<strong>in</strong>istration Board for <strong>the</strong><br />
Diocese <strong>of</strong> Brech<strong>in</strong> <strong>in</strong> <strong>the</strong> Scottish<br />
Episcopal Church. Several years<br />
ago he was appo<strong>in</strong>ted as an<br />
Honorary Sherriff, which <strong>in</strong> <strong>the</strong><br />
Scottish legal system is <strong>the</strong><br />
equivalent <strong>of</strong> a judge. However,<br />
while he has <strong>the</strong> power to give<br />
custodial sentences, he is not<br />
allowed to preside at trials by jury.<br />
Peter enjoys classical<br />
music,<br />
especially<br />
opera,<br />
<strong>and</strong><br />
believes<br />
that <strong>the</strong><br />
K<strong>in</strong>dle is<br />
one <strong>of</strong> <strong>the</strong><br />
most<br />
useful<br />
devices to<br />
have been<br />
developed<br />
RETIREMENT<br />
<strong>in</strong> <strong>the</strong> past 10 years. So, although<br />
it looks as if read<strong>in</strong>g is on his<br />
retirement agenda, erect<strong>in</strong>g more<br />
bookshelves is not!<br />
Over a long <strong>and</strong> successful<br />
career, Peter’s contribution to<br />
medical physics has been<br />
<strong>in</strong>calculable, even for a physicist<br />
or ma<strong>the</strong>matician, <strong>and</strong> IPEM <strong>and</strong><br />
<strong>the</strong> pr<strong>of</strong>ession <strong>in</strong> general <strong>in</strong> <strong>the</strong><br />
UK will be <strong>the</strong> poorer to lose his<br />
active presence. His outst<strong>and</strong><strong>in</strong>g<br />
contribution has, however,<br />
recently been recognised by <strong>the</strong><br />
award to him <strong>of</strong> an OBE <strong>in</strong> <strong>the</strong><br />
Queen’s Birthday Honours List,<br />
for services to healthcare<br />
science. However, with his<br />
retirement from employment, <strong>the</strong><br />
UK’s loss is Europe’s ga<strong>in</strong>, for a<br />
few more years at least, as he<br />
br<strong>in</strong>gs his accumulated wisdom<br />
to bear on medical physics<br />
matters European. Peter has also<br />
agreed to be <strong>the</strong> President <strong>of</strong><br />
ICMP 2013 (<strong>the</strong> International<br />
Congress <strong>of</strong> Medical <strong>Physics</strong>), to<br />
be hosted by IPEM <strong>in</strong> Brighton <strong>in</strong><br />
September 2013, <strong>and</strong> which will<br />
<strong>in</strong>corporate, with IOMP’s 50th<br />
anniversary congress, IPEM’s<br />
annual Medical <strong>Physics</strong> <strong>and</strong><br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> Conference<br />
(MPEC) <strong>and</strong> EFOMP’s<br />
biennial European<br />
Medical <strong>Physics</strong><br />
Congress (EMPC).<br />
So, as Peter retires<br />
from his career <strong>in</strong><br />
medical physics <strong>in</strong><br />
Aberdeen, for IPEM it<br />
will not be a complete<br />
‘goodbye’, but ‘au revoir’,<br />
<strong>and</strong> we wish him well <strong>in</strong><br />
his far-from-<strong>in</strong>active<br />
retirement.<br />
SCOPE | SEPTEMBER 2012 | 39
SCOPE | BOOK REVIEWS<br />
Welcome to ano<strong>the</strong>r<br />
issue <strong>of</strong> Scope<br />
‘Book Reviews’!<br />
This time around<br />
we have had <strong>the</strong><br />
highest number <strong>of</strong><br />
reviews submitted<br />
by our team <strong>of</strong> Ubidesk book reviewers. A<br />
special thanks to our reviewers who have,<br />
for <strong>the</strong> first time this year, supplied more<br />
than <strong>the</strong> target number <strong>of</strong> book reviews!<br />
Textbook reviews cover both <strong>the</strong> medical<br />
physics <strong>and</strong> popular science genres. A list<br />
<strong>of</strong> <strong>the</strong> reviewed titles with reviewers can be<br />
found below <strong>in</strong> table 1.<br />
As with each Scope issue, <strong>the</strong>re are a<br />
number <strong>of</strong> new medical physics textbooks<br />
<strong>in</strong> <strong>the</strong> ‘Just Published’ section. You will<br />
f<strong>in</strong>d some <strong>in</strong>terest<strong>in</strong>g reports listed <strong>in</strong> <strong>the</strong><br />
‘New Reports’ section, such as ‘Health<br />
Effects from Radi<strong>of</strong>requency<br />
Electromagnetic Fields’. I have <strong>in</strong>cluded a<br />
reference to a relatively recent report<br />
published by <strong>the</strong> Department <strong>of</strong> Health <strong>in</strong><br />
2011, ‘Radio<strong>the</strong>rapy Dataset Annual<br />
Report’, for completeness. You may also<br />
want to have a look at <strong>the</strong> ‘Safer<br />
Radio<strong>the</strong>rapy’ newsletter <strong>of</strong> <strong>the</strong> HPA, <strong>the</strong><br />
last <strong>of</strong> which was published <strong>in</strong> 2011 (issue<br />
6). Reader(s) who are <strong>in</strong>terested <strong>in</strong><br />
review<strong>in</strong>g listed/unlisted books please do<br />
get <strong>in</strong> touch with me so I can arrange to<br />
send you <strong>the</strong> required material directly<br />
from <strong>the</strong> publisher. Note that some <strong>of</strong> <strong>the</strong><br />
new reports are freely available to<br />
download from <strong>the</strong> respective websites.<br />
A warm welcome to ano<strong>the</strong>r book<br />
reviewer – Ms Rebecca Quest, Pr<strong>in</strong>cipal<br />
Cl<strong>in</strong>ical Scientist specialis<strong>in</strong>g <strong>in</strong> MRI <strong>and</strong><br />
work<strong>in</strong>g at <strong>the</strong> Imperial College Healthcare<br />
NHS Trust <strong>in</strong> London. Dr Mark McJury,<br />
Consultant Cl<strong>in</strong>ical Scientist, rejo<strong>in</strong>ed us<br />
after mov<strong>in</strong>g hospitals – he now works at<br />
<strong>the</strong> Beatson Cancer Centre as <strong>the</strong> Head <strong>of</strong><br />
Research <strong>and</strong> Development <strong>in</strong><br />
Radio<strong>the</strong>rapy <strong>Physics</strong>.<br />
We do require more book reviewers to<br />
allow us to consistently hit our 2012 target<br />
TABLE 1<br />
40 | SEPTEMBER 2012 | SCOPE<br />
<strong>of</strong> eight book reviews per quarter, so please<br />
drop me an email if you are <strong>in</strong>terested <strong>in</strong><br />
becom<strong>in</strong>g a reviewer. The review<strong>in</strong>g<br />
process is relatively relaxed, <strong>and</strong> <strong>the</strong>re are<br />
no tight deadl<strong>in</strong>es. If you are new to<br />
review<strong>in</strong>g, <strong>the</strong>n <strong>the</strong>re is a process<br />
document on f<strong>in</strong>d<strong>in</strong>g your way around<br />
Ubidesk as well as a guidance document<br />
on review<strong>in</strong>g textbooks.<br />
Usman I. Lula, Cl<strong>in</strong>ical Scientist, Radio<strong>the</strong>rapy<br />
<strong>Physics</strong>, Poole Hospital NHS Trust<br />
usman.lula@poole.nhs.uk<br />
Cardiac Fibrillation–<br />
Defibrillation<br />
This is an impressive book <strong>of</strong>fer<strong>in</strong>g a review<br />
<strong>of</strong> current biomedical concepts <strong>in</strong> atrial <strong>and</strong><br />
ventricular fibrillation – <strong>in</strong>itiation,<br />
ma<strong>in</strong>tenance, pharmacological <strong>the</strong>rapies <strong>and</strong><br />
eng<strong>in</strong>eer<strong>in</strong>g solutions for treatment are all<br />
given <strong>the</strong>ir due. Chapters cover fibrillation<br />
mechanisms, <strong>in</strong>clud<strong>in</strong>g <strong>the</strong> multiple ectopic<br />
foci, re-entry <strong>and</strong> rotor <strong>the</strong>ories <strong>of</strong><br />
fibrillation, as well as general concepts <strong>of</strong><br />
defibrillation (m<strong>in</strong>imum defibrillatory mass,<br />
pharmacological <strong>and</strong> electrical defibrillation,<br />
monophasic <strong>and</strong> biphasic DC shocks, etc.).<br />
The design <strong>and</strong> generic build <strong>of</strong> external<br />
defibrillators is discussed, as are algorithms<br />
that adjust delivered energy based on<br />
measures <strong>of</strong> transthoracic impedance.<br />
Implantable cardiac defibrillators (ICD) are<br />
passed over <strong>in</strong> brief, ma<strong>in</strong>ly <strong>in</strong> reference to<br />
s<strong>of</strong>tware methods to discrim<strong>in</strong>ate ventricular<br />
Book title Reviewer<br />
Cardiac Fibrillation–Defibrillation James Stirrup<br />
The Emperor <strong>of</strong> All Maladies Jennifer Lowe<br />
<strong>Physics</strong> <strong>of</strong> Societal Issues Malcolm Sperr<strong>in</strong><br />
The Fundamentals <strong>of</strong> Imag<strong>in</strong>g Lisa Davenport<br />
The Essential <strong>Physics</strong> <strong>of</strong> Medical Imag<strong>in</strong>g Elizabeth Berry<br />
Susceptibility Weighted Imag<strong>in</strong>g <strong>in</strong> MRI Glyn Coutts<br />
Biohybrid Systems Julie Wooldridge<br />
Quantitative MRI <strong>in</strong> Cancer John McLean<br />
Proton Therapy <strong>Physics</strong> Angela New<strong>in</strong>g<br />
tachycardia/fibrillation from normal or<br />
benign cardiac rhythms. From a personal<br />
perspective, this section was fasc<strong>in</strong>at<strong>in</strong>g<br />
given <strong>the</strong> cl<strong>in</strong>ical issues that can arise which<br />
necessitate device reprogramm<strong>in</strong>g to<br />
prevent <strong>in</strong>appropriate discharge. The real<br />
focus <strong>in</strong> this section though is on <strong>the</strong><br />
application <strong>of</strong> such s<strong>of</strong>tware to automated<br />
external defibrillators, which I suppose<br />
makes <strong>the</strong> book useful to any reader who<br />
regularly frequents large public spaces.<br />
Approaches to fibrillation detection are<br />
discussed <strong>in</strong> escalat<strong>in</strong>g order <strong>of</strong> complexity,<br />
from probability density functions <strong>and</strong><br />
threshold cross<strong>in</strong>g <strong>in</strong>tervals through to<br />
time-frequency Fourier techniques <strong>and</strong><br />
phase space analysis.<br />
The biggest sell<strong>in</strong>g po<strong>in</strong>t <strong>of</strong> <strong>the</strong> book is,<br />
to my m<strong>in</strong>d, <strong>the</strong> balance between <strong>the</strong> cl<strong>in</strong>ical<br />
<strong>and</strong> eng<strong>in</strong>eer<strong>in</strong>g content. As a cl<strong>in</strong>ician, I<br />
found <strong>the</strong> electrophysiology sections to be<br />
<strong>the</strong> most useful, but <strong>the</strong>re is plenty <strong>of</strong><br />
material to keep <strong>the</strong> eng<strong>in</strong>eer happy. There<br />
were sections that were harder go<strong>in</strong>g for me<br />
– I confess that <strong>the</strong> section on <strong>the</strong>oretical<br />
models went over my head (non-l<strong>in</strong>ear<br />
microscopic models <strong>of</strong> cardiac dynamics), as<br />
did <strong>the</strong> chapter on electrodes <strong>and</strong> pastes –<br />
but this is only really a reflection <strong>of</strong> <strong>the</strong><br />
multidiscipl<strong>in</strong>ary appeal <strong>of</strong> <strong>the</strong> book.<br />
Although now more than 16 months old<br />
(more consider<strong>in</strong>g <strong>the</strong> st<strong>and</strong>ard delay<br />
between submission <strong>and</strong> publication), this is<br />
a very readable account <strong>of</strong> current<br />
underst<strong>and</strong><strong>in</strong>g based on a broad analysis <strong>of</strong><br />
<strong>the</strong> field. I read <strong>the</strong> book from cover to cover<br />
over three W<strong>in</strong>chester–London tra<strong>in</strong> rides,<br />
which should give some idea <strong>of</strong> its length<br />
<strong>and</strong> easy accessibility. Like many textbooks<br />
purport<strong>in</strong>g to cover <strong>the</strong> current state-<strong>of</strong>-<strong>the</strong>art,<br />
<strong>the</strong>re is <strong>the</strong> significant danger <strong>of</strong> be<strong>in</strong>g<br />
out <strong>of</strong> date almost upon publication.<br />
Indeed, it is likely that those most <strong>in</strong>terested<br />
<strong>in</strong> this field will refra<strong>in</strong> from an outright<br />
purchase <strong>in</strong> favour <strong>of</strong> one or more journal<br />
subscriptions. This would be a shame as <strong>the</strong><br />
majority <strong>of</strong> <strong>the</strong> material discusses<br />
established concepts. I give this book a
confident recommendation to biomedical<br />
eng<strong>in</strong>eers, <strong>and</strong> for that matter, anyone for<br />
whom cardiac electrophysiology forms a<br />
significant part <strong>of</strong> <strong>the</strong>ir work<strong>in</strong>g life.<br />
Dr James Stirrup is a Cl<strong>in</strong>ical Research<br />
Fellow at <strong>the</strong> Cardiac Imag<strong>in</strong>g National Heart<br />
<strong>and</strong> Lung <strong>Institute</strong>, Imperial College, London.<br />
He is also a Cardiology Specialist Registrar at<br />
