Current Status of Renal <strong>Transplantation</strong> 23 59. Calne, R. Y. (1987) Cyclosporin in cadaveric renal transplantation: 5-year follow-up of a multicentre trial. Lancet. 2, 506–507. 60. Curtis, J. J., Barbeito, R., Pirsch, J., Lewis, R. M., Van Buren, D. H., and Choudhury, S. (1999) Differences in bioavailability between oral cyclosporine formulations in maintenance renal transplant patients. Am. J. Kidney Dis. 34, 869–874. 61. Knoll, G. A. and Bell, R. C. (1999) Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. BMJ 318, 1104–1107. 62. Halloran, P., Mathew, T., Tomlanovich, S., Groth, C., Hooftman, L., and Barker, C. (1997) Mycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The International Mycophenolate Mofetil Renal Transplant Study Groups. <strong>Transplantation</strong> 63, 39–47. 63. Birkeland, S. A. (2001) Steroid-free immunosuppression in renal transplantation: a long-term follow-up of 100 consecutive patients. <strong>Transplantation</strong> 71, 1089–1090. 64. Ahsan, N., Hricik, D., Matas, A., et al. (1999) Prednisone withdrawal in kidney transplant recipients on cyclosporine and mycophenolate mofetil—a prospective randomized study. Steroid Withdrawal Study Group. <strong>Transplantation</strong> 68, 1865– 1874. 65. Oberbauer, R., Kreis, H., Johnson, R. W., et al.; Rapamune Maintenance Regimen Study Group. (2003) Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study. <strong>Transplantation</strong> 76, 364–370. 66. Watson, C. J. (2001) Sirolimus (rapamycin) in clinical transplantation. Transplant. Rev. 15, 165–168. 67. Humar, A., Kerr, S., Gillingham, K. J., and Matas, A. J. (1999) Features of acute rejection that increase risk for chronic rejection. <strong>Transplantation</strong> 68, 1200–1203. 68. Furness, P. N., Philpott, C. M., Chorbadjian, M. T., et al. (2003) Protocol biopsy of the stable renal transplant: a multicenter study of methods and complication rates. <strong>Transplantation</strong> 76, 969–973. 69. Racusen, L. C., Colvin, R. B., Solez, K., et al. (2003) Antibody-mediated rejection criteria—an addition to the Banff 97 classification of renal allograft rejection. Am. J. Transplant. 3, 708–714. 70. Racusen, L. C., Solez, K., Colvin, R. B., et al. (1999) The Banff 97 working classification of renal allograft pathology. Kidney Int. 55, 713–723. 71. Roberts, I. S., Reddy, S., Russell, C., et al. (2004) Subclinical rejection and borderline changes in early protocol biopsy specimens after renal transplantation. <strong>Transplantation</strong> 77, 1194–1198. 72. Legendre, C., Thervet, E., Skhiri, H., et al. (1998) Histologic features of chronic allograft nephropathy revealed by protocol biopsies in kidney transplant recipients. <strong>Transplantation</strong> 65, 1506–1509. 73. Rush, D., Nickerson, P., Gough, J., et al. (1998) Beneficial effects of treatment of early subclinical rejection: a randomized study. J. Am. Soc. Nephrol. 9, 2129– 2134.
24 Callaghan and Bradley 74. Matas, A. J., Gillingham, K. J., Payne, W. D., and Najarian, J. S. (1994) The impact of an acute rejection episode on long-term renal allograft survival (t1/2). <strong>Transplantation</strong> 57, 857–859. 75. Simon, T., Opelz, G., Wiesel, M., Ott, R. C., and Susal, C. (2003) Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients. Am. J. Transplant. 3, 1121–1127. 76. Vasconcellos, L. M., Schachter, A. D., Zheng, X. X., et al. (1998) Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. <strong>Transplantation</strong> 66, 562–566. 77. Lederer, S. R., Friedrich, N., Regenbogen, C., Getto, R., Toepfer, M., and Sitter, T. (2003) Non-invasive monitoring of renal transplant recipients: urinary excretion of soluble adhesion molecules and of the complement-split product C4d. Nephron Clin. Pract. 94, 19–26. 78. Magee, C. C., Denton, M. D., Womer, K. L., Khoury, S. J., and Sayegh, M. H. (2004) Assessment by flow cytometry of intracellular cytokine production in the peripheral blood cells of renal transplant recipients. Clin. Transplant. 18, 395– 401. 79. Hricik, D. E., Rodriguez, V., Riley, J., et al. (2003) Enzyme linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients. Am. J. Transplant. 