Transplantation Immunology.pdf - E-Lib FK UWKS

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Contents Preface ..............................................................................................................v Contributors .....................................................................................................ix 1 Current Status of Renal Transplantation Christopher J. Callaghan and J. Andrew Bradley ................................. 1 2 Current Status of Liver Transplantation Peter J. Friend and Charles J. Imber ................................................... 29 3 Current Status of Clinical Islet Cell Transplantation Jonathan R. T. Lakey, Mohammadreza Mirbolooki, and A. M. James Shapiro ................................................................ 47 4 Current Status of Lung Transplantation Allan R. Glanville .............................................................................. 105 5 Chronic Rejection in the Heart Philip Hornick and Marlene Rose ..................................................... 131 6 Direct and Indirect Allorecognition Philip Hornick ................................................................................... 145 7 HLA Typing and Its Influence on Organ Transplantation Stephen Sheldon and Kay Poulton .................................................... 157 8 Strategies for Gene Transfer to Solid Organs: Viral Vectors Charlotte Lawson .............................................................................. 175 9 Nonviral Vectors Louise Collins .................................................................................... 201 10 Detection and Clinical Relevance of Antibodies After Transplantation John D. Smith and Marlene Rose ...................................................... 227 11 Reprogramming the Immune System Using Antibodies Luis Graca and Herman Waldmann ................................................. 247 12 In Vitro Assays for Immune Monitoring in Transplantation Maria P. Hernandez-Fuentes and Alan Salama ................................ 269 13 Proteomics and Laser Microdissection Emma McGregor and Ayesha De Souza ........................................... 291 vii
viii Contents 14 Real-Time Quantitative Polymerase Chain Reaction in Cardiac Transplant Research Leanne E. Felkin, Anne B. Taegtmeyer, and Paul J. R. Barton.......... 305 15 Organ Preservation Mark Hicks, Alfred Hing, Ling Gao, Jonathon Ryan, and Peter S. MacDonald ............................................................... 331 16 Pharmacological Manipulation of the Rejection Response Peter Mark Anthony Hopkins ........................................................... 375 17 Experimental Models of Graft Arteriosclerosis Bezhad Soleimani and Victor C. Shi ................................................. 401 Index ............................................................................................................ 425
Page 1 and 2: METHODS IN MOLECULAR BIOLOGY 333 T
Page 3 and 4: M E T H O D S I N M O L E C U L A R
Page 5 and 6: © 2006 Humana Press Inc. 999 River
Page 10 and 11: Contributors PAUL J. R. BARTON •
Page 12 and 13: Current Status of Renal Transplanta
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Page 43 and 44: 30 Friend and Imber meaningful surv
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44 Friend and Imber 21. Heffron, T.
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46 Friend and Imber 53. Saudubray,
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48 Lakey et al. There are an estima
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50 Lakey et al. diabetic to burn su
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52 Lakey et al. ber 31, 2000, less
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54 Lakey et al. Fig. 1. Schematic v
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56 Lakey et al. Table 1 Effect of I
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58 Lakey et al. from suitable donor
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60 Lakey et al. mined by high-perfo
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62 Lakey et al. Fig. 3. (A) Mean po
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64 Lakey et al. Fig. 5. HbA1c at 3-
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66 Lakey et al. All patients enjoy
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68 Lakey et al. 6. Sirolimus-based
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70 Lakey et al. Fig. 7. Two-layer (
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72 Table 2 Human Islet Transplantat
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74 Lakey et al. 3.4. Single-Donor I
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76 Lakey et al. difficult to isolat
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78 Lakey et al. 4.2. Islet Transpla
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80 Lakey et al. Table 3 Major Targe
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82 Lakey et al. CD40L (anti-CD154)
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84 Lakey et al. as kidney, heart, o
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86 Lakey et al. 14. Despres, J. P.,
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88 Lakey et al. tion despite a weak
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90 Lakey et al. 77. Maffi, P., Bert
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92 Lakey et al. 108. Idezuki, Y., G
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94 Lakey et al. 138. http://www.imm
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96 Lakey et al. tory reaction trigg
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98 Lakey et al. 198. O’Neil, J. J
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100 Lakey et al. 232. Delves, P. J.