<strong>the</strong> Wessex Deanery, UK<br />
CARDIAC FIBRILLATION–DEFIBRILLATION:<br />
CLINICAL AND ENGINEERING ASPECTS –<br />
SERIES ON BIOENGINEERING AND BIOMEDICAL<br />
ENGINEERING<br />
Author: Max E. Valent<strong>in</strong>uzzi<br />
Publisher: World Scientific<br />
Volume: 6<br />
ISBN: 978-9814293631<br />
Pages: 304<br />
The Emperor <strong>of</strong> All<br />
Maladies<br />
I loved this book which was a slight relief<br />
as it would have been <strong>in</strong>terest<strong>in</strong>g to write a<br />
review <strong>in</strong> opposition to <strong>the</strong> many people<br />
who decided that this book was worthy <strong>of</strong><br />
a Pulitzer Prize (General Nonfiction, 2011),<br />
<strong>the</strong> Guardian First Book Award 2011 <strong>and</strong><br />
shortlisted for both <strong>the</strong> Duff Cooper Prize<br />
2011 <strong>and</strong> <strong>the</strong> Wellcome Trust Book Prize.<br />
The author, Siddhartha Mukherjee, is a<br />
well-published cancer physician <strong>and</strong><br />
researcher who lives <strong>in</strong> New York. He<br />
started research<strong>in</strong>g <strong>the</strong> history <strong>of</strong> cancer<br />
when he began his advanced tra<strong>in</strong><strong>in</strong>g <strong>in</strong><br />
medical oncology <strong>in</strong> Boston, which after<br />
about 7 years resulted <strong>in</strong> this book. The text<br />
follows a roughly chronological path<br />
through <strong>the</strong> history <strong>of</strong> cancer from its first<br />
description around 2500 BC <strong>in</strong> Egypt, to<br />
recent discoveries <strong>in</strong> <strong>the</strong> underst<strong>and</strong><strong>in</strong>g <strong>of</strong><br />
<strong>the</strong> activation or <strong>in</strong>activation <strong>of</strong> genes or<br />
pathways that result <strong>in</strong> cancer. The<br />
‘biography’ is also <strong>in</strong>terspersed with <strong>the</strong><br />
very human stories <strong>of</strong> a few <strong>of</strong> Mukherjee’s<br />
own patients <strong>and</strong> <strong>the</strong> successes <strong>and</strong> failures<br />
<strong>of</strong> <strong>the</strong>ir cancer treatments.<br />
The book is very well written, <strong>and</strong> <strong>in</strong><br />
spite <strong>of</strong> be<strong>in</strong>g packed with lots <strong>of</strong><br />
<strong>in</strong>terest<strong>in</strong>g facts <strong>and</strong> historical references, I<br />
found it to be a gripp<strong>in</strong>g read. I<br />
particularly liked how each <strong>the</strong>me was<br />
developed by pull<strong>in</strong>g toge<strong>the</strong>r different<br />
str<strong>and</strong>s from different researchers,<br />
hospitals <strong>and</strong> countries across <strong>the</strong> world.<br />
The ‘chapters’ are <strong>in</strong>troduced with a wide<br />
variety <strong>of</strong> quotations – historical, literary,<br />
<strong>and</strong> from contemporary media, activists,<br />
researchers <strong>and</strong> cancer patients which gave<br />
added <strong>in</strong>terest <strong>and</strong> context to <strong>the</strong> material.<br />
The book is predom<strong>in</strong>antly pla<strong>in</strong> text<br />
but <strong>in</strong> <strong>the</strong> middle section <strong>the</strong>re are eight<br />
pages <strong>of</strong> black-<strong>and</strong>-white photos, cartoons<br />
<strong>and</strong> draw<strong>in</strong>gs <strong>of</strong>fer<strong>in</strong>g, <strong>in</strong> my op<strong>in</strong>ion, a<br />
limited <strong>and</strong> r<strong>and</strong>om selection <strong>of</strong> pictures <strong>of</strong><br />
vary<strong>in</strong>g significance to cancer treatment. I<br />
did feel somewhat disappo<strong>in</strong>ted when <strong>the</strong><br />
book abruptly ended a significant distance<br />
from <strong>the</strong> back cover. However, for <strong>the</strong><br />
reader who wants to delve deeper, <strong>the</strong> 70<br />
or so pages <strong>of</strong> notes, references <strong>and</strong><br />
bibliography at <strong>the</strong> end <strong>of</strong> <strong>the</strong> book will be<br />
<strong>in</strong>valuable. A comprehensive <strong>in</strong>dex is also<br />
<strong>in</strong>cluded to facilitate return<strong>in</strong>g to passages<br />
<strong>of</strong> <strong>in</strong>terest.<br />
“<br />
The text follows a<br />
roughly chronological path<br />
through <strong>the</strong> history <strong>of</strong><br />
cancer from its first<br />
description around 2500<br />
BC <strong>in</strong> Egypt<br />
”<br />
I doubt that I will directly make use <strong>of</strong><br />
any knowledge ga<strong>in</strong>ed from this book <strong>in</strong><br />
my future radio<strong>the</strong>rapy work, but I feel<br />
that I am more <strong>in</strong>formed about <strong>the</strong> field <strong>in</strong><br />
general <strong>and</strong> will have a better appreciation<br />
<strong>of</strong> how far medic<strong>in</strong>e has come (<strong>and</strong> still has<br />
to go) <strong>in</strong> <strong>the</strong> treatment <strong>of</strong> cancer.<br />
Specifically I found it very <strong>in</strong>terest<strong>in</strong>g to<br />
see how cl<strong>in</strong>ical trials <strong>and</strong> r<strong>and</strong>omisation<br />
developed <strong>and</strong> learn<strong>in</strong>g <strong>of</strong> some <strong>of</strong> <strong>the</strong><br />
nam<strong>in</strong>g conventions for cancer drugs.<br />
I highly recommend this book to anyone<br />
with an <strong>in</strong>terest <strong>in</strong> medical history <strong>and</strong>/or<br />
who is work<strong>in</strong>g <strong>in</strong>, or close to, <strong>the</strong> field <strong>of</strong><br />
oncology. I found it to be highly<br />
<strong>in</strong>formative, a real page-turner <strong>and</strong> a<br />
welcome Christmas present. As <strong>the</strong><br />
paperback edition is currently available on<br />
Amazon.co.uk for a barga<strong>in</strong> price <strong>of</strong> £6.79,<br />
I th<strong>in</strong>k it would be rude not to.<br />
Mrs Jennifer Lowe is a Cl<strong>in</strong>ical Scientist<br />
(Radio<strong>the</strong>rapy) currently on a career break,<br />
Falls Church, VA, USA<br />
THE EMPEROR OF ALL MALADIES:<br />
A BIOGRAPHY OF CANCER<br />
Author: Siddhartha Mukherjee<br />
Publisher: HarperColl<strong>in</strong>s<br />
ISBN-13: 978-1439107959 (US)<br />
Format: Hardback<br />
Pages: 592<br />
USMAN I. LULA | SCOPE<br />
<strong>Physics</strong> <strong>of</strong> Societal<br />
Issues<br />
This title is not necessarily one that jumps<br />
<strong>of</strong>f <strong>the</strong> shelf at you as a prime text for<br />
medical physics applications, but I would<br />
strongly urge you to at least have a browse<br />
through it. One implication from <strong>the</strong> title is<br />
that <strong>the</strong> content is accessible to a lay public;<br />
however, I would suggest that <strong>the</strong> content<br />
does require a good deal <strong>of</strong> advanced<br />
scientific competence. The reviewed edition<br />
was published <strong>in</strong> 2007 <strong>and</strong> although only 5<br />
years old <strong>the</strong> implications <strong>of</strong> <strong>the</strong> Fukushima<br />
nuclear disaster clearly play no part <strong>in</strong> <strong>the</strong><br />
scientific analysis. That be<strong>in</strong>g said, it is an<br />
easy extrapolation <strong>of</strong> <strong>the</strong> book’s analysis to<br />
those events <strong>in</strong> Japan. This book looks to<br />
provide a well considered scientific<br />
approach to many <strong>of</strong> <strong>the</strong> <strong>in</strong>fluences on<br />
everyday life <strong>and</strong> <strong>the</strong>re is considerable<br />
cross-over with our pr<strong>of</strong>ession.<br />
The book is broadly divided <strong>in</strong>to:<br />
national security, environment <strong>and</strong> energy,<br />
but <strong>the</strong>se broad categories do not fully<br />
convey <strong>the</strong>ir content. For <strong>in</strong>stance, Chapter 7<br />
discusses nuclear pollution, albeit not from a<br />
medical st<strong>and</strong>po<strong>in</strong>t; never<strong>the</strong>less, <strong>the</strong><br />
analysis is applicable for those <strong>of</strong> us who<br />
have a pr<strong>of</strong>essional <strong>in</strong>terest <strong>in</strong> radiation<br />
protection. Similarly, Chapter 9 discusses<br />
electromagnetic fields <strong>and</strong> epidemiology<br />
which cont<strong>in</strong>ue to be very much <strong>in</strong> <strong>the</strong><br />
news. O<strong>the</strong>r chapters such as Chapter 16 on<br />
energy economics are reasonably considered<br />
to be peripheral to our pr<strong>of</strong>ession,<br />
none<strong>the</strong>less <strong>the</strong> analytical approach <strong>and</strong><br />
important subject matters are <strong>of</strong> general<br />
<strong>in</strong>terest. In addition, <strong>the</strong>re are useful<br />
appendices <strong>and</strong> reference/bibliography lists<br />
at <strong>the</strong> end <strong>of</strong> each chapter which, whilst<br />
limited, certa<strong>in</strong>ly do provide routes for more<br />
<strong>in</strong>sight <strong>in</strong>to some <strong>of</strong> <strong>the</strong> complex social<br />
arguments discussed with<strong>in</strong> <strong>the</strong> text.<br />
As might be expected, <strong>the</strong> text is<br />
American <strong>and</strong> allowances need to be made<br />
for <strong>the</strong> units <strong>and</strong> also some <strong>of</strong> <strong>the</strong> content<br />
which is American-centric, but that aside,<br />
<strong>the</strong> text is very readable. One useful aspect<br />
<strong>of</strong> each chapter is <strong>the</strong> <strong>in</strong>clusion <strong>of</strong> ‘problems’<br />
<strong>and</strong> I have used many <strong>of</strong> <strong>the</strong>se to discuss<br />
aspects <strong>of</strong> general physics with my tra<strong>in</strong>ees<br />
SCOPE | SEPTEMBER 2012 | 41<br />
▼
▼<br />
SCOPE | BOOK REVIEWS<br />
<strong>and</strong> to encourage a breadth <strong>of</strong> awareness <strong>of</strong><br />
physics <strong>in</strong> addition to <strong>the</strong> specialist<br />
applications more familiar to us.<br />
To my knowledge <strong>the</strong>re are very few<br />
o<strong>the</strong>r books ei<strong>the</strong>r <strong>of</strong> this type or with <strong>the</strong><br />
same general usefulness, although <strong>the</strong><br />
Internet does give access to some <strong>of</strong> <strong>the</strong><br />
material albeit <strong>in</strong> a less consolidated form.<br />
Unfortunately, many <strong>of</strong> <strong>the</strong> diagrams <strong>and</strong><br />
images could be clearer but that is more <strong>of</strong> a<br />
convenience than a limit<strong>in</strong>g factor. I would<br />
highly recommend this text, probably as an<br />
<strong>in</strong>clusion to a departmental library ra<strong>the</strong>r<br />
than to an <strong>in</strong>dividual but I can see it be<strong>in</strong>g<br />
well used.<br />
Pr<strong>of</strong>essor Malcolm Sperr<strong>in</strong> is <strong>the</strong> Director <strong>of</strong><br />
Medical <strong>Physics</strong> <strong>and</strong> Cl<strong>in</strong>ical <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> at <strong>the</strong><br />
Royal Berkshire Hospital NHS Trust, Read<strong>in</strong>g, UK<br />
PHYSICS OF SOCIETAL ISSUES: CALCULATIONS<br />
ON NATIONAL SECURITY, ENVIRONMENT, AND<br />
ENERGY<br />
Author: David Hafemeister<br />
Publisher: Spr<strong>in</strong>ger<br />
ISBN: 978-0-387-95560-5<br />
Pages: 488<br />
The Fundamentals <strong>of</strong><br />
Imag<strong>in</strong>g<br />
I was a bit worried that this book was go<strong>in</strong>g<br />
to be massive <strong>and</strong> maybe a bit dull. It<br />
encompasses, as <strong>the</strong> title suggests, almost<br />
all imag<strong>in</strong>g techniques, which is quite a big<br />
subject (especially everyth<strong>in</strong>g <strong>the</strong> author<br />
considers to be imag<strong>in</strong>g – more on that<br />
later) <strong>and</strong> potentially a hard slog for<br />
someone who doesn’t read physics books<br />
for fun (I’d just like to po<strong>in</strong>t that out now).<br />
However, not only is it compact, but it is<br />
also very easy to read <strong>and</strong> I even found it<br />
quite endear<strong>in</strong>g <strong>in</strong> parts.<br />
The author sets <strong>the</strong> scene by expla<strong>in</strong><strong>in</strong>g<br />
why sight is by far <strong>the</strong> best human sense<br />
before tell<strong>in</strong>g us about <strong>the</strong> human visual<br />
system <strong>and</strong> <strong>the</strong> evolution <strong>of</strong> all different<br />
eyes (I now know all about flatworm <strong>and</strong><br />
nautilus eyes if you have any questions).<br />
Then we embark on <strong>the</strong> proper physics<br />
