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The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

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Toxicophore development<br />

• <strong>The</strong> next step was to prioritise the toxicophores,<br />

using a weight <strong>of</strong> evidence approach<br />

• Prioritised toxicophores were then further<br />

developed using information in the published<br />

literature including<br />

� Mechanistic evidence<br />

� Additional example compounds

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