The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
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<strong>Chromosomal</strong> effect mechanisms<br />
Disruption or inhibition <strong>of</strong> DNA synthesis or repair<br />
Spindle function disruption<br />
Generation <strong>of</strong> reactive oxygen species<br />
Energy depletion<br />
Thiol reactivity<br />
Intercalation<br />
Psoralens:<br />
Disruption <strong>of</strong> DNA helix<br />
O<br />
O O O<br />
Hydroxyanthraquinones:<br />
Disruption <strong>of</strong> DNA helix<br />
OH O OH<br />
O<br />
(5-Methoxypsoralen)<br />
(Danthron)
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