sections. There is <strong>the</strong> obligatory bit on<br />
medical imag<strong>in</strong>g but that is only a t<strong>in</strong>y bit<br />
<strong>of</strong> a book that covers waves <strong>and</strong> image<br />
formation, microscopes, photography, film,<br />
42 | SEPTEMBER 2012 | SCOPE<br />
television, <strong>in</strong>frared imag<strong>in</strong>g, radar, imag<strong>in</strong>g<br />
<strong>the</strong> universe, imag<strong>in</strong>g with sound <strong>and</strong><br />
imag<strong>in</strong>g atoms <strong>and</strong> particles. As I<br />
mentioned at <strong>the</strong> beg<strong>in</strong>n<strong>in</strong>g, <strong>the</strong>re are a few<br />
bits I wasn’t sure about as to <strong>the</strong>ir imag<strong>in</strong>g<br />
credentials, but <strong>the</strong>y were some <strong>of</strong> my<br />
favourite bits: classical map mak<strong>in</strong>g, trig<br />
po<strong>in</strong>ts <strong>and</strong> aerial archaeology. Not that <strong>the</strong><br />
book isn’t up to date – 3D television <strong>and</strong><br />
imag<strong>in</strong>g <strong>the</strong> Eyjafjallajökull ash cloud are <strong>in</strong><br />
here too.<br />
The author’s writ<strong>in</strong>g style is friendly <strong>and</strong><br />
charm<strong>in</strong>g, <strong>and</strong> <strong>the</strong> book <strong>in</strong>cludes lots <strong>of</strong><br />
historical bits. The physics throughout are<br />
expla<strong>in</strong>ed simply with equations where<br />
need be <strong>and</strong> plenty <strong>of</strong> pictures <strong>and</strong><br />
diagrams.<br />
I would not recommend this book if you<br />
are look<strong>in</strong>g specifically for an <strong>in</strong>troduction<br />
to medical imag<strong>in</strong>g as <strong>the</strong> section is really<br />
brief. Likewise, I found <strong>the</strong> seismic imag<strong>in</strong>g<br />
section a bit short. On <strong>the</strong> o<strong>the</strong>r h<strong>and</strong>, <strong>the</strong><br />
universe sections seemed to take up quite a<br />
lot <strong>of</strong> <strong>the</strong> book, but I have to confess<br />
skipp<strong>in</strong>g those, hav<strong>in</strong>g managed to avoid<br />
anyth<strong>in</strong>g space-related <strong>in</strong> my life to date.<br />
However, <strong>the</strong> book is clearly <strong>in</strong>tended as a<br />
basic <strong>in</strong>troduction to everyth<strong>in</strong>g <strong>and</strong> for<br />
that it serves its purpose really well.<br />
As for <strong>the</strong> target audience, well, <strong>the</strong><br />
<strong>in</strong>troduction states that it should be<br />
accessible to those with an <strong>in</strong>terest <strong>in</strong><br />
science <strong>and</strong> who have studied it at school –<br />
I can only agree with that. It’s good for<br />
expla<strong>in</strong><strong>in</strong>g all those th<strong>in</strong>gs you (or at least I)<br />
never thought about before such as how an<br />
<strong>in</strong>truder alarm works.<br />
The book is clearly<br />
<strong>in</strong>tended as a basic<br />
<strong>in</strong>troduction to everyth<strong>in</strong>g<br />
<strong>and</strong> for that it serves its<br />
purpose really well<br />
“<br />
”<br />
In conclusion, I th<strong>in</strong>k that any physics<br />
book that mentions beluga whales <strong>and</strong><br />
Bradford Media Museum can only be a<br />
good th<strong>in</strong>g. And did you know that <strong>in</strong> 1880<br />
<strong>the</strong>y could detect <strong>the</strong> heat radiated by a cow<br />
at a distance <strong>of</strong> 400 m?<br />
Mrs Lisa Davenport is a Cl<strong>in</strong>ical Scientist <strong>in</strong><br />
Radiation Protection at <strong>the</strong> Radiation <strong>Physics</strong><br />
Department, Bradford Teach<strong>in</strong>g Hospitals NHS<br />
Foundation Trust, Bradford, UK<br />
THE FUNDAMENTALS OF IMAGING – FROM<br />
PARTICLES TO GALAXIES<br />
Author: Michael M. Woolfson<br />
Publisher: Imperial College Press<br />
ISBN: 9781848166851<br />
Format: Paperback<br />
Pages: 360<br />
Price: £32.00<br />
The Essential <strong>Physics</strong><br />
<strong>of</strong> Medical Imag<strong>in</strong>g<br />
This is <strong>the</strong> third edition <strong>of</strong> a well-respected<br />
text on <strong>the</strong> physics <strong>of</strong> medical imag<strong>in</strong>g. It<br />
covers all <strong>the</strong> expected imag<strong>in</strong>g modalities<br />
toge<strong>the</strong>r with radiation biology <strong>and</strong><br />
radiation protection. Although <strong>the</strong> earlier<br />
editions were <strong>in</strong>tended for radiologists-<strong>in</strong>tra<strong>in</strong><strong>in</strong>g,<br />
<strong>the</strong> comprehensive coverage made<br />
<strong>the</strong> book a popular graduate-level text for<br />
medical physicists too. In this third edition,<br />
<strong>the</strong> physicist readership has been recognised<br />
with <strong>the</strong> <strong>in</strong>clusion <strong>of</strong> an appendix on Fourier<br />
transforms <strong>and</strong> <strong>in</strong>creased ma<strong>the</strong>matical<br />
rigour throughout.<br />
The content <strong>of</strong> <strong>the</strong> book has been<br />
thoroughly overhauled. In l<strong>in</strong>e with <strong>the</strong><br />
spread <strong>of</strong> digital technologies, <strong>the</strong> section on<br />
<strong>in</strong>formatics has been moved <strong>in</strong>to <strong>the</strong> basic<br />
concepts section <strong>and</strong> has been exp<strong>and</strong>ed<br />
upon. There have been correspond<strong>in</strong>g<br />
reductions <strong>in</strong> <strong>the</strong> material on analogue<br />
techniques. Modalities that have entered<br />
cl<strong>in</strong>ical use s<strong>in</strong>ce <strong>the</strong> last edition, such as<br />
digital breast tomosyn<strong>the</strong>sis <strong>and</strong> dual<br />
modality imag<strong>in</strong>g systems, have now been<br />
<strong>in</strong>cluded.<br />
The book is surpris<strong>in</strong>gly colourful <strong>in</strong>side,<br />
not only giv<strong>in</strong>g it a contemporary feel, but<br />
also help<strong>in</strong>g to communicate <strong>in</strong>formation.<br />
There are coloured text head<strong>in</strong>gs, tables,<br />
photographs <strong>and</strong> figures. Many <strong>of</strong> <strong>the</strong><br />
figures have been redrawn for this edition,<br />
<strong>and</strong> with colour <strong>the</strong>y get <strong>the</strong>ir messages<br />
across very well <strong>in</strong>deed. Figures <strong>and</strong><br />
photographs have been brought up to date,<br />
show<strong>in</strong>g <strong>the</strong> thoroughness <strong>of</strong> <strong>the</strong> revisions.<br />
For example, a photo <strong>of</strong> a film badge<br />
belong<strong>in</strong>g to one <strong>of</strong> <strong>the</strong> authors now shows a<br />
badge dated 2011; <strong>the</strong> badge <strong>in</strong> <strong>the</strong> second<br />
edition was dated 2000.<br />
Ano<strong>the</strong>r <strong>in</strong>novation is <strong>the</strong> <strong>in</strong>clusion <strong>of</strong><br />
access to onl<strong>in</strong>e content. You scratch a sticker<br />
<strong>in</strong>side <strong>the</strong> book to reveal a code, visit <strong>the</strong><br />
publisher’s website <strong>and</strong> use <strong>the</strong> code to<br />
register. Once registered, you can access<br />
onl<strong>in</strong>e content – this comprises <strong>the</strong> entire<br />
content <strong>of</strong> <strong>the</strong> book, displayed <strong>in</strong> your<br />
browser us<strong>in</strong>g Adobe Flash Player<br />
technology format. The content is searchable<br />
<strong>and</strong>, for a book <strong>of</strong> this length, this provides a<br />
welcome alternative to us<strong>in</strong>g <strong>the</strong> <strong>in</strong>dex.
Books <strong>in</strong> this subject area can become<br />
somewhat unbalanced <strong>in</strong> <strong>the</strong>ir later<br />
editions, with ra<strong>the</strong>r short chapters on<br />
modalities such as ultrasound <strong>and</strong> MRI<br />
dom<strong>in</strong>ated by <strong>the</strong> ionis<strong>in</strong>g radiation<br />
content. Whilst this is true to a degree here,<br />
<strong>the</strong> balance <strong>in</strong> this book is good.<br />
Fur<strong>the</strong>rmore, <strong>in</strong> spite <strong>of</strong> <strong>the</strong> range <strong>of</strong> topics<br />
<strong>and</strong> multiple authors, <strong>the</strong> style is clear <strong>and</strong><br />
consistent throughout <strong>the</strong> book. This is very<br />
much a reference text, <strong>and</strong> does not <strong>in</strong>clude<br />
questions or exercises to help radiologists<br />
with <strong>the</strong>ir exam preparation. One concern<br />
about us<strong>in</strong>g this book outside <strong>the</strong> US is <strong>the</strong><br />
lack <strong>of</strong> <strong>in</strong>formation on European <strong>and</strong> more<br />
specifically UK legislation <strong>and</strong> regulation<br />
concern<strong>in</strong>g ionis<strong>in</strong>g radiation.<br />
The book is comprehensive,<br />
authoritative, well illustrated <strong>and</strong> bang up<br />
to date. It makes a suitable masters level<br />
textbook, <strong>and</strong> is an ideal reference text for<br />
<strong>the</strong> tra<strong>in</strong><strong>in</strong>g or practic<strong>in</strong>g medical physicist.<br />
It provides good value for money, <strong>and</strong><br />
owners <strong>of</strong> <strong>the</strong> second edition will not regret<br />
buy<strong>in</strong>g a replacement.<br />
Dr Elizabeth Berry <strong>of</strong> Elizabeth Berry Ltd <strong>in</strong><br />
Leeds, UK<br />
THE ESSENTIAL PHYSICS OF MEDICAL IMAGING,<br />
3RD EDITION – INTERNATIONAL EDITION<br />
Authors: Jerrold T. Bushberg, J. Anthony Seibert,<br />
Edw<strong>in</strong> M. Leidholdt Jr <strong>and</strong> John M. Boone<br />
Publisher: Lipp<strong>in</strong>cott Williams & Wilk<strong>in</strong>s<br />
ISBN: 9781451118100<br />
Format: Hardback<br />
Pages: 1,048<br />
Susceptibility<br />
Weighted Imag<strong>in</strong>g <strong>in</strong><br />
MRI<br />
‘Susceptibility weighted imag<strong>in</strong>g (SWI)<br />
consists <strong>of</strong> us<strong>in</strong>g both magnitude <strong>and</strong> phase<br />
images from a high-resolution threedimensional<br />
fully velocity compensated<br />
gradient echo sequence.’ The reader will<br />
encounter this sentence or similar many<br />
times <strong>in</strong> this text, followed by a brief<br />
description <strong>of</strong> <strong>the</strong> use <strong>of</strong> phase masks <strong>and</strong><br />
m<strong>in</strong>imum <strong>in</strong>tensity projections (mIP).<br />
However, this is merely a symptom <strong>of</strong> <strong>the</strong><br />
ambition <strong>of</strong> this volume <strong>in</strong> which 66<br />
contributors seek to cover every aspect <strong>of</strong><br />
fully exploit<strong>in</strong>g <strong>the</strong> phase <strong>in</strong>formation<br />
content <strong>in</strong> <strong>the</strong> acquired MR signal <strong>in</strong> a<br />
manner that is accessible to an audience <strong>of</strong><br />
radiologists, physicists, cardiologists,<br />
oncologists, biochemists <strong>and</strong> students.<br />
The first eight (arguably n<strong>in</strong>e) chapters<br />
(<strong>of</strong> Part I: ‘Basic Concepts’) serve as an<br />
<strong>in</strong>troduction to <strong>the</strong> technique, rang<strong>in</strong>g from<br />
what many will f<strong>in</strong>d familiar such as signal<br />
formation <strong>in</strong> gradient echo imag<strong>in</strong>g through<br />
to advanced but necessary concepts – for<br />
<strong>in</strong>stance, high-pass filter<strong>in</strong>g <strong>and</strong> <strong>the</strong><br />
<strong>in</strong>fluence <strong>of</strong> voxel aspect ratio – to <strong>the</strong> more<br />
daunt<strong>in</strong>g, such as <strong>the</strong> formation <strong>of</strong> phase<br />
images from multiple receiver coils. This<br />
<strong>the</strong>n leads <strong>in</strong>to <strong>the</strong> application <strong>of</strong> <strong>the</strong>se<br />
concepts to MR venography, with <strong>the</strong> by<br />
now familiar high-resolution, high-contrast<br />
images, <strong>and</strong> bra<strong>in</strong> imag<strong>in</strong>g.<br />
Part II covers current cl<strong>in</strong>ical applications<br />
<strong>and</strong> may well be <strong>the</strong> start<strong>in</strong>g po<strong>in</strong>t for those<br />
just beg<strong>in</strong>n<strong>in</strong>g to use this technique.<br />
Included are vascular applications along<br />
with imag<strong>in</strong>g cerebral microbleeds <strong>and</strong><br />
haemorrhage, imag<strong>in</strong>g <strong>of</strong> bra<strong>in</strong> tumours,<br />
exploit<strong>in</strong>g iron content <strong>in</strong><br />
neurodegenerative disease <strong>and</strong> imag<strong>in</strong>g <strong>of</strong><br />
