Transplantation Immunology.pdf - E-Lib FK UWKS

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Contributors PAUL J. R. BARTON • National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, England J. ANDREW BRADLEY • Department of Surgery, University of Cambridge, Cambridge, Cambridgeshire, England CHRISTOPHER J. CALLAGHAN • Wellcome Trust Research Training Fellow, University Department of Surgery, Addenbrooke’s Hospital, Cambridge, England LOUISE COLLINS • Clinical Sciences, GKT School of Medicine, Kings College; The Rayne Institute, London, England AYESHA DE SOUZA • Transplant Immunology, National Heart and Lung Institute, Imperial College London; Heart Science Centre, Harefield Hospital, Harefield, Middlesex, England LEANNE E. FELKIN • National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, England PETER J. FRIEND • Nuffield Department of Surgery, John Radcliffe Hospital, Oxfordshire, Oxford, England LING GAO • Transplant Programme, Victor Chang Cardiac Research Institute, Sydney, Australia ALLAN R. GLANVILLE • Department of Thoracic Medicine, St. Vincent’s Hospital, Darlinghurst, New South Wales, Australia LUIS GRACA • Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxfordshire, Oxford, England MARIA P. HERNANDEZ-FUENTES • Immunoregulation Laboratory, Department of Nephrology and Transplantation, School of Medicine, Kings College London, University of London, London, England MARK HICKS • Heart and Lung Transplant Unit and Department of Clinical Pharmacology, St. Vincent’s Hospital, Sydney and Department of Physiology and Pharmacology, University of New South Wales, Australia ALFRED HING • Transplant Programme, Victor Chang Cardiac Research Institute, Sydney, Australia PHILIP HORNICK • Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College Hammersmith Campus, London, England ix
x Contributors PETER MARK ANTHONY HOPKINS • Queensland Heart-Lung Transplant Unit, The Prince Charles Hospital, Chermside, Brisbane, Queensland, Australia CHARLES J. IMBER • Queen Elizabeth Liver Unit, Queen Elizabeth Hospital, Birmingham, England JONATHAN R. T. LAKEY • Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada CHARLOTTE LAWSON • Veterinary Basic Sciences, The Royal Veterinary College, London, England PETER S. MACDONALD • Heart and Lung Transplant Unit, St. Vincent’s Hospital, Sydney and Transplant Programme, Victor Chang Cardiac Research Institute, Sydney, Australia EMMA MCGREGOR • Department of Vascular Surgery, Imperial College School of Medicine, Charing Cross Hospital, London, England MOHAMMADREZA MIRBOLOOKI • Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada KAY POULTON • Transplantation Laboratory, Central Manchester and Manchester, Children’s University Hospitals NHS Trust, Manchester Royal Infirmary, Manchester, England MARLENE ROSE • Heart Science Centre, National Heart and Lung Institute, Imperial College, Harefield Hospital, Harefield, England JONATHON RYAN • Heart and Lung Transplant Unit, St. Vincent’s Hospital, Sydney, Australia ALAN SALAMA • Renal Section, Division of Medicine, Hammersmith Hospital, Imperial College London, London, England A. M. JAMES SHAPIRO • Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada STEPHEN SHELDON • Transplantation Laboratory, Central Manchester and Manchester, Children’s University Hospitals NHS Trust, Manchester Royal Infirmary, Oxford Road, Manchester, England VICTOR C. SHI • Transplantational Research, Novartis Pharmaceutical Corp., Summit, NJ JOHN D. SMITH • Tissue Typing Laboratory, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Harefield, Middlesex, England BEZHAD SOLEIMANI • Cardiothoracic Surgery, National Heart and Lung Institute, London, England ANNE B. TAEGTMEYER • National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, England HERMAN WALDMANN • Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxfordshire, Oxford, England
Page 1 and 2: METHODS IN MOLECULAR BIOLOGY 333 T
Page 3 and 4: M E T H O D S I N M O L E C U L A R
Page 5 and 6: © 2006 Humana Press Inc. 999 River
Page 8 and 9: Contents Preface ..................
Page 12 and 13: Current Status of Renal Transplanta
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Page 41 and 42: METHODS IN MOLECULAR BIOLOGY 333 T
Page 43 and 44: 30 Friend and Imber meaningful surv
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Page 49 and 50: 36 Friend and Imber inotrope use, c
Page 51 and 52: 38 Friend and Imber very experience
Page 53 and 54: 40 Friend and Imber 14. Auxiliary L
Page 55 and 56: 42 Friend and Imber subsequent isol
Page 57 and 58: 44 Friend and Imber 21. Heffron, T.