3, 878–884. 80. Gaber, A. O., First, M. R., Tesi, R. J., et al. (1998) Results of the double-blind, randomized, multicenter, phase III clinical trial of thymoglobulin versus Atgam in the treatment of acute graft rejection episodes after renal transplantation. <strong>Transplantation</strong> 66, 29–37. 81. Midtvedt, K., Fauchald, P., Lien, B., et al. (2003) Individualized T cell monitored administration of ATG versus OKT3 in steroid-resistant kidney graft rejection. Clin. Transplant. 17, 69–74. 82. Casadei, D. H., del C Rial, M., Opelz, G., et al. (2001) A randomized and prospective study comparing treatment with high-dose intravenous immunoglobulin with monoclonal antibodies for rescue of kidney grafts with steroid-resistant rejection. <strong>Transplantation</strong> 71, 53–58. 83. Vincenti, F., Kirkman, R., Light, S., et al. (1998) Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group. N. Engl. J. Med. 338,161–165. 84. Nashan, B., Moore, R., Amlot, P., Schmidt, A. G., Abeywickrama, K., and Soulillou, J. P. (1997) Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. CHIB 201 International Study Group. Lancet 350, 1193–1198. 85. Chilcott, J. B., Holmes, M. W., Walters, S., Akehurst, R. L., and Nashan, B. (2002) The economics of basiliximab (Simulect) in preventing acute rejection in renal transplantation. Transplant. Int. 15, 486–493. 86. Lederer, S. R., Kluth-Pepper, B., Schneeberger, H., Albert, E., Land, W., and Feucht, H. E. (2001) Impact of humoral alloreactivity early after transplantation on the long-term survival of renal allografts. Kidney Int. 59, 334–341.
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- Page 8 and 9: Contents Preface ..................
- Page 10 and 11: Contributors PAUL J. R. BARTON •
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- Page 43 and 44: 30 Friend and Imber meaningful surv
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- Page 49 and 50: 36 Friend and Imber inotrope use, c
- Page 51 and 52: 38 Friend and Imber very experience
- Page 53 and 54: 40 Friend and Imber 14. Auxiliary L
- Page 55 and 56: 42 Friend and Imber subsequent isol
- Page 57 and 58: 44 Friend and Imber 21. Heffron, T.
- Page 59 and 60: 46 Friend and Imber 53. Saudubray,
- Page 61 and 62: 48 Lakey et al. There are an estima
- Page 63 and 64: 50 Lakey et al. diabetic to burn su
- Page 65 and 66: 52 Lakey et al. ber 31, 2000, less
- Page 67 and 68: 54 Lakey et al. Fig. 1. Schematic v
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- Page 75 and 76: 62 Lakey et al. Fig. 3. (A) Mean po
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- Page 79 and 80: 66 Lakey et al. All patients enjoy
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72 Table 2 Human Islet Transplantat
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74 Lakey et al. 3.4. Single-Donor I
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76 Lakey et al. difficult to isolat
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78 Lakey et al. 4.2. Islet Transpla
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80 Lakey et al. Table 3 Major Targe
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82 Lakey et al. CD40L (anti-CD154)
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84 Lakey et al. as kidney, heart, o
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86 Lakey et al. 14. Despres, J. P.,
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88 Lakey et al. tion despite a weak
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90 Lakey et al. 77. Maffi, P., Bert
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92 Lakey et al. 108. Idezuki, Y., G
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94 Lakey et al. 138. http://www.imm
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96 Lakey et al. tory reaction trigg
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98 Lakey et al. 198. O’Neil, J. J
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100 Lakey et al. 232. Delves, P. J.
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102 Lakey et al. 259. Grewal, I. S.