breast calcification. The book <strong>in</strong>cludes<br />
repr<strong>in</strong>ts <strong>of</strong> three sem<strong>in</strong>al papers published<br />
<strong>in</strong> 1997, 2004 <strong>and</strong> 2006, but it is a mark <strong>of</strong><br />
how much this technique is <strong>in</strong> its <strong>in</strong>fancy <strong>in</strong><br />
that much <strong>of</strong> <strong>the</strong> work presented here is<br />
based on relatively small studies from<br />
s<strong>in</strong>gle research centres.<br />
The f<strong>in</strong>al chapter <strong>in</strong> Part II <strong>in</strong>troduces<br />
SWI at ultrahigh field strengths (7T or even<br />
9.4T) with a balanced summary <strong>of</strong> both <strong>the</strong><br />
opportunities <strong>and</strong> challenges. The last <strong>and</strong><br />
largest section, Part III, is headed<br />
‘Advanced Concepts’ <strong>and</strong> ranges across<br />
applications which may well bear fruit for<br />
SWI, such as quantification <strong>of</strong> iron content,<br />
<strong>the</strong> effects <strong>of</strong> contrast agents, quantification<br />
<strong>of</strong> oxygen saturation <strong>and</strong> <strong>the</strong> <strong>in</strong>terplay with<br />
<strong>the</strong> BOLD effect, as well as advanced<br />
acquisition methods. Also discussed <strong>in</strong><br />
<strong>the</strong>se chapters is susceptibility mapp<strong>in</strong>g<br />
which effectively <strong>in</strong>verts <strong>the</strong> problem <strong>in</strong><br />
order to produce maps <strong>of</strong> <strong>the</strong> susceptibility<br />
sources that are produc<strong>in</strong>g <strong>the</strong> measured<br />
phase patterns, with <strong>the</strong> aim <strong>of</strong> produc<strong>in</strong>g<br />
quantitative <strong>in</strong>formation about, say, <strong>the</strong> iron<br />
or calcium content <strong>of</strong> tissues.<br />
There is <strong>in</strong>evitably some variation <strong>in</strong><br />
style across <strong>the</strong> many contributors but for a<br />
work <strong>of</strong> this size <strong>and</strong> scope <strong>the</strong> errors <strong>of</strong><br />
grammar, presentation <strong>and</strong> suchlike are<br />
relatively few. Throughout, <strong>the</strong> text is<br />
supported well by <strong>the</strong> images, <strong>in</strong>clud<strong>in</strong>g<br />
colour images where needed.<br />
It will be <strong>of</strong> <strong>in</strong>terest <strong>in</strong> a few years’ time<br />
to see how much progress has been made <strong>in</strong><br />
fully exploit<strong>in</strong>g susceptibility differences as<br />
a basis for (quantitative) MR imag<strong>in</strong>g. For<br />
USMAN I. LULA | SCOPE<br />
now this volume will be a useful reference<br />
for any MRI department.<br />
Dr Glyn Coutts is a Cl<strong>in</strong>ical Scientist at <strong>the</strong><br />
Christie Medical <strong>Physics</strong> <strong>and</strong> <strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong>, The<br />
Christie NHS Foundation Trust, Manchester<br />
Department, UK<br />
SUSCEPTIBILITY WEIGHTED IMAGING IN MRI<br />
Editors: E. Mark Haacke <strong>and</strong> Jürgen R.<br />
Reichenbach<br />
Publisher: Wiley-Blackwell<br />
ISBN: 978-0-470-04343-1<br />
Format: Hardback<br />
Pages: 776<br />
Biohybrid Systems<br />
This text <strong>of</strong>fers a detailed overview <strong>of</strong> recent<br />
advances <strong>in</strong> biohybrid systems <strong>in</strong>terfac<strong>in</strong>g<br />
nerves, muscles <strong>and</strong> mach<strong>in</strong>es. It conta<strong>in</strong>s<br />
numerous ma<strong>the</strong>matical models <strong>of</strong><br />
neurophysiology, rang<strong>in</strong>g from models <strong>of</strong> <strong>the</strong><br />
cell biology such as membrane equivalent<br />
circuits to <strong>the</strong> ma<strong>the</strong>matical descriptions <strong>of</strong><br />
neural spike tra<strong>in</strong>s. The text also considers<br />
<strong>the</strong> hardware required to <strong>in</strong>terface with a<br />
neuron, <strong>in</strong> particular <strong>the</strong> dynamic clamp<br />
which is used to <strong>in</strong>fluence membrane<br />
potentials <strong>and</strong> <strong>the</strong> latest nanotransducers,<br />
be<strong>in</strong>g developed us<strong>in</strong>g carbon nanotubes.<br />
This book is primarily aimed at researchers<br />
<strong>in</strong> <strong>the</strong> field with recommendations on <strong>the</strong><br />
best s<strong>of</strong>tware for implement<strong>in</strong>g a dynamic<br />
clamp <strong>and</strong> suppliers <strong>of</strong> real-time control<br />
boards for neuronal models.<br />
Each chapter commences with a short<br />
<strong>in</strong>troduction, plac<strong>in</strong>g <strong>the</strong> subject matter <strong>in</strong>to<br />
context with <strong>the</strong> o<strong>the</strong>r chapters. Each also<br />
closes with a conclusion which generally<br />
does a good job <strong>of</strong> summ<strong>in</strong>g up <strong>the</strong> salient<br />
po<strong>in</strong>ts <strong>of</strong> <strong>the</strong> text, particularly useful for <strong>the</strong><br />
first-time reader. Much <strong>of</strong> <strong>the</strong> modell<strong>in</strong>g<br />
assumes a high level <strong>of</strong> background<br />
knowledge <strong>in</strong> ma<strong>the</strong>matics, electronics <strong>and</strong><br />
neuroscience. This should probably not be<br />
considered an <strong>in</strong>troductory text; however,<br />
even <strong>the</strong> casual reader will come away with<br />
an enhanced underst<strong>and</strong><strong>in</strong>g <strong>of</strong> <strong>the</strong> field.<br />
The chapters are well written <strong>and</strong> despite<br />
be<strong>in</strong>g a multi-authored work <strong>the</strong>re is little<br />
repetition <strong>and</strong> appropriate l<strong>in</strong>ks to o<strong>the</strong>r<br />
sections are provided. There are a good<br />
number <strong>of</strong> illustrations, most <strong>of</strong> which are ▼<br />
SCOPE | SEPTEMBER 2012 | 43
▼<br />
SCOPE | BOOK REVIEWS<br />
very useful, <strong>in</strong> particular <strong>in</strong> Chapter 6 with<br />
its scann<strong>in</strong>g electron micrographs <strong>of</strong><br />
microelectrode arrays <strong>and</strong> Chapter 7 with<br />
numerous Simul<strong>in</strong>k diagrams provid<strong>in</strong>g<br />
excellent support to an <strong>in</strong>troduction <strong>of</strong><br />
biohybrid systems analysis.<br />
The medical physicist<br />
will f<strong>in</strong>d little description<br />
<strong>of</strong> <strong>the</strong> practical<br />
applications <strong>of</strong> this<br />
technology until <strong>the</strong> last<br />
three chapters<br />
“<br />
”<br />
Aside from a very <strong>in</strong>terest<strong>in</strong>g short<br />
section <strong>in</strong> <strong>the</strong> first chapter on an actuated<br />
articulated false-foot orthosis (designed to<br />
aid crutch-free walk<strong>in</strong>g for <strong>in</strong>jured combat<br />
troops), <strong>the</strong> medical physicist will f<strong>in</strong>d<br />
little description <strong>of</strong> <strong>the</strong> practical<br />
applications <strong>of</strong> this technology until <strong>the</strong><br />
last three chapters. This makes some <strong>of</strong> <strong>the</strong><br />
<strong>in</strong>terven<strong>in</strong>g chapters ra<strong>the</strong>r ‘dry’ <strong>and</strong> it’s a<br />
shame that more short examples <strong>of</strong> <strong>the</strong><br />
applications weren’t <strong>in</strong>cluded. The last<br />
part <strong>of</strong> <strong>the</strong> book is dedicated to a few<br />
examples <strong>of</strong> medical applications,<br />
<strong>in</strong>clud<strong>in</strong>g neuromorphic hardware for<br />
audition <strong>and</strong> vision, neurocardiology <strong>and</strong><br />
sens<strong>in</strong>g <strong>of</strong> <strong>in</strong>sul<strong>in</strong> dem<strong>and</strong>. This is where<br />
<strong>the</strong> readers’ hard work <strong>in</strong> <strong>the</strong> earlier<br />
chapters will pay <strong>of</strong>f! Chapter 9,<br />
‘Neuromorphic Hardware for Control’, is<br />
particularly <strong>in</strong>terest<strong>in</strong>g, demonstrat<strong>in</strong>g a<br />
biohybrid system to restore lost locomotor<br />
control <strong>and</strong> a silicon ret<strong>in</strong>a <strong>in</strong> which spatial<br />
<strong>and</strong> temporal filter<strong>in</strong>g are computed at<br />
pixel level allow<strong>in</strong>g low-power real-time<br />
control <strong>of</strong> a system.<br />
As a research text, this book will f<strong>in</strong>d<br />
little immediate application <strong>in</strong> <strong>the</strong> majority<br />
<strong>of</strong> cl<strong>in</strong>ical eng<strong>in</strong>eer<strong>in</strong>g departments. Many<br />
<strong>of</strong> <strong>the</strong> systems demonstrated will be<br />
conf<strong>in</strong>ed to studies <strong>in</strong> research laboratories<br />
for some time to come. However, for<br />
anyone <strong>in</strong>trigued by <strong>the</strong> latest<br />
neuropros<strong>the</strong>ses showcased <strong>in</strong> <strong>the</strong> news or<br />
nature, this publication <strong>of</strong>fers a fasc<strong>in</strong>at<strong>in</strong>g<br />
<strong>in</strong>sight <strong>in</strong>to <strong>the</strong> field.<br />
Ms Julie Wooldridge is a Tra<strong>in</strong>ee Cl<strong>in</strong>ical<br />
Scientist <strong>in</strong> Electrodiagnostics <strong>and</strong> Cl<strong>in</strong>ical<br />
<strong>Eng<strong>in</strong>eer<strong>in</strong>g</strong> at <strong>the</strong> University Hospitals <strong>of</strong><br />
Leicester NHS Trust, UK<br />
BIOHYBRID SYSTEMS: NERVES, INTERFACES<br />
AND MACHINES<br />
Editor: Ranu Jung<br />
Publisher: Wiley-VCH<br />
ISBN: 9783527409495<br />
Format: Hardback<br />
Pages: 224<br />
44 | SEPTEMBER 2012 | SCOPE<br />
Quantitative MRI <strong>in</strong><br />
Cancer<br />
I was keen to review this book as I have an<br />
<strong>in</strong>terest <strong>in</strong> QMRI methods. Probably <strong>the</strong><br />
most comprehensive book to date on this<br />
topic is <strong>the</strong> QMRI <strong>in</strong> <strong>the</strong> bra<strong>in</strong> book by Paul<br />
T<strong>of</strong>ts. However, it has been several years<br />
s<strong>in</strong>ce it was published <strong>and</strong> I was <strong>in</strong>terested<br />
to see how o<strong>the</strong>rs presented <strong>the</strong>se <strong>the</strong>mes.<br />
The unique sell<strong>in</strong>g po<strong>in</strong>t <strong>of</strong> this new book<br />
is its focus on <strong>the</strong> application <strong>of</strong> QMRI<br />
methods <strong>in</strong> <strong>the</strong> treatment <strong>of</strong> cancer. This<br />
book provides a focussed, disease-led<br />
approach to present<strong>in</strong>g QMRI methods. This<br />
reflects <strong>the</strong> target audience, who <strong>in</strong> this case<br />
is likely to be researchers <strong>and</strong> cl<strong>in</strong>icians with<br />
an <strong>in</strong>terest <strong>in</strong> <strong>the</strong> application <strong>of</strong> novel<br />
imag<strong>in</strong>g methods to cancer.<br />
A fur<strong>the</strong>r feature <strong>of</strong> this textbook is that it<br />
does not focus solely on <strong>the</strong> bra<strong>in</strong> by<br />
cover<strong>in</strong>g QMRI techniques applied to a<br />
range <strong>of</strong> o<strong>the</strong>r areas <strong>of</strong> <strong>the</strong> body such as <strong>the</strong><br />
breast <strong>and</strong> prostate.<br />
The book itself is structured <strong>in</strong>to five<br />
sections, namely: ‘The Physical Basis <strong>of</strong><br />
MRI’; ‘Characteris<strong>in</strong>g Tissue Properties with<br />
Endogenous Contrast Mechanisms’;<br />
‘Characteris<strong>in</strong>g Tissue Properties with<br />
Exogenous Contrast Mechanisms’, <strong>and</strong><br />
end<strong>in</strong>g with ‘Image Process<strong>in</strong>g <strong>in</strong> Cancer<br />
<strong>and</strong> Emerg<strong>in</strong>g Trends’.<br />
The <strong>in</strong>troductory chapters on <strong>the</strong> biology<br />
<strong>and</strong> imag<strong>in</strong>g <strong>of</strong> cancer set <strong>the</strong> scene for <strong>the</strong><br />
rest <strong>of</strong> <strong>the</strong> book. The chapters on <strong>the</strong> physics<br />
<strong>of</strong> MRI <strong>and</strong> <strong>in</strong> particular <strong>the</strong> chapter on<br />
hardware <strong>and</strong> data acquisition are some <strong>of</strong><br />
<strong>the</strong> best I’ve seen where <strong>the</strong> text is well<br />
supported by clear figures <strong>and</strong> equations.<br />
Beyond <strong>the</strong> <strong>in</strong>troductory chapters <strong>of</strong> <strong>the</strong><br />
book <strong>the</strong> QMRI methods beg<strong>in</strong> to be<br />
