Senior Design Expo 2023

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Biomedical Engineering NanoCath Yvonne Anang, Caroline Bell, Jocelyn Chen, Jordan Popov, and Justin Yun Intravenous drug delivery is common for many current medical treatments across various diseases. In particular, central line catheters are often used to directly connect an external drug source to major arteries and veins. This delivery method poses a significant risk to both the patient due to the possibility of dangerous infections, as well as to hospitals that take on the financial burden of such infections. Therefore, the design and maintenance of drug delivery through long-term access points to patients’ bloodstreams need improvements to be safer. To address this problem, we propose an improved catheter dressing to better protect the catheter access point, especially for long-term catheter patients experiencing multiple regular dressing changes. Inspired by existing catheter dressings and novel research on advanced antiseptic drug delivery methods, we created a multi-layered catheter dressing with an electrospun fiber mesh doped with the antiseptic chlorhexidine gluconate (CHG) and superabsorbent materials enforced by a transparent structural support made out of silicone. With nanoCath, intravenous access points will be better protected and more infections will be prevented. InCerv Griffin Daly, Johanna Jackson, Sopho Kevlishvili, Jose Pomarino Nima, and Carly Rivera Cervical dilation is used in Obstetrics-Gynecology procedures from family planning to oncology. Roughly 80 million gynecological procedures require cervical dilation for instruments such as IUD inserters, cameras, or catheters to pass through the cervix into the uterus for the deployment of medicines, biopsies, diagnostic tests, and treatments. The current dilation process involves repeatedly sliding metal dilators in and out of the endocervical canal, which results in lengthy procedures and pain due to friction. It can also lead to the creation of false passages in the cervical tissue resulting in bleeding, cervical laceration, and uterine perforation. Therefore, we need a way to atraumatically dilate the cervix for uterine procedures. Atraumatic dilation does not have the possibility of piercing cervical tissue or injuring the smooth muscle. InCerv is a cervical dilator that consists of a compliant, biocompatible balloon, connected to a graduated syringe filled with an incompressible fluid. As the syringe is depressed, it injects a controllable volume of fluid into the compliant balloon, causing it to expand. Due to the incompressibility of the injected fluid, the diameter and rate of expansion of the balloon can be controlled by the rate of depression of the syringe. InCerv consists of a single insertion and can achieve dilation from anywhere from 1 mm to 18 mm and uses concentric expansion of the cervix to lessen pain associated with cervical dilation 12
Biomedical Engineering Mindful Mouthguards Timothy Simmons, Cason Hancock, Olivia Hansen, Schuyler Fuller, and Matthew Wahl Every year, roughly 3.8 million concussions occur due to sports-related injuries in the United States. However, there exists a lack of accurate and affordable methods to detect in-game concussions in high school athletes. Some concussion symptoms appear within minutes of the injury, while others may take several hours or days to appear. To make matters worse, after the first concussion, athletes are three-to-five times more likely to have another concussion. Repeated concussions can make symptoms last longer, induce slower recovery time, and even increase the chances for long-lasting or permanent problems (i.e., post-concussion syndrome, higher risk for anxiety and depression, structural brain injuries, problems with memory, naming, word-finding, dementia). Without properly identifying concussions and their severity quickly and accurately, athletes may be kept in games or fail to recognize their injury completely, leading to more permanent damage or even death. Thus, there is a need for a more accurate and affordable approach to detect in-game concussions for high school athletes in order to avoid severe complications that have the potential to cause permanent damage or death. To address this problem our device is a mouthguard fashioned with LEDs, an accelerometer, and Bluetooth connection. By using an accelerometer, data on hits to the head can be detected without the need for spotters or other expensive equipment. Also, since the mouthguard will light up upon a large enough impact, there is no question as to whether a student-athlete should remain on the field. Furthermore, our device is designed to transmit real-time data to the sideline via Bluetooth and could have an eventual integration with a mobile app to make comprehensive concussion management simpler. Overall, our instrumented mouthguard device is a thorough and proactive approach to concussion safety that will be able to keep track of the amount and magnitude of hits in-game, enabling timely intervention and reducing the chance of long-term injuries or death for athletes. FractUS Ayi Agboglo, Dreyton Amador, Daniel Garcia, Nathan Ocampo, and Yi Qu Osteoporosis is characterized by a decrease in bone mineral density, which compromises bone integrity and ultimately results in fractures. Osteoporosis affects nearly 20% of women and 5% of men over 50 years of age, and often goes undetected until after a bone fracture has already occurred. To avoid these fractures, regular monitoring of bone density would be ideal, but this involves the use of ionizing radiation, which can be expensive and only accessible beyond primary care. Thus, there is a need for an alternative way to characterize bone health in patients at risk for decreased bone mineral density before a fracture can occur. To this end, FractUS seeks to characterize bone density by providing a software that analyzes ultrasound images collected from a dual-probe setup. By utilizing ultrasound technology, physicians will be able to track patient bone mineral density regularly without concern about radiation exposure or cost. This could prevent future fractures by detecting trends of decreasing bone mineral density over time and providing preemptive care. 13
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Senior Design Expo 2023

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