Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
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Dobson 1989<br />
Methods RCT<br />
Study aim clearly defined: yes<br />
Blinded assessor <strong>of</strong> primary outcome: not stated<br />
Double blind study: yes<br />
Participants comparable at baseline <strong>for</strong> age: yes Sex: yes Duration <strong>of</strong> complaint: yes<br />
Inclusion <strong>and</strong> exclusion criteria specified: yes<br />
Interventions well described: yes<br />
Assessment <strong>of</strong> compliance: not stated<br />
Reoccurrence status: yes<br />
Intention to treat analysis: not stated<br />
A Priori sample size calculation: not stated<br />
Fungi identified: yes<br />
Distribution <strong>of</strong> species between groups: no<br />
Adverse events reported: yes<br />
Number <strong>of</strong> drop outs stated: 41<br />
Participants Total evaluable sample size: 183<br />
Inclusion criteria: 12 yrs <strong>and</strong> older<br />
Exclusion criteria: Hyperkeratotic plantar type tinea pedis<br />
Treatment setting: eight different sites<br />
Interventions a. Naftifine 1% cream<br />
Duration: four weeks<br />
Frequency: applied once daily<br />
b. Placebo cream<br />
Duration: four weeks<br />
Frequency: applied once daily<br />
Outcomes Primary outcome: Cure<br />
Secondary Outcomes: Signs <strong>and</strong> symptoms<br />
- ery<strong>the</strong>ms, maceration, pruritus<br />
Global improvement<br />
Adverse events: a. 2 b. 5 soreness, burning, eczema, exacerbation <strong>of</strong> folliculitis, itching<br />
Notes<br />
Risk <strong>of</strong> bias<br />
Item Authors’ judgement Description<br />
Allocation concealment? Unclear B - Unclear<br />
<strong>Topical</strong> <strong>treatments</strong> <strong>for</strong> <strong>fungal</strong> <strong>infections</strong> <strong>of</strong> <strong>the</strong> <strong>skin</strong> <strong>and</strong> <strong>nails</strong> <strong>of</strong> <strong>the</strong> <strong>foot</strong>. (Review)<br />
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.<br />
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