<strong>in</strong>troduced. Many <strong>of</strong> <strong>the</strong> chapters follow <strong>the</strong><br />
structure <strong>of</strong> hav<strong>in</strong>g both quantitative <strong>and</strong><br />
<strong>the</strong>n qualitative descriptions. This makes <strong>the</strong><br />
book accessible to readers who may just<br />
want an overview <strong>of</strong> <strong>the</strong> topic as well as<br />
provid<strong>in</strong>g more detailed quantitative <strong>and</strong><br />
ma<strong>the</strong>matical descriptions for those who<br />
may wish to try <strong>and</strong> implement or develop<br />
<strong>the</strong> methods for <strong>the</strong>mselves.<br />
The structure <strong>and</strong> choice <strong>of</strong> sections <strong>of</strong> <strong>the</strong><br />
book are sensible <strong>and</strong> <strong>the</strong>re is an entire<br />
section (five chapters) devoted to image<br />
process<strong>in</strong>g methods <strong>in</strong> cancer. This reflects<br />
<strong>the</strong> importance <strong>of</strong> modern image process<strong>in</strong>g<br />
methods <strong>in</strong> facilitat<strong>in</strong>g quantitative<br />
methods. The <strong>in</strong>dividual chapters conta<strong>in</strong><br />
<strong>the</strong> essential descriptions <strong>and</strong> underly<strong>in</strong>g<br />
ma<strong>the</strong>matics for each <strong>of</strong> <strong>the</strong> topics.<br />
Throughout this book each chapter is well<br />
referenced <strong>and</strong> importantly <strong>the</strong> authors<br />
direct <strong>the</strong> reader to associated s<strong>of</strong>tware tools<br />
that have been used to perform image<br />
process<strong>in</strong>g tasks.<br />
The f<strong>in</strong>al section <strong>of</strong> <strong>the</strong> book <strong>in</strong>troduces<br />
emerg<strong>in</strong>g trends <strong>of</strong> QMRI <strong>in</strong> cancer. These<br />
are <strong>the</strong> use <strong>of</strong> MRI <strong>in</strong> radiation <strong>the</strong>rapy;<br />
molecular <strong>and</strong> cellular imag<strong>in</strong>g <strong>and</strong> <strong>the</strong> use<br />
<strong>of</strong> hyperpolarised MR <strong>in</strong> cancer. These topics<br />
are excit<strong>in</strong>g <strong>and</strong> it is right that <strong>the</strong>y have<br />
been <strong>in</strong>cluded <strong>in</strong> a text such as this to enable<br />
<strong>the</strong> reader to get <strong>the</strong> best perspective on <strong>the</strong><br />
current status <strong>of</strong> active research <strong>in</strong> this<br />
particular field.<br />
Overall, this is an excellent book for<br />
anyone <strong>in</strong>terested <strong>in</strong> <strong>the</strong> application <strong>of</strong><br />
QMRI methods ‘to cancer’. This textbook<br />
would also be useful for anyone <strong>in</strong>terested<br />
<strong>in</strong> QMRI methods, irrespective <strong>of</strong> <strong>the</strong>ir<br />
disease <strong>of</strong> <strong>in</strong>terest.<br />
Dr John McLean is a Cl<strong>in</strong>ical Scientist <strong>in</strong><br />
Neuroradiology at <strong>the</strong> <strong>Institute</strong> <strong>of</strong> Neurological<br />
Sciences, Glasgow, Scotl<strong>and</strong>, UK<br />
QUANTITATIVE MRI IN CANCER<br />
Editors: T. Yankeelov, D. Pickens <strong>and</strong> R. Price<br />
Publisher: CRC Press (Taylor & Francis)<br />
ISBN: 9781439820575<br />
Format: Hardback<br />
Pages: 338<br />
Proton Therapy<br />
<strong>Physics</strong><br />
Did you know that <strong>the</strong> possibility <strong>of</strong> us<strong>in</strong>g<br />
protons <strong>in</strong> radio<strong>the</strong>rapy was first postulated<br />
as long ago as 1946 by R. R.Wilson at<br />
Harvard University? He suggested that <strong>the</strong><br />
f<strong>in</strong>ite range <strong>and</strong> Bragg peak <strong>of</strong> proton beams<br />
could be used to treat deep targets <strong>in</strong> <strong>the</strong><br />
body with m<strong>in</strong>imal damage to normal<br />
tissue. The idea was taken up a few years<br />
later by Tobias <strong>and</strong> his colleagues at<br />
Berkeley Laboratories <strong>in</strong> California <strong>and</strong> <strong>the</strong>
first small group <strong>of</strong> patients was treated<br />
<strong>the</strong>re <strong>in</strong> 1954.<br />
This was a revelation to me <strong>and</strong>, I<br />
imag<strong>in</strong>e, to most readers <strong>of</strong> Scope today. In<br />
<strong>the</strong> UK at Clatterbridge, protons have been<br />
used to treat ocular tumours, with good<br />
results, s<strong>in</strong>ce 1989. Worldwide, many<br />
different sites have been treated s<strong>in</strong>ce <strong>the</strong><br />
1970s, with Russia <strong>and</strong> Japan lead<strong>in</strong>g <strong>in</strong><br />
contention with <strong>the</strong> United States. There<br />
has been an exponential rise <strong>in</strong> <strong>in</strong>terest<br />
over <strong>the</strong> last 30 years as demonstrated by<br />
<strong>the</strong> rise <strong>in</strong> papers <strong>in</strong> peer-reviewed<br />
journals. From one or two <strong>in</strong> 1980, <strong>the</strong>re<br />
were almost 150 <strong>in</strong> 2010. You will f<strong>in</strong>d all<br />
this <strong>in</strong> Chapter 1 <strong>of</strong> this amaz<strong>in</strong>g book.<br />
There are 22 contributors, mostly<br />
American physicists, but with <strong>in</strong>put from<br />
Germany, Switzerl<strong>and</strong>, NPL (UK) <strong>and</strong> <strong>the</strong><br />
Ne<strong>the</strong>rl<strong>and</strong>s. The editor, who provides<br />
several chapters himself, is <strong>of</strong> German<br />
orig<strong>in</strong> but has been <strong>the</strong> Director <strong>of</strong> <strong>Physics</strong><br />
Research <strong>in</strong> Boston, Massachusetts, for<br />
some years.<br />
The basic physics is thoroughly<br />
explored <strong>in</strong> <strong>the</strong> 60 pages <strong>of</strong> Chapter 2.<br />
Cyclotrons, synchrotrons <strong>and</strong> accelerator<br />
technologies are dealt with <strong>in</strong> Chapter 3,<br />
followed by several chapters on cl<strong>in</strong>ical<br />
uses, dosimetry <strong>and</strong> treatment plann<strong>in</strong>g.<br />
There is comprehensive coverage <strong>of</strong> all<br />
aspects <strong>of</strong> proton radio<strong>the</strong>rapy here, set out<br />
<strong>in</strong> a concise manner for readers who have a<br />
good knowledge <strong>of</strong> physics to start with.<br />
“<br />
Did you know that <strong>the</strong><br />
possibility <strong>of</strong> us<strong>in</strong>g protons<br />
<strong>in</strong> radio<strong>the</strong>rapy was first<br />
postulated as long ago as<br />
1946?<br />
”<br />
I th<strong>in</strong>k that this book will be an<br />
<strong>in</strong>dispensable aid for physicists beg<strong>in</strong>n<strong>in</strong>g<br />
to work <strong>in</strong> <strong>the</strong> area <strong>of</strong> proton <strong>the</strong>rapy <strong>and</strong> I<br />
have no hesitation <strong>in</strong> recommend<strong>in</strong>g it.<br />
The future <strong>of</strong> radio<strong>the</strong>rapy depends<br />
upon precise beam shap<strong>in</strong>g <strong>and</strong> be<strong>in</strong>g able<br />
to use <strong>the</strong> distal fall <strong>of</strong>f <strong>in</strong> dose due to f<strong>in</strong>ite<br />
beam range.<br />
Pr<strong>of</strong>essor Angela New<strong>in</strong>g is a Retired<br />
Director <strong>of</strong> Medical <strong>Physics</strong> for<br />
Gloucestershire, UK<br />
PROTON THERAPY PHYSICS (SERIES IN<br />
MEDICAL PHYSICS AND BIOMEDICAL<br />
ENGINEERING)<br />
Editor: Harald Paganetti<br />
Publisher: CRC Press (Taylor & Francis)<br />
ISBN: 9781439836446<br />
Format: Hardback<br />
Pages: 704<br />
Just Published!<br />
Electrical Safety H<strong>and</strong>book by John Cadick,<br />
Mary Capelli-Schellpfeffer, Al W<strong>in</strong>field <strong>and</strong><br />
Dennis K. Neitzel (McGraw-Hill) is an<br />
essential, fully updated on-<strong>the</strong>-job safety<br />
resource cover<strong>in</strong>g every major electrical<br />
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electrical construction safety <strong>and</strong> medic<strong>in</strong>e<br />
as a practical guide for electrical workers<br />
<strong>and</strong> o<strong>the</strong>rs exposed to electrical hazards.<br />
Biomedical Signals <strong>and</strong> Sensors I by<br />
Eugenijus Kaniusas (Spr<strong>in</strong>ger) focuses on <strong>the</strong><br />
<strong>in</strong>terface between physiologic mechanisms<br />
<strong>and</strong> diagnostic human eng<strong>in</strong>eer<strong>in</strong>g. This is<br />
<strong>the</strong> first part <strong>of</strong> a two-volume set <strong>and</strong> this<br />
volume describes <strong>the</strong> basic cellular level up<br />
to <strong>the</strong>ir advanced mutual co-ord<strong>in</strong>ation<br />
level dur<strong>in</strong>g sleep.<br />
Walter & Miller’s Textbook <strong>of</strong><br />
Radio<strong>the</strong>rapy by Paul Symonds, Charles<br />
Deehan, Ca<strong>the</strong>r<strong>in</strong>e Meredith <strong>and</strong> John Mills<br />
(Elsevier Health Sciences) covers underly<strong>in</strong>g<br />
pr<strong>in</strong>ciples <strong>of</strong> physics <strong>and</strong> <strong>of</strong>fers a systematic<br />
review <strong>of</strong> tumour sites, concentrat<strong>in</strong>g on <strong>the</strong><br />
role <strong>of</strong> radio<strong>the</strong>rapy <strong>in</strong> <strong>the</strong> treatment <strong>of</strong><br />
malignant disease <strong>and</strong> sett<strong>in</strong>g its use <strong>in</strong><br />
context with chemo<strong>the</strong>rapy <strong>and</strong> surgery.<br />
Technologies <strong>of</strong> Medical Sciences by<br />
Renato Jorge, Joao Tavares, Marcos Barbosa <strong>and</strong><br />
Alan Slade (Spr<strong>in</strong>ger) explores some <strong>of</strong> <strong>the</strong><br />
latest <strong>in</strong>novations be<strong>in</strong>g employed <strong>in</strong><br />
medic<strong>in</strong>e. It covers areas such as<br />
computation modell<strong>in</strong>g <strong>and</strong> simulation,<br />
image process<strong>in</strong>g <strong>and</strong> analysis, medical<br />
imag<strong>in</strong>g, human motion <strong>and</strong> posture, tissue<br />
eng<strong>in</strong>eer<strong>in</strong>g, design <strong>and</strong> development <strong>of</strong><br />
medical devices <strong>and</strong> mechanic biology.<br />
How to L<strong>and</strong> a Top-pay<strong>in</strong>g Medical<br />
<strong>Physics</strong> Pr<strong>of</strong>essors Job by R<strong>and</strong>y Spencer<br />
(Emereo Ltd) is a complete guide to<br />
opportunities, resumés, cover letters,<br />
<strong>in</strong>terviews, salaries <strong>and</strong> promotions.<br />
Towards Practical Bra<strong>in</strong>–Computer<br />
Interfaces by Brendan Allison, Stephen<br />
Dunne, Robert Leeb, Jose Millan <strong>and</strong> Anton<br />
Nijholt (Spr<strong>in</strong>ger) features contributions by<br />
many <strong>of</strong> <strong>the</strong> top bra<strong>in</strong>–computer <strong>in</strong>terface<br />
researchers <strong>and</strong> developers. This book<br />
reviews <strong>the</strong> latest progress <strong>in</strong> <strong>the</strong><br />
components <strong>of</strong> BCIs with a discussion that<br />
<strong>in</strong>cludes a range <strong>of</strong> practical issues <strong>in</strong> an<br />
emerg<strong>in</strong>g BCI-enabled community.<br />
Po<strong>in</strong>t-<strong>of</strong>-Care Diagnostics on a Chip by<br />
David Issadore <strong>and</strong> Robert Westervelt<br />
(Spr<strong>in</strong>ger) reviews <strong>the</strong> latest biochip<br />
technology, exam<strong>in</strong><strong>in</strong>g progress <strong>in</strong> mov<strong>in</strong>g<br />
medical tests out <strong>of</strong> <strong>the</strong> laboratory <strong>and</strong> <strong>in</strong>to<br />
<strong>the</strong> home, with automated <strong>and</strong> <strong>in</strong>expensive<br />
USMAN I. LULA | SCOPE<br />
technology that provides cl<strong>in</strong>icians with<br />
real-time biochemical data.<br />
External Beam Radio<strong>the</strong>rapy, 2nd Edition<br />
by Peter Hosk<strong>in</strong>s (Oxford University Press)<br />
provides practical guidance <strong>of</strong> <strong>the</strong> use <strong>of</strong><br />
external beam <strong>the</strong>rapy. It takes <strong>the</strong> reader<br />
through <strong>the</strong> basic pr<strong>in</strong>ciples cover<strong>in</strong>g<br />
<strong>in</strong>dication, treatment <strong>and</strong> <strong>the</strong>n develop<strong>in</strong>g<br />
this by <strong>in</strong>dividual sites.<br />
New Reports<br />
n Functionality <strong>and</strong> Operation <strong>of</strong><br />
Fluoroscopic Automatic Brightness<br />
Control/Automatic Dose Rate Control<br />
Logic <strong>in</strong> Modern Cardiovascular <strong>and</strong><br />