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Status of Lung Transplantation 105
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Status of Lung Transplantation 107
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Status of Lung Transplantation 109
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Status of Lung Transplantation 111
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Status of Lung Transplantation 113
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Status of Lung Transplantation 115
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Status of Lung Transplantation 117
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Status of Lung Transplantation 119
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Status of Lung Transplantation 121
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Status of Lung Transplantation 123
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Status of Lung Transplantation 125
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Status of Lung Transplantation 127
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Status of Lung Transplantation 129
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Chronic Rejection in the Heart 131
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Chronic Rejection in the Heart 133
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Chronic Rejection in the Heart 135
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Chronic Rejection in the Heart 137
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Chronic Rejection in the Heart 139
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Chronic Rejection in the Heart 141
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Chronic Rejection in the Heart 143
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Direct and Indirect Allorecognition
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Direct and Indirect Allorecognition
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Direct and Indirect Allorecognition
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Direct and Indirect Allorecognition
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Direct and Indirect Allorecognition
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Direct and Indirect Allorecognition
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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HLA Typing and Organ Transplantatio
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Gene Transfer to Solid Organs 175 8
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Gene Transfer to Solid Organs 177 t
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Gene Transfer to Solid Organs 179 5
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Gene Transfer to Solid Organs 181
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183 Adenovirs (Ad) Nonenveloped vir
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Gene Transfer to Solid Organs 185 t
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Gene Transfer to Solid Organs 187 A
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Gene Transfer to Solid Organs 189 c
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Gene Transfer to Solid Organs 191 2
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Gene Transfer to Solid Organs 193 5
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Gene Transfer to Solid Organs 195 8
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Gene Transfer to Solid Organs 197 1
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Gene Transfer to Solid Organs 199 1
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202 Collins Table 1 Advantages and
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204 Collins The advantage of these
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206 Collins have used liposomal del
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208 Table 2 Ligands Used for Recept
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210 Collins It must not be forgotte
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212 Collins Fig. 3. Receptor-mediat
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214 Collins Receptor-mediated polyl
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216 Collins there are, to date, mor
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218 Collins 29. Niculescu-Duvaz, D.
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220 Collins 59. Wolfert, M. A. and
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222 Collins 91. Simoes, S., Slepush
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224 Collins 122. Hart, S. L., Harbo
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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Antibody Relevance After Transplant
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248 Graca and Waldmann 2. The Use o
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250 Graca and Waldmann Fig. 1. Indu
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252 Graca and Waldmann Despite this
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254 Graca and Waldmann transforming
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256 Graca and Waldmann The role of
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258 Graca and Waldmann Fig. 5. A re
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260 Graca and Waldmann 4. Kahan, B.
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262 Graca and Waldmann 35. Powrie,
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264 Graca and Waldmann 67. Annacker
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266 Graca and Waldmann 96. Bommired
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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283 Table 1 Current and Potential F
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Immune Monitoring in Transplantatio
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Proteomics and Laser Microdissectio
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Proteomics and Laser Microdissectio
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Proteomics and Laser Microdissectio
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Proteomics and Laser Microdissectio
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Proteomics and Laser Microdissectio
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Proteomics and Laser Microdissectio
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Proteomics and Laser Microdissectio
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Real-Time PCR 305 14 Real-Time Quan
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Real-Time PCR 307 Table 1 Real-Time
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Real-Time PCR 309 Fig. 2. Determina
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Real-Time PCR 311 such as Applied B
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Real-Time PCR 313 Table 2 Compariso
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315 Fig. 4. Quantification of RNA u
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Real-Time PCR 317 correlate directl
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319 Table 4 Common Internal Control
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321 Table 5 Examples of Single-Nucl
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Real-Time PCR 323 3.2. Real-Time PC
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Real-Time PCR 325 3.3.2. Sources of
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Real-Time PCR 327 9. Barton, P. J.
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Real-Time PCR 329 40. Primer expres
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Organ Preservation 331 15 Organ Pre
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Organ Preservation 333 2. Managemen
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Organ Preservation 335 tal observat
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Organ Preservation 337 donors, depe
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Organ Preservation 339 Table 1 Lung
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Organ Preservation 341 obtained wit
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Organ Preservation 343 Fig. 2. Acti
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Organ Preservation 345 Fig. 3. Outl
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Organ Preservation 347 and related
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Organ Preservation 349 mic, ischemi
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Organ Preservation 351 While these
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Organ Preservation 353 experimental
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Organ Preservation 355 with inhaled
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Organ Preservation 357 cellular sol
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Organ Preservation 359 4. Rosengard
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Organ Preservation 361 35. Powner,
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Organ Preservation 363 64. Hendry,
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Organ Preservation 365 factor-media
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Organ Preservation 367 120. Bonser,
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Organ Preservation 369 150. Macdona
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Organ Preservation 371 180. Carbogn
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209. Szabo, G., Soos, P., Bahrle, S
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376 Hopkins the extent of cold isch
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378 Hopkins or sequential administr
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380 Hopkins Table 2 Current Availab
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382 Hopkins 2. Renal failure: acute
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384 Table 4 Comparison of Azathiopr
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386 Hopkins Table 6 Side-Effect Pro
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388 Hopkins baseline immunosuppress
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390 Hopkins supplement to maintenan
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392 Hopkins 3. Kauppinen, H., Soots
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394 Hopkins uline versus no inducti
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396 Hopkins 62. Mycophenolate Mofet
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398 Hopkins 89. Mentzer, R. M., Jah
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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405 Fig. 1. Variation in GA severit
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri
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Experimental Models of Graft Arteri