Topical treatments for fungal infections of the skin and nails of the foot.

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also did not show a statistically different difference in the treatment failure rates (RR 0.50, 95% CI 0.10 to 2.54; Analysis 7.2). A L’Abbé plot of the outcomes at six weeks (Figure 5) demonstrates that the allylamines had broadly similar treatment failure rates to the azoles, with a wide variation in failure rates. Figure 5. Topical treatments for fungal infections of the skin and nails of the foot. (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 17
Allylamines versus azoles four to six weeks Medium-term outcome (six weeks) A meta analysis of data collected in nine trials (n = 1003, Bergstresser 1993; Bojanovsky 1985; Evans 1993a; Haas 1985; Kagawa 1985; Plotkin 1990; Sanchez 1994; Smith 1990b; Smith 1992) found a statistically significant difference between 1% allylamines (naftifine, terbinafine) and 1% to 2% azoles (bifonazole, clotrimazole) used for 4 to 6 weeks, with a relative reduction in treatment failure of 37% favouring allylamines (RR 0.63, 95% CI 0.42 to 0.94; Analysis 8.1). There was considerable variation in the results of the individual trials (I 2 = 68%) Six of those trials (Evans 1993a; Haas 1985; Kagawa 1985; Smith 1990a; Smith 1992) reported outcomes for at least 80% of those randomised (n = 896) and produced a relative risk of treatment failure of 0.55 (95% CI 0.34 to 0.89; Analysis 8.2) for the superiority of allylamines over azoles. The variation in the results of the individual trials was still substantial (I 2 = 70%). A L’Abbé plot of the outcomes at six weeks (Figure 6) demonstrates a wide variation in observed treatment failure rates. Topical treatments for fungal infections of the skin and nails of the foot. (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 18
Page 1 and 2: Topical treatments for fungal infec
Page 3 and 4: Analysis 6.2. Comparison 6 Allylami
Page 5 and 6: atio of treatment failure RR 0.63 (
Page 7 and 8: CAB-Health and Healthstar The onlin
Page 9 and 10: Plotkin 1990; Pereda 2003; Qadripur
Page 11 and 12: Azoles Versus Placebo Six different
Page 13 and 14: Other topical antifungal treatments
Page 15 and 16: Long-term outcome (12 weeks) Terbin
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Page 19: Long term outcome (12 weeks) Data c
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2.1 Bifonazole (tx 4 weeks) vs Plac
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3.2 Naftifine (tx 2 weeks) vs Terbi
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2.1 Naftinfine/Terbinane vs Oxicona
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Comparison 11. Comparisons between
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Analysis 1.1. Comparison 1 Allylami
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(... Continued) Study or subgroup A
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Analysis 2.3. Comparison 2 Azoles (
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Analysis 3.2. Comparison 3 Other to
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Analysis 3.3. Comparison 3 Other to
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Analysis 4.3. Comparison 4 Comparis
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