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102 Lakey et al. 259. Grewal, I. S.
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Status of Lung Transplantation 105
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Chronic Rejection in the Heart 131
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Direct and Indirect Allorecognition
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HLA Typing and Organ Transplantatio
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Gene Transfer to Solid Organs 175 8
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Gene Transfer to Solid Organs 177 t
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Gene Transfer to Solid Organs 181
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183 Adenovirs (Ad) Nonenveloped vir
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Gene Transfer to Solid Organs 185 t
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Gene Transfer to Solid Organs 187 A
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Gene Transfer to Solid Organs 189 c
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202 Collins Table 1 Advantages and
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204 Collins The advantage of these
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206 Collins have used liposomal del
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208 Table 2 Ligands Used for Recept
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210 Collins It must not be forgotte
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212 Collins Fig. 3. Receptor-mediat
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214 Collins Receptor-mediated polyl
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216 Collins there are, to date, mor
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218 Collins 29. Niculescu-Duvaz, D.
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220 Collins 59. Wolfert, M. A. and
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222 Collins 91. Simoes, S., Slepush
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224 Collins 122. Hart, S. L., Harbo
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Antibody Relevance After Transplant
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248 Graca and Waldmann 2. The Use o
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250 Graca and Waldmann Fig. 1. Indu
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252 Graca and Waldmann Despite this
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254 Graca and Waldmann transforming
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256 Graca and Waldmann The role of
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258 Graca and Waldmann Fig. 5. A re
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260 Graca and Waldmann 4. Kahan, B.
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262 Graca and Waldmann 35. Powrie,
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264 Graca and Waldmann 67. Annacker
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266 Graca and Waldmann 96. Bommired
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Immune Monitoring in Transplantatio
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283 Table 1 Current and Potential F
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Proteomics and Laser Microdissectio
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Real-Time PCR 305 14 Real-Time Quan
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Real-Time PCR 307 Table 1 Real-Time
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Real-Time PCR 309 Fig. 2. Determina
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Real-Time PCR 311 such as Applied B
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Real-Time PCR 313 Table 2 Compariso
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315 Fig. 4. Quantification of RNA u
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Real-Time PCR 317 correlate directl
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319 Table 4 Common Internal Control
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321 Table 5 Examples of Single-Nucl
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Real-Time PCR 323 3.2. Real-Time PC
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Real-Time PCR 325 3.3.2. Sources of
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Real-Time PCR 327 9. Barton, P. J.
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Real-Time PCR 329 40. Primer expres
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Organ Preservation 331 15 Organ Pre
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Organ Preservation 333 2. Managemen
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Organ Preservation 335 tal observat
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Organ Preservation 337 donors, depe
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Organ Preservation 339 Table 1 Lung
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Organ Preservation 341 obtained wit
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Organ Preservation 343 Fig. 2. Acti
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Organ Preservation 345 Fig. 3. Outl
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Organ Preservation 347 and related
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Organ Preservation 349 mic, ischemi
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Organ Preservation 351 While these
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Organ Preservation 353 experimental
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Organ Preservation 355 with inhaled
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Organ Preservation 357 cellular sol
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Organ Preservation 359 4. Rosengard
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Organ Preservation 361 35. Powner,
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Organ Preservation 363 64. Hendry,
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Organ Preservation 365 factor-media
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Organ Preservation 367 120. Bonser,
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Organ Preservation 369 150. Macdona
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Organ Preservation 371 180. Carbogn
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209. Szabo, G., Soos, P., Bahrle, S
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376 Hopkins the extent of cold isch
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378 Hopkins or sequential administr
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380 Hopkins Table 2 Current Availab
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382 Hopkins 2. Renal failure: acute
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384 Table 4 Comparison of Azathiopr
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386 Hopkins Table 6 Side-Effect Pro
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388 Hopkins baseline immunosuppress
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390 Hopkins supplement to maintenan
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392 Hopkins 3. Kauppinen, H., Soots
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394 Hopkins uline versus no inducti
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396 Hopkins 62. Mycophenolate Mofet
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398 Hopkins 89. Mentzer, R. M., Jah
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Experimental Models of Graft Arteri
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405 Fig. 1. Variation in GA severit
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