The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
<strong>Chromosomal</strong> effect mechanisms<br />
Disruption or inhibition <strong>of</strong> DNA synthesis or repair<br />
Spindle function disruption<br />
Generation <strong>of</strong> reactive oxygen species<br />
Energy depletion<br />
Thiol reactivity<br />
Intercalation<br />
HO<br />
Vinca alkaloids:<br />
Numerical chromosomal aberrations<br />
N<br />
H<br />
O<br />
O<br />
O<br />
N<br />
N<br />
OH<br />
H<br />
N<br />
OH<br />
H<br />
O O<br />
O<br />
(Vinblastine)<br />
Di- or tri-phenylethylenes:<br />
Numerical chromosomal aberrations<br />
OH<br />
O<br />
(Diethylstilbestrol)
Change language