Senior Design Expo 2023

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Biomedical Engineering connectiV Helena Cirne, Anjali Santhanam, Kiara Robichaud, Caitlyn Limanto, and Elvin Canseco Within the NICU (Neonatal Intensive Care Unit), most neonates require intravenous (IV) therapy. Full-term infants receive up to 100-140 mL/kg/day, yielding an administration of 10-20 mL/hr. However, the rates can get as low as 0.1 mL/hr for concentrated drugs. Multiple inputs must be connected to a singular vascular access device, increasing variability in flow rate and risk of backflow due to flow interactions between several input sources at connection points. Improper administration of medication can cause serious adverse events such as abnormal blood pressure, anxiety from a loss of sedation, and increased pain. Thus, there is a need to reduce flow inconsistencies within NICU tubing connection ports while monitoring fluid flow for precise drug dosing in neonatal patients. To address these shortcomings in neonatal IV therapies, we have created a two-part system. The first component replaces existing connection ports with 3D-printed, medically safe, sterile millifluidic chips. The millifluidic chip increases flow rate consistency and reduces negative flow interactions to ensure more accurate drug delivery. This works in conjunction with an external, photoresistor-based flow detection system that facilitates hands-off monitoring. This device will be capable of alerting health providers to potential disruptions of flow. connectiV works to minimize the deficiencies in the current technology used in the NICU by improving the system of IV drug delivery. verifyNG Lori Luo, Catherine Medeiros, Joy Fan, and Hsinyen Huang A nasogastric (NG) tube is a soft, rubber tube inserted into the nose, down the esophagus, and into the stomach by clinicians around the world to provide nutrition and dietary supplements to individuals who otherwise cannot eat. Despite the daily use of NG tubes by clinical care teams around the world, studies have shown that 88% of nurses do not quantitatively verify that the tube is properly placed in the stomach. Moreover, out of 932 blind placements of an NG tube, around half were misplaced. Misplacement of an NG tube can lead to lethal results, especially when the NG tube is placed in the lungs, where the delivery of nutritional feed can result in serious patient injury or death via drowning. Current methods to verify placement, such as x-ray, cause delays in patient care and require specially trained staff. As a result, there remains a need for an easy-to-use, binary output sensor to accurately confirm the proper placement of the NG tube. Using inductive sensing technology, the verifyNG device is able to accurately detect if the NG tube is placed in the stomach with an intuitive binary output. The use of this device in clinical settings across the world will improve NG tube placement accuracy and patient outcomes. 10
Biomedical Engineering Nu-Jet Anjali Nair, Isa Nuñez, Athena Pagon, Vish Rao, and Elías Tzoc-Pacheco Syringes and needles are the predominant vaccine delivery model despite their reliance on single-use components, stringent storage and transportation requirements, expensive waste disposal, and laborious administration. These elements translate to high costs per dose, making this vaccination model expensive and typically accessible only in high-resource clinical contexts. Globally, this results in a high proportion of needles being poorly sterilized for reuse, raising risks of infection. Thus, there exists a need for a cost-effective method of vaccine delivery to improve accessibility, sustainability, and sanitary standards. To address this demand, we sought to construct a low-cost needleless injector. The device generates a sufficiently pressurized fluid stream using tandem pneumatic cylinders in order to deliver an intradermal dose. A specially designed combination of valve, nozzle, and splash guard reduces cross-contamination that has historically plagued prior injector technologies. An electrically-regulated valve system controls filling and injection, simplifying the functionality for a user to a two-switch procedure. Nu-Jet offers a method of delivering vaccines that reduces material waste and administration costs, making vaccinations safer and more readily available for a manifold of healthcare settings. Resonance Hannah Matin, Matthew Lange, Skylar Li, Leonardo Campos, Julia Zhao, and Athena Tsu Mucus build-up in the airways is a major issue for many patients with pulmonary diseases; for example, 50% of COPD patients have mucus hypersecretion, which correlates with a 3.5 times greater risk of dying. Oscillating positive expiratory pressure (OPEP) is commonly used to break up airway mucus for easier expulsion. Such devices oscillate to induce vibrations of resonant frequencies with the patient’s airway cilia, thus mechanically agitating the mucus and promoting its movement up the airways. However, current OPEP devices have several issues. Their patient effort requirements result in contraindications that exclude certain populations, and variability between devices makes it difficult to predict efficacy. In addition, depending on the OPEP device utilized, patient utilization is complicated by uninformative controls and precise handling. Thus, there exists a need for improved treatment for patients who experience mucus build-up in the airways. To address these issues with current OPEP devices, our device leverages fundamental principles of OPEP therapeutic parameters with electronic capabilities for optimized performance across a wider range of patients. Using a fully automated solenoid-based oscillation mechanism that is adjustable by the patient for their specific needs, we not only provide transparent therapeutic measures of frequency, but streamlined controls and reduced patient effort necessary for therapeutic effect 11
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Senior Design Expo 2023

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