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Experience the Elekta Differ - Institute of Physics and Engineering in ...

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confident recommendation to biomedical<br />

eng<strong>in</strong>eers, <strong>and</strong> for that matter, anyone for<br />

whom cardiac electrophysiology forms a<br />

significant part <strong>of</strong> <strong>the</strong>ir work<strong>in</strong>g life.<br />

Dr James Stirrup is a Cl<strong>in</strong>ical Research<br />

Fellow at <strong>the</strong> Cardiac Imag<strong>in</strong>g National Heart<br />

<strong>and</strong> Lung <strong>Institute</strong>, Imperial College, London.<br />

He is also a Cardiology Specialist Registrar at<br />

<strong>the</strong> Wessex Deanery, UK<br />

CARDIAC FIBRILLATION–DEFIBRILLATION:<br />

CLINICAL AND ENGINEERING ASPECTS –<br />

SERIES ON BIOENGINEERING AND BIOMEDICAL<br />

ENGINEERING<br />

Author: Max E. Valent<strong>in</strong>uzzi<br />

Publisher: World Scientific<br />

Volume: 6<br />

ISBN: 978-9814293631<br />

Pages: 304<br />

The Emperor <strong>of</strong> All<br />

Maladies<br />

I loved this book which was a slight relief<br />

as it would have been <strong>in</strong>terest<strong>in</strong>g to write a<br />

review <strong>in</strong> opposition to <strong>the</strong> many people<br />

who decided that this book was worthy <strong>of</strong><br />

a Pulitzer Prize (General Nonfiction, 2011),<br />

<strong>the</strong> Guardian First Book Award 2011 <strong>and</strong><br />

shortlisted for both <strong>the</strong> Duff Cooper Prize<br />

2011 <strong>and</strong> <strong>the</strong> Wellcome Trust Book Prize.<br />

The author, Siddhartha Mukherjee, is a<br />

well-published cancer physician <strong>and</strong><br />

researcher who lives <strong>in</strong> New York. He<br />

started research<strong>in</strong>g <strong>the</strong> history <strong>of</strong> cancer<br />

when he began his advanced tra<strong>in</strong><strong>in</strong>g <strong>in</strong><br />

medical oncology <strong>in</strong> Boston, which after<br />

about 7 years resulted <strong>in</strong> this book. The text<br />

follows a roughly chronological path<br />

through <strong>the</strong> history <strong>of</strong> cancer from its first<br />

description around 2500 BC <strong>in</strong> Egypt, to<br />

recent discoveries <strong>in</strong> <strong>the</strong> underst<strong>and</strong><strong>in</strong>g <strong>of</strong><br />

<strong>the</strong> activation or <strong>in</strong>activation <strong>of</strong> genes or<br />

pathways that result <strong>in</strong> cancer. The<br />

‘biography’ is also <strong>in</strong>terspersed with <strong>the</strong><br />

very human stories <strong>of</strong> a few <strong>of</strong> Mukherjee’s<br />

own patients <strong>and</strong> <strong>the</strong> successes <strong>and</strong> failures<br />

<strong>of</strong> <strong>the</strong>ir cancer treatments.<br />

The book is very well written, <strong>and</strong> <strong>in</strong><br />

spite <strong>of</strong> be<strong>in</strong>g packed with lots <strong>of</strong><br />

<strong>in</strong>terest<strong>in</strong>g facts <strong>and</strong> historical references, I<br />

found it to be a gripp<strong>in</strong>g read. I<br />

particularly liked how each <strong>the</strong>me was<br />

developed by pull<strong>in</strong>g toge<strong>the</strong>r different<br />

str<strong>and</strong>s from different researchers,<br />

hospitals <strong>and</strong> countries across <strong>the</strong> world.<br />

The ‘chapters’ are <strong>in</strong>troduced with a wide<br />

variety <strong>of</strong> quotations – historical, literary,<br />

<strong>and</strong> from contemporary media, activists,<br />

researchers <strong>and</strong> cancer patients which gave<br />

added <strong>in</strong>terest <strong>and</strong> context to <strong>the</strong> material.<br />

The book is predom<strong>in</strong>antly pla<strong>in</strong> text<br />

but <strong>in</strong> <strong>the</strong> middle section <strong>the</strong>re are eight<br />

pages <strong>of</strong> black-<strong>and</strong>-white photos, cartoons<br />

<strong>and</strong> draw<strong>in</strong>gs <strong>of</strong>fer<strong>in</strong>g, <strong>in</strong> my op<strong>in</strong>ion, a<br />

limited <strong>and</strong> r<strong>and</strong>om selection <strong>of</strong> pictures <strong>of</strong><br />

vary<strong>in</strong>g significance to cancer treatment. I<br />

did feel somewhat disappo<strong>in</strong>ted when <strong>the</strong><br />

book abruptly ended a significant distance<br />

from <strong>the</strong> back cover. However, for <strong>the</strong><br />

reader who wants to delve deeper, <strong>the</strong> 70<br />

or so pages <strong>of</strong> notes, references <strong>and</strong><br />

bibliography at <strong>the</strong> end <strong>of</strong> <strong>the</strong> book will be<br />

<strong>in</strong>valuable. A comprehensive <strong>in</strong>dex is also<br />

<strong>in</strong>cluded to facilitate return<strong>in</strong>g to passages<br />