Interventional Angiography Systems: A<br />
Report <strong>of</strong> Task Group 125, Imag<strong>in</strong>g<br />
<strong>Physics</strong> Committee. Medical <strong>Physics</strong> 2012;<br />
Volume 39, No. 5.<br />
n Dose Calculations for Photon-emitt<strong>in</strong>g<br />
Brachy<strong>the</strong>rapy Sources with Average<br />
Energy Higher than 50 keV: Report <strong>of</strong> <strong>the</strong><br />
AAPM <strong>and</strong> ESTRO. Medical <strong>Physics</strong> 2012;<br />
Volume 39, No. 5.<br />
n Avoidance <strong>of</strong> Unnecessary Dose to<br />
Patient while Transition<strong>in</strong>g from<br />
Analogue to Digital Radiology. Medical<br />
<strong>Physics</strong> 2012; IAEA TECDOC 1667.<br />
n Guidance on <strong>the</strong> Import <strong>and</strong> Export <strong>of</strong><br />
Radioactive Sources. IAEA; 2012.<br />
n Communications with <strong>the</strong> Public <strong>in</strong> a<br />
Nuclear or Radiological Emergency,<br />
Emergency Preparedness <strong>and</strong> Response,<br />
EPR-Public Communications. IAEA; 2012.<br />
n Risk <strong>of</strong> Solid Cancers follow<strong>in</strong>g Radiation<br />
Exposure: Estimates for <strong>the</strong> UK<br />
Population, RCE 19. HPA; 2012.<br />
n Health Effects from Radi<strong>of</strong>requency<br />
Electromagnetic Fields, RCE 20. HPA;<br />
2012.<br />
n Doses to Patients from Radiographic <strong>and</strong><br />
Fluoroscopic X-ray Imag<strong>in</strong>g Procedures<br />
<strong>in</strong> <strong>the</strong> UK – 2010 Review, HPA-CRCE-034.<br />
HPA; 2012.<br />
n The Measurement <strong>of</strong> X-Ray Beam Size<br />
from Dental Panoramic Radiography<br />
Equipment, HPA-CRCE-032. HPA; 2012.<br />
n Radio<strong>the</strong>rapy Dataset Annual Report<br />
2009/2010. Department <strong>of</strong> Health,<br />
Gateway Reference 16350; 2011.<br />
n Safety Is No Accident – A Framework for<br />
Quality Radiation Oncology <strong>and</strong> Care.<br />
ASTRO Blue Book; 2012.<br />
SCOPE | SEPTEMBER 2012 | 45
A HISTORY OF MEDICAL PHYSICS<br />
THE STORY OF JULES GAVARRET (1809–1890)<br />
FRANCIS DUCK returns to Paris for <strong>the</strong> seventh part <strong>of</strong> his history series<br />
ules Gavarret<br />
(1809–1890) was<br />
Pr<strong>of</strong>essor <strong>of</strong> Medical<br />
<strong>Physics</strong> <strong>in</strong> <strong>the</strong> Faculty <strong>of</strong><br />
Medic<strong>in</strong>e <strong>in</strong> Paris for 33<br />
years. By <strong>the</strong> time <strong>of</strong> his<br />
death he had earned an enviable<br />
national <strong>and</strong> <strong>in</strong>ternational<br />
reputation, <strong>and</strong> many tributes were<br />
paid for his contributions to physics, 1<br />
to medic<strong>in</strong>e2 <strong>and</strong> to education. 3 He<br />
was <strong>the</strong>n largely forgotten. Recently,<br />
his name has reappeared <strong>in</strong> <strong>the</strong><br />
histories <strong>of</strong> medic<strong>in</strong>e <strong>and</strong> science. 4,5<br />
J<br />
This is his story.<br />
46 | SEPTEMBER 2012 | SCOPE<br />
FIGURE 1.<br />
Jules Gavarret<br />
(1809–1890) (BIU<br />
Santé, Paris).<br />
▼<br />
Louis-Dom<strong>in</strong>ique-Jules Gavarret<br />
(figure 1) was <strong>the</strong> second son <strong>of</strong> a<br />
prov<strong>in</strong>cial doctor. He was born on<br />
28th January 1809, <strong>in</strong> <strong>the</strong> small town<br />
<strong>of</strong> Astaffort <strong>in</strong> sou<strong>the</strong>rn France. His<br />
<strong>in</strong>telligence <strong>and</strong> ability was<br />
recognised early <strong>and</strong>, on leav<strong>in</strong>g his<br />
local town college <strong>in</strong> Agen, he<br />
ga<strong>in</strong>ed a place at <strong>the</strong> prestigious<br />
École polytechnique <strong>in</strong> Paris, a<br />
gateway to high <strong>of</strong>fice <strong>in</strong> <strong>the</strong><br />
pr<strong>of</strong>essions, education <strong>and</strong><br />
government. Here he met some <strong>of</strong><br />
<strong>the</strong> greatest men <strong>in</strong> French science<br />
<strong>in</strong>clud<strong>in</strong>g Siméon Poisson<br />
(1781–1840) <strong>and</strong> Claude-Louis<br />
Navier (1785–1836). He <strong>in</strong>itially<br />
turned away from <strong>the</strong> family’s<br />
pr<strong>of</strong>ession, medic<strong>in</strong>e. For a young<br />
man who would be later described<br />
by a friend as a pense-libre, a<br />
freeth<strong>in</strong>ker, 3 his first career choice<br />
was surpris<strong>in</strong>g: he jo<strong>in</strong>ed <strong>the</strong> army.<br />
But his own character <strong>and</strong> army<br />
discipl<strong>in</strong>e were <strong>in</strong>compatible, <strong>and</strong><br />
after 2 years at <strong>the</strong> artillery <strong>of</strong>ficers’<br />
tra<strong>in</strong><strong>in</strong>g school at Metz, he had a<br />
row <strong>and</strong> resigned. Some <strong>of</strong> his<br />
military colleagues never forgave<br />
this <strong>in</strong>sult.
GAVARRET’S CAREER IN<br />
MEDICINE<br />
Back <strong>in</strong> Paris <strong>in</strong> early 1833, now 24years-old<br />
<strong>and</strong> with a strong <strong>in</strong>terest <strong>in</strong><br />
ma<strong>the</strong>matics <strong>and</strong> physics, but also <strong>the</strong><br />
need to ga<strong>in</strong> a pr<strong>of</strong>essional<br />
qualification, Gavarret turned to<br />
medic<strong>in</strong>e. He spent <strong>the</strong> next 10 years<br />
<strong>in</strong> <strong>the</strong> Faculty <strong>of</strong> Medic<strong>in</strong>e, at first <strong>in</strong><br />
medical tra<strong>in</strong><strong>in</strong>g, <strong>and</strong> subsequently <strong>in</strong><br />
physiological research.<br />
It is usually possible to see early<br />
evidence <strong>in</strong> publications <strong>of</strong> a creative<br />
talent that will later flower <strong>in</strong>to a full<br />
scientific career. Not so with<br />
Gavarret. His first publication, <strong>in</strong><br />
1840, was a full-length monograph on<br />
medical statistics. 4,6 At that time, <strong>the</strong><br />
term statistics meant, for <strong>the</strong> medical<br />
pr<strong>of</strong>ession, simply <strong>the</strong> careful<br />
ga<strong>the</strong>r<strong>in</strong>g <strong>and</strong> tabulation <strong>of</strong><br />
comparative data.<br />
Our present underst<strong>and</strong><strong>in</strong>g <strong>of</strong><br />
probabilities, correlations <strong>and</strong><br />
associations was entirely absent, <strong>and</strong><br />
Gavarret’s book was <strong>the</strong> first time<br />
that such analysis had been applied<br />
to medical data. Built around<br />
Poisson’s methods <strong>of</strong> statistical<br />
analysis, Gavarret used many<br />
examples to demonstrate <strong>the</strong><br />
importance <strong>of</strong> us<strong>in</strong>g large numbers <strong>of</strong><br />
observations, <strong>of</strong> ascerta<strong>in</strong><strong>in</strong>g limits <strong>of</strong><br />
error from laws <strong>of</strong> probability, <strong>and</strong><br />
<strong>the</strong> erroneous nature <strong>of</strong> results drawn<br />
without such analysis. It is perhaps<br />
unsurpris<strong>in</strong>g that this sem<strong>in</strong>al work,<br />
by a <strong>the</strong>n unknown author, failed to<br />
make <strong>the</strong> impact it deserved. Medical<br />
reputations were potentially<br />
threatened, be<strong>in</strong>g <strong>of</strong>ten based on<br />
particular treatment regimes. It<br />
would not be until <strong>the</strong> twentieth<br />
century that such statistical methods<br />
started to make any <strong>in</strong>roads <strong>in</strong>to<br />
medical th<strong>in</strong>k<strong>in</strong>g.<br />
Gavarret <strong>the</strong>n engaged <strong>in</strong> an<br />
<strong>in</strong>tensive <strong>and</strong> highly productive 4year<br />
period <strong>of</strong> orig<strong>in</strong>al physiological<br />
research, under <strong>the</strong> renowned<br />
physiologist Gabriel Andral<br />
(1797–1876). He published work on<br />
haematological pathology, 7<br />
emphysema <strong>and</strong> cardiopulmonary<br />
disease (his MD <strong>the</strong>sis), analysis <strong>of</strong><br />
exhaled CO 2 (figure 2) <strong>and</strong> body<br />
temperature dur<strong>in</strong>g <strong>in</strong>termittent<br />
fever. His emerg<strong>in</strong>g talent started to<br />
be appreciated outside France. The<br />
Lancet gave his work positive<br />
reviews, <strong>the</strong> studies on<br />
haematological pathology were<br />
published <strong>in</strong> America, 7 <strong>and</strong> his book<br />
on medical statistics was translated<br />
<strong>in</strong>to German.<br />
THE CONCOURS FOR THE<br />
CHAIR OF MEDICAL PHYSICS<br />
The chair <strong>of</strong> medical physics <strong>in</strong> <strong>the</strong><br />
Faculty <strong>of</strong> Medic<strong>in</strong>e <strong>in</strong> Paris fell<br />
vacant on 20th July 1843, when Pierre<br />
Pelletan resigned. Pelletan had<br />
become heavily <strong>in</strong>volved <strong>in</strong> bus<strong>in</strong>ess<br />
<strong>and</strong> <strong>in</strong>dustrial enterprises <strong>and</strong> had<br />
overstretched himself f<strong>in</strong>ancially.<br />
Pressed by creditors, he resigned<br />
from his post <strong>and</strong> left France. 8<br />
The method by which senior<br />
academic posts were filled <strong>in</strong> France<br />
at this time was known as <strong>the</strong><br />
concours (contest), a gruell<strong>in</strong>g process<br />
<strong>of</strong> competitive <strong>in</strong>terviews <strong>and</strong><br />
exam<strong>in</strong>ations. The 1843 concours for<br />
<strong>the</strong> chair <strong>of</strong> medical physics consisted<br />
<strong>of</strong> four exam<strong>in</strong>ations, one written,<br />
two oral <strong>and</strong> a practical, <strong>and</strong> <strong>the</strong><br />
defence <strong>of</strong> a <strong>the</strong>sis. The c<strong>and</strong>idates<br />
appeared before a formidable<br />
academic panel consist<strong>in</strong>g <strong>of</strong> n<strong>in</strong>e<br />
pr<strong>of</strong>essors from <strong>the</strong> Faculty <strong>of</strong><br />
Medic<strong>in</strong>e <strong>and</strong> four from <strong>the</strong> Faculty<br />
<strong>of</strong> Science. The panel was chaired by<br />
Claude Pouillet (1790–1868), a<br />
physicist whose name appears<br />
repeatedly <strong>in</strong> <strong>the</strong> story <strong>of</strong> medical<br />
physics. 8,9<br />
The field was very strong. Of <strong>the</strong><br />
six c<strong>and</strong>idates, three had taken part<br />
<strong>in</strong> <strong>the</strong> previous concours, 13 years<br />
earlier. 8 Jacques-Henri Maissiat<br />
(1805–1878) had been Pelletan’s<br />
assistant (agrégé) <strong>and</strong> had been giv<strong>in</strong>g<br />
<strong>the</strong> medical physics course s<strong>in</strong>ce<br />
1839. The prize was highly attractive.<br />
The post was tenured. The salary was<br />
6,000 francs, about 10 times <strong>the</strong><br />
average wage <strong>of</strong> a work<strong>in</strong>g man at<br />
that time, <strong>and</strong> well towards <strong>the</strong> upper<br />
end <strong>of</strong> government-supported<br />
salaries. Fur<strong>the</strong>rmore, <strong>the</strong>re was no<br />
comparable post elsewhere at this<br />
time: <strong>in</strong> <strong>the</strong> o<strong>the</strong>r two full medical<br />
schools <strong>in</strong> France, at Montpellier <strong>and</strong><br />
Strasbourg, <strong>the</strong> teach<strong>in</strong>g <strong>of</strong> medical<br />
physics was still comb<strong>in</strong>ed with that<br />
<strong>of</strong> hygiene.<br />
The written exam<strong>in</strong>ation was<br />
about <strong>the</strong> human voice. For <strong>the</strong> first<br />
oral exam<strong>in</strong>ation <strong>the</strong> c<strong>and</strong>idates were<br />
each given <strong>the</strong>ir own topic, with 24<br />
hours’ notice to prepare a lecture. The<br />
six topics were: atmospheric<br />
humidity <strong>and</strong> its physiological<br />
effects; electrical phenomena <strong>in</strong> fish<br />
(Gavarret’s subject); sight; animal<br />
heat; capillarity <strong>and</strong> endosmosis, <strong>and</strong><br />
radiant heat. There were only three<br />
topics for <strong>the</strong> second oral, which <strong>the</strong><br />
c<strong>and</strong>idates had to prepare with only<br />
3 hours’ notice: <strong>the</strong> microscope <strong>in</strong><br />
medical science; physiology <strong>of</strong> gas<br />
“ Gavarret’s<br />
book was<br />
<strong>the</strong> first<br />
time that<br />
such<br />
analysis<br />
had been<br />
applied to<br />
medical<br />
data<br />
”<br />
HISTORICAL FEATURE | SCOPE<br />
<strong>and</strong> liquid pressure, <strong>and</strong> atmospheric<br />
electricity. The 25-m<strong>in</strong>ute physics<br />
