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Overview Organ-on-a-chip<br />
Precision-Cut Tissue Slices: Enhancing In Vivo Research and Results<br />
Made with BioRender <strong>2023</strong><br />
Precision-cut lung, heart, and brain slices are valuable tools<br />
used in research to study various aspects of these organs in a<br />
controlled and detailed manner as they also preserve in-vivo<br />
niches. These slices are thin sections of tissues obtained<br />
through specialized techniques and equipment, ensuring<br />
minimal damage to the tissue's architecture and cellular<br />
structure.<br />
They can help in disease modelling, drug testing and<br />
development, toxicology studies, pharmacokinetics studies,<br />
electrophysiological studies, imaging and histology, and<br />
disease biomarker discovery.<br />
These slices maintain the tissue's native architecture, allowing<br />
researchers to study organs in a physiologically relevant three<br />
-dimensional context. Cellular interactions and complexity are preserved,<br />
mimicking the in vivo environment more accurately. Organ specific functions,<br />
such as air exchange, electrical activity, and contractility, are retained, enhancing<br />
the fidelity of research findings. Furthermore, precision-cut slices enable the<br />
investigation of drug permeability and interactions across natural barriers within<br />
organs. Compared to cell cultures, these slices reduce experimental artefacts and<br />
offer more realistic pharmacokinetic data and are more ethical making them a<br />
valuable tool in various research applications.<br />
Want to test out precision cut tissue slices? Scan the QR code to contact us for<br />
more details!<br />
Apricell 3-in-1 plate<br />
To study co-culture<br />
Tumour invasion<br />
ECM study<br />
Drug screening<br />
Scilia ExtraGel ECM<br />
Reconstituted matrix hydrogel<br />
3D cell culture<br />
Angiogenesis<br />
Stem cell maintenance and<br />
differentiation<br />
In-vivo xenograft generation<br />
Organoid kits<br />
With cell culture medium and<br />
cytokines to create cardiac,<br />
biliary, breast, brain, lung,<br />
liver, vascular organoids<br />
Organoid products in R&D quality<br />
• Organoid kits with cytokines, media and cells included for culture of organoids<br />
• Recombinant human laminins for various cell types, including cardiomyocytes (iMatrix-211),<br />
endothelial cells (iMatrix-411), pluripotent stem cells (iMatrix-511), corneal epithelial cells<br />
(iMatrix-332), and hepatocytes (iMatrix-111). iMatrix-511 is also available in a ready-to-use<br />
formulation for your convenience.<br />
• Scilia ExtraGel ECM equivalent to the gold-standard in the industry.<br />
• Apricell 3-in-1 plate for high-throughput drug testing.<br />
Scan/click the QR code to learn about out ECM for 2D & 3D cell culture.<br />
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