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48 Lakey et al. There are an estima
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50 Lakey et al. diabetic to burn su
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52 Lakey et al. ber 31, 2000, less
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54 Lakey et al. Fig. 1. Schematic v
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56 Lakey et al. Table 1 Effect of I
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58 Lakey et al. from suitable donor
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60 Lakey et al. mined by high-perfo
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62 Lakey et al. Fig. 3. (A) Mean po
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64 Lakey et al. Fig. 5. HbA1c at 3-
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66 Lakey et al. All patients enjoy
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68 Lakey et al. 6. Sirolimus-based
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70 Lakey et al. Fig. 7. Two-layer (
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72 Table 2 Human Islet Transplantat
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74 Lakey et al. 3.4. Single-Donor I
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76 Lakey et al. difficult to isolat
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78 Lakey et al. 4.2. Islet Transpla
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80 Lakey et al. Table 3 Major Targe
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82 Lakey et al. CD40L (anti-CD154)
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84 Lakey et al. as kidney, heart, o
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86 Lakey et al. 14. Despres, J. P.,
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88 Lakey et al. tion despite a weak
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90 Lakey et al. 77. Maffi, P., Bert
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92 Lakey et al. 108. Idezuki, Y., G
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94 Lakey et al. 138. http://www.imm
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96 Lakey et al. tory reaction trigg
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98 Lakey et al. 198. O’Neil, J. J
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100 Lakey et al. 232. Delves, P. J.
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102 Lakey et al. 259. Grewal, I. S.
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Status of Lung Transplantation 105
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Chronic Rejection in the Heart 131
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Direct and Indirect Allorecognition
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HLA Typing and Organ Transplantatio
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Gene Transfer to Solid Organs 175 8
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Gene Transfer to Solid Organs 177 t
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Gene Transfer to Solid Organs 181
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183 Adenovirs (Ad) Nonenveloped vir
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Gene Transfer to Solid Organs 185 t
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Gene Transfer to Solid Organs 187 A
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Gene Transfer to Solid Organs 189 c
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202 Collins Table 1 Advantages and
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204 Collins The advantage of these
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206 Collins have used liposomal del
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208 Table 2 Ligands Used for Recept
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210 Collins It must not be forgotte
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212 Collins Fig. 3. Receptor-mediat
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214 Collins Receptor-mediated polyl
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216 Collins there are, to date, mor
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218 Collins 29. Niculescu-Duvaz, D.
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220 Collins 59. Wolfert, M. A. and
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222 Collins 91. Simoes, S., Slepush
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224 Collins 122. Hart, S. L., Harbo
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Antibody Relevance After Transplant
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248 Graca and Waldmann 2. The Use o
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250 Graca and Waldmann Fig. 1. Indu
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252 Graca and Waldmann Despite this
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254 Graca and Waldmann transforming
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256 Graca and Waldmann The role of
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258 Graca and Waldmann Fig. 5. A re
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260 Graca and Waldmann 4. Kahan, B.
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262 Graca and Waldmann 35. Powrie,
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264 Graca and Waldmann 67. Annacker
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266 Graca and Waldmann 96. Bommired
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Immune Monitoring in Transplantatio
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283 Table 1 Current and Potential F
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Proteomics and Laser Microdissectio
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Real-Time PCR 305 14 Real-Time Quan
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Real-Time PCR 307 Table 1 Real-Time
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Real-Time PCR 309 Fig. 2. Determina
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Real-Time PCR 311 such as Applied B
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Real-Time PCR 313 Table 2 Compariso
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315 Fig. 4. Quantification of RNA u
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Real-Time PCR 317 correlate directl
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319 Table 4 Common Internal Control
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321 Table 5 Examples of Single-Nucl
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Real-Time PCR 323 3.2. Real-Time PC
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Real-Time PCR 325 3.3.2. Sources of
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Real-Time PCR 327 9. Barton, P. J.
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Real-Time PCR 329 40. Primer expres
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Organ Preservation 331 15 Organ Pre
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Organ Preservation 333 2. Managemen
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Organ Preservation 335 tal observat
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Organ Preservation 337 donors, depe
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Organ Preservation 339 Table 1 Lung
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Organ Preservation 341 obtained wit
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Organ Preservation 343 Fig. 2. Acti
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Organ Preservation 345 Fig. 3. Outl
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Organ Preservation 347 and related
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Organ Preservation 349 mic, ischemi
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Organ Preservation 351 While these
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Organ Preservation 353 experimental
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Organ Preservation 355 with inhaled
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Organ Preservation 357 cellular sol
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Organ Preservation 359 4. Rosengard
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Organ Preservation 361 35. Powner,
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Organ Preservation 363 64. Hendry,
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Organ Preservation 365 factor-media
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Organ Preservation 367 120. Bonser,
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Organ Preservation 369 150. Macdona
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Organ Preservation 371 180. Carbogn
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209. Szabo, G., Soos, P., Bahrle, S
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376 Hopkins the extent of cold isch
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378 Hopkins or sequential administr
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380 Hopkins Table 2 Current Availab
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382 Hopkins 2. Renal failure: acute
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384 Table 4 Comparison of Azathiopr
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386 Hopkins Table 6 Side-Effect Pro
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388 Hopkins baseline immunosuppress
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390 Hopkins supplement to maintenan
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392 Hopkins 3. Kauppinen, H., Soots
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394 Hopkins uline versus no inducti
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396 Hopkins 62. Mycophenolate Mofet
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398 Hopkins 89. Mentzer, R. M., Jah
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Experimental Models of Graft Arteri
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405 Fig. 1. Variation in GA severit
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