<strong>of</strong> <strong>in</strong>terest.<br />

“<br />

The text follows a<br />

roughly chronological path<br />

through <strong>the</strong> history <strong>of</strong><br />

cancer from its first<br />

description around 2500<br />

BC <strong>in</strong> Egypt<br />

”<br />

I doubt that I will directly make use <strong>of</strong><br />

any knowledge ga<strong>in</strong>ed from this book <strong>in</strong><br />

my future radio<strong>the</strong>rapy work, but I feel<br />

that I am more <strong>in</strong>formed about <strong>the</strong> field <strong>in</strong><br />

general <strong>and</strong> will have a better appreciation<br />

<strong>of</strong> how far medic<strong>in</strong>e has come (<strong>and</strong> still has<br />

to go) <strong>in</strong> <strong>the</strong> treatment <strong>of</strong> cancer.<br />

Specifically I found it very <strong>in</strong>terest<strong>in</strong>g to<br />

see how cl<strong>in</strong>ical trials <strong>and</strong> r<strong>and</strong>omisation<br />

developed <strong>and</strong> learn<strong>in</strong>g <strong>of</strong> some <strong>of</strong> <strong>the</strong><br />

nam<strong>in</strong>g conventions for cancer drugs.<br />

I highly recommend this book to anyone<br />

with an <strong>in</strong>terest <strong>in</strong> medical history <strong>and</strong>/or<br />

who is work<strong>in</strong>g <strong>in</strong>, or close to, <strong>the</strong> field <strong>of</strong><br />

oncology. I found it to be highly<br />

<strong>in</strong>formative, a real page-turner <strong>and</strong> a<br />

welcome Christmas present. As <strong>the</strong><br />

paperback edition is currently available on<br />

Amazon.co.uk for a barga<strong>in</strong> price <strong>of</strong> £6.79,<br />

I th<strong>in</strong>k it would be rude not to.<br />

Mrs Jennifer Lowe is a Cl<strong>in</strong>ical Scientist<br />

(Radio<strong>the</strong>rapy) currently on a career break,<br />

Falls Church, VA, USA<br />

THE EMPEROR OF ALL MALADIES:<br />

A BIOGRAPHY OF CANCER<br />

Author: Siddhartha Mukherjee<br />

Publisher: HarperColl<strong>in</strong>s<br />

ISBN-13: 978-1439107959 (US)<br />

Format: Hardback<br />

Pages: 592<br />

USMAN I. LULA | SCOPE<br />

<strong>Physics</strong> <strong>of</strong> Societal<br />

Issues<br />

This title is not necessarily one that jumps<br />

<strong>of</strong>f <strong>the</strong> shelf at you as a prime text for<br />

medical physics applications, but I would<br />

strongly urge you to at least have a browse<br />

through it. One implication from <strong>the</strong> title is<br />

that <strong>the</strong> content is accessible to a lay public;<br />

however, I would suggest that <strong>the</strong> content<br />

does require a good deal <strong>of</strong> advanced<br />

scientific competence. The reviewed edition<br />

was published <strong>in</strong> 2007 <strong>and</strong> although only 5<br />

years old <strong>the</strong> implications <strong>of</strong> <strong>the</strong> Fukushima<br />

nuclear disaster clearly play no part <strong>in</strong> <strong>the</strong><br />

scientific analysis. That be<strong>in</strong>g said, it is an<br />

easy extrapolation <strong>of</strong> <strong>the</strong> book’s analysis to<br />

those events <strong>in</strong> Japan. This book looks to<br />

provide a well considered scientific<br />

approach to many <strong>of</strong> <strong>the</strong> <strong>in</strong>fluences on<br />

everyday life <strong>and</strong> <strong>the</strong>re is considerable<br />

cross-over with our pr<strong>of</strong>ession.<br />

The book is broadly divided <strong>in</strong>to:<br />

national security, environment <strong>and</strong> energy,<br />

but <strong>the</strong>se broad categories do not fully<br />

convey <strong>the</strong>ir content. For <strong>in</strong>stance, Chapter 7<br />

discusses nuclear pollution, albeit not from a<br />

medical st<strong>and</strong>po<strong>in</strong>t; never<strong>the</strong>less, <strong>the</strong><br />

analysis is applicable for those <strong>of</strong> us who<br />

have a pr<strong>of</strong>essional <strong>in</strong>terest <strong>in</strong> radiation<br />

protection. Similarly, Chapter 9 discusses<br />

electromagnetic fields <strong>and</strong> epidemiology<br />

which cont<strong>in</strong>ue to be very much <strong>in</strong> <strong>the</strong><br />

news. O<strong>the</strong>r chapters such as Chapter 16 on<br />

energy economics are reasonably considered<br />

to be peripheral to our pr<strong>of</strong>ession,<br />

none<strong>the</strong>less <strong>the</strong> analytical approach <strong>and</strong><br />

important subject matters are <strong>of</strong> general<br />

<strong>in</strong>terest. In addition, <strong>the</strong>re are useful<br />

appendices <strong>and</strong> reference/bibliography lists<br />

at <strong>the</strong> end <strong>of</strong> each chapter which, whilst<br />

limited, certa<strong>in</strong>ly do provide routes for more<br />

<strong>in</strong>sight <strong>in</strong>to some <strong>of</strong> <strong>the</strong> complex social<br />

arguments discussed with<strong>in</strong> <strong>the</strong> text.<br />

As might be expected, <strong>the</strong> text is<br />

American <strong>and</strong> allowances need to be made<br />

for <strong>the</strong> units <strong>and</strong> also some <strong>of</strong> <strong>the</strong> content<br />

which is American-centric, but that aside,<br />

<strong>the</strong> text is very readable. One useful aspect<br />

<strong>of</strong> each chapter is <strong>the</strong> <strong>in</strong>clusion <strong>of</strong> ‘problems’<br />

<strong>and</strong> I have used many <strong>of</strong> <strong>the</strong>se to discuss<br />

aspects <strong>of</strong> general physics with my tra<strong>in</strong>ees<br />

SCOPE | SEPTEMBER 2012 | 41<br />

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