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The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

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<strong>Chromosomal</strong> effect mechanisms<br />

Disruption or inhibition <strong>of</strong> DNA synthesis or repair<br />

Spindle function disruption<br />

Generation <strong>of</strong> reactive oxygen species<br />

Energy depletion<br />

Thiol reactivity<br />

Intercalation<br />

Polynitrophenols:<br />

Uncoupling <strong>of</strong> oxidative phosphorylation<br />

O 2 N<br />

OH<br />

NO 2<br />

(2,4-Dinitrophenol)

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