Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
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Bergstresser 1993<br />
Methods RCT<br />
Study aim clearly defined: yes<br />
Blinded assessor <strong>of</strong> primary outcome: not stated<br />
Double blind study: yes<br />
Participants comparable at baseline <strong>for</strong> age: yes Sex: yes Duration <strong>of</strong> complaint: yes<br />
Inclusion <strong>and</strong> exclusion criteria specified: yes<br />
Interventions well described: yes<br />
Assessment <strong>of</strong> compliance: not stated<br />
Intention to treat analysis: yes<br />
A Priori sample size calculation: not stated<br />
Fungi identified: yes<br />
Distribution <strong>of</strong> species between groups: not stated<br />
Adverse events reported: not stated<br />
Number <strong>of</strong> drop outs stated: not stated<br />
Participants Total evaluable sample size: 193<br />
Inclusion criteria: baseline total score <strong>for</strong> <strong>the</strong> target lesion <strong>of</strong> six or more, including a score <strong>of</strong> at least two<br />
<strong>for</strong> ery<strong>the</strong>ma or a score <strong>of</strong> two or more <strong>for</strong> each <strong>of</strong> <strong>the</strong> two o<strong>the</strong>r signs<br />
Treatment setting: eight multicentres<br />
Interventions a. Terbinafine<br />
Duration: one week<br />
Frequency: applied twice daily<br />
b. Terbinafine<br />
Duration: four weeks<br />
Frequency: applied twice daily<br />
Outcomes Primary outcome: cure<br />
Secondary Outcomes: Signs <strong>and</strong> symptoms<br />
- ery<strong>the</strong>ma, scaling, fissuring, exudation, pruritus, maceration, vesiculation, burning <strong>and</strong> stinging<br />
Notes<br />
Risk <strong>of</strong> bias<br />
Item Authors’ judgement Description<br />
Allocation concealment? Unclear B - Unclear<br />
<strong>Topical</strong> <strong>treatments</strong> <strong>for</strong> <strong>fungal</strong> <strong>infections</strong> <strong>of</strong> <strong>the</strong> <strong>skin</strong> <strong>and</strong> <strong>nails</strong> <strong>of</strong> <strong>the</strong> <strong>foot</strong>. (Review)<br />
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.<br />
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