practical exam<strong>in</strong>ation followed: <strong>the</strong><br />
explanation <strong>and</strong> use <strong>of</strong> Rumford’s<br />
calorimeter <strong>and</strong> Cagniard de Latour’s<br />
siren (figure 3). F<strong>in</strong>ally, Gavarret<br />
defended his <strong>the</strong>sis on <strong>the</strong> laws <strong>of</strong><br />
dynamic electricity.<br />
A report <strong>in</strong> <strong>the</strong> press (<strong>the</strong> concours<br />
was public) said that all c<strong>and</strong>idates<br />
performed to a very high st<strong>and</strong>ard.<br />
Gavarret himself was deemed to have<br />
<strong>the</strong> best m<strong>in</strong>d. The votes <strong>of</strong> <strong>the</strong> panel<br />
were equally divided between<br />
Gavarret <strong>and</strong> Maissiat, six each,<br />
leav<strong>in</strong>g Pouillet to make <strong>the</strong> cast<strong>in</strong>g<br />
vote. Maissiat represented <strong>the</strong> safe<br />
option, known by <strong>the</strong> medical faculty,<br />
<strong>and</strong> capable <strong>of</strong> competent delivery <strong>of</strong><br />
<strong>the</strong> first-year physics lectures to a high<br />
st<strong>and</strong>ard. Gavarret had presented as<br />
an outst<strong>and</strong><strong>in</strong>g <strong>and</strong> clear-m<strong>in</strong>ded<br />
<strong>in</strong>tellect, with a high-quality, though<br />
brief, track record <strong>in</strong> research, but<br />
with no teach<strong>in</strong>g experience.<br />
But Pouillet knew that he was<br />
liv<strong>in</strong>g <strong>in</strong> a time <strong>of</strong> extraord<strong>in</strong>ary<br />
change, both <strong>in</strong> physics <strong>and</strong> <strong>in</strong><br />
medic<strong>in</strong>e, <strong>and</strong> this was a critical<br />
appo<strong>in</strong>tment if Paris had any chance<br />
<strong>of</strong> ma<strong>in</strong>ta<strong>in</strong><strong>in</strong>g its <strong>in</strong>ternational<br />
position as a centre <strong>of</strong> medical<br />
excellence. He chose Jules Gavarret.<br />
The endorsement <strong>of</strong> his appo<strong>in</strong>tment<br />
was announced as a m<strong>in</strong>isterial order<br />
on 16th January 1844.<br />
GAVARRET AS A TEACHER<br />
The record <strong>of</strong> Gavarret’s life for <strong>the</strong><br />
next 10 years is muted. He settled<br />
himself <strong>in</strong>to his new role, his ideas on<br />
how to apply physics to medic<strong>in</strong>e<br />
undergo<strong>in</strong>g a slow gestation. He<br />
engaged quickly with <strong>the</strong> life <strong>of</strong> <strong>the</strong><br />
faculty, <strong>and</strong> <strong>in</strong> <strong>the</strong> year <strong>of</strong> his<br />
appo<strong>in</strong>tment as pr<strong>of</strong>essor he also<br />
became assessor to <strong>the</strong> Dean. But<br />
those who might have expected<br />
fur<strong>the</strong>r research output were<br />
disappo<strong>in</strong>ted, <strong>and</strong> no new textbook on<br />
medical physics appeared to replace<br />
Pelletan’s Physique general et médicale.<br />
His defence might have been that, <strong>in</strong><br />
common with all academics, <strong>the</strong><br />
comb<strong>in</strong>ation <strong>of</strong> lecture preparation,<br />
exam<strong>in</strong>ations, tutorials <strong>and</strong><br />
adm<strong>in</strong>istration left no time for<br />
anyth<strong>in</strong>g else; <strong>and</strong> fur<strong>the</strong>rmore,<br />
medical tra<strong>in</strong><strong>in</strong>g at that time required<br />
no laboratory experience, so he had no<br />
space for experimental work. Perhaps<br />
Pouillet’s confidence had been<br />
misplaced, <strong>and</strong> he had selected<br />
ano<strong>the</strong>r time-serv<strong>in</strong>g middle-rate<br />
academic.<br />
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But Gavarret had not ceased<br />
th<strong>in</strong>k<strong>in</strong>g. In 1849 we see <strong>the</strong> next<br />
example <strong>in</strong> which he demonstrated<br />
that he was follow<strong>in</strong>g developments at<br />
<strong>the</strong> <strong>in</strong>terface between physics <strong>and</strong><br />
medic<strong>in</strong>e, <strong>in</strong> this case electricity.<br />
Conventional wisdom <strong>in</strong> France still<br />
broadly held to Volta’s electrochemical<br />
model to expla<strong>in</strong> all galvanic sources,<br />
reject<strong>in</strong>g Galvani’s view <strong>of</strong> animal<br />
electricity as an <strong>in</strong>nate property <strong>of</strong><br />
liv<strong>in</strong>g tissues. Gavarret published a<br />
careful review based on <strong>the</strong> best<br />
evidence he could f<strong>in</strong>d, conclud<strong>in</strong>g<br />
that much criticism <strong>of</strong> Galvani had<br />
been <strong>in</strong>appropriate, <strong>and</strong> that <strong>the</strong>re was<br />
much new evidence to suggest that<br />
electric phenomena were <strong>in</strong>herent to<br />
all liv<strong>in</strong>g matter.<br />
HEAT AND ELECTRICITY<br />
Gavarret planned to write a book<br />
about animal electricity. He said so <strong>in</strong><br />
<strong>the</strong> <strong>in</strong>troduction to his next book, on<br />
animal heat. 10 This book was a<br />
thorough review <strong>of</strong> a topic for which<br />
considerable advances <strong>in</strong> measurement<br />
techniques (figure 4) <strong>and</strong><br />
underst<strong>and</strong><strong>in</strong>g had recently occurred.<br />
This was to be <strong>the</strong> first <strong>in</strong> his Medical<br />
<strong>Physics</strong> series, <strong>in</strong> which he <strong>in</strong>tended to<br />
review carefully each aspect <strong>of</strong> physics<br />
<strong>in</strong> its relationship to medic<strong>in</strong>e. (In fact,<br />
none <strong>of</strong> his later books bore this series<br />
title.) Animal electricity would have<br />
been Volume 2 <strong>in</strong> this series. But<br />
controversy still surrounded this<br />
subject: Du Bois Reymond’s visit to<br />
Paris <strong>in</strong> 1850 did little to clear <strong>the</strong> air. 9<br />
So, <strong>in</strong>stead, Gavarret’s next book was a<br />
thorough review on <strong>the</strong> current state <strong>of</strong><br />
electricity as a whole, publish<strong>in</strong>g his<br />
Traité d’Électricitié <strong>in</strong> two volumes <strong>in</strong><br />
1858 <strong>and</strong> 1859. However, he omitted<br />
biomedical electricity, which he says<br />
needed to mature fur<strong>the</strong>r before a<br />
proper review could be written. This<br />
book established his reputation as an<br />
academic author who could expla<strong>in</strong><br />
difficult concepts <strong>in</strong> easily-understood<br />
prose, without compromis<strong>in</strong>g scientific<br />
accuracy. The book was also soon<br />
published <strong>in</strong> German.<br />
He was immediately <strong>in</strong>vited to<br />
serve as a member <strong>of</strong> a commission <strong>of</strong><br />
<strong>the</strong> M<strong>in</strong>istry <strong>of</strong> F<strong>in</strong>ance to give advice<br />
on <strong>the</strong> electric telegraph. This was at<br />
<strong>the</strong> start <strong>of</strong> <strong>the</strong> n<strong>in</strong>eteenth-century<br />
communications revolution, both <strong>in</strong><br />
extent <strong>and</strong> speed, with an impact<br />
comparable with that which arose from<br />
<strong>the</strong> <strong>in</strong>troduction <strong>of</strong> <strong>the</strong> World Wide<br />
Web. Up to 1844, when <strong>the</strong> first electric<br />
telegraph l<strong>in</strong>e was <strong>in</strong>stalled from Paris<br />
to Tours, <strong>the</strong>re were only five<br />
semaphore l<strong>in</strong>es <strong>in</strong> France, <strong>and</strong> a<br />
message took 20 m<strong>in</strong>utes to reach<br />
Toulon. With<strong>in</strong> 7 years, London <strong>and</strong><br />
Paris were <strong>in</strong> <strong>in</strong>stantaneous<br />
communication by a telegraph cable<br />
under <strong>the</strong> English Channel, <strong>and</strong> by<br />
1860 <strong>the</strong>re were 22,000 km <strong>of</strong> l<strong>in</strong>es<br />
criss-cross<strong>in</strong>g <strong>the</strong> whole <strong>of</strong> France. In<br />
1861 Gavarret published a detailed<br />
book on <strong>the</strong> telegraph (figure 5). 11 This<br />
book was aga<strong>in</strong> followed by a German<br />
translation.<br />
LIGHT AND SOUND<br />
Gavarret’s next books, on optics <strong>and</strong><br />
acoustics, endorsed his reputation as<br />
an outst<strong>and</strong><strong>in</strong>g educational<br />
communicator. They also serve to<br />
emphasise his underst<strong>and</strong><strong>in</strong>g <strong>of</strong> his<br />
unique role – to underst<strong>and</strong><br />
contemporary developments <strong>in</strong><br />
physics <strong>in</strong> depth, <strong>and</strong> to <strong>in</strong>terpret<br />
<strong>the</strong>m for his colleagues <strong>in</strong> medic<strong>in</strong>e.<br />
Much had already been written on <strong>the</strong><br />
optics <strong>of</strong> <strong>the</strong> eye, <strong>and</strong> he saw it as<br />
unnecessary to go over this well-tilled<br />
soil. So, <strong>in</strong>stead, he wrote an<br />
<strong>in</strong>terpretation <strong>of</strong> Gauss’s 1840<br />
Dioptrishe Untersuchungen. In his book,<br />
entitled Images par reflexion et par<br />
refraction (1866), he gave a clear<br />
exposition <strong>of</strong> Gauss’s paraxial<br />
approximation for focal systems,<br />
giv<strong>in</strong>g a tool us<strong>in</strong>g pr<strong>in</strong>cipal <strong>and</strong><br />
nodal po<strong>in</strong>ts that could be easily<br />
applied <strong>in</strong> physiological optics. The<br />
preface <strong>of</strong> <strong>the</strong> 1891 translated Russian<br />
edition <strong>of</strong> Gavarret’s book emphasises<br />
its considerable value <strong>in</strong> <strong>the</strong> teach<strong>in</strong>g<br />
<strong>of</strong> optics.<br />
In his last book 12 he reviewed <strong>the</strong><br />
mechanisms <strong>of</strong> speech <strong>and</strong> hear<strong>in</strong>g,<br />
draw<strong>in</strong>g on <strong>the</strong> work <strong>of</strong> Helmholtz<br />
<strong>and</strong> Fourier, <strong>in</strong>clud<strong>in</strong>g several<br />
appendices <strong>of</strong> a more ma<strong>the</strong>matical<br />
nature. The text itself draws strongly<br />
on experimental physics, <strong>in</strong>clud<strong>in</strong>g<br />
many examples <strong>of</strong> physical<br />
measurements applied to<br />
physiological acoustics (figure 6).<br />
BIOLOGICAL PHYSICS<br />
Gavarret was always concerned to<br />
avoid a too narrow <strong>in</strong>terpretation <strong>of</strong><br />
<strong>the</strong> physics syllabus for first-year<br />
medical students. He knew that <strong>the</strong>re<br />
was <strong>in</strong>sufficient time dur<strong>in</strong>g his three<br />
physics lectures per week to do justice<br />
to <strong>the</strong> broader applications <strong>of</strong> physics<br />
to medic<strong>in</strong>e. In response to this<br />
conflict, around 1866 he started to<br />
<strong>of</strong>fer an advanced course called<br />
Biological <strong>Physics</strong>, where he assumed<br />
his audience had some knowledge not<br />
only <strong>of</strong> physics, but also <strong>of</strong><br />
FIGURE 2.<br />
[TOP LEFT]<br />
Gavarret’s<br />
apparatus for <strong>the</strong><br />
measurement <strong>of</strong><br />
expired CO2 . 10<br />
▼<br />
FIGURE 3.<br />
[TOP RIGHT]<br />
Cagniard de<br />
Latour’s siren.<br />
▼<br />
FIGURE 4.<br />
[MIDDLE LEFT]<br />
Intra-muscular<br />
temperature<br />
us<strong>in</strong>g<br />
<strong>the</strong>rmocouples by<br />
A.-C. Becquerel<br />
(1788–1878):<br />
1835. 10<br />
▼<br />
FIGURE 5.<br />
[BOTTOM RIGHT]<br />
Electrical<br />
telegraph<br />
transmitter c.<br />
1850. 11<br />
▼<br />
FIGURE 6.<br />
[BOTTOM LEFT]<br />
Voice analysis<br />
us<strong>in</strong>g <strong>the</strong> danc<strong>in</strong>g<br />
flame. 12<br />
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HISTORICAL FEATURE | SCOPE<br />
physiology, pathology <strong>and</strong> anatomy.<br />
Such was <strong>the</strong> <strong>in</strong>terest <strong>in</strong> <strong>the</strong>se lectures<br />
that typically more than half his<br />
audience consisted <strong>of</strong> qualified<br />
doctors, anxious to update <strong>the</strong>mselves<br />
on <strong>the</strong> possible impact on <strong>the</strong>ir<br />
medical practice <strong>of</strong> new developments<br />
<strong>in</strong> physics.<br />
In 1869, he published a book<br />
derived from this course, Phénomènes<br />
physique de la vie. Once more we see<br />
him apply<strong>in</strong>g modern physics<br />
concepts to medical problems,<br />
allow<strong>in</strong>g him to peer <strong>in</strong>to <strong>the</strong> future<br />
