Topical treatments for fungal infections of the skin and nails of the foot.

T A B L E O F C O N T E N T S
HEADER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
OBJECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
Figure 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Figure 2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Figure 3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Figure 4. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Figure 5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Figure 6. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
CHARACTERISTICS OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
DATA AND ANALYSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
Analysis 1.1. Comparison 1 Allylamines vs Placebo, Outcome 1 Short term (2 weeks) treatment failure. . . . . . 118
Analysis 1.2. Comparison 1 Allylamines vs Placebo, Outcome 2 Medium term (6 weeks) treatment failure. . . . . 119
Analysis 1.3. Comparison 1 Allylamines vs Placebo, Outcome 3 Medium term (6 weeks) treatment failure. Only >80%
follow-up included. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 120
Analysis 2.1. Comparison 2 Azoles (tx 4-6 weeks) vs Placebo, Outcome 1 Short term (2 weeks) treatment failure. . . 121
Analysis 2.2. Comparison 2 Azoles (tx 4-6 weeks) vs Placebo, Outcome 2 Medium term (6 weeks) treatment failure. 122
Analysis 2.3. Comparison 2 Azoles (tx 4-6 weeks) vs Placebo, Outcome 3 Medium term (6 weeks) treatment failure. Only
>=80% follow-up included. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
Analysis 3.1. Comparison 3 Other topical antifungal treatments vs Placebo, Outcome 1 Short term (2 weeks) treatment
failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Analysis 3.2. Comparison 3 Other topical antifungal treatments vs Placebo, Outcome 2 Medium term (6 weeks) treatment
failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126
Analysis 3.3. Comparison 3 Other topical antifungal treatments vs Placebo, Outcome 3 Medium term (6 weeks) treatment
failure. Only >=80% follow-up included.. . . . . . . . . . . . . . . . . . . . . . . . . 128
Analysis 4.1. Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 1 Short term (2
weeks) treatment failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
Analysis 4.2. Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 2 Medium term
(6 weeks) treatment failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
Analysis 4.3. Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 3 Medium term
(6 weeks) treatment failure. Only >=80% follow-up included.. . . . . . . . . . . . . . . . . . 130
Analysis 4.4. Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 4 Long term (12
weeks onwards) treatment failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . 130
Analysis 5.1. Comparison 5 Comparisons between different azoles or azole regimes, Outcome 1 Short term (2 weeks)
treatment failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
Analysis 5.2. Comparison 5 Comparisons between different azoles or azole regimes, Outcome 2 Medium term (6 weeks)
treatment failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
Analysis 5.3. Comparison 5 Comparisons between different azoles or azole regimes, Outcome 3 Medium term (6 weeks)
treatment failure. Only >=80% follow-up included.. . . . . . . . . . . . . . . . . . . . . 134
Analysis 5.4. Comparison 5 Comparisons between different azoles or azole regimes, Outcome 4 Long term (12 weeks
onwards) treatment failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135
Analysis 6.1. Comparison 6 Allylamines 1-2 weeks vs Azoles 1-2 weeks, Outcome 1 Short term (2 weeks) treatment
failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 136
Topical treatments for fungal infections of the skin and nails of the foot. (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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