Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
Topical treatments for fungal infections of the skin and nails of the foot.
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Bagatell 1991a<br />
Methods RCT<br />
Study aim clearly defined: yes<br />
Blinded assessor <strong>of</strong> primary outcome: not stated<br />
Double blind study: yes<br />
Participants comparable at baseline <strong>for</strong> age: yes Sex: yes Duration <strong>of</strong> complaint: not stated<br />
Inclusion <strong>and</strong> exclusion criteria specified: not stated<br />
Interventions well described: yes<br />
Assessment <strong>of</strong> compliance: no<br />
Intention to treat analysis: no<br />
A Priori sample size calculation: no<br />
Fungi identified: yes<br />
Distribution <strong>of</strong> species between groups: no<br />
Adverse events reported: yes<br />
Number <strong>of</strong> drop outs stated: 13<br />
Participants Total evaluable sample size: 88<br />
Treatment setting: Four different sites<br />
Interventions a. Naftifine 1% gel<br />
Duration: four weeks<br />
Frequency: applied twice daily<br />
b. Placebo gel<br />
Duration: four weeks<br />
Frequency: applied twice daily<br />
Outcomes Primary outcome: Cure<br />
Secondary Outcomes: Signs <strong>and</strong> symptoms<br />
- fissuring, pruritus,vesiculation<br />
Global improvement<br />
Adverse events: a. 8 b. 18 burning, stinging, itching<br />
Notes<br />
Risk <strong>of</strong> bias<br />
Item Authors’ judgement Description<br />
Allocation concealment? Unclear B - Unclear<br />
<strong>Topical</strong> <strong>treatments</strong> <strong>for</strong> <strong>fungal</strong> <strong>infections</strong> <strong>of</strong> <strong>the</strong> <strong>skin</strong> <strong>and</strong> <strong>nails</strong> <strong>of</strong> <strong>the</strong> <strong>foot</strong>. (Review)<br />
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.<br />
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