Diacylglycerol Signaling

3 Phorbol Esters and Diacylglycerol: The PKC Activators
O
OH
N
O
OH
O O
O
O
N
H
O
O
H
N
O
Aplysiatoxin
13
OH
B
O
HO
O HO
O
O O
20
O
OH
O
OH
OH
O H
O
HO
9
Lyngbyatoxin A
OH
O Br
O
A
O
3
O
7
HO
O
1
O
26
OH
3
O
O
1
HO
Phorbol 12-myristate
13-acetate
26
O
R1 O
H
HO
10
Bryostatin 1
sn-1,
2-diacylglycerol
OH
O
R 2
Iridal
Fig. 3.2 Structural diversity of ligands with high affinity for typical C1 domains
O
29