Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
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Ellis 1989<br />
Methods RCT<br />
Study aim clearly defined: yes<br />
Blinded assessor <strong>of</strong> primary outcome: not stated<br />
Double blind study: yes<br />
Participants comparable at baseline <strong>for</strong> age: yes Sex: yes Duration <strong>of</strong> complaint: yes<br />
Inclusion <strong>and</strong> exclusion criteria specified: yes<br />
Interventions well described: yes<br />
Assessment <strong>of</strong> compliance: yes<br />
Intention to treat analysis: yes<br />
A Priori sample size calculation: not stated<br />
Fungi identified:yes<br />
Distribution <strong>of</strong> species between groups: yes<br />
Adverse events reported: yes<br />
Number <strong>of</strong> drop outs stated: 108<br />
Participants Total evaluable sample size: 163<br />
Exclusion criteria: use <strong>of</strong> topical anti<strong>fungal</strong> <strong>the</strong>rapy within 7 days prior to study<br />
use <strong>of</strong> systemic anti<strong>fungal</strong> <strong>the</strong>rapy within 30 days prior to study<br />
Treatment setting: twelve centres<br />
Interventions a. Oxiconazole nitrate cream<br />
Duration: four weeks<br />
Frequency: once daily plus once daily Placebo<br />
b. oxiconazole nitrate cream<br />
Duration: four weeks<br />
Frequency: twice daily<br />
c. Placebo<br />
Duration: four weeks<br />
Frequency: twice daily<br />
Outcomes Primary outcome: cure<br />
Secondary Outcomes: Signs <strong>and</strong> symptoms<br />
- ery<strong>the</strong>ma, scaling, fissuring, pustules, maceration, burning, crusting<br />
Global response<br />
Adverse events: burning, irritation, pruritus<br />
Notes<br />
Risk <strong>of</strong> bias<br />
Item Authors’ judgement Description<br />
Allocation concealment? Unclear B - Unclear<br />
<strong>Topical</strong> <strong>treatments</strong> <strong>for</strong> <strong>fungal</strong> <strong>infections</strong> <strong>of</strong> <strong>the</strong> <strong>skin</strong> <strong>and</strong> <strong>nails</strong> <strong>of</strong> <strong>the</strong> <strong>foot</strong>. (Review)<br />
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.<br />
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