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The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

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Derek for Windows<br />

• Derek for Windows is a knowledge-based expert system<br />

that predicts the toxicity <strong>of</strong> a compound from its<br />

chemical structure<br />

• <strong>Prediction</strong>s are qualitative <strong>and</strong> based upon structural<br />

alerts, rules <strong>and</strong> examples<br />

• A broad range <strong>of</strong> toxicological endpoints are covered<br />

� Carcinogenicity<br />

� Genotoxicity<br />

� Hepatotoxicity<br />

� HERG channel inhibition<br />

� Reproductive toxicity<br />

� Skin sensitisation

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