Diacylglycerol Signaling

142 E. Rozengurt
In conclusion, studies on PKD thus far indicate a remarkable diversity of both
its signal generation and distribution and its potential for complex regulatory
interactions with multiple downstream pathways. It is increasingly apparent that
the members of the PKD subfamily are key players in the regulation of cell signaling,
organization, migration, inflammation and normal and abnormal cell
proliferation. PKD emerges as a valuable target for the development of novel
therapeutic approaches in common diseases, including cardiac hypertrophy and
cancer.
Acknowledgments The help of Mr. James Sinnett-Smith in the preparation of this chapter is
greatly appreciated. Studies from our laboratory presented here were supported in part by National
Institutes of Health Grants R01-DK 55003, R0-1DK56930 and P30-DK41301.
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