Infantile Diarrhea

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Invasive pathogens ↓ invade and multiply within intestinal mucosa ↓ inflammatory changes (congestion, swollen, inflammatory cells infiltration, effusion and ulcer) ↓ water and electrolyte are not absorbed entirely ↓ diarrhea / \ WBC,RBC increase severe general in stools toxic symptoms Figure 3. Pathogenesis of invasive enteritis
Feeding fault (overfeeding, unsuitable nutrients) ↓immature immature digestive function ↓ overburdened GI tract Disturbances of digestive function ↓ Nutrients can not be digested and absorbed properly ↓ Accumulated in upper intestinal tract. Acidity of contents decrease decrease ↓ Bacteria resided in lower IT immigrate into and multiply in upper upper IT ↓ (endogenous infection) Nutrients are resolved by bacteria ↓ ↓ Fermentative process putrid process ↓ ↓ Organic acids are increased toxic products(amines etc.) (Lactic and acetic acid) ↓ ↓ ↓ liver Hyperosmolarity irritate ↓ ↓ ↓ Blood stream hyperperistalsis of intestinal wall ↓ ↓ General toxic symptoms <strong>Diarrhea</strong> Figure 4. Pathogenesis of dietary diarrhea
Page 1 and 2: Infantile Diarrhea SUN Mei Pediatri
Page 3 and 4: Major causes of death among childre
Page 5 and 6: 3. Predisposing age Peak incidence
Page 7 and 8: Predisposing factors 1. Immature di
Page 9 and 10: 3. Poor immune function (host defen
Page 11 and 12: 5. Formula feeding: Bottle-fed Bott
Page 13 and 14: Bacteria Etiology Escherichia coli
Page 15 and 16: Etiology Fungi: especially Candida
Page 17 and 18: Etiology Antibiotic-associated Anti
Page 19 and 20: Pathogenesis Each kind of diarrhea
Page 21: Ingested ETEC (ID=10 8 ) ↓ adhere
Page 25 and 26: According to severity of diarrhea i
Page 27: Dehydration: Excessive Loss of Wate
Page 34 and 35: (go go on) mild moderate severe muc
Page 36 and 37: Table 2. The types of dehydration I
Page 38 and 39: Metabolic acidosis The more severe
Page 40 and 41: Clinical manifestations: lassitude,
Page 42 and 43: Prior to rehydration, rehydration,
Page 44 and 45: Hypocalcemia and hypomagnesemia Nor
Page 46 and 47: Hypocalcemia and hypomagnesemia Man
Page 48 and 49: Vomiting usually precedes diarrhea.
Page 50 and 51: 3. Invasive bacterial enteritis. a
Page 52 and 53: Differential diagnosis 1.Physiologi
Page 54 and 55: Differential diagnosis 3. Acute nec
Page 56 and 57: Dietary therapy Oral fluids may be
Page 58 and 59: Reasonable medicine administration
Page 60 and 61: Good care and symptomatic treatment
Page 62 and 63: Electrolyte solutions 0.9% Natri ch
Page 64 and 65: Mixed solution Table 3. Components
Page 66 and 67: ORS may be used with unlimited wate
Page 68 and 69: The therapy for the first day. When
Page 70 and 71: In summary the total volume of flui
Page 72 and 73:
Infusing rates Phase Ⅰ: : rapid e
Page 74 and 75:
Infusing rates Phase Ⅲ: For reple
Page 76 and 77:
Replacement of potassium For mild h
Page 78 and 79:
Supplement of Calcium and magnesium
Page 82:
CHECKPOINTS Predisposing factors fo
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Infantile Diarrhea

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