Topical treatments for fungal infections of the skin and nails of the foot.

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$Interventions for treating proximal humeral fractures in adults (Review)$

Bojanovsky 1985 Methods RCT Study aim clearly defined: yes Blinded assessor of primary outcome: not stated Double blind study: no Participants comparable at baseline for age: yes Sex: yes Duration of complaint: yes Inclusion and exclusion criteria specified: yes Interventions well described: yes Assessment of compliance: not stated Intention to treat analysis: not stated A Priori sample size calculation: not stated Fungi identified: yes Distribution of species between groups: yes Adverse events reported: yes Number of drop outs stated: no Participants Total evaluable sample size: 99 Exclusion criteria: onychomycosis Interventions a. Bifonazol cream Duration: five weeks Frequency: applied once a day b. Naftifine cream Duration: five weeks Frequency: applied once a day Outcomes Primary outcome: cure Secondary Outcomes: Signs and symptoms - itching, erythema, scaling, fissuring, exudation, pustules, maceration, vesiculation Adverse events: a. dermatitis,dry skin, burning sensation (5) Notes Translated from German Risk of bias Item Authors’ judgement Description Allocation concealment? Unclear B - Unclear Topical treatments for fungal infections of the skin and nails of the foot. (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 39
Buck 1994 Methods RCT Study aim clearly defined: yes Blinded assessor of primary outcome: yes Double blind study: yes Participants comparable at baseline for age: yes Sex: yes Duration of complaint: yes Inclusion and exclusion criteria specified: yes Interventions well described: yes Assessment of compliance: yes Intention to treat analysis: not stated A Priori sample size calculation: yes Fungi identified: yes Distribution of species between groups: yes Adverse events reported: yes Number of drop outs stated: yes Participants Total evaluable sample size:117 Exclusion criteria:immune suppressant therapy within the previous 6 months. Had used a topical agent on the toenails in the previous two weeks, a history of HIV or psoriasis Interventions a. 1% clotrimazole soln b. Tea tree oil Outcomes Primary outcome; cure Secondary outcomes; a. measuring the distance between the cuticle and the most proximal onychomycotic border b. recording the percentage of involvement in 25% increments Notes Risk of bias Item Authors’ judgement Description Allocation concealment? Yes A - Adequate Topical treatments for fungal infections of the skin and nails of the foot. (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 40
Page 1 and 2: Topical treatments for fungal infec
Page 3 and 4: Analysis 6.2. Comparison 6 Allylami
Page 5 and 6: atio of treatment failure RR 0.63 (
Page 7 and 8: CAB-Health and Healthstar The onlin
Page 9 and 10: Plotkin 1990; Pereda 2003; Qadripur
Page 11 and 12: Azoles Versus Placebo Six different
Page 13 and 14: Other topical antifungal treatments
Page 15 and 16: Long-term outcome (12 weeks) Terbin
Page 17 and 18: Figure 3. Topical treatments for fu
Page 19 and 20: Long term outcome (12 weeks) Data c
Page 21 and 22: Allylamines versus azoles four to s
Page 23 and 24: ment failure at 2 weeks (RR 2.00, 9
Page 25 and 26: Adverse events Adverse events were
Page 27 and 28: Bagatell 1991a {published data only
Page 29 and 30: Schachner 1990 {published data only
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Smith 1990b Methods RCT Study aim c
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Spiekermann 1976a Methods RCT Study
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Sushka 2001 Methods RCT Study aim c
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Syed 2000 Methods RCT Study aim cle
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Tschen 1997 Methods RCT Study aim c
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Weller 1998 Methods RCT Study aim c
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Zaug 1992 Methods RCT Study aim cle
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(Continued) Duncan 1975 Only half p
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(Continued) Qadripur 1984 Cannot se
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2.1 Bifonazole (tx 4 weeks) vs Plac
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3.2 Naftifine (tx 2 weeks) vs Terbi
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2.1 Naftinfine/Terbinane vs Oxicona
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Comparison 11. Comparisons between
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Analysis 1.1. Comparison 1 Allylami
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(... Continued) Study or subgroup A
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(... Continued) Study or subgroup A
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Analysis 2.3. Comparison 2 Azoles (
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Analysis 3.2. Comparison 3 Other to
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Analysis 3.3. Comparison 3 Other to
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Analysis 4.3. Comparison 4 Comparis
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Analysis 11.1. Comparison 11 Compar
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Analysis 11.4. Comparison 11 Compar
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Analysis 12.2. Comparison 12 Treatm
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Feedback on section ’Effects of i
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I N D E X T E R M S Medical Subject
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