whilst rema<strong>in</strong><strong>in</strong>g cautious about<br />
<strong>in</strong>appropriate extrapolation from<br />
present knowledge. In <strong>the</strong><br />
<strong>in</strong>troduction he applauds <strong>the</strong> value <strong>of</strong><br />
physical measurement, us<strong>in</strong>g <strong>the</strong><br />
example <strong>of</strong> Marey’s multichannel<br />
measurements on <strong>in</strong>tra-cardiac<br />
pressure: he was Marey’s exam<strong>in</strong>er for<br />
his <strong>the</strong>sis <strong>in</strong> 1859.<br />
Étienne-Jules Marey (1830–1904)<br />
later became famous for his use <strong>of</strong><br />
photographic methods for analysis <strong>of</strong><br />
animal locomotion. He even <strong>in</strong>cluded<br />
<strong>the</strong> comment that, s<strong>in</strong>ce <strong>the</strong> bra<strong>in</strong> is<br />
do<strong>in</strong>g work dur<strong>in</strong>g th<strong>in</strong>k<strong>in</strong>g,<br />
compar<strong>in</strong>g, want<strong>in</strong>g <strong>and</strong> so on, its<br />
energy use may be sufficient cause<br />
<strong>and</strong> not just a necessary condition for<br />
all mental activity, <strong>and</strong> by implication<br />
subject to <strong>the</strong> same energy<br />
considerations as any o<strong>the</strong>r organ. In<br />
this he draws on <strong>the</strong> new concepts <strong>in</strong><br />
physics that clearly excited him most,<br />
<strong>the</strong> reciprocity <strong>of</strong> forces <strong>and</strong> <strong>the</strong><br />
conservation <strong>of</strong> energy. Us<strong>in</strong>g <strong>the</strong><br />
term<strong>in</strong>ology <strong>of</strong> <strong>the</strong> time, he says that<br />
travaille is as universal as mass, <strong>and</strong><br />
that its conservation is as<br />
fundamentally true <strong>in</strong> liv<strong>in</strong>g as <strong>in</strong><br />
<strong>in</strong>organic materials. It is here, he says,<br />
that physiological phenomena, heat,<br />
bio-electricity, muscular power <strong>and</strong><br />
nutrition, will f<strong>in</strong>d <strong>the</strong>ir true<br />
explanation. In comparison with his<br />
British contemporaries, he felt no need<br />
to mention any apparent conflict with<br />
religious thought, although he had to<br />
fight aga<strong>in</strong>st a residual belief <strong>in</strong> a vital<br />
life force, still ma<strong>in</strong>ta<strong>in</strong>ed by <strong>the</strong><br />
dom<strong>in</strong>ant French physiologist Claude<br />
Bernard (1813–1878).<br />
It was left to his younger colleagues<br />
Desplats <strong>and</strong> Gariel to write <strong>the</strong> next<br />
full medical physics text 13 <strong>in</strong> 1870, to<br />
which Gavarret added an<br />
<strong>in</strong>troduction.<br />
POLITICS<br />
Jules Gavarret lived through a highly<br />
turbulent time <strong>in</strong> French history. He<br />
was just 4 years old when Napoleon<br />
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lost <strong>the</strong> battle <strong>of</strong> Waterloo. Dur<strong>in</strong>g his<br />
formative teenage years, <strong>the</strong> country<br />
was under <strong>the</strong> strict right-w<strong>in</strong>g<br />
regime <strong>of</strong> Charles X. The year after<br />
his arrival as a student <strong>in</strong> Paris, he<br />
watched <strong>the</strong> violent riots that<br />
deposed Charles <strong>and</strong> established <strong>the</strong><br />
July Monarchy <strong>of</strong> Louis Phillipe.<br />
Gavarret lived through <strong>the</strong> 1848<br />
revolution <strong>and</strong> <strong>the</strong> coup d’état <strong>of</strong> 1852,<br />
which created <strong>the</strong> second Empire<br />
under Napoleon III. He survived <strong>the</strong><br />
siege <strong>of</strong> Paris, <strong>the</strong> subsequent<br />
commune, <strong>and</strong> observed its bloody<br />
suppression <strong>and</strong> <strong>the</strong> formation <strong>of</strong> <strong>the</strong><br />
Republic. At each sw<strong>in</strong>g <strong>of</strong> <strong>the</strong><br />
political pendulum, academic<br />
positions, be<strong>in</strong>g public appo<strong>in</strong>tments,<br />
were potentially under threat.<br />
Pouillet, for example, lost his<br />
pr<strong>of</strong>essorship at <strong>the</strong> Conservatoire des<br />
arts et métiers <strong>in</strong> 1852 when he refused<br />
to swear allegiance to <strong>the</strong> Emperor.<br />
Gavarret’s name is nowhere l<strong>in</strong>ked to<br />
political activity <strong>and</strong> he was able to<br />
ga<strong>in</strong> <strong>the</strong> approval <strong>of</strong> each new<br />
adm<strong>in</strong>istration.<br />
Decorated with <strong>the</strong> Legion<br />
d’honneur <strong>in</strong> 1847, towards <strong>the</strong> end <strong>of</strong><br />
<strong>the</strong> July Monarchy, he was made an<br />
Officer <strong>of</strong> this order <strong>in</strong> 1862 dur<strong>in</strong>g<br />
<strong>the</strong> second Empire, <strong>and</strong> f<strong>in</strong>ally raised<br />
to Comm<strong>and</strong>er <strong>in</strong> 1882 by <strong>the</strong><br />
Republic. Liberal by <strong>in</strong>cl<strong>in</strong>ation, <strong>the</strong><br />
only reference l<strong>in</strong>k<strong>in</strong>g his name to a<br />
political event occurred at <strong>the</strong> start <strong>of</strong><br />
<strong>the</strong> 1867 academic year. Some<br />
students, object<strong>in</strong>g nom<strong>in</strong>ally to<br />
changes <strong>in</strong> <strong>the</strong> open<strong>in</strong>g ceremony,<br />
started s<strong>in</strong>g<strong>in</strong>g <strong>the</strong> Marseillaise as he<br />
entered <strong>the</strong> lecture hall. The row<br />
cont<strong>in</strong>ued <strong>and</strong>, after an hour,<br />
Gavarret reportedly looked at his<br />
REFERENCES<br />
50 | SEPTEMBER 2012 | SCOPE<br />
watch <strong>and</strong> left. It seems that this<br />
demonstration was directed towards<br />
<strong>the</strong> establishment ra<strong>the</strong>r than<br />
aga<strong>in</strong>st him.<br />
GAVARRET’S LATER LIFE<br />
Dur<strong>in</strong>g his early life Gavarret<br />
rema<strong>in</strong>ed s<strong>in</strong>gle. Eventually, on 14th<br />
September 1860, he married Eudoxie<br />
B<strong>in</strong>esse de Sa<strong>in</strong>t-Victor, a lady <strong>in</strong> her<br />
late 30s from an aristocratic family.<br />
They set up home <strong>in</strong> rue de Grenelle on<br />
<strong>the</strong> Left Bank, <strong>and</strong> became part <strong>of</strong><br />
Parisian society. Affable <strong>and</strong> replete<br />
with anecdotes, told with manners <strong>of</strong><br />
speech from his sou<strong>the</strong>rn childhood,<br />
Gavarret presided over many<br />
Saturday night soirees with ‘<strong>the</strong> ladies<br />
<strong>of</strong> medical assistants who were<br />
seek<strong>in</strong>g pr<strong>of</strong>essorships’. 5<br />
In 1873 he was appo<strong>in</strong>ted to review<br />
<strong>the</strong> preparatory medical schools, with<br />
a view to recommend<strong>in</strong>g those<br />
appropriate for upgrad<strong>in</strong>g, <strong>and</strong> 6<br />
years later became <strong>the</strong> <strong>in</strong>spectorgeneral<br />
for higher medical education.<br />
He cont<strong>in</strong>ued writ<strong>in</strong>g, contribut<strong>in</strong>g<br />
articles on popular science to <strong>the</strong><br />
Moniteur universel <strong>and</strong> compil<strong>in</strong>g all<br />
17 physics def<strong>in</strong>itions <strong>in</strong> <strong>the</strong><br />
Dictionnaire encyclopédique des sciences<br />
médicales. Still active <strong>in</strong> his 70s, he<br />
became President <strong>of</strong> <strong>the</strong> Academy <strong>of</strong><br />
Medic<strong>in</strong>e <strong>in</strong> 1882, <strong>and</strong> presided over<br />
<strong>the</strong> revision <strong>of</strong> <strong>the</strong> French<br />
pharmacopoeia <strong>in</strong> 1884. He retired <strong>in</strong><br />
1885 <strong>and</strong> was subsequently awarded<br />
an honorary pr<strong>of</strong>essorship. He was<br />
replaced by Charles-Marie Gariel<br />
(1841–1924). 1,13 His death came on 30th<br />
August 1890, whilst on holiday with a<br />
friend, <strong>and</strong> only 5 months after that <strong>of</strong><br />
his wife.<br />
1 Gariel C-M. Médec<strong>in</strong>e. In École polytechnique. Livre du<br />
centenaire 1794–1894, 1897; Vol. 3: 394–408.<br />
2 Corlieu A. Centenaire de la Faculté de médec<strong>in</strong>e de Paris<br />
(1794–1894). Ch IV: Chaire de Physique. 1896.<br />
3 Laborde M. Le pr<strong>of</strong>esseur Gavarret. Bull Soc<br />
d’Anthropologie de Paris, 4th ser, 1890; 1: 645–51.<br />
4 Huth E. Jules Gavarret’s Pr<strong>in</strong>cipes Généraux de Statistique<br />
Médicale. J R Soc Med 2008; 101: 205–12.<br />
5 Beyneix A. Le pr<strong>of</strong>esseur Jules Gavarret (1809–1890) et<br />
l’application des méthodes mathématiques et physiques à<br />
la médec<strong>in</strong>e. Bull Acad Natle Med 2001; 185: 1327–35.<br />
6 Gavarret J. Pr<strong>in</strong>cipes généraux de statistique médicale.<br />
Paris, 1840.<br />
7 Andral G. An Essay on <strong>the</strong> Blood <strong>in</strong> Disease. Translated by<br />
Meigs & Stillé. Philadelphia, 1844.<br />
His<br />
high<br />
academic<br />
status<br />
ensured a<br />
legacy for<br />
medical<br />
physics<br />
“<br />
”<br />
GAVARRET’S CONTRIBUTION<br />
TO MEDICAL PHYSICS<br />
The n<strong>in</strong>eteenth century saw<br />
extraord<strong>in</strong>ary advances <strong>in</strong> science,<br />
technology <strong>and</strong> medic<strong>in</strong>e. By his<br />
appo<strong>in</strong>tment as <strong>the</strong> only full pr<strong>of</strong>essor<br />
<strong>of</strong> medical physics <strong>in</strong> France at that<br />
time, Gavarret was placed <strong>in</strong> a unique<br />
position to develop <strong>and</strong> clarify this<br />
new discipl<strong>in</strong>e. It is difficult to fault<br />
him. He ga<strong>in</strong>ed considerable respect<br />
from his medical colleagues as an<br />
outst<strong>and</strong><strong>in</strong>g communicator <strong>and</strong> for<br />
his ability to expla<strong>in</strong> difficult concepts<br />
<strong>of</strong> physics without compromis<strong>in</strong>g<br />
scientific <strong>in</strong>tegrity. He understood<br />
that a medical physicist must<br />
constantly keep abreast <strong>of</strong><br />
developments <strong>in</strong> physics <strong>and</strong><br />
ma<strong>the</strong>matics, which for him <strong>in</strong>cluded<br />
Poisson’s statistics, <strong>the</strong> optics <strong>of</strong><br />
Gauss, <strong>and</strong> <strong>in</strong>sights <strong>in</strong>to acoustics <strong>and</strong><br />
energy conservation from Helmholtz,<br />
<strong>and</strong> be prepared to underst<strong>and</strong> <strong>the</strong>se<br />
<strong>in</strong> depth <strong>in</strong> order to apply <strong>the</strong>m <strong>and</strong><br />
expla<strong>in</strong> <strong>the</strong>m to his medical<br />
colleagues. His high academic status<br />
ensured a legacy for medical physics<br />
both <strong>in</strong> his own highly-respected<br />
department <strong>and</strong> elsewhere <strong>in</strong><br />
France. 14,15,16 With<strong>in</strong> a decade <strong>of</strong> his<br />
death, <strong>the</strong> discovery <strong>of</strong> x-rays <strong>and</strong><br />
radioactivity permanently cemented<br />
<strong>the</strong> relationship between medic<strong>in</strong>e<br />
<strong>and</strong> physics <strong>in</strong> a way that would<br />
probably not have surprised him.<br />
ABOUT THE AUTHOR<br />
Francis Duck is Honorary Consultant<br />
Medical Physicist <strong>in</strong> <strong>the</strong> Department <strong>of</strong><br />
Medical <strong>Physics</strong> <strong>and</strong> Bioeng<strong>in</strong>eer<strong>in</strong>g at<br />
<strong>the</strong> Royal United Hospital Bath NHS<br />
Trust <strong>and</strong> visit<strong>in</strong>g pr<strong>of</strong>essor at <strong>the</strong><br />
University <strong>of</strong> Bath.<br />
Email: f.duck@bath.ac.uk<br />
8 www.scopeonl<strong>in</strong>e.co.uk/pages/articles/history/history.shtml<br />
9 Duck F. A history <strong>of</strong> medical physics – Adolf Fick <strong>and</strong><br />
physiological physics. Scope June 2012: 50–54.<br />
10 Gavarret J. Physique Médicale – de la Chaleur Produite par<br />
les Êtres Vivants. Paris, 1855.<br />
11 Gavarret J. Télégraphie Électrique. Paris, 1861.<br />
12 Gavarret J. Acoustique Biologique – Phénomènes<br />
Physiques de la Phonation et de l’Audition. Paris, 1877.<br />
13 Desplats V, Gariel C-M. Nouveaux Éléments de Physique<br />
Médicale. Paris, 1870.<br />
14 Gréhant N. Manuel de Physique Médicale. Paris, 1869.<br />
15 Wundt W, Monoyer F. Traité Élémentaire de Physique<br />
Médicale. Paris, 1871.<br />
16 Lefèvre J. Manuel de Physique Médicale. Paris, 1889.
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