Infantile Diarrhea
Infantile Diarrhea
Infantile Diarrhea
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Ingested ETEC (ID=10 8 )<br />
↓<br />
adhere to and colonize in upper intestinal mucosa<br />
via colonization factors (CF) and multiply<br />
↓<br />
Produce enterotoxins (ST and/or LT)<br />
↓ ↓<br />
heat-stable heat stable enterotoxin heat-labile heat labile enterotoxin<br />
↓ bind to receptors and activate ↓<br />
Guanyl cyclase Adenyl cyclase<br />
↓ ↓<br />
GTP → cGMP↑ cGMP<br />
cAMP↑← cAMP↑←<br />
ATP<br />
↓ ↓<br />
→→ Promote ←←<br />
secretion of sodium, chloride, water<br />
↓↓<br />
watery diarrhea<br />
Figure 2. Pathogenesis of ETEC enteritis
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